dc.contributor.author | Elmas, Dursun | |
dc.contributor.author | Sahin, Ali | |
dc.contributor.author | Kucuksahin, Orhan | |
dc.contributor.author | Turkcapar, Nuran | |
dc.contributor.author | Toruner, Murat | |
dc.contributor.author | Cetinkaya, Hulya | |
dc.contributor.author | Kulahcioglu, Emre | |
dc.contributor.author | Okoh, Alexis K. | |
dc.contributor.author | Turgay, Murat | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:47:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:47:49Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1309-0291 | |
dc.identifier.issn | 2148-5046 | |
dc.identifier.uri | https://dx.doi.org/10.5606/ArchRheumatol.2015.5064 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7727 | |
dc.description | WOS: 000363083300002 | en_US |
dc.description.abstract | Objectives: This study aims to investigate whether clinical measures of disease activity and function in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are associated with matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase -1 (TIMP-1), and if MMPs can be more useful than C-reactive protein and erythrocyte sedimentation rate in predicting disease activity in AS. Patients and methods: MMP-3, MMP-9 and TIMP-1 levels were measured by ELISA in 20 patients with AS, 20 patients with IBD, 20 patients with IBD and AS (35 males, 25 females; mean age 38.1 years; range 19 to 62 years), and 20 healthy volunteers (10 males, 10 females; median age 38.5 years; range 24 to 63 years) as a control group. Bath Ankylosing Spondylitis Disease Activity Index, Truelove-Witts activity criteria for ulcerative colitis, and Crohn's Disease of Activity Index scoring systems were used. Results: Highest MMP-3 level was in IBD group (33.51 59.56 ng/mL, p<0.045). MMP-3 levels were significantly higher in patients with IBD and IBD+AS than in patients with AS (p<0.007 and p<0.035, respectively). Highest MMP-9 levels were in the control group (10.35 +/- 2.61 ng/mL, p<0.48). MMP-9 levels were higher in AS group patients than those in IBD and IBD+AS groups, but the difference was not statistically significant (p<0.494 and p<0.260, respectively). Highest TIMP-1 levels were in the IBD group (8.11 ng/mL, p<0.006).TIMP-1 levels of IBD group were significantly higher than both AS and IBD+AS groups (p<0.033 and p<0.008, respectively). A statistically significant correlation was detected between serum MMP-3 levels and disease activity and Bath Ankylosing Spondylitis Disease Activity Index score in patients with AS (r=0.841, p<0.05). Conclusion: We concluded that serum MMP-3 levels may be a better biomarker than C-reactive protein and erythrocyte sedimentation rate in showing disease activity in AS. | en_US |
dc.description.sponsorship | Ankara Tip War Vakfi | en_US |
dc.description.sponsorship | This study was funded by Ankara Tip War Vakfi. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TURKISH LEAGUE AGAINST RHEUMATISM | en_US |
dc.relation.isversionof | 10.5606/ArchRheumatol.2015.5064 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Ankylosing spondylitis | en_US |
dc.subject | inflammatory bowel disease | en_US |
dc.subject | metalloproteinase-3 | en_US |
dc.subject | metalloproteinase-9 | en_US |
dc.subject | tissue matrix metalloproteinase inhibitor-1 | en_US |
dc.title | Association of Matrix Metalloproteinases and Their Tissue Inhibitor With Disease Activity and Development in Spondyloarthropathy and Inflammatory Bowel Disease | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF RHEUMATOLOGY | en_US |
dc.contributor.department | [Elmas, Dursun -- Kulahcioglu, Emre -- Okoh, Alexis K.] Ankara Univ, Dept Internal Med, Fac Med, TR-06100 Ankara, Turkey -- [Sahin, Ali] Cumhuriyet Univ, Dept Internal Med, Div Rheumatol, Fac Med, TR-58140 Sivas, Turkey -- [Kucuksahin, Orhan] Yildirim Beyazit Univ, Dept Internal Med, Div Rheumatol, Fac Med, Ankara, Turkey -- [Turkcapar, Nuran -- Turgay, Murat] Ankara Univ, Dept Internal Med, Div Rheumatol, Fac Med, TR-06100 Ankara, Turkey -- [Toruner, Murat -- Cetinkaya, Hulya] Ankara Univ, Dept Internal Med, Div Gastroenterol, Fac Med, TR-06100 Ankara, Turkey | en_US |
dc.identifier.volume | 30 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 197 | en_US |
dc.identifier.startpage | 191 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |