Is sustained release of vancomycin from fibrin glue effective to prevent methicillin-resistant Staphylococcus aureus graft infection?
Tarih
2012Yazar
Katrancioglu, NurkayKarahan, Oguz
Kilic, Ahmet Turhan
Katrancioglu, Ozgur
Celik, Cem
Bakici, Mustafa Zahir
Atahan, Erhan
Üst veri
Tüm öğe kaydını gösterÖzet
Prosthetic vascular graft infection remains one of the most serious complications seen after vascular surgery. Recently, fibrin glue has gained attention as a possible means to deliver drug therapies. In this study, the efficacy of vancomycin incorporated fibrin glue for preventing methicillin-resistant Staphylococcus aureus (MRSA) infection of prosthetic grafts was investigated. The vascular grafts were implanted into subcutaneous pockets in the backs of 32 rats. Group 1: no graft contamination; Group 2: MRSA contamination; Group 3: vancomycin incorporated fibrin glue graft and MRSA contamination; and Group 4: vancomycin soaked graft and MRSA contamination. The grafts were removed after 7 days and evaluated by a quantitative culture analysis. The quantitative culture values for Groups 2, 3, and 4 were 1.8x10(11) +/- 1.4x10(11), 1.1x10(7) +/- 2.4x10(7), and 2.6x10(8) +/- 3.9x10(8), respectively. The culture values of the Group 2 was significantly higher than those of the Group 3 and Group 4 (p=0.014 and p=0.016, respectively), however, Groups 3 and 4 were comparable (p=0.161). In our study, efficacies of vancomycin-incorporated fibrin and vancomycin alone were comparable. The finding of the current study indicated that a fibrin-based delivery system might not be as effective an option as a vancomycin delivery.
Kaynak
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCHCilt
6Sayı
4Koleksiyonlar
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