dc.contributor.author | Turan, Ibrahim | |
dc.contributor.author | Demir, Selim | |
dc.contributor.author | Misir, Sema | |
dc.contributor.author | Kilinc, Kagan | |
dc.contributor.author | Mentese, Ahmet | |
dc.contributor.author | Aliyazicioglu, Yuksel | |
dc.contributor.author | Deger, Orhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:10Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:10Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1596-5996 | |
dc.identifier.uri | https://dx.doi.org/10.4314/tjpr.v14i5.5 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/7866 | |
dc.description | WOS: 000355931400005 | en_US |
dc.description.abstract | Purpose: To investigate the total polyphenolic and flavonoid contents, antioxidant power and cytotoxic activity of ethanol extracts of Turkish propolis (EEP). Methods: The total polyphenolic and flavonoid contents of EEP were determined by spectrometric methods. Antioxidant power and cytotoxic activity of EEP were evaluated using ferric reducing antioxidant power (FRAP) and MTT assays, respectively. Results: The total polyphenolic and flavonoid contents, and FRAP value of EEP were 124.6 +/- 1.5 mg gallic acid/g sample dry weight, 42.0 +/- 0.8 mg quercetin/g sample dry weight and 311.0 +/- 2.5 mg trolox/g sample dry weight, respectively. EEP exhibited powerful cytotoxic effects against the five human cancer cell lines. The highest cytotoxic activity of Turkish EEP was demonstrated on PC-3 cell line (IC50 = 20.7 +/- 3.4 mu g/mL). Conclusion: The results demonstrate that EEP is a good source of antioxidant and a natural antitumor agent capable of reducing cancer cell proliferation. | en_US |
dc.description.sponsorship | Foundation of Scientific Research of Karadeniz Technical University, Trabzon, Turkey [2007.114.001.3, 2008.114.001.5] | en_US |
dc.description.sponsorship | This work was supported by Foundation of Scientific Research of Karadeniz Technical University (Project numbers: 2007.114.001.3 and 2008.114.001.5), Trabzon, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | PHARMACOTHERAPY GROUP | en_US |
dc.relation.isversionof | 10.4314/tjpr.v14i5.5 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Propolis | en_US |
dc.subject | Polyphenols | en_US |
dc.subject | Cytotoxic effect | en_US |
dc.subject | Cancer cell lines | en_US |
dc.subject | Antioxidant activity | en_US |
dc.title | Cytotoxic Effect of Turkish Propolis on Liver, Colon, Breast, Cervix and Prostate Cancer Cell Lines | en_US |
dc.type | article | en_US |
dc.relation.journal | TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH | en_US |
dc.contributor.department | [Turan, Ibrahim -- Kilinc, Kagan] Gumushane Univ, Fac Engn & Nat Sci, Dept Genet & Bioengn, TR-29100 Gumushane, Turkey -- [Turan, Ibrahim] Gumushane Univ, Med Plants Tradit Med Practice & Res Ctr, TR-29100 Gumushane, Turkey -- [Demir, Selim -- Misir, Sema] Karadeniz Tech Univ, Inst Hlth Sci, Dept Med Biochem, TR-61080 Trabzon, Turkey -- [Misir, Sema] Cumhuriyet Univ, Fac Pharm, Dept Biochem, TR-58140 Sivas, Turkey -- [Mentese, Ahmet -- Aliyazicioglu, Yuksel -- Deger, Orhan] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, TR-61080 Trabzon, Turkey | en_US |
dc.contributor.authorID | Demir, Selim -- 0000-0002-1863-6280 | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 782 | en_US |
dc.identifier.startpage | 777 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |