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    Clinical application of second generation trombosite concentration
    (2012) Koçyi?it, Ismail Doruk; Tunali, Mustafa; Özdemir, Hakan; Kartal, Yasemin; Süer, Berkay Tolga
    The therapeutic use of autologous platelet-rich fibrin constitutes a relatively new biotechnology that has been a breakthrough in the stimulation and acceleration of soft-tissue and bone healing. The efficiency of this process lies in the local and continuous delivery of a wide range of growth factors and proteins, mimicking the needs of the physiological wound healing and reparative tissue processes. Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. This easy protocol allows the production of leukocyte and platelet-rich fibrin clots starting from autologous blood samples. PRF is used especially in clinical Periodontal and Oral and Maxillofacial Surgery applications. The significance of the PRF is gradually increasing.
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    Tip II diyabetli kronik periodontitis ve kronik periodontitis hastalarında periodontal tedavinin dişeti oluğu sıvısı myeloperoksidaz aktivite düzeyine etkisi
    (Cumhuriyet Üniversitesi, 2007) Özdemir, Hakan; Develioğlu, Hakan
    Özdemir H. Effect Of Phase I Periodontal Therapy On Gingival Crevicular Fluid Myeloperoxidase Levels Of Chronic Periodontitis Patients With And Without Type II Diabetes Mellitus. Cumhuriyet University Graduate School of Health Sciences, Ph.D. Thesis in Periodontology, Sivas, This study aimed to evaluate the effect of Phase I periodontal therapy on gingival crevicular fluid myeloperoxidase levels of Type II diabetes mellitus and systemically healthy chronic periodontitis patients and analyzed the correlation between clinical parameters and myeloperoxidase levels. Study population (34 female, 31 male) formed three groups: 1) Chronic periodontitis patients with Type II Diabetes mellitus, 2) Systemically healthy chronic periodontitis patients, 3) Healthy subjects. Plaque index, Gingival index, Bleeding time index, probing pocket depth, and attachment level measurements were done to analyze periodontal status of the subjects. Myeloperoxidase activity levels were measured from the gingival crevicular fluid samples collected from the subjects in the morning between 8:30-10:00 a.m. All measurements and sample collections repeated in 1,5 and 3 months after. Analysis of variance and Tukey tests were used in statistical analyzis. Results showed a statistical improvement in clinical parameters of periodontitis patients (p<0,05). Clinical parameters did not change in control group (p>0,05). Also, while a significant decrease in the gingival crevicular fluid myeloperoxidase levels in periodontitis groups were observed (p<0,05), no significant difference was seen in control group (p>0,05). As a result, we can suggest a destructive role for myeloperioxidase as it was present both in the gingival crevicular fluid of systemically healthy and Type II diabetic chronic patient groups. Also we think that, gingival crevicular myeloperoxidase may help us to better understand the diminished host response in these patient groups