dc.contributor.author | Korkmaz, Ozge | |
dc.contributor.author | Yucel, Hasan | |
dc.contributor.author | Zorlu, Ali | |
dc.contributor.author | Berkan, Ocal | |
dc.contributor.author | Kaya, Hakki | |
dc.contributor.author | Goksel, Sebahattin | |
dc.contributor.author | Beton, Osman | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:29Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:29Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1516-3180 | |
dc.identifier.uri | https://dx.doi.org/10.1590/1516-3180.2015.00131806 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7682 | |
dc.description | WOS: 000368271900006 | en_US |
dc.description | PubMed ID: 26648276 | en_US |
dc.description.abstract | CONTEXT AND OBJECTIVE: The location of embolism is associated with clinical findings and disease severity in cases of acute pulmonary embolism. The level of gamma-glutamyl transferase increases under oxidative stress-related conditions. In this study, we investigated whether gamma-glutamyl transferase levels could predict the location of pulmonary embolism. DESIGN AND SETTING: Hospital-based cross-sectional study at Cumhuriyet University, Sivas, Turkey. METHODS: 120 patients who were diagnosed with acute pulmonary embolism through computed tomography-assisted pulmonary angiography were evaluated. They were divided into two main groups (proximally and distally located), and subsequently into subgroups according to thrombus localization as follows: first group (thrombus in main pulmonary artery; n = 9); second group (thrombus in main pulmonary artery branches; n = 71); third group (thrombus in pulmonary artery segmental branches; n = 34); and fourth group (thrombus in pulmonary artery subsegmental branches; n = 8). RESULTS: Gamma-glutamyl transferase levels on admission, heart rate, oxygen saturation, right ventricular dilatation/ hypokinesia, pulmonary artery systolic pressure and cardiopulmonary resuscitation requirement showed prognostic significance in univariate analysis. The multivariate logistic regression model showed that gamma-glutamyl transferase level on admission (odds ratio, OR = 1.044; 95% confidence interval, CI: 1.011-1.079; P = 0.009) and pulmonary artery systolic pressure (OR = 1.063; 95% CI: 1.005-1.124; P = 0.033) remained independently associated with proximally localized thrombus in pulmonary artery. CONCLUSIONS: The findings revealed a significant association between increased existing embolism load in the pulmonary artery and increased serum gamma-glutamyl transferase levels. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ASSOCIACAO PAULISTA MEDICINA | en_US |
dc.relation.isversionof | 10.1590/1516-3180.2015.00131806 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Gamma-glutamyltransferase | en_US |
dc.subject | Pulmonary embolism | en_US |
dc.subject | Biological markers | en_US |
dc.subject | Pulmonary artery | en_US |
dc.subject | Multidetector computed tomography | en_US |
dc.title | Elevated gamma glutamyl transferase levels are associated with the location of acute pulmonary embolism. Cross-sectional evaluation in hospital setting | en_US |
dc.type | article | en_US |
dc.relation.journal | SAO PAULO MEDICAL JOURNAL | en_US |
dc.contributor.department | [Korkmaz, Ozge -- Yucel, Hasan -- Zorlu, Ali -- Berkan, Ocal -- Kaya, Hakki -- Goksel, Sebahattin -- Beton, Osman -- Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey | en_US |
dc.contributor.authorID | YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628 | en_US |
dc.identifier.volume | 133 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 494 | en_US |
dc.identifier.startpage | 488 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |