dc.contributor.author | Abadoglu, Oznur | |
dc.contributor.author | Berk, Serdar | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:11Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:11Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1752-6981 | |
dc.identifier.issn | 1752-699X | |
dc.identifier.uri | https://dx.doi.org/10.1111/crj.12230 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7274 | |
dc.description | WOS: 000379940400002 | en_US |
dc.description | PubMed ID: 25335652 | en_US |
dc.description.abstract | Background and AimsSome patients with asthma have poorly controlled disease despite the use of high-dose inhaled corticosteroids (ICS), long-acting 2 agonists (LABAs) and antileukotrienes. The aim of the study was to assess the effectiveness of tiotropium as an add-on therapy to the standard treatment with high-dose ICS/LABA on asthma control and lung function in patients with severe asthma. MethodsOf the 633 asthmatic patients, 64 (10.1%) patients with severe asthma who were add-on treated at least for 3 months were evaluated. Number of exacerbations, emergency department visits, hospitalizations and lung functions of patients belonging to 12 months before starting add-on treatment were compared with those of 12 months after starting add-on treatment. ResultsThe mean duration of add-on tiotropium treatment was 8.30.5 months. For patients with severe asthma that was poorly controlled with standard combination therapy, tiotropium improved asthma control in 42.2%, decreased the number of emergency department visits in 46.9% and decreased the number of hospitalizations in 50.0% of them. The mean baseline forced expiratory volume in 1s before add-on tiotropium was 57.5 +/- 1.9% and forced vital capacity was 74.3 +/- 15.6%. However, after 12 months of add-on tiotropium treatment, these rates became 65.5 +/- 1.9% and 82.5 +/- 15.1%, respectively. The addition of tiotropium significantly improved the percentages of the number of emergency department visits, the number of hospitalizations (P<0.05). ConclusionOur study has suggested that, for patients with poorly controlled asthma despite of the use of ICS/LABA, the addition of tiotropium to standard care may be beneficial. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/crj.12230 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | airway obstruction | en_US |
dc.subject | asthma | en_US |
dc.subject | high-dose inhaled steroid | en_US |
dc.subject | tiotropium | en_US |
dc.title | Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the real-life data | en_US |
dc.type | article | en_US |
dc.relation.journal | CLINICAL RESPIRATORY JOURNAL | en_US |
dc.contributor.department | [Abadoglu, Oznur] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Subdept Immunol & Allergy Dis, TR-58000 Sivas, Turkey -- [Berk, Serdar] Cumhuriyet Univ, Fac Med, Dept Chest Dis, Sivas, Turkey | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 427 | en_US |
dc.identifier.startpage | 421 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |