dc.contributor.author | Arslan, Serdal | |
dc.contributor.author | Silig, Yavuz | |
dc.contributor.author | Pinarbasi, Hatice | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:04:59Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:04:59Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1792-0981 | |
dc.identifier.uri | https://dx.doi.org/10.3892/etm.2011.334 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9433 | |
dc.description | WOS: 000295543400022 | en_US |
dc.description.abstract | Sulfotransferase 1A1 (SULT1A1) is a member of the sulfotransferase family that plays an important role in the biotransformation of numerous carcinogenic and mutagenic compounds through sulfation. A transition, G to A at position 638, in the SULT1A1 gene, results in the Arg(213)His change. This single nucleotide polymorphism reduces the activity and thermostability of the SULT1A1 enzyme. In the present study, the relationship between the SULT1A1 Arg(213)His polymorphism and prostate cancer was investigated using PCR-RFLP. No significant difference in genotype and allele distribution was noted between the prostate cancer and control populations (P=0.072; P=0.099, respectively). The risk of prostate cancer in individuals carrying the SULT1A1*2 allele (His(213) allele) was determined by combining the SULT1A1*1/SULT1A1*2 (Arg/His(213)) and SULT1A1*2/SULT1A1*2 (His/His(213)) genotypes. No association was observed between SULT1A1 Arg(213)His polymorphism and prostate cancer incidence (P=0.24; OR, 1.36; 95% CI, 0.84-2.25). However, the His(213) allele was found to increase the risk of prostate cancer by 1.36-fold. In smoker and non-smoker populations, no significant relationship was determined between the prostate cancer and control population (P=0.45; P=0.34, respectively). | en_US |
dc.description.sponsorship | Research Council of Cumhuriyet University (CUBAP), Sivas, Turkey [F-217] | en_US |
dc.description.sponsorship | This study was supported by the Research Council of Cumhuriyet University (CUBAP, project no. F-217), Sivas, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPANDIDOS PUBL LTD | en_US |
dc.relation.isversionof | 10.3892/etm.2011.334 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | sulfotransferase 1A1 | en_US |
dc.subject | prostate cancer | en_US |
dc.subject | genetic polymorphism | en_US |
dc.subject | Turkish population | en_US |
dc.title | Sulfotransferase 1A1 Arg(213)His polymorphism and prostate cancer risk | en_US |
dc.type | article | en_US |
dc.relation.journal | EXPERIMENTAL AND THERAPEUTIC MEDICINE | en_US |
dc.contributor.department | [Silig, Yavuz -- Pinarbasi, Hatice] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Arslan, Serdal] Cumhuriyet Univ, Dept Mol Biol & Genet, Fac Sci, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 2 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 1162 | en_US |
dc.identifier.startpage | 1159 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |