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    Antileukemic activity of Alchemilla mollis (Buser) Rothm. and its contituents; hyperoside and isoquercetin
    (Lippincott Williams & Wilkins, 2015) Kurtul, Ekin; Karabay, Arzu Zeynep; Acikara, Ozlem Bahadir; Tekin, Mehmet
    [Abstract Not Available]
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    Antimicrobial and Anti-Inflammatory Activity of Some Lathyrus L. (Fabaceae) Species Growing in Turkey
    (TURKISH PHARMACISTS ASSOC, 2019) Heydari, Hajar; Iscan, Gulcin Saltan; Eryilmaz, Mujde; Acikara, Ozlem Bahadir; Sarialtin, Sezen Yilmaz; Tekin, Mehmet; Coban, Tulay
    Objectives: The present study aimed to evaluate the antimicrobial and anti-inflammatory activities of methanol extracts and n-hexane, ethyl acetate, chloroform, and water fractions of five Lathyrus species, namely Lathyrus armenus, Lathyrus aureus, Lathyrus cilicicus, Lathyrus laxiflorus subsp. laxiflorus, and Lathyrus pratensis, growing in Turkey. Materials and Methods: The antimicrobial activities were screened against Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10231. Broth dilution was used to determine the antimicrobial activities of extracts and fractions. In vitro anti-inflammatory activity of these extracts and fractions was determined using human red blood cell membrane stabilization. Results: The results demonstrated that ethyl acetate fractions of the tested species exhibited higher antimicrobial activity than the other extracts. Among all of the tested extracts and fractions, the highest anti-inflammatory activity was detected in water fractions. Furthermore, water fractions of L. pratensis showed better anti-inflammatory activity than acetylsalicylic acid and diclofenac sodium, which were used as standard drugs in this assay. Conclusion: The results indicate the membrane stabilizing effect of the various extracts and fractions of the Lathyrus species and could constitute preliminary work for in vivo anti-inflammatory activity experiments.
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    Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
    (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017) Ozbek, Hanefi; Acikara, Ozlem Bahadir; Keskin, Ilknur; Kirmizi, Neriman Ipek; Ozbilgin, Serkan; Oz, Burcin Ergene; Kurtul, Ekin; Ozrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gulcin
    Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100 mg/kg and 200 mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200 mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties. (C) 2016 Elsevier Masson SAS. All rights reserved.
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    Phytochemical analyses and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model
    (SPRINGER HEIDELBERG, 2015) Akkol, Esra Kupeli; Demirel, Murside Ayse; Acikara, Ozlem Bahadir; Suntar, Ipek; Ergene, Burcin; Ilhan, Mert; Ozbilgin, Serkan; Saltan, Gulcin; Keles, Hikmet; Tekin, Mehmet
    The aim of the present study is to evaluate the treatment potential of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in the experimentally induced endometriosis model in rats. Endometriosis was surgically induced in rats by autotransplanting endometrial tissue to abdominal wall. Thirty-six rats were randomly divided into six groups. The groups were orally treated with the methanol:water (80:20) extracts of aerial parts and roots of A. mollis and A. persica. Buserelin acetate (20 mg) was used as the reference drug. The phytochemical contents of the most active extracts were determined by high performance liquid chromatography. The cystic formation was determined to be significantly decreased with the aerial part extract of A. mollis. A reduction in the endometrioma was also determined for the aerial part extract of A. persica group. However, significant reduction on the levels of cytokine were recorded for the A. mollis aerial part extract group. Therefore, the phytochemical contents of the aerial part extracts of A. mollis. and A. persica were analyzed. The results of the present study revealed that the aerial part extracts of A. mollis and A. persica could be beneficial in the treatment of endometriosis.