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Crizotinib-induced toxicity in an experimental rat model

dc.contributor.authorGumusay, Ozge
dc.contributor.authorEsendagli-Yilmaz, Guldal
dc.contributor.authorUner, Aytug
dc.contributor.authorCetin, Bulent
dc.contributor.authorBuyukberber, Suleyman
dc.contributor.authorBenekli, Mustafa
dc.contributor.authorIlhan, Mustafa N.
dc.contributor.authorCoskun, Ugur
dc.contributor.authorGulbahar, Ozlem
dc.contributor.authorOzet, Ahmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:45:19Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:45:19Z
dc.date.issued2016
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.urihttps://dx.doi.org/10.1007/s00508-016-0984-y
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7304
dc.descriptionWOS: 000378779800006en_US
dc.descriptionPubMed ID: 26975454en_US
dc.description.abstractThe aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model. Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.en_US
dc.language.isoengen_US
dc.publisherSPRINGER WIENen_US
dc.relation.isversionof10.1007/s00508-016-0984-yen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCrizotiniben_US
dc.subjectRaten_US
dc.subjectToxicityen_US
dc.subjectPulmonary intraalveolar hemorrhageen_US
dc.titleCrizotinib-induced toxicity in an experimental rat modelen_US
dc.typearticleen_US
dc.relation.journalWIENER KLINISCHE WOCHENSCHRIFTen_US
dc.contributor.department[Gumusay, Ozge] Gaziosmanpasa Univ, Div Med Oncol, Dept Internal Med, Fac Med, TR-60250 Tokat, Turkey -- [Esendagli-Yilmaz, Guldal] Gazi Univ, Dept Med Pathol, Fac Med, Ankara, Turkey -- [Uner, Aytug -- Buyukberber, Suleyman -- Benekli, Mustafa -- Coskun, Ugur -- Ozet, Ahmet] Gazi Univ, Div Med Oncol, Dept Internal Med, Fac Med, Ankara, Turkey -- [Cetin, Bulent] Cumhuriyet Univ Sivas, Div Med Oncol, Dept Internal Med, Sivas, Turkey -- [Ilhan, Mustafa N.] Gazi Univ, Dept Publ Hlth, Fac Med, Ankara, Turkey -- [Gulbahar, Ozlem] Gazi Univ, Dept Biochem, Fac Med, Ankara, Turkeyen_US
dc.contributor.authorIDbenekli, mustafa -- 0000-0003-3184-4946en_US
dc.identifier.volume128en_US
dc.identifier.issue11.Decen_US
dc.identifier.endpage441en_US
dc.identifier.startpage435en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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