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Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from lawsone
(5 June 202)
Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bisnapthoquinone ...
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials
(09 October)
b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All
compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical
spectral data. Then, ...
Synthesis and docking calculations of tetrafluoronaphthalene derivatives and their inhibition profiles against some metabolic enzymes
(5 February)
Syntheses of tetrahydroepoxy, O‐allylic, O‐prenylic, and O‐propargylic tetrafluoronaphthalene
derivatives, starting from 1‐bromo‐2,3,4,5,6‐pentafluorobenzene,
are reported here for the first time. The O‐substituted ...
1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
(09.12.2020)
In recent years, acetylcholinesterase (AChE) and a-glycosidase (a-gly) inhibition have emerged as a
promising and important approach for pharmacological intervention in many diseases such as glaucoma,
epilepsy, obesity, ...
Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentials
(Journal of Biomolecular Structure and Dynamics, 04.10.2020)
Gallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer
of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically
active ...
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and a-glycosidase enzymes inhibitors
(26.08.2020)
In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general
and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ...
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and α-glycosidase enzymes inhibitors
(27.08.2020)
In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general
and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ...
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
(Journal of Molecular Structure, 8 October )
In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ...