The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study
dc.contributor.author | Erdem, H. | |
dc.contributor.author | Ozturk-Engin, D. | |
dc.contributor.author | Elaldi, N. | |
dc.contributor.author | Gulsun, S. | |
dc.contributor.author | Sengoz, G. | |
dc.contributor.author | Crisan, A. | |
dc.contributor.author | Johansen, I. S. | |
dc.contributor.author | Inan, A. | |
dc.contributor.author | Nechifor, M. | |
dc.contributor.author | Al-Mahdawi, A. | |
dc.contributor.author | Civljak, R. | |
dc.contributor.author | Ozguler, M. | |
dc.contributor.author | Savic, B. | |
dc.contributor.author | Ceran, N. | |
dc.contributor.author | Cacopardo, B. | |
dc.contributor.author | Inal, A. S. | |
dc.contributor.author | Namiduru, M. | |
dc.contributor.author | Dayan, S. | |
dc.contributor.author | Kayabas, U. | |
dc.contributor.author | Parlak, E. | |
dc.contributor.author | Khalifa, A. | |
dc.contributor.author | Kursun, E. | |
dc.contributor.author | Sipahi, O. R. | |
dc.contributor.author | Yemisen, M. | |
dc.contributor.author | Akbulut, A. | |
dc.contributor.author | Bitirgen, M. | |
dc.contributor.author | Dulovic, O. | |
dc.contributor.author | Kandemir, B. | |
dc.contributor.author | Luca, C. | |
dc.contributor.author | Parlak, M. | |
dc.contributor.author | Stahl, J. P. | |
dc.contributor.author | Pehlivanoglu, F. | |
dc.contributor.author | Simeon, S. | |
dc.contributor.author | Ulu-Kilic, A. | |
dc.contributor.author | Yasar, K. | |
dc.contributor.author | Yilmaz, G. | |
dc.contributor.author | Yilmaz, E. | |
dc.contributor.author | Beovic, B. | |
dc.contributor.author | Catroux, M. | |
dc.contributor.author | Lakatos, B. | |
dc.contributor.author | Sunbul, M. | |
dc.contributor.author | Oncul, O. | |
dc.contributor.author | Alabay, S. | |
dc.contributor.author | Sahin-Horasan, E. | |
dc.contributor.author | Kose, S. | |
dc.contributor.author | Shehata, G. | |
dc.contributor.author | Andre, K. | |
dc.contributor.author | Alp, A. | |
dc.contributor.author | Cosic, G. | |
dc.contributor.author | Gul, H. Cem | |
dc.contributor.author | Karakas, A. | |
dc.contributor.author | Chadapaud, S. | |
dc.contributor.author | Hansmann, Y. | |
dc.contributor.author | Harxhi, A. | |
dc.contributor.author | Kirova, V. | |
dc.contributor.author | Masse-Chabredier, I. | |
dc.contributor.author | Oncu, S. | |
dc.contributor.author | Sener, A. | |
dc.contributor.author | Tekin, R. | |
dc.contributor.author | Deveci, O. | |
dc.contributor.author | Karabay, O. | |
dc.contributor.author | Agalar, C. | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:54Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:54Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1198-743X | |
dc.identifier.issn | 1469-0691 | |
dc.identifier.uri | https://dx.doi.org/10.1111/1469-0691.12478 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8168 | |
dc.description | WOS: 000345825900004 | en_US |
dc.description | PubMed ID: 24849547 | en_US |
dc.description.abstract | We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p<0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p<0.05). Combination of L-J and ACS was superior to using these tests alone (p<0.05). There were poor and inverse agreements between EZNs and L-J culture (=-0.189); ACS and L-J culture (=-0.172) (p<0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (=-0.299, p<0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.relation.isversionof | 10.1111/1469-0691.12478 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | culture | en_US |
dc.subject | diagnosis | en_US |
dc.subject | meningitis | en_US |
dc.subject | PCR | en_US |
dc.subject | tuberculosis | en_US |
dc.title | The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study | en_US |
dc.type | article | en_US |
dc.relation.journal | CLINICAL MICROBIOLOGY AND INFECTION | en_US |
dc.contributor.department | [Erdem, H. -- Oncul, O.] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ozturk-Engin, D. -- Inan, A. -- Ceran, N.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, S.] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, A.] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, DK-5000 Odense, Denmark -- [Nechifor, M.] Gr T Popa Univ Med & Pharm, Dept Pharmacol, Iasi, Romania -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Civljak, R.] Univ Zagreb Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia -- [Ozguler, M. -- Akbulut, A.] Firat Univ Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Savic, B.] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia -- [Cacopardo, B.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Inal, A. S.] Cukurova Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Namiduru, M.] Gaziantep Univ Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Dayan, S. -- Tekin, R. -- Deveci, O.] Dicle Univ Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Kayabas, U.] Inonu Univ Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey -- [Parlak, E. -- Parlak, M.] Ataturk Univ Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Khalifa, A.] Damascus Hosp, Dept Neurol, Damascus, Syria -- [Kursun, E.] Baskent Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Sipahi, O. R.] Ege Univ Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yemisen, M.] Istanbul Univ Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Bitirgen, M. -- Kandemir, B.] Necmettin Erbakan Univ Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Dulovic, O.] Univ Belgrade, Clin Infect & Trop Dis, Clin Ctr Serbia, Fac Med, Belgrade, Serbia -- [Luca, C.] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Stahl, J. P.] Joseph Fourier Univ & Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Simeon, S.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Ulu-Kilic, A. -- Alabay, S.] Erciyes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Yasar, K.] Bakrkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, G.] Ankara Univ Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Yilmaz, E.] Uludag Univ Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Beovic, B.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Catroux, M.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Lakatos, B.] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Sunbul, M.] Ondokuz Mayis Univ Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sahin-Horasan, E.] Mersin Univ Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Andre, K.] Dax Hosp, Dept Infect Dis, Dax, France -- [Alp, A.] Hacettepe Univ, Sch Med, Deparment Med Microbiol, Ankara, Turkey -- [Cosic, G.] Univ Novi Sad, Fac Med, Dept Prevent & Control Dis, IPH Vojvodina, Novi Sad, Serbia -- [Gul, H. Cem -- Karakas, A.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Chadapaud, S.] Marie Jose Treffot Hosp, Dept Infect Dis, Hyeres, France -- [Hansmann, Y.] Univ Hosp, Dept Infect Dis, Strasbourg, France -- [Harxhi, A.] Univ Hosp Ctr Tirana, Infect Dis Serv, Tirana, Albania -- [Kirova, V.] Univ Clin Infect Dis & Febrile Condit, Skopje, Macedonia -- [Masse-Chabredier, I.] Aurillac Hosp, Dept Infect Dis, Aurillac, France -- [Oncu, S.] Adnan Menderes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Sener, A.] Onsekiz Mart Univ Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Karabay, O.] Sakarya Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Agalar, C.] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey | en_US |
dc.contributor.authorID | Inal, Ayse Seza -- 0000-0002-1182-7164; Ghaydaa, Shehata -- 0000-0002-3631-893X; johansen, isik somuncu -- 0000-0002-2189-9823; Karabay, Oguz -- 0000-0003-0502-432X; Karakas, Ahmet -- 0000-0002-0553-8454; Kart Yasar, Kadriye -- 0000-0003-2963-4894; Stahl, Jean Paul -- 0000-0002-0086-3557; Elaldi, Nazif -- 0000-0002-9515-770X; ALP, ALPASLAN -- 0000-0001-7856-7590; Civljak, Rok -- 0000-0001-8766-7438 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.endpage | O608 | en_US |
dc.identifier.startpage | O600 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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