Toplam kayıt 30, listelenen: 1-20
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4D-QSAR Study of Some Pyrazole Pyridine Carboxylic Acid Derivatives By Electron Conformational-Genetic Algorithm Method
(BENTHAM SCIENCE PUBL LTD, 2018)Introduction: In the present work, pharmacophore identification and biological activity prediction for 86 pyrazole pyridine carboxylic acid derivatives were made using the electron conformational genetic algorithm approach ... -
Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and Bone Cancer
(BENTHAM SCIENCE PUBL LTD, 2015)Several oncogenic pathways may lead to cancer. Pharmaceutical research develops efficacious compounds to inhibit these pathways. Current inhibitor drugs may block several pathways simultaneously but cause adverse and side ... -
Bioconjugation of Magnetic Iron Oxide Nanoparticles and Cross-Linked Enzyme Aggregates: Characterization and Comparison of CLEAs and Magnetic CLEAs
(BENTHAM SCIENCE PUBL LTD, 2017)Background: The separation of enzymes from the bio-product medium constitutes a significant part of total process cost. Therefore, it is of crucial importance that the separation processes for enzymes be specially developed. ... -
Can We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?
(BENTHAM SCIENCE PUBL LTD, 2017)Objectives: The purpose of the study is predicting the sites of the recurrence with PET/CT by serum CA-125 level and detecting the cut-off value of CA-125 for metastatic ovarian cancer (OC) in comparison with Fluorine-18 ... -
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis
(BENTHAM SCIENCE PUBL LTD, 2016)Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target ... -
Dimerization and ion binding properties of S100P protein
(BENTHAM SCIENCE PUBL LTD, 2006)Functional S100P requires dimer formation and dimerization might form for one of the two reasons: i. producing a pair of site for target protein binding or ii. modulation of cation binding affinity. The extent of exposed ... -
Electrochemical Aptasensors for Early Cancer Diagnosis: A Review
(BENTHAM SCIENCE PUBL LTD, 2017)Aptamers are specific oligonucleotides selected invitro which bind to target molecules with high affinity and specificity like antibody-antigen interactions. For that reason, these synthetic oligonucleotides also known as ... -
Heat Shock Protein 40-Gok1 Isolation from Toxoplasma gondii RH Strain
(BENTHAM SCIENCE PUBL LTD, 2013)Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of ... -
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications
(BENTHAM SCIENCE PUBL LTD, 2016)Heat shock protein 90 (Hsp90) is an important member of the chaperone protein family and it is involved in stabilization, regulation, and maintenance of oncogenic client proteins with co-chaperones. Co-chaperones regulate ... -
Heat Shock Protein 90 Inhibitors in Oncology
(BENTHAM SCIENCE PUBL LTD, 2014)Heat shock protein 90 (Hsp90) is highly conserved chaperone protein which plays vital roles in stabilization, regulation and folding of client proteins in cancer cells. Client proteins are key macromolecules for carcinogenesis ... -
Heat shock proteins, substrate specificity and modulation of function
(BENTHAM SCIENCE PUBL LTD, 2006)Hsp70 is a universally conserved essential protein chaperone. In addition to its roles in many cellular process, Hsp70 protects cells from stress by binding partially unfolded proteins. Therefore, Hsp70 prevents protein ... -
Heat Shock Proteins; An Overview
(BENTHAM SCIENCE PUBL LTD, 2010)Heat shock proteins (Hsps) protect protein substrates against conformational damage to promote the function of the proteins, prevent aggregation and prevent formation of toxic inclusion bodies. Protein aggregates and fibrils ... -
Important Anti-Cancer Applications of Protein Based Nanoparticles
(BENTHAM SCIENCE PUBL LTD, 2013)Cancer is one of the most important health problems in the world and the treatment approaches are still challenging and generally not at desirable levels. Conventional anti-cancer agents may cause systemic toxicity, have ... -
Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems?
(BENTHAM SCIENCE PUBL LTD, 2017)Purpose: The present study aimed to analyze the researches that are at the experimental phase concerning osteosarcoma treatment. The researches included drug delivery systems which allow controlled release and imbue small ... -
Key residues involved in Hsp70 regulatory activity and affect of co-chaperones on mechanism of action
(BENTHAM SCIENCE PUBL LTD, 2006)Hsp70 proteins assist refolding of polypeptides in an ATP dependent manner. Crystal structure of intact Hsp70 protein has not been determined yet however, structures of its two domains were solved separately. Allostery ... -
MicroRNAs and Cancer; an Overview
(BENTHAM SCIENCE PUBL LTD, 2014)MiRNAs are a family of small, endogenous, and evolutionarily conserved non-coding ribonucleic acids that have been involved in the regulation of several essential, cellular, and functional processes. MicroRNAs are known ... -
A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing Thiazole Skeleton
(BENTHAM SCIENCE PUBL LTD, 2015)Inhibition of the Hsp90 function is an essential therapeutic approach and several inhibitors were designed as anti-cancer agents. These inhibitors are ATPases and they aim to deregulate Hsp90 folding function. ATPase ...
