dc.contributor.author | Guray, Yesim | |
dc.contributor.author | Ipek, Esra Gucuk | |
dc.contributor.author | Guray, Umit | |
dc.contributor.author | Demirkan, Burcu | |
dc.contributor.author | Kafes, Habibe | |
dc.contributor.author | Asarcikli, Late Dinc | |
dc.contributor.author | Cabuk, Gizem | |
dc.contributor.author | Yilmaz, Mehmet Birhan | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T09:57:18Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T09:57:18Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1875-2136 | |
dc.identifier.issn | 1875-2128 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.acvd.2014.04.008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8271 | |
dc.description | WOS: 000338901900004 | en_US |
dc.description | PubMed ID: 24923758 | en_US |
dc.description.abstract | Background. - Infective endocarditis (IE) is associated with significant morbidity and mortality. Red cell distribution width (RDW) is a recently recognized biomarker of adverse outcome in a number of acute and chronic conditions. Aim. - To investigate the relationship between RDW and 1-year survival in patients with IE. Methods. - Clinical records from two tertiary centres were used to analyze data from patients with definite IE. Clinical, echocardiographic and biochemical variables were evaluated along with RDW. One-year survival status after index hospitalization was identified for each patient. Results. - One hundred consecutive patients (mean age 47.8 +/- 16.7 years; 61% men) with definite IE were enrolled. According to receiver operating characteristic curve analysis, the optimal RDW cut-off value for predicting mortality was 15.3% (area under the curve 0.70; P=0.001). Forty-one patients (41%) died within 1 year; of these, 88% had ROW results > 15.3%. Univariate Cox proportional-hazards analysis showed that RDW > 15.3%, heart failure, renal failure, cardiac abscess, severe valvular regurgitation and presence of dehiscence were associated with increased mortality. Multivariable Cox proportional-hazards analysis revealed that renal failure (hazard ratio [HR] 3.21, 95% confidence interval [CI] 1.35-7.59; P = 0.008), heart failure (HR 2.77, 95% CI 1.1-6.97; P = 0.03) and RDW > 15.3% (HR 3.07, 95% CI 1.06-8.86; P = 0.03) were independent predictors of mortality in patients with IE. Conclusion. - According to our results, mortality is high in patients with IE. RDW is a promising biomarker for predicting 1-year survival rates in these patients. (C) 2014 Published by Elsevier Masson SAS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | ELSEVIER MASSON | en_US |
dc.relation.isversionof | 10.1016/j.acvd.2014.04.008 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Infective endocarditis | en_US |
dc.subject | Outcome | en_US |
dc.subject | Red cell distribution width | en_US |
dc.title | Red cell distribution width predicts mortality in infective endocarditis | en_US |
dc.type | article | en_US |
dc.relation.journal | ARCHIVES OF CARDIOVASCULAR DISEASES | en_US |
dc.contributor.department | [Guray, Yesim -- Ipek, Esra Gucuk -- Guray, Umit -- Demirkan, Burcu -- Kafes, Habibe -- Asarcikli, Late Dinc -- Cabuk, Gizem] Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, Ankara, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Fac Med, Dept Cardiol, Sivas, Turkey | en_US |
dc.contributor.authorID | YILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628; YILMAZ, Mehmet Birhan -- 0000-0002-8169-8628 | en_US |
dc.identifier.volume | 107 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.endpage | 307 | en_US |
dc.identifier.startpage | 299 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |