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A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
(Wiley, 2020) Kozan, Ahmet; Guner, Rukiye Yasak; Akyol, Melih
Acne vulgaris is a chronic inflammatory skin disease that mostly develops during adolescence and continues throughout adulthood. It affects the face, the main location of cosmetic appearance. Despite many developments in acne treatment, various combination therapies are needed to create the best option. Ninety patients were included in this study. We used the global acne grading system (GAGS) and the lesion counting and photographic standards that were used by Hayashi et al., to assess acne severity. The patients were randomly divided into three groups as group 1 (using only 5% BPO, twice a day), group 2 (using only the combination of 5% BPO + 3% erythromycin, twice a day), and group 3 (using only the combination of 4% niacinamide + 1% gallic acid + 1% lauric acid, twice a day). Thirty patients were included in each group. The scores were evaluated at weeks 0, 2, 4 and 8, and compared with each other. As a result of the study, all three treatment types were found to be effective. The combination of 4% niacinamide + 1% gallic acid + 1% lauric acid can be used as an alternative topical treatment for acne vulgaris to prevent resistance against topical antibiotics and the side effects of some other treatments.
Associations between health literacy and preventive Skin Cancer Prevention Strategies among University Students
(Mashhad University of Medical Sciences, 2020) Özpinar, Saliha; Çelik-Odabaşi, Nurcan; Akyol, Melih
Background and Objective: A person’s putting every behavior into practice after they receive information on health may mean that the person can exhibit the appropriate health behavior and protect his health within the context of their level of health literacy. This study was aimed at determining university students’ health literacy levels and the effects of their health literacy on their knowledge of, and attitudes and behaviors towards skin cancer prevention strategies. Materials and Methods: This descriptive study included 800 university students in the Aegean Region of Turkey. The data were collected by the researchers between March 01, 2019 and March 30, 2019. The research data were collected using the Descriptive Characteristics Form including 3 parts (the Participants' Socio-Demographic Characteristics Questionnaire, Information-AttitudeBehavior Questionnaire, Risk Factors Questionnaire) and the "Turkish Health Literacy Scale". The association between the sociodemographic characteristics of the students and their scores for protective behavior, knowledge levels and risk factors and Health Literacy was analyzed using the linear regression model (the ‘Enter’ method). The relationship between health literacy and knowledge/ attitude / behavior scores was evaluated with the Pearson’s correlation. p<0.05 was considered as statistically significant. Results: The mean age of the participating students was 21.0 ± 1.8 (18-36) years. Of them, 63.8% were women. The study results demonstrated that the participating university students’ knowledge levels regarding the harmful effects of sunshine and skin cancer prevention were inadequate. There is a positive correlation between health literacy and sun protection attitudes and behaviors. Of the participating students, those whose health literacy levels were high and those who had high knowledge / attitude scores about sun protection displayed better sun protection behaviors (p<0.05). Conclusion: A significant result of the study was that health literacy should be improved in order to improve sun protection and skin cancer prevention strategies. © 2020, Mashhad University of Medical Sciences. All rights reserved.
Behçet hastalığındaki oral ülserlerde ve rekürrent Aftöz Stomatit’de mast hücrelerinin histopatolojik değerlendirilmesi
(Cumhuriyet Üniversitesi, 1997) Akyol, Melih; Marufihah, Mehmet
54 VU-ÖZET BH'dald oral ülserler ve RAS'deki MH sayılarını kantitatif olarak araştırmak amacıyla Ekim 1995-Aralık 1996 tarihleri arasında Cumıtriyet Üniversitesi Dermatoloji polikliniğine başvuran klinik olarak 20 RAS'Ii ve Uluslararası Çalışma Grubu kriterlerine göre BH tanısı konmuş 20 hasta ve 15 sağlıklı kişiden oluşan kontrol grubu çalışmaya alındı. Çalışmaya atman hastalar son 2 ay içinde herhangi bir sistemik tedavi almamışlardı. Her hastanın oral aftöz lezyonundan ve kontrol grubunda klinik olarak normal görünümlü alt dudak mukozasından lokal anestezi altında biopsi alındı. Biopsi materyalleri Toluidin mavisi ile boyanarak mast hücreleri kantitatif olarak değerlendirildi. BH grubunda ortalama mast hücresi sayısı 10.58±1.32, RAS grubunda ortalama MH sayısı 13.25±3.37 ve kontrol grubunda ortalama MH sayısı 4.31+1.38 idi. Buna göre BH ve RAS, MH sayılan açısından karşılaştırıldığında aralarındaki farklılık istatistiksel olarak anlamsızdı (p>0.05, U=178.0). BH ve normal mukoza MH sayılan açısından karşılaştırıldığında aralanndaki farklılık istatistiksel olarak anlamlı idi (p<0.01, U=56.5) RAS ve normal mukoza MH sayılan açısmdan karşılaştuıldığmda aralanndaki farklılık istatistiksel olarak anlamlı idi (p<0.05, 11=75.5). Çalışmamızda BH ve RAS'de mast hücresi sayılarının normal mukozaya oranla istatistiki olarak anlamlı derecede yüksek olması, patogenezde mast hücrelerinin önemli rolü olduğu fikrini desteklemektedir. BH ve RAS'deki oral ülserlerde MH sayısında istatistiki olarak anlamlı farklılık olmaması, bu iki hastalığın ayıncı tanısında oral ülserlerdeki MH sayısının kullanılamayacağı fikrini vermektedir.
Blood mean platelet volume may be predictive for disease course in the cases with pemphigus vulgaris.
(SCIENTIFIC PUBLISHERS INDIA, 2017) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, Melih
Pemphigus vulgaris (PV) is an autoimmune blistering disorder treated with immunosuppressive agents. The patients with pemphigus vulgaris have remission and relapses and there is a need to have easy accessible and cheap laboratory monitoring markers. The aim of this study was to investigate the relationship between the course of the disease and the changes of the levels of neutrophil/lymphocyte ratio (NLR), platelet/lypmhocyte ratio (PLR), mean corpuscular volume (MCV) and mean platelet volume (MPV) in the patients with PV. Pemphigus patients (n=43) and healthy controls (n=40) were included in the study, retrospectively. Clinical and laboratory data, including C-reactive protein, erythrocyte sedimentation rate, hemoglobin, hematocrit, red cell distribution width, lymphocyte count, neutrophil count, platelet count, MPV, of the patients and healthy controls were obtained from our institutional computerized medical database. NLR and MPV levels in patients are higher than health controls (p<0.05) MPV changes are consistent with disease course according to variance analysis. MPV cut-off level is 8.45 and the specificity and sensitivity of this cut-off level is 65% and 76% to predict the pemphigus attacks, respectively (p=0.427). NL ratio, PL ratio and MPV may be accepted as inflammatory markers. MPV levels may be recommended as a marker for the determination of relapses in the patients with pemphigus vulgaris.
Climatotherapy in psoriasis
(2008) Özçelik, Sedat; Akyol, Melih
Hydroclimatology is used successfully as a treatment modality for psoriasis, either solely or as an adjunct to more specific treatments. Climatotherapy is a type of treatment utilizing the atmosphere, temperature, humidity, sun light, sea water, thermo-mineral water and mud. Therapeutic effect is achieved through the combined action of sun light, sea water, and fresh air and, of combinations with spa water. Some elements such as selenium, magnesium, potassium, slica, calcium, sulfates, and sodium, found in water, are believed to be absorbed through the skin, and are also beneficial for the good therapeutic response to climatotherapy. Important climatotherapy centers for psoriasis in the world are Dead Sea, Kangal Hot Spring with Fish, Blue Lagoon, Black Sea-Bulgaria, and La Roche- Possay. Climatotherapy of psoriasis are alternative therapeutic options for the management of psoriasis. The promising results together with the combination of treatment and complete physical/mental recreation result in the growing popularity of these therapeutic options amongst the patients. However, further research and larger controlled studies are needed to evaluate the mechanism of action as well as to compare the efficacy of climatherapy to conventional therapeutic modalities.
Climatotherapy in Psoriasis
(TURKISH SOC DERMATOLOGY VENEROLOGY, 2008) Ozcelik, Sedat; Akyol, Melih
Hydroclimatology is used successfully as a treatment modality for psoriasis, either solely or as an adjunct to more specific treatments. Climatotherapy is a type of treatment utilizing the atmosphere, temperature, humidity, sun light, sea water, thermo-mineral water and mud. Therapeutic effect is achieved through the combined action of sun light, sea water, and fresh air and, of combinations with spa water. Some elements such as selenium, magnesium, potassium, slica, calcium, sulfates, and sodium, found in water, are believed to be absorbed through the skin, and are also beneficial for the good therapeutic response to climatotherapy. Important climatotherapy centers for psoriasis in the world are Dead Sea, Kangal Hot Spring with Fish, Blue Lagoon, Black Sea-Bulgaria, and La Roche- Possay. Climatotherapy of psoriasis are alternative therapeutic options for the management of psoriasis. The promising results together with the combination of treatment and complete physical/mental recreation result in the growing popularity of these therapeutic options amongst the patients. However, further research and larger controlled studies are needed to evaluate the mechanism of action as well as to compare the efficacy of climatherapy to conventional therapeutic modalities. (Turkderm 2008; 42 Suppl 2: 57-5)
Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey
(WILEY, 2018) Uzun, Soner; Gurel, Mehmet S.; Durdu, Murat; Akyol, Melih; Karaman, Bilge Fettahlioglu; Aksoy, Mustafa; Aytekin, Sema; Borlu, Murat; Dogan, Esra Inan; Dogramaci, Cigdem Asena; Kapicioglu, Yelda; Akman-Karakas, Ayse; Kaya, Tamer I.; Mulayim, Mehmet K.; Ozbel, Yusuf; Toz, Seray Ozensoy; Ozgoztasi, Orhan; Yesilova, Yavuz; Harman, Mehmet
Background Cutaneous leishmaniasis ( CL) is a vector- born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged. Objectives The aim of this study was to develop diagnostic and therapeutic guidelines for the management of CL in Turkey. Methods This guideline is a consensus text prepared by 18 experienced CL specialists who have been working for many years in areas where the disease is endemic. The Delphi method was used to determine expert group consensus. Initially, a comprehensive list of items about CL was identified, and consensus was built from feedback provided by expert participants from the preceding rounds. Results Evidence- based and expert- based recommendations through diagnostic and therapeutic algorithms according to local availability and conditions are outlined. Conclusion Because CL can mimic many other skin diseases, early diagnosis and early treatment are very important to prevent complications and spread of the disease. The fastest and easiest diagnostic method is the leishmanial smear. The most common treatment is the use of local or systemic pentavalent antimony compounds.
Clinical practice guidelines for the diagnosis and treatment of scabies
(Wiley, 2024) Uzun, Soner; Durdu, Murat; Yurekli, Aslan; Mulayim, Mehmet K.; Akyol, Melih; Velipasaoglu, Sevtap; Harman, Mehmet
Scabies, caused by the Sarcoptes scabiei var hominis mite burrowing into the skin, is a highly contagious disease characterized by intense nocturnal itching. Its global impact is considerable, affecting more than 200 million individuals annually and posing significant challenges to healthcare systems worldwide. Transmission occurs primarily through direct skin-to-skin contact, contributing to its widespread prevalence and emergence as a substantial public health concern affecting large populations. This review presents consensus-based clinical practice guidelines for diagnosing and managing scabies, developed through the fuzzy Delphi method by dermatology, parasitology, pediatrics, pharmacology, and public health experts. The presence of burrows containing adult female mites, their eggs, and excreta is the diagnostic hallmark of scabies. Definitive diagnosis typically involves direct microscopic examination of skin scrapings obtained from these burrows, although dermoscopy has become a diagnostic tool in clinical practice. Treatment modalities encompass topical agents, such as permethrin, balsam of Peru, precipitated sulfur, and benzyl benzoate. In cases where topical therapy proves inadequate or in instances of crusted scabies, oral ivermectin is recommended as a systemic treatment option. This comprehensive approach addresses the diagnostic and therapeutic challenges associated with scabies, optimizing patient care, and management outcomes.
Cutaneous manifestations of Crimean-Congo haemorrhagic fever: morbilliform eruptions may reflect a favorable outcome and not low platelet levels
(JOHN LIBBEY EUROTEXT LTD, 2010) Akyol, Melih; Ozcelik, Sedat; Engin, Aynur; Hayta, Sibel Berksoy; Bicici, Fatma
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Delayed habituation in Behcet's disease
(NEUROL SOC INDIA, 2008) Gulturk, Sefa; Akyol, Melih; Kececi, Hulusi; Ozcelik, Sedat; Cinar, Ziynet; Demirkazik, Ayse
Background: The autonomic nervous system in Behcet's patients may be affected due to various reasons. This entity may be detected with the measurement of the electrodermal activities, heart rate variability and pupillometric methods. Habituation is one of the implicit forms of learning and memory and the loss of habituation can reveal pathological changes in the synaptic regions. Aim: To determine whether there is a functional decrease in the synaptic effectiveness (habituation) of the pathways to sympathetic neurons that had been repeatedly activated in Behcet's. Materials and Methods: Twelve patients with Behcet's disease and 12 healthy controls were included in the study. Sympathetic skin potential (SSP) records were taken at normal room temperature in a quiet place within a Faraday cage. Sixteen square wave single shock impulses (duration: 1200 mu s, strength: 5 mA) were applied on each case. Results: After the 1(st) stimulus, the SSP amplitudes were lower in the patients compared to the controls (P 0.001, t value = 7.69). There was no significant differences among the SSP amplitudes after the 13(th) impulse in the patients (P>0.05). Whereas there was no significant differences among the SSP amplitudes after the 9(th) impulse in the controls (P>0.05). The habituation rate of the SSP after consecutive impulses was slowest in the patients compared to controls (P<0.001, t value = 12.39). Conclusions: There is a delayed habituation in Behcet's disease and that may due to pathologic changes with vasculitis through their peripheral nerves.
Double serum sampled glomerular filtration rate measurement with technetium-99m diethylenetriamine-penta acetate for evaluation of renal functions in patients with psoriasis vulgaris
(Deri Zuhrevi Hastaliklar Dernegi, 2021) Guner, Rukiye Yasak; Hayta, Sibel Berksoy; Akyol, Melih; Hasbek, Zekiye; Ozcelik, Sedat; Timucin, Meryem
Background and Design: Psoriasis is a common chronic inflammatory skin disease believed to affect renal functions. Glomerular filtration rate (GFR) is the most important indicator used to assess renal functions. The present study aims to measure the renal function of psoriasis patients via the technetium-99m diethylenetriamine pentaacetate (Tc-99m DTPA) method and compare the values obtained with those determined through indirect measurement methods, such as the modification of diet in renal disease (MDRD) and chronic kidney disease epidemiology collaboration (CKD-EPI), considering the effects of systemic treatments and comorbidities. Materials and Methods: Eighty-seven patients diagnosed with chronic plaque-type psoriasis vulgaris were included in this study. The patients' demographic characteristics, disease duration, psoriasis area and severity index score, drugs received for psoriasis treatment, comorbidities, and drugs received for comorbidity treatment were noted. Estimated GFRs were also calculated using the MDRD and CKD-EPI formulas. Results: Tc-99m DTPA values were affected only by age. As the patient age increased, a significant decrease in GFR measured with Tc-99m DTPA (r=0.289, p<0.001) was observed. Conclusion: Psoriasis, comorbidities, and nephrotoxic drugs used for treatment did not affect renal functions. GFR measurements were affected only by age.
Effect of cervical spinal cord electrical stimulation on nitric oxide levels in brain and dermal tissues: an evaluation using by real-time nitric oxide measurement
(SPRINGER WIEN, 2012) Ozum, Unal; Akyol, Melih; Balaban, Hatice; Ozdemir, Ercan; Soydan, Serdar
Nitric oxide synthesized from L-arginine via the nitric oxide synthase enzyme family is the main regulatory molecule in many physiological systems. The level of nitric oxide can now be measured in tissues by a direct real-time amperometric method. The effect of electrical stimulation of the upper cervical spine on the arteries that supply the brain and upper extremities has been established by experimental studies, and thus it has begun to be used in clinical practice to increase blood flow in the brain and the peripheral vascular system. The mechanism of this effect is still a subject of research. This is the first report of real-time nitric oxide measurement in living brain and dermal tissue during electrical stimulation of the upper cervical spine. Using the amperometric method, nitric oxide levels in frontal subcortical and front foot skin were measured before, during and after electrical stimulation of the upper cervical spine in three groups of rabbits that received infusions of saline solution, 7-aminoguanidine or atropine. By electrical stimulation, tissue nitric oxide levels increased significantly and remained increased during stimulation in the brain and skin. The nitric oxide levels dropped back to normal value 1 min after stimulation was turned off. The results we obtained have showed that real-time nitric oxide could also be measured by an amperometric method in living tissues like brain. The effect of stimulation on nitric oxide levels of living tissues disappears immediately when the stimulation is turned off.
Effect of Isotretinoin Treatment on the Inflammatory Markers in Patients with Acne Vulgaris: A Case-Control Study
(OrtadogÂŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2024) Di?iş, Mahir; Tosun, Mustafa; Yasak Güner, Rukiye; Akyol, Melih
Objective: Oral isotretinoin can affect inflammation markers in patients with acne vulgaris. This study aims to examine the impact of isotretinoin treatment on inflammatory markers in patients diagnosed with acne vulgaris. Material and Methods: Fifty-five patients diagnosed with moderate or severe acne vulgaris according to the Global Acne Grading Scale were included in this study. Patients were evaluated at regular intervals (at 0, 2nd, and 3rd months) during the treatment period. Complete blood count [including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), plateletcrit, platelet distribution width (PDW), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW)], Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), monocyte-high-density lipoprotein (HDL) ratio, monocyte-to-lymphocyte ratio (MLR), MPV/platelet ratio, and serum biochemistry panel were assessed during isotretinoin treatment. Additionally, the Acne Quality of Life Scale was used to assess patients' quality of life. Results: A significant increase in PLR and RDW levels was observed during isotretinoin treatment (p<0.05). However, SII, SIRI, AISI, monocyte/HDL ratio, NLR, PDW, MPV, sedimentation rate, and C-reactive protein levels did not show a significant change during isotretinoin treatment (p>0.05). Furthermore, this study demonstrated that oral isotretinoin treatment reduced the severity of acne and improved patients' quality of life. Conclusion: Isotretinoin may have inflammatory effects shown with PLR and RDW. However, other inflammatory markers did not show a significant change during isotretinoin treatment. Further comprehensive studies are needed to better understand the relationship between isotretinoin treatment and inflammatory markers. Copyright © 2024 by Türkiye Klinikleri.
Epidemiology of Melanoma
(Deri Zuhrevi Hastaliklar Dernegi, 2007) Ozcelik, Sedat; Akyol, Melih
The incidence of melanoma is increasing at a rate greater than any other form of cancer in the world, especially in white race, and melanoma looks as a serious health problem. Therefore, many countries apply melanoma control programmes. For the success of these control programmes, it needs to have epidemiologic data about melanoma. The epidemiology of melanoma not only includes recording the incidence and mortality rates for the tumor, but also looking possible factors important causation. It should be known which preventions may decrease tumor incidence. Melanoma records are inadequate in our country. Epidemiologic studies on melanoma are essential for a realistic assessment of the incidence of the tumour, possible risk factors, prevention strategies and the need for caring.
Epidemiology of Pemphigus in Turkey: One-year Prospective Study of 220 Cases
(CROATION DERMATOVENEROLOGICAL SOC, 2017) Yayli, Savas; Harman, Mehmet; Baskan, Emel Bulbul; Karakas, Ayse Akman; Genc, Yeser; Turk, Bengu Gerceker; Demirsoy, Evren Odyakmaz; Gunasti, Suhan; Bilgili, Serap Gunes; Ilter, Nilsel; Ferahbas, Ayten; Savk, Ekin; Afsar, Fatma Sule; Aytekin, Sema; Kaya, Tamer Irfan; Hayta, Sibel Berksoy; Ozgen, Zuleyha; Gurel, Mehmet Salih; Caliskan, Ercan; Balci, Didem Didar; Gungor, Sule; Kapicioglu, Yelda; Ozuguz, Pinar; Aktan, Sebnem; Dogramaci, Asena; Kokcam, Ibrahim; Onsun, Nahide; Seckin, Deniz; Durdu, Murat; Dursun, Recep; Daye, Munise; Dilek, Nursel; Karabacak, Ercan; Temel, Asli Bilgic; Erdem, Cengizhan; Altun, Ece; Gungor, Dilek; Kartal, Demet; Akyol, Melih; Aksu, Esra Koku; Uzun, Soner
Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n= 192; 87.3%), followed by pemphigus foliaceus (n= 21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n= 83; 43.2%). The mean Pemphigus Disease Area Index was 28.14 +/- 22.21 (mean +/- Standard Deviation). The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.
Evaluation of cardiovascular risk in people with rosacea: A prospective study
(2022) Dirim, Yusuf Cihan; Güner, Rukiye Yasak; Tosun, Mustafa; Akyol, Melih; Turgut, İsmail
Systemic inflammation is accepted as a nontraditional cardiovascular risk factor and has been shown to play a role in all stages of atherosclerosis. Rosacea is a chronic inflammatory\rskin disease. In our study, we aimed to evaluate the cardiovascular risk in rosacea patients. 40 people with rosacea (30 women, 10 men) and a control group of\r40 age- and sex-matched individuals (28 women, 12 men) who had no chronic inflammatory skin disease were included in the study. Participants' body mass index (BMI)\rwas calculated and their blood pressure was measured. Fasting blood glucose, fasting blood insulin, lipid profile, hemogram, basic biochemical parameters, erythrocyte\rsedimentation rate, and C-reactive protein levels were analyzed after at least 8 hours of fasting. In all participants, carotid intima-media thickness (CIMT) was measured\rusing high-resolution B-mode ultrasonography (with a 4 MHz linear transducer. The mean CIMT values were 0.62 (0.18) mm in the rosacea group and 0.50 (0.14) mm in\rthe control group. Statistical comparison indicated that mean CIMT was significantly greater in the patients with rosacea compared to the control group (p=0.001). There\rwas no significant difference between the rosacea and control groups in terms of mean height, weight, BMI, or systolic and diastolic blood pressures (p>0.05). People with\rrosacea should be monitored periodically in terms of cardiovascular disease risk.
Evaluation of health literacy and drug use attitudes and behaviors of patients admitting to dermatology clinic
(Sivas Cumhuriyet University, 2021) Yasak Güner, Rukiye; Tosun, Mustafa; Akyol, Melih; Hayta, Sibel Berksoy; Özpınar, Saliha
Objective: In the present study, the purpose was to investigate the relationship between health literacy levels and drug use attitudes and behaviors of patients admitting to dermatology outpatient clinics.Method: A total of 295 volunteers admitting to Sivas Cumhuriyet University Dermatology Clinic between 1/03/2020 and 31/12/2020 were included in the study. Two forms were used to collect the data in the study. These were the Data Collection Form and the Health Literacy Scale.Results: The mean age of the participants was 33.0 ±16.36; and 62.0% of them were women. The mean score of the participants in Health Literacy Scale was 4.60±0.2; and it can be argued that the health literacy levels of the participants were high. The relations between health literacy and dermatological drug use attitudes and behaviors were evaluated with the Correlation Analysis; and a significant relation was detected between the two variables (p<0.05).Conclusions: Dermatology patients have high health literacy and their dermatological drug use attitudes and behaviors are at adequate levels.
Evaluation of sleep quality in patients with psoriasis
(TURKISH SOC DERMATOLOGY VENEROLOGY, 2015) Bicici, Fatma; Hayta, Sibel Berksoy; Akyol, Melih; Ozcelik, Sedat; Cinar, Ziynet
Background and Design: Psoriasis causes impairments in many daily activities, such as sleeping and occupational performance. One of the most important factors determining the quality of life of a person is sleeping. Studies about sleep quality in psoriasis are quite limited. In this study, we aimed to assess the quality of sleep and to examine the factors affecting the quality of sleep in patients with psoriasis. Materials and Methods: Seventy-three patients with psoriasis and 73 healthy subjects were included in the study. A sociodemographic data form was completed by all the participants and the Pittsburgh Sleep Quality Index (PSQI), 36-item Short-form Health Survey (SF-36), Hamilton Depression Rating Scale (HAM-D) and the Hamilton Anxiety Rating Scale (HAM-A) were administered to the patients and controls. Body Mass Index (BMI) was calculated in patient and control groups. The Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) were administered and pruritus was assessed in patient group. Results: PSQI global scores in patient group were found to be higher than in control group. Quality of sleep was worse in patient group. Severity of disease and sociodemographic features were found to be factors not affecting the quality of sleep. In patient group, the patients with higher sleep disturbances had higher rates of depression and anxiety scores. In patient group, the patients with severe pruritus had worse sleep quality. Conclusion: Psoriasis and psoriatic symptoms including pruritus impair sleep quality. Assessment of sleep quality and new strategies to improve sleep quality in patients with psoriasis may help improve quality of life.
Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study
(WROCLAW MEDICAL UNIV, 2017) Durmus, Kasim; Turgut, Nergiz Hacer; Dogan, Mehtap; Tuncer, Ersin; Ozer, Hatice; Altuntas, Emine Elif; Akyol, Melih
Background. Mandibular fractures are the most common facial fractures. They can be treated by conservative techniques or by surgery. The authors hypothesized that the application of a single local dose of strontium chloride would accelerate the healing of subcondylar mandibular fractures, shorten the recovery time and prevent complications. Objectives. The aim of the present pilot study was to evaluate the effects of a single local dose of strontium chloride on the healing of subcondylar mandibular fractures in rats. Material and methods. This randomized experimental study was carried out on 24 male Wistar albino rats. The rats were randomly divided into 3 groups: experimental group 1, receiving 3% strontium chloride; experimental group 2, receiving 5% strontium chloride; and the control group. A full thickness surgical osteotomy was created in the subcondylar area. A single dose of strontium solution (0.3 cc/site) was administered locally by injection on the bone surfaces of the fracture line created. Nothing was administered to the control group. The mandibles were dissected on postoperative day 21. The fractured hemimandibles were submitted to histopathological examination. Results. The median bone fracture healing score was 9 (range: 7-9) in experimental group 1; 8 (range: 7-10) in experimental group 2; and 7.50 (range: 7-8) in the control group. When the groups were compared in terms of bone healing scores, there was a statistically significant difference between experimental group 1 and the control group (p < 0.05). Conclusions. This study is the first to show that local strontium may have positive effects on the healing of subcondylar mandibular fractures. In the authors' opinion, 3% strontium was beneficial for accelerating facial skeleton consolidation and bone regeneration in rat subcondylar mandibular fractures. This treatment procedure may be combined with closed fracture treatment or a conservative approach.
Increased expressed emotion in patients with psoriasis
(TERMEDIA PUBLISHING HOUSE LTD, 2018) Hayta, Sibel Berksoy; Guner, Rukiye; Akyol, Melih; Albayrak, Funda; Kugu, Nesim; Ozcelik, Sedat
Aim of the study: The aim of this study was to determine whether patients with psoriasis are affected by expressed emotion in their family environment. Material and methods: Participants included 62 patients with psoriasis and 83 healthy controls and their biological parent, wife or husband, or adult child as a key relative. Sociodeinographic data were recorded. Psoriasis area severity index was used to evaluate psoriasis severity. Hamilton depression and anxiety scales and the Expressed Emotion Questionnaire form were used to evaluate depression, anxiety, and expressed emotion. Results: The levels of expressed emotion and its subgroups in the patient group were higher than in the group of healthy controls (p < 0.05). Gender, disease duration, disease severity, and key relatives did not affect the levels of expressed emotion (LEEtotal) in the patients with psoriasis (p > 0.05). The LEEtotal of those with low educational level in the patient group was statistically significantly higher than those with higher educational level (p < 0.05). There was no correlation between the presence depression or anxiety and expressed emotion (p> 0.05). There was a negative correlation between age and the levels of expressed emotion in the patient group (p < 0.05). There was a negative correlation between age and intrusiveness in healthy controls (p < 0.05). Conclusions: Although decreasing with age, expression of emotion in patients with psoriasis is high, and psychosocial support should be provided to these patients.

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