dc.contributor.author | Beton, Osman | |
dc.contributor.author | Kurmus, Ozge | |
dc.contributor.author | Asarcikli, Lale Dinc | |
dc.contributor.author | Alibazoglu, Buket | |
dc.contributor.author | Alibazoglu, Haluk | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:45:27Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:45:27Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1790-5427 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7336 | |
dc.description | WOS: 000383469400010 | en_US |
dc.description | PubMed ID: 27331209 | en_US |
dc.description.abstract | Objective: We aimed to differentiate ischemic heart failure (HF) from non-ischemic HF in patients presenting with non-acute onset exertional dyspnea using technetium-99m methoxyisobutylisonitrile gated single photon emission tomography (Tc-99m-MIBI gSPET) imaging. Subjects and Methods: One hundred and seventy nine consecutive patients with exertional dyspnea without concomitant chest pain referred to Tc-99m-MIBI gSPET imaging were included in this study. All patients had a newly diagnosed HF with reduced ejection fraction (HFrEF). Imaging findings were compared between ischemic HF and non-ischemic HF groups. Results: Of the 179 patients, 127 had ischemic HF and 52 had non-ischemic HF. There was no difference between ischemic and non-ischemic groups in terms of age, gender, body mass index, any smoking history, diabetes mellitus, history of hypertension and hyperlipidemia. Global dysfunction of left ventricle was more common in non-ischemic HF group than ischemic HF group (82.7% vs 41.7% respectively, P<0.001). Presence of severe (3+/4+) ischemia and large perfusion defect were higher in ischemic HF group compared to non-ischemic HF group (45.7% vs 15.4%, P<0.001 and 23.6% vs 3.8%, P=0.003, respectively). Summed stress score (SSS), summed rest score and summed difference score were higher in ischemic HF group compared to non-ischemic HF group (P<0.001, P<0.001, and P=0.021, respectively). In multivariate analysis, absence of global dysfunction (P<0.001, OR=10.338, 95% CI: 3.937-27.405) and SSS (P<0.001, OR=1.208, 95% CI: 1.090-1.339) were the independent predictors of ischemic HF. Absence of global dysfunction had 58.3% sensitivity and 86.7% specificity for diagnosis of ischemic HF at gSPET imaging in patients presenting with newly diagnosed HF and exertional dyspnea without concomitant chest pain (AUC=0.705, 95% CI: 0.632-0.771, P<0.001), whereas SSS>8 had 65.4% sensitivity and 75.0% specificity (AUC=0.732, 95% CI: 0.661-0.795, P<0.001). Conclusion: Absence of global dysfunction and SSS on SPET imaging were the independent predictors of ischemic etiology of HF presenting with dyspnea without concomitant chest pain. These findings had a low sensitivity, but acceptable specificity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | HELLENIC SOC NUCLEAR MEDICINE | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Single photon emission tomography | en_US |
dc.subject | Newly diagnosed heart failure with reduced ejection fraction | en_US |
dc.subject | Exertional dyspnea without chest pain | en_US |
dc.subject | Ishemic Non-ischemic | en_US |
dc.title | The practical value of technetium-99m-MIBI SPET to differentiate between ischemic and non-ischemic heart failure presenting with exertional dyspnea | en_US |
dc.type | article | en_US |
dc.relation.journal | HELLENIC JOURNAL OF NUCLEAR MEDICINE | en_US |
dc.contributor.department | [Beton, Osman -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Ctr Heart, Dept Cardiol, TR-58140 Sivas, Turkey -- [Kurmus, Ozge] Tarsus State Hosp, Dept Cardiol, Mersin, Turkey -- [Asarcikli, Lale Dinc] Diskapi Yildirim Beyazit Res & Training Hosp, Dept Cardiol, Ankara, Turkey -- [Alibazoglu, Buket -- Alibazoglu, Haluk] CardioCheck Nucl Imaging Ctr, Ankara, Turkey -- [Alibazoglu, Haluk] Cleveland Clin Abu Dhabi, Imaging Inst, Dept Nucl Med, Abu Dhabi, U Arab Emirates | en_US |
dc.contributor.authorID | YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628 | en_US |
dc.identifier.volume | 19 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.endpage | 154 | en_US |
dc.identifier.startpage | 147 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |