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Öğe A comparative analysis of the fatty acid profiles in the liver and muscles of male and female Salmo trutta macrostigma(ELSEVIER SCI LTD, 2009) Akpinar, Mehmet Ali; Gorgun, Salih; Akpinar, Ali EmreThe fatty acid compositions of liver and muscle of male and female Salmo trutta macrostigma, in the Tohma River, Turkey, were determined by gas chromatography. There were quantitative differences between individual fatty acids in the tissues investigated, depending on the sex. The most abundant fatty acids in both tissues of both sexes were palmitic acid (C16:0; 19.0-21.6%), stearic acid (C18:0; 5.32-11.3%), C18:1 omega-7 (5.65-9.38%), oleic acid (C18:1 omega-9; 15.6-22.4%), eicosapentaenoic acid (EPA; C20:5 omega-3; 6.34-7.88%) and docosahexaenoic acid (DHA; C22:6 omega-3; 7.38-15.6%). The omega-3/omega-6 ratio in tissues were found to be 2.89 (male) and 1.97 (female) in liver, and 2.59 (male) and 2.26 (female) in muscle. S. trutta macrostigma may be a valuable food for human consumption in terms of fatty acids. (C) 2008 Elsevier Ltd. All rights reserved.Öğe Fatty Acid Composition and omega 3/omega 6 Ratios in the Muscle of Wild and Reared Oncorhynchus mykiss(SPRINGER, 2015) Akpinar, Nukhet; Akpinar, Mehmet Ali; Gorgun, Salih; Akpinar, Ali EmreThe fatty acid composition and omega 3/omega 6 ratios in the muscle of wild and reared Oncorhynchus mykiss (rainbow trout) in the Tohma River (Sivas, Turkey) were determined by gas chromatography. There were quantitative differences between some fatty acids in the muscles of wild and reared rainbow trout. The most abundant fatty acids in both wild and reared fish were palmitic acid (16:0), stearic acid (18:0), oleic acid (18:1 omega 9), and docosahexaenoic acid (22:6 omega 3). The levels of omega 3 series and omega 6 series fatty acids in wild fish muscle were higher than in the reared fish. The omega 3/omega 6 ratios in muscle were found to be 1.92 (reared fish) and 2.28 (wild fish). The higher omega 3/omega 6 ratio in the wild fish might be a result of the season and the richer feeding conditions in the river under natural conditions. However, daily and continuously reared fish might be turned into more beneficial food for human consumption.Öğe Fatty acid composition of the seeds of some species of Peucedanum (kral otu) from Turkey(Scientific and Technical Research Council of Turkey, 2012) Akpinar, Nükhet; Görgün, Salih; Akpulat, Hüseyin Aşkin; Akpinar, Mehmet Ali; Aktümsek, Abdurrahman; Akpinar, Ali EmreThe fatty acid compositions of the seeds of Peucedanum ruthenicum, Peucedanum chryseum, Peucedanum palimbioides, Peucedanum obtusifolium, and Peucedanum zedelmeierianum were investigated by gas chromatography (GC). The main fatty acids in the species were found to be palmitic acid (C 16:0, 5.78%-14.68%), oleic acid (C 18:1 ?-9, 31.28%-68.06%), and linoleic acid (C 18:2 ?-6, 15.99%-33.74%). Trace amounts of cis-vaccenic acid (C 18:1 ?-7, 0.82%-1.40%) were found in the seed oils of all of the species investigated. © TÜBITAK.Öğe SIRT2 deacetylates and decreases the expression of FOXM1 in colon cancer(Wiley, 2024) Yildiz, Baris; Demirel, Ramazan; Staudacher, Jonas J.; Beseren, Hatice; Yildiz, Gulden; Akpinar, Ali Emre; Park, Seong-HoonNew FOXM1-specific inhibitors with the potential to be used for therapeutic purposes are under extensive research. We hypothesized that deacetylation of FOXM1 would decrease protein expression, thus providing novel therapeutic management of colon cancers. Immunostaining was used to determine FOXM1 and SIRT2 expressions in human colon cancer tissue microarrays (n = 90) from Stage I to Stage IV. SIRT2-FOXM1 interaction was evaluated in colon cancer cells using immunoprecipitation. Deacetylation of FOXM1 via SIRT2 was determined using in vitro deacetylation assays. FOXM1 could be hyper-acetylated when p300 and pCAF histone acetyltransferases were administered alongside deacetylase inhibitors. We detected that SIRT2 and FOXM1 physically interacted, and SIRT2 deacetylated FOXM1 in vitro. SIRT2 overexpression led to a significant decrease while knockdown of SIRT2 increased the FOXM1 expression in HCT116 human colon carcinoma cells. In the analysis of 90 human colorectal cancer samples, high SIRT2 expression was observed in about 49% of colorectal cancer, intermediate in 29%, and low or no staining in 22%. Strong SIRT2 expression was found to be negatively associated with the FOXM1 staining in our clinical cohort. This study reveals a molecular interaction and association between SIRT2 and FOXM1 expression in colon cancer cell lines and human colon cancer samples, and suggests that targeting SIRT2 activity using small molecule modulators may be a promising therapeutic approach for colorectal cancer. SIRT2-FOXM1 interaction in colon cancer. SIRT2 and FOXM1 physically interacted and SIRT2 deacetylated FOXM1 in vitro. Strong SIRT2 expression was negatively associated with FOXM1 staining in a human colon carcinoma tissue microarray. Resveratrol, berberine, and quercetin reduced FOXM1 expression in colon cancer cells.image Upregulation of FOXM1 may be an early molecular signal required for cancer SIRT2 and FOXM1 physically interacted, and SIRT2 deacetylated FOXM1 in vitro Strong SIRT2 expression was negatively associated with the FOXM1 staining in the TMA Resveratrol, berberine and quercetin decreased FOXM1 expression in colorectal cancer cellsÖğe Total Lipid Content and Fatty Acid Composition of Seeds of Some Wild Achillea Species(Springer, 2019) Zonuz, Nuray; Akpinar, Nukhet; Donmez, Erol; Zengin, Gokhan; Akpinar, Ali Emre; Akpinar, Mehmet Ali[Abstract Not Available]
