Synthesis of Diflunisal Thiazolidinones as Anticancer Agents
Tarih
2016Yazar
Senkardes, SevilOzakpinar, Ozlem B.
Ozsavci, Derya
Sener, Azize
Cevik, Ozge
Kucukguzel, S. Guniz
Üst veri
Tüm öğe kaydını gösterÖzet
A series of diflunisal 4-thiazolidinones were synthesized. Some selected compounds were determined at one dose towards the full panel of 60 human cancer cell lines by National Cancer Institute. 2',4'-Difluoro-4-hydroxy-N-[4-oxo-2-(thiophen-2-yl)-1,3-thiazolidin-3-yl]biphenyl-3-carboxamide (4a) demonstrated the most marked effect on K-562 cancer cell line with 58.59 % growth inhibition at 10 mu M. Compound 4a was evaluated in vitro using the MTT colorimetric method against human leukemia cell line K-562 and mouse embryonic fibroblasts cell line NIH-3T3 at different doses for cell viability and growth inhibition. Compound 4a exhibited anticancer activity with IC50 value of 5.2 mu M against K-562 cells and did not display cytotoxicity towards NIH-3T3 cells compared with diflunisal. In addition, this compound could be an interesting prototype as an antiproliferative agent.
Kaynak
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRYCilt
16Sayı
10Bağlantı
https://dx.doi.org/10.2174/1871520615666150831125337https://hdl.handle.net/20.500.12418/7621
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