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    Effect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain following arthroscopic meniscus surgery: A prospective, double-blind, randomized, placebo-controlled, clinical trial
    (AVES, 2021) Avcı, Onur; Kol, İclal Özdemir; Gündoğdu, Oğuz; Öztemur, Zekeriya; Erşan, İdris
    Objective: The aim of this study was to determine the effect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain levels and analgesic requirements following arthroscopic meniscectomy. Methods: A total of 60 American Society of Anesthesiologist physical status I-II patients, aged 20 to 62 years, and scheduled for arthroscopic partial meniscectomy under general anesthesia were included in this study. All the patients were randomly assigned to one of four groups (15 patients in each group): Group 1 (8 male, 7 female; mean age = 46.70 ± 13.13 years; 0.9% isotonic 20 ml), group 2 (7 male, 8 female; mean age = 42.60 ± 12.18 years; levobupivacaine 0.5 mg/kg plus 0.9% isotonic), group 3 (8 male, 7 female; mean age = 43.80 ± 12.63 years; 1?g/kg dexmedetomidine plus 0.9% isotonic), and group 4 (7 female, 8 male; mean age = 40.40 ± 11.79 years; levobupivacaine 0.5 mg/kg plus 1?g/kg dexmedetomidine and 0.9% isotonic). All medications were administered at the end of arthroscopic surgery. Pain levels were measured using a Visual Analogous Scale (VAS) and Verbal Rating Scale (VRS) at postoperative 1, 2, 4, 6, 12, and 24 hours. Results: VAS scores at rest were significantly lower in Group 4 at postoperative 1th,2nd,4th,6th,12th, and 24th hours than in other groups. The time to take the first analgesic was significantly higher in Group4 (964 ± 288 min), and total analgesic consumption was significantly lower in Group 4 compared to those of other groups. Conclusion: Although administration of intra-articular dexmedetomidine alone may have a weaker effect than intra-articular levobupivacaine on postoperative pain relief after arthroscopic partial meniscectomy, adding dexmedetomidine to intra-articular levobupivacaine may increase the durationand quality of postoperative analgesia without any side effect. Level of Evidence: Level I, Therapeutic Study. © 2021, AVES. All rights reserved.
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    Examination of IL-6 -174 gene polymorphism in patients diagnosed with primary knee osteoarthritis: A case-control study
    (2022) Keskinbıçkı, Mehmet Vakıf; Öztemur, Zekeriya; Öztürk, Hayati; Kılınç, Seyran; Bulut, Okay; Arslan, Serdal; Pazarcı, Özhan
    Degenerative osteoarthritis (OA) is the most common joint disease. However, its etiology has not been clearly understood. We aimed to investigate the association between the IL-6-174G/C gene variant responsible for regulating IL-6 functions and primary knee osteoarthritis (PKOA). Patients older than 40 years who presented between February 2012 and April 2013 and were diagnosed with PKOA and had grade 3 (i.e., moderate) or 4 (i.e., severe) disease constituted the case group. Healthy volunteers formed the control group. Genomic DNA was extracted from blood leukocytes in both case and control groups, and the IL6-174 G/C genotypes were determined. Two groups were compared regarding demographic, clinical, radiological findings, and IL-6-174 genotyping results. Both case and control groups included 90 patients each. No statistically significant difference was found between the two groups regarding gender distribution, patient age, and body weight. The frequency of the mutant base pairs GC and CC in the IL-6-174 promoter region were significantly higher in controls than in cases. Women with genotypes including C alleles were genetically protect ed against the clinical disease. Similar findings were not detected in the male patient group. The IL6-174 G/C gene polymorphism does not increase the risk of PKOA. However, the mutant C allele can be protective against PKOA in female patients. Studies conducted on larger patient populations from different ethnic backgrounds are needed to confirm our findings since our sample size is relatively small.
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    Vancomycin-resistant enterococci infection in the orthopedic and traumatology clinic
    (Anatolian Journal of Clinical Investigation, 2015) Pazarci, Orhan; Gölge, Umut Hatay; Kilinç, Seyran; Şahintürk, Mehmet; Bulut, Okay; Öztemur, Zekeriya; Öztürk, Hayati
    Our study aimed to identify the incidence of patients with vancomycin-resistant enterococci (VRE) colonization in the orthopedics and traumatology clinic and to present an approach for these patients. The anal swab samples of 781 patients applying to and inpatient in the orthopedic and traumatology clinic from August 2013-December 2013, taken by the infection control committee under the auspices of the VRE infection surveillance program, were investigated. Of the 781 samples investigated, 14 patients (1.79%) were found to have VRE colonization. In 4 patients there was a history of diabetes mellitus, 5 patients had dirty wounds and 5 patients had repeated inpatient stay and surgery history. Cultures taken from the patients produced E. species and E. casseliflavus/gallinarum. In Turkey, the first vancomycin-resistant E. faecium strain was reported from Akdeniz University in 1998. Since this date, VRE is encountered more and more often in the hospital environment. Resistant bacteria easily propagate in the hospital environment and this increases the possibility of colonization and infection incidence. Early identification of resistant enterococci colonization in inpatients is important for control of enterococcal infections. As a result, we believe identifying patients in the risk group may reduce VRE infections. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.