dc.contributor.author | Oztemur, Zekeriya | |
dc.contributor.author | Ozer, Hatice | |
dc.contributor.author | Golge, Umut Hatay | |
dc.contributor.author | Altuntas, Emine Elif | |
dc.contributor.author | Bulut, Okay | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:03:08Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:03:08Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 1300-0144 | |
dc.identifier.uri | https://dx.doi.org/10.3906/sag-1208-2 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/8878 | |
dc.description | WOS: 000321481200024 | en_US |
dc.description.abstract | Aim: To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was carried out. In addition, immunohistochemistry was performed by the avidin-biotin peroxidase method using vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-beta 1), and type II collagen antibodies, and the results were evaluated semiquantitatively. Results: There was a significant difference between the control group and the ESW group in terms of Pineda score and type II collagen expression; between the control group and the HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression; and between the control group and the ESW + HA group in terms of Pineda score, VEGF expression, type II collagen expression, and TGF-beta 1 expression. Conclusion: The results show that both treatment methods have positive therapeutic effects on the articular cartilage defect model in terms of the parameters studied. | en_US |
dc.description.sponsorship | Cumhuriyet University Scientific Research Projects (CUBAP) Project [T-421] | en_US |
dc.description.sponsorship | The present study was supported by Cumhuriyet University Scientific Research Projects (CUBAP) Project no T-421. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY | en_US |
dc.relation.isversionof | 10.3906/sag-1208-2 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | ESW | en_US |
dc.subject | HA | en_US |
dc.subject | cartilage defect | en_US |
dc.subject | VEGF | en_US |
dc.subject | TGF-beta 1 | en_US |
dc.subject | type II collagen | en_US |
dc.title | Comparing extracorporeal shock wave and hyaluronic acid in a rabbit cartilage defect model: the effects of ESW on cartilage defect | en_US |
dc.type | article | en_US |
dc.relation.journal | TURKISH JOURNAL OF MEDICAL SCIENCES | en_US |
dc.contributor.department | [Oztemur, Zekeriya -- Bulut, Okay] Cumhuriyet Univ, Fac Med, Dept Orthoped & Traumatol, Sivas, Turkey -- [Ozer, Hatice] Cumhuriyet Univ, Fac Med, Dept Pathol, Sivas, Turkey -- [Golge, Umut Hatay] Canakkale Onsekiz Mart Univ, Fac Med, Dept Orthoped & Traumatol, Canakkale, Turkey -- [Altuntas, Emine Elif] Cumhuriyet Univ, Fac Med, Dept Otolaryngol, Sivas, Turkey | en_US |
dc.contributor.authorID | Oztemur, Zekeriya -- 0000-0003-2134-8797 | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 492 | en_US |
dc.identifier.startpage | 484 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |