dc.contributor.author | Arslan, Serdal | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:06:54Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:06:54Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0006-2928 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s10528-010-9387-3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/9735 | |
dc.description | WOS: 000284331300010 | en_US |
dc.description | PubMed ID: 20936502 | en_US |
dc.description.abstract | Sulfotransferases (SULTs) play a significant role in the biotransformation of a variety of xenobiotics and endogenous compounds. SULTs are genetically polymorphic enzymes; to date, 12 human cytosolic SULT isoforms have been identified. This study investigated SULT1A1 and SULT1A2 gene polymorphism using a PCR-RFLP method (n = 303). The frequency of the SULT1A1*1 allele was 76.2% and SULT1A1*2 was 23.8%. The SULT1A1*3 allele could not be identified. The SULT1A2 frequencies were 69.2% (SULT1A2*1), 18.3% (SULT1A2*2), and 12.5% (SULT1A2*3). The SULT1A1 and SULT1A2 loci were in Hardy-Weinberg equilibrium (SULT1A1 chi(2) = 0.58, P = 0.44; SULT1A2 chi(2) = 7.28, P = 0.06). Linkage analysis indicated a close linkage between these two genes (chi(2) = 5.31, P < 0.01); therefore, the statistical hypothesis that SULT1A1 and SULT1A2 alleles are independently distributed was rejected. Additionally, a strongly positive linkage was detected between SULT1A1*2 and SULT1A2*2 alleles in this population (D' = 0.79, chi(2) = 33.33). | en_US |
dc.description.sponsorship | Research Council of Cumhuriyet University (CUBAP), Sivas, Turkey [F-217] | en_US |
dc.description.sponsorship | This study has been supported by the Research Council of Cumhuriyet University (CUBAP, Project No: F-217), Sivas, Turkey. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | en_US |
dc.relation.isversionof | 10.1007/s10528-010-9387-3 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Sulfotransferases | en_US |
dc.subject | Linkage disequilibrium | en_US |
dc.subject | SULT1A1 | en_US |
dc.subject | SULT1A2 | en_US |
dc.title | Genetic Polymorphisms of Sulfotransferases (SULT1A1 and SULT1A2) in a Turkish Population | en_US |
dc.type | article | en_US |
dc.relation.journal | BIOCHEMICAL GENETICS | en_US |
dc.contributor.department | Cumhuriyet Univ, Fac Sci & Literature, Dept Mol Biol & Genet, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 11.Dec | en_US |
dc.identifier.endpage | 994 | en_US |
dc.identifier.startpage | 987 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |