dc.contributor.author | Kaplan, Ibrahim | |
dc.contributor.author | Sancaktar, Enver | |
dc.contributor.author | Ece, Aydin | |
dc.contributor.author | Sen, Velat | |
dc.contributor.author | Tekkesin, Nilgun | |
dc.contributor.author | Basarali, Mustafa Kemal | |
dc.contributor.author | Kelekci, Selvi | |
dc.contributor.author | Evliyaoglu, Osman | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:56:56Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:56:56Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1643-3750 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8174 | |
dc.description | WOS: 000342647900001 | en_US |
dc.description | PubMed ID: 25262176 | en_US |
dc.description.abstract | Background: Hypertension is a major global public health problem that affects both pediatric and adult populations. ACE I/D, AGT M235T, and ADD Gly460Trp polymorphisms are thought to be associated with primary hypertension. In the present study, we examined the frequency of these polymorphisms in a pediatric population with secondary hypertension. Material/Methods: Included in the study were 58 hypertensive and 58 normotensive pediatric patients. ACE I/D and AGT M235T polymorphisms are determined by conventional PCR; ADD Gly460Trp polymorphism was investigated using PCR amplification of genomic DNA. Results: There were significant differences between the control group and pediatric hypertensive group in terms of ACE I/D (P<0.05) and AGT M235T (P<0.05) polymorphisms, but there were no differences in ADD Gly460Trp (P>0.05) polymorphism. Conclusions: We suggest that RAS gene polymorphisms (ACE-I/D, AGT M235T) are significantly associated with susceptibility to diseases that lead to secondary hypertension. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | INT SCIENTIFIC LITERATURE, INC | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Genes | en_US |
dc.subject | ras | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Genetic | en_US |
dc.title | Gene Polymorphisms of Adducin GLY460TRP, ACE I/D, and AGT M235T in Pediatric Hypertension Patients | en_US |
dc.type | article | en_US |
dc.relation.journal | MEDICAL SCIENCE MONITOR | en_US |
dc.contributor.department | [Kaplan, Ibrahim -- Basarali, Mustafa Kemal -- Evliyaoglu, Osman] Dicle Univ, Dept Med Biochem, Diyarbakir, Turkey -- [Sancaktar, Enver] Cumhuriyet Univ, Dept Med Biochem, Sivas, Turkey -- [Ece, Aydin -- Sen, Velat -- Kelekci, Selvi] Dicle Univ, Dept Pediatry, Diyarbakir, Turkey -- [Tekkesin, Nilgun] Mem Hosp Sisli, Cent Biochem Lab, Istanbul, Turkey | en_US |
dc.contributor.authorID | Sancaktar, Erol -- 0000-0003-0165-587X; ECE, AYDIN -- 0000-0001-9130-2431; Evliya, Osman -- 0000-0002-5780-9068; Ece, Aydin -- 0000-0001-6764-8336 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.endpage | 1750 | en_US |
dc.identifier.startpage | 1745 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |