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Öğe 2004-2014 yılları arasında Sivas ilinde görülen kanser vakalarının değerlendirilmesi(Cumhuriyet Üniversitesi, 2016) Çelikgün, Serkan; Nur, NaimKanser, son yıllarda hem insidans hem de mortalite açısından hızla artış gösteren bir hastalıktır. Ölüme neden olan hastalıklar sıralamasında daha önceleri 7. 8. sıralarda yer alırken bugün birçok ülkede kardiyovasküler hastalıklardan sonra ikinci sırada yer almaktadır. Bu çalışmada 2004 - 2014 yılları arasında Sivas ilinde kanser tanısı alan hastaların, cinsiyet dağılımlarına, yaş gruplarına, yaşam yerlerine ve görülen kanserin türüne göre değerlendirilmesi amacıyla, Sivas Halk Sağlığı Kanser Şube Müdürlüğü, Cumhuriyet Üniversitesi Uygulama ve Araştırma Hastanesi Kanser Kayıt Birimi ile Cumhuriyet Üniversitesi Uygulama ve Araştırma Hastanesi Patoloji Anabilim Dalı verileri incelenmiştir. 01.01.2004 – 31.12.2014 yılları arasında Sivas ilinde kanser tanısı alan 13,858 hasta cinsiyet, yaş, yaşam yeri ve kanser hastalığının türüne göre sınıflandırılmıştır. 13,858 hastanın % 57'si erkek, % 43'ü kadın hastadır. Kanser vakaları en sık ( % 38) 65 ve üzeri yaşlarda, en az (%2) ise 0-14 yaş grubunda görülmektedir. Kanser tanısı alan hastaların % 70'i Sivas il merkezinde, % 26'sı Sivas'a bağlı ilçelerde, % 4'ü de il dışında ikamet etmektedir. İlçelere bakıldığında en fazla kanser tanısı alan hasta sayısı Yıldızeli (%29), Zara (%12), Kangal (%10) olarak sıralanmaktadır. İl dışından gelenler incelendiğinde 11 yıl içerisinde en fazla Tokat'tan (%74) gelen hastaların kanser tanısı aldığı görülmektedir. 2004-2014 yılları arasında Sivas ilinde görülen toplam 13 858 hasta, kanser türü sıklık sırasıyla; gastrointestinal sistem kanserleri (%17), akciğer kanseri (%15), erkek genital sistem kanserleri (%12), tiroid kanseri (%11) ve hemopoietik sistem kanserleri (%10) olarak belirlenmiştir. Cinsiyete göre değerlendirme yapıldığında en sık görülen kanser türü erkeklerde akciğer kanseri (%25), gastrointestinal sistem kanserleri (%25) ve erkek genital sistem kanserleri (%25) iken kadınlarda tiroid kanseri (%26), meme kanseri (%25) ve gastrointestinal sistem kanserleri (%19) şeklinde sıralanmaktadır.Öğe Cancer Incidence During The Covid-19 Pandemic In A Middle Anatolian City In Turkey(Sivas Cumhuriyet University, 2022) Çelikgün, Serkan; Koç, Tülay; Uçku, ReyhanObjective: Cancer-related deaths in all countries of the world, including our country, are the second leading cause of deaths after cardiovascular diseases. Covid-19 is a pandemic disease affecting many organs but primarily the lung. The aim of this study is to compare the cancer incidences in the pre-Covid-19 period and during Covid-19 pandemic period in Sivas province by means of age, gender and cancer type distribution of the patients.Methods: The population of the study consists of the patients who applied to health institutions in Sivas between 01.11.2018 and 30.06.2021 and were diagnosed as cancer for the first time. The main variable of the study was cancer incidence. The time variable was the 16-monthtime period comprising before Covid-19 pandemic and during the pandemic period separately. In addition, patients diagnosed with cancer in both periods wasevaluated and compared according to age groups, gender and the type of cancer.Results: In this study, the pre-pandemic period and the pandemic period were compared. It was determined that 1355 patients were diagnosed as cancer during the pre-pandemic period and 1720 patients during the pandemic period. The incidence, which was 212.1 per hundred thousand in the previous period, increased to 270.5 per hundred thousand during the 16-month pandemic period.Conclusion: The incidence of cancer increased during the pandemic period compared to the pre-pandemic period.Öğe Combination of infra-red light with nanogold targeting macrophages in the treatment of Leishmania major infected BALB/C mice(2022) Yasak Güner, Rukiye; Berksoy Hayta, Sibel; Tosun, Mustafa; Akyol, Melih; Özpınar, Necati; Akın Polat, Zübeyde; Eğilmez, Hatice Reyhan; Çelikgün, Serkan; Çam, SelimPurpose: In the treatment of cutaneous leishmaniasis (CL), developing drug resistance, existing toxic effects of drugs and failure respond to treatment cause the need to try different treatment methods. We investigated the effect of gold-conjugated macrophage-specific antibody on amastigotes under infra-red light for the treatment of CL. Methods: Female BALB/c (4–8 weeks old, 20 ± 5 g weight) mice were used in the study. The L. major strain was inoculated on the soles of mice in amastigote form and subpassed. Nanogold (Au), Auþ macrophage-specific antibody (MSA) modification and near infra-red (NIR) (5 seconds) were applied to mice groups that developed cutaneous leishmaniasis on their soles. On the 5th and 10th days of the treatment, the lesions were examined clinically and pathologically. Results: When the erythema values were examined, the highest decrease was calculated in the Auþ MSAþ NIR group in the measurements made on the 10th day (p < 0.014). The best improvement in 10th day measurements is in the NIR and Auþ MSAþ NIR groups when area values were examined (p ¼ 0.011, p ¼ 0.001). There was a statistically significant difference between the groups in terms of parasite load (PL) (p < 0.005) in pathological evaluation. According to PL grouping, the best result is NIR (p ¼ 0.002). When both main titles (clinical and pathological) are examined, the Au þ MSAþ NIR group is thought to have an optimal therapeutical feature. Conclusions: Auþ MSAþ NIR combination could be a new treatment approach for CL treatment.Öğe Comparison of Fractures Seen In Elderly Before And During Pandemic(Sivas Cumhuriyet University, 2022) Çelikgün, Serkan; Kılınç, Seyran; Uçku, ReyhanAim: The aim of this study is to compare the fractures seen before and during the pandemic in individuals over the age of 65. Method: The universe of this retrospective cohort Study consists of elderly patients with a fracture diagnosis between 01.09.2018-30.08.2021 at University Hospital. Results: In the pre-pandemic periods, the total number of elderly patients diagnosed with fractures is 509. 57.0% of the patients are women. The average age was founded as 76.7± 8.2 (65 - 106).The most common type of accidents that cause fractures with 85% are low energy trauma injuries. 70.9% of the elderly admitted with fractures underwent surgical intervention. The total number of patients diagnosed with fractures is 736 during the pandemic period. 53.3% are women. The average age is 76.1± 8.2 (65-105).The most common fractures observed in patients are femur fractures. 42.7% of this rate is significantly lower than before the pandemic (p=0.002). The most common type of accidents caused fractures significantly higher rate (89.2%) are low energy trauma injuries (p=0.027). 63.9% of fractures seen during the pandemic period underwent surgical intervention. The surgical intervention rate was significantly lower than before the pandemic (p=0.010). Conclusion: When the data obtained in this study are evaluated, it appears that the fractures occured during the pandemic period have increased numerically compared to the pre-pandemic period.Öğe How does the presence of the pathologist affect the tissue adequacy and what are the factors affecting the pathologist in proficiency assessment, during percutaneous kidney biopsy?(Sivas Cumhuriyet Üniversitesi, 2023) Kaya, Şeyhmus; Şenol, Ayhan; Dursun, Fatma Şule Kutlar; Çelikgün, SerkanObjectives: For optimal histomorphological examination, adequacy of kidney biopsy tissue should be obtained. In this study, the effect of a pathologist informing the radiologist about tissue adequacy during the biopsy procedure on obtaining tissue adequacy was examined. Furthermore, we aimed to determine the criteria that the pathologist considered in determining tissue adequacy and the conditions affecting the decision to increase the number of core biopsies, as these have not been previously examined in the literature. Materials and Methods: Tissues containing less than 10 glomeruli were considered inadequate. In some patients, a pathologist accompanied the radiologist during the procedure. Tissue adequacy ratios and biopsy sample numbers were calculated between the two conditions. In the samples taken with the pathologist, the factors affecting the locality decision of the pathologist (cortex/medulla amount, presence of glomerular pathology(global, segmental, crescentic glomeruli) presence of tubular injury, proteinuria; interstitial inflammation and interstitial fibrosis/tubular atrophy ratios, account of normal glomeruli) were examined. Results: Giving tissue adequacy information during the biopsy procedure had a positive effect on tissue adequacy. The amount of cortex is one of the qualification criteria for the pathologist. The presence of proteinuria and 50% or more inflammation in tissues with sufficient cortex increased the number of biopsy samples. Conclusion: Determination of tissue adequacy during kidney biopsy is an important and necessary method. The amount of cortex is one of the important parameters in tissue adequacy.Öğe Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas(Bolu Abant İzzet Baysal Üniversitesi, 2023) Yeldir, Neşe; Doğan, Ezgi; Özer, Hatice; Söylemez, Burçak; Çelikgün, Serkan; Eğilmez, ReyhanObjective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization (WHO) classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit (cut-off) value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3% for grade 1, 11.2% for grade 2 and 26% for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 (p>0.05). Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.Öğe Pathological Prognostic Features and Analysis of Renal Cell Carcinoma(Sivas Cumhuriyet University, 2022) Öztürk, Sena; Çelikgün, Serkan; Yeldir, NeşeRenal cell carcinomas is 2-3% of all adult cancers. Kidney cancer is currently the seventh most common cancer in men and the tenth most common in women 1. There were 19,3 million new cancer diagnoses and 10 million cancer deaths worldwide in 2020 2. Survival in renal cell carcinomas has a strong correlation with the stage of diagnosis. 5-year survival in stage 1 tumors is 93%, 72,5% in cases with local lymph node metastases and 12% in metastatic carcinomas cases 3. There is an inverse correlation between age / tumor size and survival. Metastatic lymph node, tumor necrosis and adipose tissue invasion are associated with poor prognosis 4. The study is including 179 renal cell carcinoma cases. The clinical and pathological datas of these cases were retrospectively analyzed from the Cumhuriyet University Hospital patient system. The distribution sex of cases are 111 males (62%) and 68 females (38%). The mean age of the 179 cases was 58,5±11,9 years (range of 21-90). The mean tumor diameter is 5,7±3,4 (range of 1-19 cm). The nuclear grades of cases are 53,1% with low grade and 46,8% with high grade. Radical nephrectomies were evaluated for vascular invasion, ureter invasion, capsule/adipose tissue invasion, lymph node metastasis and adrenal gland metastasis. There is a statistically significant relationship between nuclear grade and vein invasion, microvascular invasion, capsule/adipose tissue invasion (pÖğe Tavşan Vajinal Yara Modelinde Propolis Uygulamasının Yara İyileştirici Etkisi(Tokat Gaziosmanpasa University, 2022) Kurt, Begüm; Yıldız, Çaglar; Özkaya, Neşe Kurt; Koç, Tülay; Çelikgün, SerkanAmaç: Bu çalışmanın amacı, tavşan vajinal yara modelinde propolis uygulamasının yara iyileştirici etkisini değerlendirmektir. Gereç ve Yöntemler: Hayvanlar kontrol grubu ve propolis uygulama grubu olarak rastgele iki gruba ayrıldı ve her grupta 5'er adet tavşan kullanıldı. Tüm tavşanlarda vajinal yaralanma introitustan orta vajinal epitel ve stromaya kadar tam kat arka duvar insizyonu ile gerçekleştirildi. Çalışma grubundaki hayvanlara lokal olarak %15 saf Anadolu Propolisi uygulandı ve uygulamaya üç günde bir devam edildi. Kontrol grubuna herhangi bir uygulama yapılmadı. 21 gün sonunda tavşanlar sakrifiye edildi. Diseksiyon ile vajina ve çevresindeki perineal doku çıkarıldı. 3 mikron kalınlığında vajinal kesitler alındı. Bu kesitlerin bir kısmı hematoksilin-eozin (HE) ve Mason's Tricrome (MT) boyaması için normal lamlara, bir kısmı da anti-vasküler endotelyal büyüme faktörü (VEGF-1) immünohistokimya boyaması için pozitif yüklü bir lam üzerine alındı. Bulgular: Her iki grup fibrozis ve MT boyaması açısından karşılaştırıldı. Her iki grup arasında istatistiksel olarak anlamlı fark bulundu (p=0,039, p=0.039). Her iki grup inflamasyon ve VEGF açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulunmadı (p=0,285, p=0,428). Sonuç: Birinci derece perineal yaraların iyileşme sürecinde yarada aktif kanama yoksa ve yara kenarları düzgün ve birbirine yakın ise propolis uygulaması olumlu katkı sağlayabilir.Öğe The Level of Expressed Emotion (LEE) Scale (Short Version): The Turkish Validity and Reliability Study in Patients Admitting to Dermatology Clinic(Ümit Muhammet KOÇYİĞİT, 2021) Tosun, Mustafa; Yasak Güner, Rukiye; Hayta, Sibel Berksoy; Akyol, Melih; Çelikgün, SerkanPurpose: The purpose of the present study was to determine the Turkish validity and reliability of the LEE Scale (short version) in patients admitted to the Dermatology Clinic, and to ensure its use in patient evaluations for dermatology and other branches. Material and Methods: The LEE Scale (short version) had 38 items, and was developed originally in English. The scale was translated into Turkish by following the proper translation steps. The Turkish scale that was created was applied to the patients. A total of 510 people, 279 of whom were women (54.7%), and 231 men (45.3%), applying to Sivas Cumhuriyet University Hospital Dermatology Clinic were included in the study. The internal structure consistency and test-retest reliability were measured for reliability analyses. The Cronbach’s Alpha Coefficient was estimated for internal consistency. The scale was applied to 50 patients twice, at baseline and two weeks later for test-retest reliability, which was also statistically evaluated with the Pearson Correlation Test. The Exploratory Factor Analysis was performed to evaluate the construct validity of the scale. The significance level was taken as p
