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    GENE EXPRESSION LEVELS IN BRONCHIAL ASTHMA PATIENTS OF DUHOK POPULATION IN IRAQ
    (Parlar Scientific Publications (P S P), 2021) Issa, Hamdia Yousif; Al-Habib, Omar A. M.; Dastan, Sevgi Durna; Ramadhan, Ali A.; Sevindik, Mustafa; Selamoglu, Zeliha
    Bronchitis, asthma, allergy and bronchial asthma diseases are very common in these years. These diseases, which have increased with the age in the past, are nowadays frequently seen from very early ages and even from infancy. In addition. the frequency of these diseases varies according to different populations. It is suggested that environmental factors, genotypic structure of individuals have special effects or additive effects in these diseases which are also associated with the immune system not working effectively. The aim of our study is to determine the expression levels in some genes that are suggested to be related to these diseases in blood samples between the patient and control groups. In this study, gene expression values performed with the RT-PCR analysis are compared between brochititis-asthma patient group and control group by using 16 gene region. According to RTPCR gene expression analysis, individuals with bronchial-asthma have had remarkable increases or decreases in some gene regions. Some of these changes were found statistically significant.
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    Inflammatory protein levels in asthmatic bronchitis: A study in the Duhok population, Iraq
    (Elsevier Science Inc, 2025) Al-Habib, Omar A. M.; Issa, Hamdia Yousif; Dastan, Taner; Dastan, Sevgi Durna; Ramadhan, Ali A.; Selamoglu, Zeliha
    Objectives: This study aims to determine the levels of TNF-alpha, IGF-1, IL-6, and IL-10 protein in blood samples and their potential link to bronchitis-asthma diseases in the Iraq Duhok population, highlighting the prevalence of these long-term inflammatory diseases. Methods: Sixty blood samples were used and separated into patients (n = 43) and control (n = 17) groups. Serum samples were separated for each individual. Elisa method was used in terms of 4 different proteins investigated in blood samples with the manufacturer's instruction brand kits. Results: This study evaluated TNF-alpha, IGF-1, IL-6, and IL-10 protein levels in blood samples from asthmatic bronchitis patients in Duhok. Although these levels were elevated compared to controls, the differences were not statistically significant. Conclusion: The differences thought to be related to the bronchitis-asthma diseases could not be demonstrated between the patient and control groups in Iraq Duhok population. Future research should explore larger sample sizes and stratified patient groups to identify potential biomarkers.