Yazar "Çelik, Nurullah" seçeneğine göre listele
Listeleniyor 1 - 14 / 14
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Clinical Management in Systemic Type Pseudohypoaldosteronism Due to SCNN1B Variant and Literature Review(Galenos Yayıncılık, 2021) Karacan Küçükali, Gülçin; Çetinkaya, Sema; Tunç, Gaffari; Oğuz, M. Melek; Çelik, Nurullah; Akkaş, Kardelen Yağmur; Şenel, Salih; Naz, Güleray; Erdeve Savaş, ŞenaySystemic pseudohypoaldosteronism (PHA) is a rare, salt-wasting syndrome that is caused by inactivating variants in genes encoding epithelial sodium channel subunits. Hyponatremia, hyperkalemia, metabolic acidosis, increased aldosterone and renin levels are expected findings in PHA. Clinical management is challenging due to high dose oral replacement therapy. Furthermore, patients with systemic PHA require life-long therapy. Here we report a patient with systemic PHA due to SCNN1B variant whose hyponatremia and hyperkalemia was detected at the 24th hour of life. Hyperkalemia did not improve with conventional treatments and dialysis was required. He also developed myocarditis and hypertension in follow-up. Challenges for diagnosis and treatment in this patient are discussed herein. In addition, published evidence concerning common features of patients with SCNN1B variant are reviewed.Öğe Determination of the frequency and the affecting factors of obesity in school age children and adolescents in a rural area in sivas province(Ankara Yildirim Beyazit University, 2019) Agadayi, Ezgi; Çelik, Nurullah; Çetinkaya, Selma; Karaca, Sanem NemmeziObjectives: Our aim was to investigate the prevalence of and the risk factors associated with obesity among adolescents and children between the ages of 6-18 years in a rural area in Sivas province in Turkey. Materials and Methods: The universe of our descriptive cross-sectional study was consisting of 485 students who educate in Sivas Akincilar district. The study was carried out on 1-8 June 2018 and was conducted in 449 students who accepted to participate and met the criteria of inclusion in the study. The height, weight, waist and hip circumference of the children whose family signed the ethical consent form were measured by researcher and the standardized questionnaire consisting of 24 questions was conveyed to the parents. It was used Olcay Neyzi standards (created by the data of the national study) and Centers for Disease Control and Prevention, CDC standards in order to evaluate the measurements. The data were uploaded SPSS program. Shapiro Wilk, Chi-square, Mann-Whitney U, Kruskal Wallis, Kappa, Pearson correlation and Roc analyzes were performed. The results were evaluated at 95% confidence interval and p<0.05 at significance level. Results: Of the participants, 45.21% were girls and 54.78% were boys. The ages of the students varied between 6-17 years and the mean age was 11.82 ± 0.13 years. According to the CDC standards, body mass index percentages were 3.34% weak, 75.50% normal, 13.80% overweight and 7.34% obese. 55.00% of the families of obese children and 87.80% of the families of overweight children thought that their children were in normal weight. When the children's weight and parents' weight assessment of their children were compared, a significant difference was found between both CDC and Olcay Neyzi standards (p<0.001(CDC); p<0.001(Olcay Neyzi)). The cut-off value of the students' waist-to-height ratio was calculated as 0.46 for our study (CDC sensitivity %86.4, specificity %78.1; Olcay Neyzi sensitivity %89.1; specificity %74.3). There was no significant difference between the weight of the children and playing with their phone/tablet before going to bed (p=0.191(Olcay Neyzi); p=0.331(CDC)). Conclusion: In conclusion, we found the prevalence of obesity was significantly increased also in rural areas and the awareness of families about their children's weight was low. We concluded that the family-oriented approach should be strengthened in the fight against childhood obesity and that the number of trainings for parents should be increased. © 2019 Ankara Yildirim Beyazit University. All rights reserved.Öğe Different threshold levels of circulating total and free 25-hydroxyvitamin D for the diagnosis of vitamin D deficiency in obese adolescents(Springer Nature, 2021) Çelik, Nurullah; Doğan, Okan halef; Zararsız, GökmenThe total serum 25-hydroxyvitamin D [25(OH)DT] level is lower in obese individuals than in their nonobese peers, despite similar bone turnover markers and bone mineral density. This study aimed to investigate whether the threshold level of 25(OH)D for the diagnosis of vitamin D deficiency (VDD) in obese adolescents was lower than that in controls and to compare 25(OH)DT, free [25(OH)DF] and bioavailable [25(OH)DB] vitamin D with VDBP levels in obese individuals and their controls. A total of 173 adolescents (90 obese individuals and 83 controls) aged 12–18 years were included in the study. The metabolic and anthropometric parameters of the participants were recorded, the 25(OH)DT, 25(OH)DF, and VDBP levels were measured, and the 25(OH)DB levels were calculated. The cutoff values for VDD were estimated according to the level of 25(OH)D below which parathyroid hormone begins to rise. The obese subjects had lower 25(OH)DT (12.1 ± 5.8 vs. 16.4 ± 9.3 ng/mL, p < 0.001), 25(OH)DF (12.6 ± 4.2 vs. 16.7 ± 7.6 pg/mL, p < 0.001), 25(OH)DB [4.8 (2.3) vs. 6.1 (5.2) ng/mL, p = 0.012], and VDBP [112.2 (51.3) vs. 121.9 (95.5) μg/mL, p < 0.001] levels than the controls. The cutoff values for 25(OH)DT and 25(OH)DF levels for VDD were lower in the obese group than in the control group (9.4 vs. 14.1 ng/mL; 12.2 vs. 16.8 pg/mL, respectively). Conclusion: The vitamin D cutoff values for the diagnosis of VDD were different in the obese and control groups. Using the same cutoff value for VDD may cause overtreatment in obese adolescents.Öğe Evaluation of hematological parameters and iron level in obese children and adolescents(Ankara Yildirim Beyazit University, 2019) Şimsek, Cemile Ece Ça?lar; Çelik, Nurullah; Aygünes, Utku; Dönmez, Amine Yavuz; Avci, Ezgi; Ekici, MahmutObjectives: The aim of the study was to investigate hematological parameters and iron level in obese children and adolescents in different age groups. Materials and Methods: The study population consisted of hundred fifty-four obese children and adolescents aged between 3 and 18 years, who were being followed at the Cumhuriyet University Faculty of Medicine Hospital, Pediatric Endocrinology Clinic. As the control group, 158 healthy age and sex-matched children were also included. The children were divided into three groups according to age: Group 1 (3-7 years), Group 2 (7-12 years), and Group 3 (12-18 years). Hematological parameters, serum iron, total iron-binding capacity, and ferritin levels were compared, and their correlations with body mass index (BMI) were investigated. Results: The mean ages of the control (10.66±3.40; %55.80 girls) and case (10± 4.16; %62 girls) groups were similar. When compared serum iron, total iron-binding capacity, transferrin saturation and ferritin levels, in obese children aged between 12-18 years, serum iron and transferrin saturation was lower whereas ferritin level and total iron-binding capacity were higher (p<0.001). On the other hand, the ferritin level and total iron-binding capacity were higher in obese children aged between 7-12 years, while the other parameters were similar. When the correlations between BMI-SDS and hematological parameters were evaluated; positive correlations with white blood cell count (r = 0.46, p< 0.001), absolute neutrophil count (r = 0.40, p< 0.001) and ferritin levels (r = 0.36, P <0.001), while a negative correlation with transferrin saturation percentage (r = -0.22, p = 0.02) were found. Conclusion: Obese adolescents are prone to iron deficiency with low saturation index. Therefore, ferritin level may be misled for investigating iron deficiency status in obese adolescents. © 2019 Ankara Yildirim Beyazit University. All rights reserved.Öğe EVALUATION OF INSULIN RESISTANCE IN PATIENTS WITH PREMATURE ADRENARCHE(Ümit Muhammet KOÇYİĞİT, 2023) Çelik, Nurullah; Ünsal, GülşahPurpose: There is a conflicting result in terms of insulin resistance (IR) in children with Premature Adrenarche (PA). The study aimed to investigate the IR and Trıglycerıde-Glucose (Ty-G) index in patıents wıth PA. Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old. The study group (n=75) were selected cases diagnosed with PA. Seventy-nine age and sex-matched children were also selected as a control group. Ty-G İndex, Homeostasis Model of Insulin Resistance (HOMA-IR), and atherogenic index of plasma (AIP) were calculated. Results: Trıglycerıde-Glucose index, AIP, and HOMA-IR were similar (p>0.05). Ty-G İndex was positively correlated with AIP (r=0.61, pÖğe GATA-4 Variants in Two Unrelated Cases with 46, XY Disorder of Sex Development and Review of the Literature(Galenos Publishing House, 2022) Çelik, Nurullah; Kurtulgan, Hande Küçük; Kılıçbay, Fatih; Tunç, Gaffari; Kömürlüoğlu, Ayça; Taşçı, Onur; Şimşek, Cemile Ece ÇağlarThe genetic cause of 46, XY disorder of sex development (DSD) still cannot be determined in about half of the cases. GATA-4 haploinsufficiency is one of the rare causes of DSD in genetic males (46, XY). Twenty-two cases with 46, XY DSD due to GATA-4 haploinsufficiency (nine missense variant, two copy number variation) have been previously reported. In these cases, the phenotype may range from a mild undervirilization to complete female external genitalia. The haploinsufficiency may be caused by a sequence variant or copy number variation (8p23 deletion). The aim of this study was to present two unrelated patients with DSD due to GATA-4variants and to review the phenotypic and genotypic characteristics of DSD cases related to GATA-4 deficiency. © 2022 by Turkish Society for Pediatric Endocrinology and Diabetes.Öğe Investigation of Metabolic Syndrome Frequency and Subclinical Hypothyroidism in Obese Children and Adolescents: A Retrospective Single Center Observational Study(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2022) Beysel, Perihan; Çelik, NurullahObjective: The prevalence of obesity, as an important public health problem, has been raised in our country as well as all over the world. There is insufficient data in terms of metabolic syndrome (MS) prevalence and its risk factors in Turkey. The aim of this study is to determine the frequency and risk factors of MS in 6-18 years old obese children and adolescents, to compare thyroid function test results, and to calculate the frequency of sub clinical hypothyroidism in patients with and without MS. Material and Methods: This retrospective single-center observational study was conducted on 957 obese children and adolescents aged 6-18 years. The cases were divided into 2 groups as 6-12 years old (Group 1) and 12-18 years old (Group 2). Than, the frequencies of MS were calculated according to the criteria of the International Diabetes Federation (IDF), Cook et al. and de Ferranti et al. Thyroid function test (thyroid-stimulating hormone and free T4) results were compared in patients with and without MS. Results: The prevalence of MS in Group 1 and Group 2 were found as 7.7% and 12.5%, respectively for IDF criteria, 12.9% and 26.4% for Cook criteria, and 25 and 37.4% for de Ferranti criteria. In Group 2, obese girls had lower free T4 levels than boys (p=0.04). The frequency of subclinical hypothyroidism was similar in the groups with and without MS (p>0.05). Conclusion: In this study, the frequency of MS according to different diagnostic criteria varied, similar to previous studies in our country. So it is necessary to develop an internationally acceptable MS diagnostic criterion in childhood age group. © 2022 OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.. All rights reserved.Öğe Nutrisyonel Raşitizmde D Vitamini Profilaksisi Programının Sürdürülebilirliğinin Önemi Üzerine Bir Araştırma(2020) Çamtosun, Emine; Akıncı, Ayşehan; Çelik, Nurullah; Dündar, İsmailGiriş-Amaç: Türkiye’de, çocuklarda D vitaminieksikliğinin ve nutrisyonel raşitizmin (NR) önlenmesiamacıyla 2005 yılında başlatılan proje ile bebeklereilk 12 ay ücretsiz D vitamini sağlanmış ve sonuçtaüç yaş altı raşitizm sıklığında belirgin azalmagörülmüştür. Ancak günümüzde halen NR vakalarısaptanmakta ve bu vakaların D vitamini profilaksisikullanmadığı görülmektedir.Materyal-Metod: Bu çalışmada Ocak 2013-Nisan2018 tarihleri arasında Malatya’da iki ÇocukEndokrin ünitesinde tanı alan üç yaş altı 36 olgubaşvuru şikayetleri, fizik muayene, laboratuvar vegörüntüleme bulguları ve aldıkları tedaviler ilesunulmuştur.Bulgular: Olguların %25’i (9/36) son dört ayda tanıalmıştır. Olguların tümünde D vitamini düzeyi?12,4 ng/mL’dir, ortalama 3,8±2,5 ng/mL. Dvitamini profilaksisi sorgulanan 30 hastadan 16’sıhiç profilaksi almamış, 14’ü ise düzensiz almıştır.Sonuç: Kliniğimize başvuran NR vakalarının sonyıllarda artması profilaksi programının başlangıçtakikadar sıkı takip edilmediğine işaret ediyor olabilir. Dvitamini profilaksisinin öneminin ve etkinliğininhekimlerimizce kavranması, programın sıkı birşekilde takip edilmesi, ailelerin uygun bir şekildebilgilendirilerek programa dahil edilmesi ile programcanlandırılacak ve etkinliği artırılacaktır.Öğe Sivas İl Merkezinde Dokuz-On Altı Yaş Grubu Çocuklarda Kızamık, Kızamıkçık ve Kabakulak Seroprevalansının Araştırılması(İstanbul Üniversitesi, 2011) Çelik, Sibel; Çelik, Nurullah; Gültekin, Asım; Yüksel, Fadime Okur; Kara, Sema; İçağasıoğlu, Füsun Dilara; Cevit, ÖmerAmaç: Aşı ile önlenebilir hastalıkların seroprevalansının belirlenmesi immünizasyon programlarının değerlendirilmesinde oldukça önemlidir. Bu çalışmanın amacı, Sivas’ta adolesan popülasyonda, yaşa spesifik kızamık, kızamıkçık ve kabakulak KKK seroprevalansını belirlemek ve bunu etkileyen risk faktörlerini tanımlamaktır. Yöntemler: Bu çalışma, Şubat 2006 ile şubat 2007 tarihleri arasında Sivas il merkezinde, yaşları 9-16 arası değişen 401 okul çağı çocuğu ile yapılmıştır. Bu çocukların 205 % 51.1 ’i erkek, 196 % 48.4 ’sı kızdı. Her bir katılımcı için anket dolduruldu ve kızamık, kızamıkçık ve kabakulak için IgG antikor titresi kantitatif olarak Enzim-Lınked İmmunosorbent Assay ELİSA yöntemi ile çalışıldı. Bulgular: Dokuz-16 yaş grubu çocuklarda kızamık, kızamıkçık ve kabakulak seroprevalansı sırası ile % 82,5, % 85.5 ve % 72,5 olarak bulundu. Seropozitiflik oranını yaş, cinsiyet, anne ve babanın eğitim durumu, sosyoekonomik durum, evde yaşayan kişi sayısı, konut tipi ve kreşe gidip gitmeme durumu etkilemiyordu. Sonuç: Bu seroprevalans çalışması kızamık, kızamıkçık ve kabakulak aşılarının rutin aşı takviminde yer alması ve rapel doz gerekliliği vurgulamaktadırÖğe Sivas il merkezinde ilköğretim çağı çocuklarında allerjik hastalık sıklığının belirlenmesi(Cumhuriyet Üniversitesi, 2006) Çelik, Nurullah; Cevit, ÖmerBu çalışmanın amacı, astma ve diğer allerjik hastalıkların sıklığını ve bu hastalıklar için risk faktörlerini tanımlamak, ayrıca Sivas'ta 1997 ve 2005 yıllarında yapılan iki çalışmada ki allerjik hastalık prevalanslarını karşılaştırmaktır. Bu çalışma, ISAAC protokolü kullanılarak, 2005 yılı mart ve haziran aylarında, yaşları 7-14 arası değişen 2978 okul çağı çocukları ile yapılmıştır. Bu çocukların 1544 (% 51.8)'ü erkek, 1434 (%48.2)'ü kızdı. Astma, allerjik rinit ve egzema sıklığı sırası ile %11.8, %10.2, %10,1 olarak bulunmuştur. 1997 yılında yapılan çalışmada ise bu oranlar sırası ile %9.7, %5.4 ve %3.0 olarak bulunmuştur. Bu çalışmada, doktor tanılı astım sıklığı %3.6 olarak bulunmuştur. Kümülatif ve son 1 yıldaki vizing sıklığı ise sırası ile %29.7 ve %13.4 olarak bulunmuştur. Allerjik hastalıkların kümülatif prevalansı ise %32.1 olarak bulunmuştur. Allerjik hastalıklar için aile öyküsünün olması, anne ve baba arasında akrabalık olması, sigaraya maruziyet ve düşük sosyoekonomik düzey allerjik hastalık gelişimi için bir risk faktörü olarak bulundu. Yaş, cinsiyet obesite, ve anne sütü alımı ile allerjik hastalık gelişimi arasında bir ilişki saptanamadı. Sonuç olarak, son 8 yıl içinde, 7-14 yaş arası çocuklarda allerjik hastalık sıklığı anlamlı bir şekilde artmıştır. Anahtar Kelimeler: Allerji, astma, prevalans, risk faktörleri, ISAACÖğe THE IMPACTS OF DIABETES ON FAMILIES WITH A CHILD DIAGNOSED WITH TYPE 1 DIABETES MELLITUS AND INFLUENCING FACTORS(Ankara Yildirim Beyazit University, 2022) Karahan, Seher; Agadayi, Ezgi; Çelik, NurullahObjectives: This study aimed to determine the impacts of diabetes on families with a child diagnosed with Type 1 Diabetes Mellitus (DM) and influencing factors using the Diabetes Family Impact Scale (DFIS). Materials and Methods: The population of our study, which is a descriptive cross-sectional type, consists of the parents of 289 school-aged children diagnosed with Type 1 DM and followed for at least one year in the Department of Pediatric Endocrinology of Sivas Cumhuriyet University Faculty of Medicine. The study questionnaire was completed in a face-to-face interview with the parents of 121 of the 289 children who volunteered to participate in the study. The first 21 questions of the research questionnaire were related to sociodemographic data, and the following 14 questions, which included some characteristics of the disease, were related to DFIS. Results: The mean DFIS scale score of the participants was 14.60±10.82. In our study, the mean DFIS scale score and the mean scores of the School and Work subscales were significantly higher in families with a child who had a high mean HbA1c and had been hospitalized for diabetes in the last year. It was also found that the DFIS scale score was significantly higher in low-income families than in high-income families. While there was a negative correlation between the DFIS scale score and the child's age with Type 1 DM, and the mother's age, there was a positive correlation between the DFIS scale score and the HBA1c values. Conclusion: The impact of Type 1 DM on families is widespread and multifactorial. In our study, as the diabetic control deteriorates and the age of the child decreases, the level of influence of the families in different aspects increases. © 2022 Ankara Yildirim Beyazit University. All Rights Reserved.Öğe Thyroid hormones as a potential prognostic markers for neonates with hypoxic ischemic encephalopathy(Ümit Muhammet KOÇYİĞİT, 2022) Tunç, Gaffari; Çelik, Nurullah; Kılıçbay, Fatih; Ekici, MahmutBACKGROUND: Hypoxic ischemic encephalopathy (HIE) is one of the most important causes of mortality and morbidity in newborns. Few studies with conflicting results have been conducted on the effect of perinatal asphyxia and thyroid hormones METHODS: A total of 96 newborns (46 patients with HIE and 50 controls) were included in the study. Electroencephalography (EEG) results, cranial magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), Sarnat Stages, and the presence of seizures of the HIE group were recorded. Thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels of all cases were also measured between 5-10 days. Patients with HIE were separated into 3 groups according to the fT4 (≤1.52 ng / dL, 1.52-1.84 ng / dL, and ≥1.84 ng / dL), and TSH (≤2.56 IU / mL. 2.56-5.3 1IU / Ml, and ≥5.31 IU / mL) levels. RESULTS: All the newborns with seizures were in the 1st or 2nd tertiles of fT4, none of those with high fT4 (>1.84 ng/dL), and the difference was statistically significant (x2=6.61; p=0.036). A negative correlation was determined between fT4 level and duration of hospitalization (=-0.43; p=0.03), duration of respiratory support (r=-0.32; p=0.029), duration of intubation (r=-0.40; p=0.006), and time to full oral feeding (r=-0.40; p=0.006). The TSH level was only correlated with the duration of hospitalization (r=-0.34, p=0.02). CONCLUSIONS: Free T4 level may be used as a prognostic marker in newborns with HIE. Further multicenter, larger, and prospective studies are needed to support and confirm these findings.Öğe Triglyceride-Glucose index as a surrogate marker for insulin resistance in obese adolescents(Sivas Cumhuriyet University, 2021) Taştanoğlu, Hüseyin; Çelik, NurullahObjective: There is a lot of study in adults investigating the Triglyceride-Glucose (Ty-G) index. However, a limited study has been searched in the pediatric age group. Moreover, to the best of our knowledge, there is no study on Turkish children. The aim of this study, to investigate the usability of the triglyceride-glucose index as an indicator of insulin resistance in obese adolescents and to calculate the cut-off values.Method: Six hundred twenty-three pubertal obese adolescents (266 boys, and 357 girls) were retrospectively evaluated. Ty-G index and HOMA-IR levels were calculated. ROC analysis was used for the estimations of the Ty-G index cutoff value.Results: There was positive correlation between HOMA-IR and Ty-G index in boys (r=0.255, p<0.001), in girls (r=0.402, p<0.001), and all study groups (r=0.323, p<0.001). Ty-G index cutoff value for insülin resistance in pubertal obese adolescents was calculated as 8.42 with 70.1 % sensitivity and 59.3 % specificity for all study groups; 8,38 with 71.1 % sensitivity, and 48.3 % specificity for boys; 8,27 with 80% sensitivity, and 52.9% specificity for girls.Conclusions: Ty-G index may be a reliable indicator for insülin resistance in pubertal obese adolescents. More attention should be given fort his marker with prospective studies.Öğe Wrist Radiography for Hand Bone Age Tells A Lot; A Girl with SHOX Deficiency(2022) Maraşlı, Hüsnü; Çelik, Nurullah; Duman, Yeşim Sıdar[Abstract Not Available]
