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Öğe Can We Predict the Sites of the Recurrence of Ovarian Cancer by F-18 FDG PET/CT Depending on CA-125 Level?(BENTHAM SCIENCE PUBL LTD, 2017) Turgut, Bulent; Ciftci, Esra; Erturk, Seyit Ahmet; Cetin, Bulent; Aker, Handan; Hasbek, ZekiyeObjectives: The purpose of the study is predicting the sites of the recurrence with PET/CT by serum CA-125 level and detecting the cut-off value of CA-125 for metastatic ovarian cancer (OC) in comparison with Fluorine-18 FDG PET/CT. Materials & Methods: For 38 patients with histological stage III-IV OC, F-18 FDG PET/CT studies (n=59) referred for suspicion of relapsing of OC were conducted. PET/CT images were assessed as positive/negative in 4 categories based on similar location as local recurrence, peritoneal metastasis, lymph node metastases and distant metastases. Patients were divided into five groups according to the levels of CA-125. The results of PET/CT imaging were compared with the level of CA-125. Results: Recurrence was confirmed in all FDG-PET/CT studies. In 7 of them (11.9%) CA-125 levels were normal (mean: 18.9 +/- 5.9) whereas in 52 of them (88%) were high (mean: 433.9 +/- 798.3). Moderate but highly significant positive correlation between CA-125 level and the number of metastatic foci detected by PET/CT was found. There was no statistically significant difference between CA-125 level subgroups and metastatic sites. However, the difference between CA-125 levels and location of metastasis was statistically significant only for distant metastasis and peritoneal metastasis with moderate accuracy (71% and %66, respectively). Conclusion: Since CA-125 has moderate but highly significant positive correlation with the number of metastatic foci, it is important in clinical management of OC patients. However, it may not predict the localization of the recurrence. When suspicious findings were reported at radiodiagnostic techniques in OC patients, FDG-PET is a useful technique for detecting recurrent ovarian carcer regardless of CA-125 level.Öğe Endometriyal Patolojilerde Prostat Spesifik Antijen Ekspresyonunun İncelenmesi(2018) Sümer, Dinçer; Yenisu, Ayşe Gonca; Boztosun, Abdullah; Özer, Hatice; Aker, Handan; Yanık, AliAmaç: Bu çalışmanın amacı Prostat Spesifik Antijen ekspresyonunu proliferatif endometriyum, endometriyal hiperplazi ve endometriyum kanseri dokularında immünhistokimyasal olarak araştırmak ve kıyaslamaktır.Hastalar ve Yöntemler: Endometrioid tip Endometrial Karsinom tanısı almış 31,Endometriyal Hiperplazi tanısı almış 29 ve Proliferatif Endometriyum tanısı almış28 olmak üzere toplam 88 olguya ait histerektomi materyali araştırma kapsamınaalınmıştır. Her olguda patolojiyi en iyi gösteren bir parafin blok prostat spesifik antijenile immünhistokimyasal boyama için kullanılmıştır. Pozitif boyanan hücre sayısı veboyanma yoğunluğu semikantitatif olarak belirlenmiştir. Her bir vaka için iki parametreçarpılarak 0 ile 12 arası nihai puan elde edilmiştir.Bulgular: Çalışmaya alınan toplam 88 histerektomi materyalinin 70’inde (%79.5)PSA ekspresyonu olduğu görülmüştür. İmmünhistokimyasal boyanma puanlarınabakıldığında proliferatif endometriyum ortalama puanın 3,4±3, Endometriyal hiperplazi grubunda 4,1±3,Endometriyum kanseri grubunda 2,2±3 olduğu görülmüştür.Grupların boyanma puanları arasındaki fark istatistiksel olarak anlamlı bulunmamıştır.Karsinom grubunda hastalığın evresi ve grade’i PSA ekspresyonu açısından farklılıkgöstermemektedir.Sonuç: Çalışmamız Prostat spesifik antijenin endometriyum dokusunda yüksekoranda eksprese olduğunu göstermektedir. Bu ekspresyon endometriyal patolojilerarasında istatistiksek olarak anlamlı fark kazanmamaktadır ve PSA’nın endometriyalkarsinom ile ilişkili olmadığını işaret etmektedir.Öğe Servi?kovaji?nal smearde epi?telyal hücre anomali?si? saptanan hastalarin, kolposkopi?k bi?yopsi? sonuçlarinin de?erlendi?ri?lmesi?(2012) Boztosun, Abdullah; Mutlu, Ahmet Emin; Özer, Hatice; Aker, Handan; Yanik, AliObjective: The aim of this study was evaluate a colposcopy and cervical biopsy results of patients who had diagnosed epithelial cell abnormalities. Material and Method: Between January 2007 - May 2011, outpatient clinic records of 303 patients that obtained from Department of Gynecology and Pathology of Cumhuriyet University School of Medicine were evaluated. Results: Total examined in 11,681 cervicovaginal smear of 303 (%2,6) is "epithelial cell abnormalities" were found. Epithelial cell abnormalities cases with in 194 (%64) patient is Atypical Squamous Cells of Undetermined Significance (ASC-US); 35 (%11,5) patient is Atypical Squamous Cells, Suggestive of High Grade (ASC-H); 36 (%11,9) patient is Low Grade Squamous Intraepithelial Lesion (LSIL); 9 (%3) patient is High Grade Squamous Intraepithelial Lesion (HSIL); 9 (%3) patient is Squamous Cell Carcinoma (SCC); 2 (%0,6) patient is Adenocarcinoma as defined. İn 18 patient (%6) had Atypical Glandular Cells (AGC). In premalignant lesions, cervical intraepithelial neoplasia (CIN), carcinoma in situ and invasive carcinoma that were diagnosed by cervical biopsy were considered positive results. Patients in 10 cases ASC-US (%3,3), 6 cases ASC-H (%2), 6 cases LSIL (%2), 6 cases HSIL (%2), 1 case AGC (%0,3), 6 cases SCC (%2) and 2 cases Adenocarcinoma (%0,6) were detected positive results. In total, 81 (26.7%) patients of cervical biopsy taken and 37 (12.2%) patients, positive results were obtained. Conclusion: Follow-up of patients with glandular or epithelial cell abnormalities in smear is important to both early detection and reduction of incidance of invasive cervical cancer in smear is important to both early detection and reduction of incidance of invasive cervical cancer.Öğe Triple synchronous primary cervical, endometrial and fallopian cancer: A case report(Gunes Kitap Kirtasiye, 2014) Boztosun, Abdullah; Sümer, Dinçer; Özer, Hatice; Eriten, Berna; Şeker, Metin; Yeniocak, Hidayet; Aker, HandanOccurrence of synchronous triple primary gynecological cancers is extremely rare,only few cases has been reported. Fifty one years old patient had ‘atypical glandular cells’ at cervical Papanicolaou test and ‘endometrial adenocarcinoma’ at endometrial sampling and was performed Type 3 total abdominal hysterectomy, bilateral salpingooopherectomy, infracolic omentectomy, complete pelvic-paraaortic lymphadenectomy and appendectomy. Final pathologies were concomitant primary cervical, endometrial and fallopian cancer. © 2014, Gunes Kitap Kirtasiye, All rights reserved.
