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Öğe Bevacizumab-treated pregnant rats may constitute an experimental model for studying preeclampsia(2018) Boztosun, Abdullah; Olgan, Şafak; Özer, Hatice; Atılgan, Remzi; Pala, ŞehmusPurpose: To develop a rat model of preeclampsia by administering bevacizumab, an angiogenesis inhibitor.Materials and methods: Sixteen pregnant rats were randomly allocated to intraperitoneal injection of 10 mg/kgbevacizumab or 0.1 cc intraperitoneal serum physiologic on the 4th and 8th days of gestation. Blood pressure,body weight, and proteinuria were measured on both day 0 (D0) and day 20 (D20). Blood samples were collectedon D20 for analysis, including for determining vascular endothelial growth factor (VEGF) and soluble Fms-liketyrosine kinase 1 (sFlt-1) levels. On the same day, the mice were euthanized, the placentas and pups wereweighted, and the angiogenesis markers and microvessel density were evaluated using immunohistochemicalmethods.Results: Lower serum VEGF (p=0.038) and higher SFlt-1 (p=0.015) levels were observed in bevacizumabtreated pregnant rats. Bevacizumab-treated pregnant rats had significantly higher systolic (p=0.050) anddiastolic (p = 0.046) blood pressures compared to the controls. Additionally, the bevacizumab group showed asignificant increase in proteinuria on D20 compared to that on D0 (p=0.026). Although higher serum AST, ALT,BUN, and creatinine levels and renal glomerular endotheliosis scores as well as lower placental VEGF andmicrovessel density were noted in bevacizumab-treated rats, these differences were not statistically significant(p > 0.05 for each).Conclusion: The promising results of this trial show that bevacizumab treatment in pregnant rats might providea model to study human preeclampsia.Öğe Distinctive Histopathological Features of Fasciola Hepatica Adult(2024) Kartal, Sümeyra; Aslan, Sema; Öz, Murtaza; Soylu, Sinan; Özer, HaticeFasciola hepatica is a parasite of the Trematoda class, found worldwide but primarily seen in cattle-raising countries. It usually settles in the biliary tract and causes nonspecific gastrointestinal symptoms such as abdominal pain, right upper quadrant tend erness, and fever in humans. Parasitological examination of stool or bile samples is required for definitive diagnosis. In our case, demonstrative histopathological features of Fasciola hepatica adult parasite seen in a 38-year-old female patient suffering from abdominal pain were evaluated. Fasciola hepat- ica, a rare parasite in pathology practice, should be considered in the diagnosis in the presence of nonspecific gastrointestinalcomplaints because it can be seen worldwide as well as in endemic regions.Öğe Endometriyal Patolojilerde Prostat Spesifik Antijen Ekspresyonunun İncelenmesi(2018) Sümer, Dinçer; Yenisu, Ayşe Gonca; Boztosun, Abdullah; Özer, Hatice; Aker, Handan; Yanık, AliAmaç: Bu çalışmanın amacı Prostat Spesifik Antijen ekspresyonunu proliferatif endometriyum, endometriyal hiperplazi ve endometriyum kanseri dokularında immünhistokimyasal olarak araştırmak ve kıyaslamaktır.Hastalar ve Yöntemler: Endometrioid tip Endometrial Karsinom tanısı almış 31,Endometriyal Hiperplazi tanısı almış 29 ve Proliferatif Endometriyum tanısı almış28 olmak üzere toplam 88 olguya ait histerektomi materyali araştırma kapsamınaalınmıştır. Her olguda patolojiyi en iyi gösteren bir parafin blok prostat spesifik antijenile immünhistokimyasal boyama için kullanılmıştır. Pozitif boyanan hücre sayısı veboyanma yoğunluğu semikantitatif olarak belirlenmiştir. Her bir vaka için iki parametreçarpılarak 0 ile 12 arası nihai puan elde edilmiştir.Bulgular: Çalışmaya alınan toplam 88 histerektomi materyalinin 70’inde (%79.5)PSA ekspresyonu olduğu görülmüştür. İmmünhistokimyasal boyanma puanlarınabakıldığında proliferatif endometriyum ortalama puanın 3,4±3, Endometriyal hiperplazi grubunda 4,1±3,Endometriyum kanseri grubunda 2,2±3 olduğu görülmüştür.Grupların boyanma puanları arasındaki fark istatistiksel olarak anlamlı bulunmamıştır.Karsinom grubunda hastalığın evresi ve grade’i PSA ekspresyonu açısından farklılıkgöstermemektedir.Sonuç: Çalışmamız Prostat spesifik antijenin endometriyum dokusunda yüksekoranda eksprese olduğunu göstermektedir. Bu ekspresyon endometriyal patolojilerarasında istatistiksek olarak anlamlı fark kazanmamaktadır ve PSA’nın endometriyalkarsinom ile ilişkili olmadığını işaret etmektedir.Öğe Evaluation of histopathologic and immunohistochemical features of gastrointestinal stromal tumors(Turkish Surgical Society, 2006) Elagöz, Şahande; Arici, Sema; Karakaya, Esra Aydin; Özer, Hatice; Turan, MustafaPurpose: To determine the importance of immunohistochemical panel including CD117 in the differential diagnosis of gastrointestinal mesenchymal tumors. Introduction: Gastrointestinal stromal tumors are rare mesenchymal tumors of the gut wall. The most important features of these tumors are the expression of CD117 and CD34. There are difficulties in their differential diagnosis with other mesenchymal tumors. In this contexte immunohistochemical panel including CD117, CD34, actin and desmin should be utilized. The variability of their biological behaviour and their eventual curability, increase the importance of these tumors. Material and Methods: In this study mesenchymal tumors of the gastrointestinal tract diagnosed in the Pathology Department of Cumhuriyet University Faculty of Medicine were revised. The immunohistochemical panel necessary for the diagnosis of stromal tumors was applied to all of these cases, to find the rate of occurrence of stromal tumors. Results: Six tumors previously diagnosed as mesenchymal tumor and 11 cases diagnosed as stromal tumor were positive for CD117. After CD117 staining 17 tumors among 20 were diagnosed as stromal tumors. Conclusion: CD117 and CD34 are important markers and it seems that by performing immunohisto-staining to all mesenchymal tumors, stromal tumors will be diagnosed more frequently.Öğe Gastric heterotopia in the gallbladder: Mimicking the tumor imagine in radiology(Sivas Cumhuriyet University, 2021) Yeldir, Neşe; Bozbıyık, Nisa; Özer, Hatice; Topçu, ÖmerHeterotopia is mass of tissue normal to the site in abnormal location. Heterotopic gastric mucosa has been described in almost every part of the gastrointestinal tract including the tongue, oesophagus, epiglottis, small bowel, appendix vermiformis, rectum and gallbladder. The diagnosis of heterotopic gastric mucosa in gallbladder can be difficult clinically . Heterotopic gastric mucosa in gallbladder can be symptomatic or detected incidentally. It is relevant to distinguish heterotopic gastric mucosa from benign polyps, gallbladder carcinoma or metastasis. We present a case of a 51 year old female patient who represented suspicious lesion on computed tomography (CT). After cholecystectomy, in the microscopical examination gastric mucosa consisting of fundic glands and pyloric glands and typical features of chronic cholecystitis are seen.Öğe Isolated Gallbladder Perforation As a Result of With a Knitt Ing Needle: a Home Accident(Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2012) Cankorkmaz, Levent; Atalar, Mehmet Haydar; Özer, Hatice; Köylüoğlu, GökhanIsolated gallbladder perforation following penetrating abdominal trauma is rare. We present hereby an isolated gallbladder rupture caused by penetrating abdominal trauma in a boy; since the of gallbladder is rarely affected in this setting. A 5- year-old boy presented with a penetrating inj ury with knitting needles to the abdomen while playing at home. He had abdominal pain, vomiting and was lethargic at admission. On physical examination, there was abdominal tenderness. Ultrasonography and computed tomography of the ab domen revealed pericholecystic free fluid, while there was no free gas in abdominal X-ray. Urgent laparotomy was perfo rmed. Exploration revealed isolated gallbladder perforation for which cholecystectomy was doneÖğe Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas(Bolu Abant İzzet Baysal Üniversitesi, 2023) Yeldir, Neşe; Doğan, Ezgi; Özer, Hatice; Söylemez, Burçak; Çelikgün, Serkan; Eğilmez, ReyhanObjective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization (WHO) classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit (cut-off) value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3% for grade 1, 11.2% for grade 2 and 26% for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 (p>0.05). Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.Öğe Meme karsinomlarında tenaskin c-erB2 ve CD31’in prognostik önemi ve diğer prognostik faktörlerle karşılaştırılması(Cumhuriyet Üniversitesi, 2004) Özer, Hatice; Elagöz, ŞahandeIV ÖZET Meme karsinomlarında tenaskin, c-erbB-2 ve CD31' in prognostik önemi ve diğer prognostik faktörlerle karşılaştırılması Son yıllarda yapılan çalışmalar, meme kanserinde c-erbB-2, anjiogenez ve tenaskinin, prognostik bir belirleyici olarak kullanılabileceğini göstermekle birlikte bunların prognozdaki rolleri henüz netlik kazanmamıştır. Bu çalışma, 50 invaziv duktal karsinom olgusunda immünohistokimyasal olarak c-erbB-2 ve tenaskin ekspresyonu ile anjiogenez sonuçlarını araştırmak, elde edilen sonuçları günümüzde kullanılan diğer klinikopatolojik faktörlerle karşılaştırarak, bunların meme kanserinin prognozunu belirlemedeki yerini ve güvenilir prognostik faktörler olarak kullanılıp kullanılamayacağını ortaya koymak amacıyla yapıldı. Cumhuriyet Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı arşivinden, mastektomi uygulanan ve invaziv duktal karsinom tanısı alan 50 hastaya ait formalin- fıkse parafin bloklardan elde edilen preparatlar grade, stromal inflamatuar reaksiyon, nekroz ve damar invazyonu yönünden ışık mikroskopisinde yeniden değerlendirildi. Histolojik grade'leme, modifıye Bloom-Richardson yöntemine göre yapıldı. Hasta yaşı, tümör çapı ve metastatik aksiller lenf bezi sayısına ait bilgiler patololoji kayıtlarından elde edildi. Kontrol grubu olarak 20 fıbrokistik değişiklik (FKD) ve 20 fibroadenom (FA) olgusu seçildi. Olgulara Avidin-Biyotin-peroksidaz yöntemi ile immünohistokimyasal boyama uygulandı. Bu boyamada c-erbB-2, tenaskin ve damar endotel belirleyicisi olarak CD31 antikorları kullanıldı. Bunlardan elde edilen sonuçlar, prognostik faktörlerle karşılaştırıldı. c-erbB-2 ile nekroz arasında anlamlı bir ilişki saptanırken, diğer faktörlerle anlamlı bir ilişki bulunmadı. Anjiogenez ile parametrelerin hiçbirisi arasında anlamlı ilişki tespit edilmedi. Tümör stromasındaki tenaskin pozitifliği yaşlı hastalarda önemli derecede daha yüksek bulundu. Tümör hücrelerindeki sitoplazmik tenaskin pozitifliği ise kuvvetli inflamatuar reaksiyon, damar invazyonu ile pozitif korelasyon gösterdi. Sonuç olarak; c-erbB-2'nin ve tümör hücrelerindeki tenaskin pozitifliğinin kötü prognozla birlikte olabileceği düşünülmekle birlikte, majör faktörlerle ilişkisiz çıkmaları nedeniyle daha az önemli prognostik belirleyici olarak kullanılabilecekleri kanısına varıldı. Anjiogenezin ise prognostik faktör olarak bir yarar sağlamayacağı düşünüldü. Ancak bu bulguların geniş serilerde ve teknik şartların standardize edildiği koşullarda çalışılarak doğrulanması ve netlik kazanması gerektiği sonucuna varıldı. Anahtar kelimeler: Meme kanseri, c-erbB-2, anjiogenez, tenaskin, prognostik faktör.Öğe On Bir Yaşındaki Çocukta Dev Seröz Kistadenoma Bağlı Over Torsiyonu: Bir Olgu Sunumu(2018) Cankorkmaz, Levent; Özer, Hatice; Güney, CengizAdölesanlarda over torsiyonu sıklıkla overdeki benign ya da malign tümörlerinbir komplikasyonudur. Bu yazıda, akut karın ağrısı yakınmasıyla başvuranseröz kist adenoma bağlı sağ over torsiyonu tanısı konulan on bir yaşında kızolgu sunulmuştur. Adölesanlarda overin seröz kist adenomu ender olsa daover kitleleri ve torsiyonlarında epitelyal tümörlerin ayırıcı tanıda akılda tutulması,ameliyat sonrasında nüksler nedeniyle yakın takip yapılması açısındanönemlidir. Çocukluk çağı over torsiyonlarında ameliyat sırasındaki makroskopiktanı ameliyatta bırakılacak over dokusunun planlaması ve izlemde önemlidir.Öğe Ozone improves autogenous graft healing in experimental diabetes mellitus: A morphometric and immunohistochemical study(2020) Alpan, Aysan Lektemur; Toker, Hülya; Özer, HaticeBackground: Diabetes mellitus (DM) is a metabolic disorder whichplays crucial role in the pathogenesis of periodontitis. Ozone haveseveral actions such as antimicrobial, immunostimulating,antihypoxic effects, and activates antioxidant enzymes andangiogenesis. The aim of this study is to investigate the effect ofgaseous ozone on bone healing in diabetic rat calvarial defectstreated with autogenous bone graft, morphometrically andimmunohistochemically.Material and Methods: Diabetes was induced and critical sizedefects were created on rats. Study groups: 1-Empty defect(Control, n=14) group, 2-Autograft (AG, n=14) group, 3-Emptydefect+ozone therapy (Control+Ozone, n=14) group, 4-Autograft+ozone application (AG+Ozone, n=14) group. Gaseousozone was applied on the operation day and the following 2 weeksdaily (140ppm @ 2L/d, 2.24 mg). Total bone area was measured.Osteocalcin and Bone morphogenic protein-2 protein expressionswere evaluated.Results: Control and Control+Ozone groups had no osteoclastand residuel lacunae during the study . Osteoblasts in AG+Ozonegroup were higher than AG group at 4th week (p>0.05).AG+Ozone group had more total bone area than AG group at 4thweek. AG+Ozone group revealed more BMP-2 immune positivitycompared to the other groups. Osteocalcin immune positivity inAG groups was higher than those of the Control groups.Conclusion: Within the limitations of this study, gaseous ozoneapplication decreased osteoclast number and increasedosteoblast number and bone regeneration, especially, in earlystages of bone regeneration in diabetic ratsÖğe OZONE IMPROVES AUTOGENOUS GRAFT HEALING IN EXPERIMENTAL DIABETES MELLITUS: A MORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY(Selcuk University, 2020) Alpan, Aysan Lektemür; Toker, Hülya; Özer, HaticeAmaç: Diabetes mellitus (DM) is a metabolic disorder which plays crucial role in the pathogenesis of periodontitis. Ozone have several actions such as antimicrobial ,immunostimulating, antihypoxic effects, and activates antioxidant enzymes and angiogenesis. The aim of this study is to investigate the effect of gaseous ozone on bone healing in diabetic rat calvarial defects treated with autogenous bone graft, morphometrically and immunohistochemicallyGereç ve Yöntemler:Diabetes was induced and critical size defects were created on rats. Study groups: 1-Empty defect (Control, n=14) group, 2-Autograft (AG, n=14) group, 3-Empty defect+ozone therapy (Control+Ozone, n=14) group, 4-Autograft+ozone application (AG+Ozone, n=14) group. Gaseous ozone was applied on the operation day and the following 2 weeks daily (140ppm @ 2L/d, 2.24 mg). Total bone area was measured. Osteocalcin and Bone morphogenic protein-2 protein expressions were evaluated.Bulgular:Control and Control+Ozone groups had no osteoclast and residuel lacunae during the study . Osteoblasts in AG+Ozone group were higher than AG group at 4th week (p>0.05). AG+Ozone group had more total bone area than AG group at 4th week. AG+Ozone group revealed more BMP-2 immune positivity compared to the other groups. Osteocalcin immune positivity in AG groups was higher than those of the Control groups.Sonuçlar:Anahtar Kelimeler:Öğe Predictive Value of the Intestinal Free Fatty Acid Binding Protein in Celiac Disease(2022) Gökçen, Pınar; Çakmak, Erol; Adalı, Gupse; Doğan, Halef Okan; Özer, Hatice; Ozturk, Oguzhan; Doğanay, Hamdi LeventPurpose: Non-invasive tests used in the screening and follow-up of celiac disease (CD) are currently below expectations because they show false negatives/positives and are not always correlated with duodenal histology. We aimed to investigate the predictive value of intestinal free fatty acid binding protein (FABP-I) which can easily be released into the circulation in the presence of enterocyte damage in a short time in CD. Methods: This study included 59 patients with CD who were not on gluten free diet (GFD)(n=24) and who were on GFD(n=35) and 52 healthy controls. Demographic variables, complete blood count, ferritin, vitamin D, calcium, phosphorus, vitamin B12, prothrombin time, INR, and serum FABP-I levels were recorded for all groups. Results: There was no difference between the groups in terms of complete blood count, ferritin, calcium, phosphorus, vitamin B12, prothrombin time and INR (all p>0.05). Mean serum FABP-I was determined as 499.2±33.3 ng/L for patients with CD who were not on GFD and as 487.7±48.0 ng/L for who were on GFD, and these values were significantly higher when compared to the healthy controls 432.2±63.8 ng/L(p<0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of FABP-I for a cut-off value of 456.8 ng/L were 84.7%, 69.2%, 10.2% and 61.5%, respectively(AUC=0.785). Conclusion: This study has shown that FABP-I can serve as a non-invasive predictive marker for CD diagnosis. Overlooked diagnosis in serology-negative patients and false serology positivity for reasons other than CD will be prevented with its use in clinical practice since FABP-I directly reflects intestinal damage.Öğe Prognosis in IDH-Mutant and IDH-wild type glioblastoma(Sivas Cumhuriyet University, 2021) Kılıç, Eren; Yeldir, Neşe; Özüm, Ünal; Yücel, Birsen; Yılmaz, Mukaddes; Özer, Hatice; Eğilmez, ReyhanGlioblastoma (GBM) is the most common brain tumor in adults with a poor prognosis and predominantly astrocytic differentiation. GBM is classified according to the isocitrate dehydrogenase (IDH) mutation according to the World Health Organization (WHO) Brain Tumors 2016 classification. IDH-1 gene mutations are evaluated immunohistochemically (IHC) and molecular methods in current pathology laboratory practice.The aim of this study was to determine the overall survival in GBM cases according to IDH-1 mutation status and Ki-67 proliferation index.Total of 53 patients diagnosed as GBM between 2007-2020 in Sivas Cumhuriyet University Faculty of Medicine, Department of Pathology were evaluated. Disease-free median survival of 7 (13%) GBM patients with IDH mutation was 2 months (2-year survival 14%), disease-free median survival 9 months (2-year survival 24 %) in GBM IDH-wild type cases. In cases with a higher Ki-67 proliferation index, the median disease-free survival were shorter.In conclusion statistically significant results could not be obtained between disease-free survival in GBM IDH-mutant type and GBM IDH-wild type. However, the mean Ki-67 proliferation index of GBM IDH-wild type cases was found to be much higher than GBM IDH-mutant cases. High Ki-67 proliferation index was found to be associated with a significantly shorter survival.Öğe Servi?kovaji?nal smearde epi?telyal hücre anomali?si? saptanan hastalarin, kolposkopi?k bi?yopsi? sonuçlarinin de?erlendi?ri?lmesi?(2012) Boztosun, Abdullah; Mutlu, Ahmet Emin; Özer, Hatice; Aker, Handan; Yanik, AliObjective: The aim of this study was evaluate a colposcopy and cervical biopsy results of patients who had diagnosed epithelial cell abnormalities. Material and Method: Between January 2007 - May 2011, outpatient clinic records of 303 patients that obtained from Department of Gynecology and Pathology of Cumhuriyet University School of Medicine were evaluated. Results: Total examined in 11,681 cervicovaginal smear of 303 (%2,6) is "epithelial cell abnormalities" were found. Epithelial cell abnormalities cases with in 194 (%64) patient is Atypical Squamous Cells of Undetermined Significance (ASC-US); 35 (%11,5) patient is Atypical Squamous Cells, Suggestive of High Grade (ASC-H); 36 (%11,9) patient is Low Grade Squamous Intraepithelial Lesion (LSIL); 9 (%3) patient is High Grade Squamous Intraepithelial Lesion (HSIL); 9 (%3) patient is Squamous Cell Carcinoma (SCC); 2 (%0,6) patient is Adenocarcinoma as defined. İn 18 patient (%6) had Atypical Glandular Cells (AGC). In premalignant lesions, cervical intraepithelial neoplasia (CIN), carcinoma in situ and invasive carcinoma that were diagnosed by cervical biopsy were considered positive results. Patients in 10 cases ASC-US (%3,3), 6 cases ASC-H (%2), 6 cases LSIL (%2), 6 cases HSIL (%2), 1 case AGC (%0,3), 6 cases SCC (%2) and 2 cases Adenocarcinoma (%0,6) were detected positive results. In total, 81 (26.7%) patients of cervical biopsy taken and 37 (12.2%) patients, positive results were obtained. Conclusion: Follow-up of patients with glandular or epithelial cell abnormalities in smear is important to both early detection and reduction of incidance of invasive cervical cancer in smear is important to both early detection and reduction of incidance of invasive cervical cancer.Öğe Small bowel tumors in emergency surgery(Turkish Association of Trauma and Emergency Surgery, 2010) Turan, Mustafa; Karadayi, Kursat; Duman, Mustafa; Özer, Hatice; Arici, Sema; Yildirir, Cihan; Koçak, OsmanBACKGROUND The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting. METHODS From 1996 to 2008, 13 consecutive surgical cases of small bowel tumors were treated at the Cumhuriyet University Faculty of Medicine, Department of General Surgery, and Kütahya State Hospital, Department of General Surgery. Clinical and radiological charts of these patients were reviewed retrospectively from the department database. RESULTS Intestinal obstruction (7 cases) and perforation (5 cases) were the most common clinical presentations, followed by intussusception (1 case). Adenocarcinoma was the most frequent histologic type (4 cases), while small bowel sarcoma was seen in three cases and non-Hodgkin lymphoma in two cases. The remaining cases had carcinoid tumor, small bowel angioleiomyoma, Brunner's gland adenoma, and inflammatory pseudotumor of the small intestine. CONCLUSION Small bowel tumors are rare, the symptoms often non-specific, and the accuracy of different diagnostic tests remains to be improved. Timing and type of the intervention to the process and biological behavior of the pathological cells predict the prognosis.Öğe Supernumerary Ovary Characterized byCystic Changes in the Omentum: A Rare Pathology(2022) Cankorkmaz, Levent; Atalar, Mehmet Haydar; Özer, Hatice; Köylüoğlu, Gökhan; Başpınar, NisaSupernumerary ovary is a rarest gynecologic condition in children. The presence of cystic changes within the supernumerary ovary\ris extremely rare. We report a case of neonate with supernumerary ovary. The patient was 3-month-old girl with a right-side cyst diagnosed by\ra prenatal ultrasonographic evaluation. Ultrasonography performed right after birth, and a magnetic resonance imaging examination had revealed\rthat the abdominal cystic mass contained patchy semisolid components within a hemorrhagic or mucinous fluid. Laparotomy revealed a cystic\rmass which has no connection with the normal reproductive organs. Two normal ovaries were identified in the abdominal cavity. After excision,\rhistopathologic study revealed that cystic mass was supernumerary ovary on the omentum. The baby had no postoperative complications. Prenatal\rdifferential diagnosis of abdominal cystic masses in infants with supernumerary ovary will be useful to keep in mind.Öğe The Effect of Low Molecular Weight Heparins on Placentation: A Rat Model Study(2022) Özer, Gülizar; Yildiz, Caglar; Özer, Hatice; Çetin, AliLow molecular weight heparins (LMWHs) have been used for the treatment for recurrent pregnancy loss (RPL) for a long time. We aimed to investigate the efficacy of the LMWHs on angiogenesis and apoptosis during placentation. A total of twenty-four rats were randomly divided into three groups each containing 8 rats: normal saline; enoxaparine sodium 0.4 ml, and enoxaparine sodium 0.8 ml were given to the Group 1, 2 and 3, respectively. Normal saline and enoxaparine sodium 0.4 ml or 0.8 ml were given to the rats beginning on the day the pregnancy was detected and continued until the 15th day of the pregnancy. The tissues containing placental decidual zone were immunostained for vascular endothelial growth factor A (VEGF-A) and caspase 7. The decidual and placental VEGF-A and the decidual caspase 7 immunostaining scores of all of the groups were high, however, there were no statistically significant differences among the groups (p>0.05). On the other hand, the placental caspase 7 immunostaining scores of the normal saline group were significantly lower than those of the enoxaparine sodium 0.4 and the enoxaparine sodium 0.8 groups (p<0.05). LMWHs seem to have effects on placental angiogenesis and apoptosis.Öğe The Effect of Microsatellite Instability on Clinicopathological Data and Survival in Colorectal Cancer(2022) Bostancı, Meriç Emre; Mollaoğlu, Murat Can; Özer, Hatice; Karadayı, KürsatObjectives: Colorectal cancer is known as the third most common type of cancer worldwide. The microsatellite instability (MSI) pathway is effective in the development of 15-20% of colorectal cancers. MSI is mainly caused by mutational inactivation of one of the four main MMR genes (MSH2, MLH1, MSH6 or PMS2). This study was planned to investigate clinicopathological features of MSI in colorectal cancer and its effect on prognosis. For this purpose, demographic and clinicopathological data of patient groups with MSI and microsatellite stability (MSS) were compared. Materials and Methods: In this study, the pathology reports of 109 patients who were diagnosed with colorectal cancer and were operated on between 01.01.2015 and 01.01.2019 in the Surgery Oncology Clinic of Cumhuriyet University Medical Faculty Hospital were analyzed retrospectively. MLH-1, MSH-2, MSH-6, and PMS-2 antibodies were evaluated together with demographic and histopathological features and survival time of the patients. Results: The histological grade distribution difference between the MSS and MSI groups was not statistically significant (p=0.838). Mostly observed T-stage was T3 in both groups, and the differences between the groups were not statistically significant (p=0.405). Regarding the N stage, N0 was more common in MSS and N2 in MSI; however, no significant difference was observed between the two groups (p=0.844). Lymphovascular invasion (LVI) was not observed in most cases in both groups, and the differences between the groups were not statistically significant (p=0.493). Perineural invasion (PNI) was present in most cases in both groups, and the differences between the groups were not statistically significant (p=0.987). Survival rates according to the groups were evaluated using the Kaplan Meier test, and no statistically significant difference was found in the 2-year survival rates (p>0.05). Conclusion: In this study, the relationship of MLH1, MSH2, MSH6, and PMS2’s immunohistochemical expression with clinicopathological parameters and survival in patients with colorectal cancer was investigated. According to study results, the losses of expression in the cases were 13.7% for MLH1, 9.1% for MSH2, 12.8% for MSH6, and 14.6% for PMS2. Although it was not statistically significant in the study, we think that the survival rate is higher in cases with MSI. However, there was no statistical difference in MSI in terms of gender, age, grade, localization, LVI, and PNI. More parameters should be studied to detect MSI.Öğe The Effects of Lapatinib and Trastuzumab in a Rat Model of Endometriosis(2022) Yildiz, Caglar; Özsoy, Aker Zeki; Kacan, Turgut; Özer, HaticeTrastuzumab and lapatinib are drugs belonging to tyrosine kinase inhibitors family that are used in cancer treatment to prevent cell proliferation. Trastuzumab is an inhibitor of human epidermal growth factor receptor–2 (HER2) tyrosine kinase, and lapatinib is an inhibitor of epidermal growth factor receptor (EGFR). Tyrosine kinase inhibitors have also been investigated for treatment of endometriosis. In the present study, we aimed to investigate the effects of lapatinib and trastuzumab on rat endometriosis model. Endometriosis was surgically induced by the autologous transplantation of endometrial tissue and formation of endometriosis was confirmed via secondary laparotomy in 32 rats. Initially, 4 mg/kg dose of trastuzumab was applied intraperitoneally, and two additional doses of 2 mg/kg were applied 7 days and 14 days after the initial dose. Lapatinib was administered as 100 mg/kg daily doses for 14 days. Rats were randomly divided into four groups and were subjected to lapatinib, trastuzumab, anastrozole (0.004 mg/day, p.o.) and normal saline (0.1 ml, i.p.) treatments for 14 days. Then, endometriosis foci were excised, and endometriosis scores were calculated in a semi-quantitative manner. Immunohistochemical (IHC) examinations were also performed using VEGF, CD117 and Bax antibodies. Both anastrozole and tyrosine kinase inhibitors lowered endometriosis scores. Significant decreases in ovarian follicle numbers were observed in lapatinib and anastrozole groups but not trastuzumab group. Lapatinib and trastuzumab decreased endometriotic foci through suppressing cell proliferation and promoting programmed cell death.Öğe Triple synchronous primary cervical, endometrial and fallopian cancer: A case report(Gunes Kitap Kirtasiye, 2014) Boztosun, Abdullah; Sümer, Dinçer; Özer, Hatice; Eriten, Berna; Şeker, Metin; Yeniocak, Hidayet; Aker, HandanOccurrence of synchronous triple primary gynecological cancers is extremely rare,only few cases has been reported. Fifty one years old patient had ‘atypical glandular cells’ at cervical Papanicolaou test and ‘endometrial adenocarcinoma’ at endometrial sampling and was performed Type 3 total abdominal hysterectomy, bilateral salpingooopherectomy, infracolic omentectomy, complete pelvic-paraaortic lymphadenectomy and appendectomy. Final pathologies were concomitant primary cervical, endometrial and fallopian cancer. © 2014, Gunes Kitap Kirtasiye, All rights reserved.
