Yazar "Abdo, Luceyn" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Ammi visnaga L. and Nanocarrier Approaches in the Treatment of Skin Diseases
    (Marmara Univ, 2022) Esenturk-Guzel, Imren; Topuzoglu, Sehernaz; Abdo, Luceyn; Gurer, Eda Sonmez; Yapar, Evren Algin
    Ammi visnaga L. is a plant that grows naturally in Europe and is very common in Turkiye. It has various pharmacological effects due to its gamma-pyrones, coumarins, flavonoids and essential oils content. And its major phytocontituent khellin, which has a furanochrorne structure obtained by extraction from the seeds of the Armin visnaga L. is effective on the photochemotherapy of skin diseases. In this context, researches on topical delivery of khellin has been increased and the use of nanocarriers has gain attention to achieve optimised efficacy and stability related khellin, for the treatment of some skin diseases especially psoriasis and vitiligo. In this review, studies on the efficacy of khellin, which is the major phytocontituent of Atnnti visnaga L.in the treatment of skin diseases and topical delivery of it via nanocarrier systems has been overviewed to draw attention to the potential of herbal sources accompained modern carrier systems in the treatment.
  • Küçük Resim Yok
    Öğe
    An Overview of Nanofiber Applications for Development of Phytopharmaceuticals
    (Galenos Publ House, 2022) Esenturk-Guzel, Imren; Abdo, Luceyn; Algin Yapar, Evren; Esenturk, Engin; Buyukkayhan, Derya; Sindhu, Rakesh K.
    Herbal sources contain a variety of bio-actives, which are also called phytochemicals. Many of the herbal bio-actives have therapeutic effects and distinguished chemical properties that allow them favorable candidates for phytomedicines. The history of traditional herbal medicines, which are the precursors of phytopharmaceuticals, dates back to ancient times. Today, many of the officially approved and widely used medicines are produced by isolating active substances from herbal sources. Although traditional pharmaceutical dosage forms such as tablets, capsules, syrups, solutions, decoctions and ointments are still used today, problems related with the absorption, biotransformation and stability of phytochemicals reduces the efficacy, bioavailability and in some cases safety of herbal medicines. Also, conventional pharmaceutical dosage forms are often providing an immediate release of phytoconstituents. Besides the use of advanced drug delivery systems offer advantages to overcome mentioned problems, they also provide extended release with maximum efficacy associated with minimum side effects. Researches on development of herbal formulations by using novel drug delivery systems have gain attention and the use of nanotechnology-based systems have special attention. One of the nano drug carrier systems is nanofibers which have unique properties making them widely used in different treatments such as infections, allergy, rheumatic diseases, inflammatory diseases, cancers, etc. In this study, the use Bitkisel kaynaklar, fitokimyasallar olarak da adlandirilan cesitli biyoaktif maddeler icerirler. Bitkisel biyo-aktiflerin cogu, bitkisel ilaclar icin uygun aday olmalarini saglayan terapotik etkilere ve kimyasal ozelliklere sahiptirler. Fitofarmasotiklerin oncusu olan geleneksel bitkisel ilaclarin tarihi cok eskilere dayanmaktadir. Gunumuzde resmi olarak onaylanmis ve yaygin olarak kullanilan ilaclarin bircogu bitkisel kaynaklardan etken maddelerin izole edilmesiyle uretilmektedir. Tabletler, kapsuller, suruplar, solusyonlar, dekoksiyonlar ve merhemler gibi geleneksel farmasotik dozaj formlari gunumuzde hala kullanilmasina ragmen, fitokimyasallarin absorpsiyonu, biyotransformasyonu ve stabilitesi ile ilgili problemler, bitkisel ilaclarin etkinligini, biyoyararlanimini ve bazi durumlarda guvenligini azaltmaktadir. Ayrica, geleneksel farmasotik dozaj formlari genellikle bitkisel bilesiklerin hemen salinmasini saglar. Gelismis ilac tasiyici sistemlerin kullanilmasi, bahsedilen sorunlarin ustesinden gelmek icin avantajlar sunmanin yani sira, minimum yan etkilerle iliskili maksimum etkinlik ile uzun sureli salim saglar. Yeni ilac tasiyici sistemler kullanilarak bitkisel formulasyonlarin gelistirilmesi uzerine yapilan arastirmalar dikkat cekmis ve nanoteknoloji tabanli sistemlerin kullanimina ayrica onem verilmistir. Nano ilac tasiyici sistemlerden biri de benzersiz ozelliklere sahip olan ve bu sayede enfeksiyon, alerji, romatizmal hastaliklar, enflamatuvar hastaliklar, kanser gibi farkli hastaliklarin of the nanofiber-based carrier systems to deliver herbal bio-actives through various drug application routes is overviewed.
  • Küçük Resim Yok
    Öğe
    DEVELOPMENT OF HERBAL BIOACTIVE LOADED NANOPARTICLES FOR TOPICAL APPLICATION IN VITILIGO
    (Soc Stiinte Farmaceutice Romania, 2023) Abdo, Luceyn; Esenturk-Guzel, Imren; Topuzoglu, Sehernaz; Yurtsever, Asli Gurbuz; Erdal, Meryem Sedef; Yapar, Evren Algin
    Vitiligo is characterised by the appearance of white lesions on the skin, which are mainly caused by depigmentation of the skin due to the destruction of selective melanocytes. Ammi visnaga L. is a plant that grows widely in Mediterranean climate regions and khellin is one of its major components. Khellin stimulates the migration and proliferation of melanocytes in hair follicles. Both oral and dermal use of khellin is available, but some systemic side effects such as nausea and hepatotoxicity can be accompanied by oral administration. In the case of dermal application, poor skin penetration of khellin related to its lipophilicity needs to be overcome. In this study, khellin loaded cellulose acetate phthalate nanoparticles were developed to be used in the topical treatment of vitiligo by using Taguchi Orthogonal Array Design in the preliminary formulation studies. The characterization studies were carried out by determination of the size, zeta potential and encapsulation efficiency of nanoparticles and in vitro drug release and ex vivo penetration studies were carried out to evaluate their performance. The optimum nanoparticle formulation was found as an average size of 217.8 nm, PDI value of 0.11, zeta potential of -18.4 mV and encapsulation efficiency of 34.2%. Khellin loaded nanoparticles released 75% of khellin during 24 hours in a controlled manner. In addition, incorporation of khellin nanoparticles into HPMC gel increased the amount of khellin accumulated in the deep layers of the skin.