dc.contributor.author | Pinarbasi, Ergun | |
dc.contributor.author | Gunes, Emine Gulsen | |
dc.contributor.author | Pinarbasi, Hatice | |
dc.contributor.author | Donmez, Gonca | |
dc.contributor.author | Silig, Yavuz | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:04:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:04:49Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1357-0560 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s12032-010-9588-y | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9402 | |
dc.description | WOS: 000297256400065 | en_US |
dc.description | PubMed ID: 21069480 | en_US |
dc.description.abstract | Polymorphism of AXIN2, a component of Wnt signaling, has been shown to play a role in tumorigenesis and dysregulated in cancer cells. In order to find out if AXIN2 polymorphism is a risk factor for prostate cancer, we analyzed eight polymorphic regions of this gene in 84 patients with prostate cancer and compared the results with 100 healthy controls in a Turkish population using PCR-RFLP methods. The genotype frequencies and risk factors of prostate cancer and control groups were analyzed by Chi-square test. We found a statistically significant result between prostate cancer risk and AXIN2 Intron2-956 + 16A/G (rs35285779) SNP. The frequency of the homozygous G/G (0%) and heterozygous A/G (18%) genotypes was significantly less in patients with prostate cancer than in healthy controls (7 and 32%, respectively) (P < 0.05) for this SNP. When compared with the wild-type A/A genotype of the controls, prostate cancer patients with the A/G and G/G genotype showed reduced risk of cancer; the adjusted odds ratio (OR) for patients with the homozygous G/G genotype was 0.87 (95% CI: 0.81-0.95) and for heterozygous A/G genotype was 0.42 (95% CI: 0.20-0.85). We found no statistically significant association between controls and prostate cancer for other seven SNPs of AXIN2 including Exon1-148 C/T (rs2240308), Exon1-432 T/C (rs2240308), Exon5-1365 G/A (rs9915936), Exon5-1386 C/T (rs1133683), Intron5-1712 + 19 T/G, Exon7-2062 C/T, and Intron7-2141 + 73 G/A (rs4072245) (P > 0.05). These results suggest that the AXIN2 Intron2 rs35285779 SNP is associated with development of prostate cancer as a protective SNP, while an association between other seven SNPs of the AXIN2 and risk of prostate cancer was not observed. | en_US |
dc.description.sponsorship | Cumhuriyet University CUBAP, Sivas, Turkey [T-299] | en_US |
dc.description.sponsorship | This study was supported by Grant no. T-299 from Cumhuriyet University CUBAP, Sivas, Turkey. The technical assistance of Ms. Meral Yilmaz is gratefully acknowledged. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | HUMANA PRESS INC | en_US |
dc.relation.isversionof | 10.1007/s12032-010-9588-y | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | AXIN2 | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Prostate cancer | en_US |
dc.subject | Turkish population | en_US |
dc.title | AXIN2 polymorphism and its association with prostate cancer in a Turkish population | en_US |
dc.type | article | en_US |
dc.relation.journal | MEDICAL ONCOLOGY | en_US |
dc.contributor.department | [Pinarbasi, Ergun -- Gunes, Emine Gulsen -- Donmez, Gonca] Cumhuriyet Univ, Dept Med Biol, Fac Med, TR-58140 Sivas, Turkey -- [Pinarbasi, Ergun -- Silig, Yavuz] Cumhuriyet Univ, Fac Med, Dept Med Biochem, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 1378 | en_US |
dc.identifier.startpage | 1373 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |