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Öğe Comparison of Analgesic Effects Induced by Different Strengths of Extremely Low-Frequency Electromagnetic Fields(AVES PRESS LTD, 2018) Demirkazik, Ayse; Ozdemir, Ercan; Turkay, Yavuz; Pelit, Aykut; Kilinc, Olca; Taskiran, Ahmet Sevki; Arslan, GokhanObjective: Our aim was to compare the results of the most commonly used analgesic measurement techniques and to determine the time and intensity at which the analgesic effects of the magnetic field (MF) are most effective. Methods: This study compared the analgesic effect of MF strengths (1, 5, and 10 mT) in 30 adults, male Wistar albino rats weighing 200-250 g. The analgesic effects were measured using tail-flick (TF) and hot-plate (HP) tests. To determine the optimum MF strength, rats were assigned into four groups: sham group and exposed to 1, 5, and 10 mT MF groups. Rats were placed in a solenoid, and MF of 50 Hz for 165 min was administered daily for 15 days. All four groups were kept in the solenoid for 165 min/15 days and exposed to MF. However, the analgesic effect was measured only on day 0, 4, 7, 11, and 15 using TF and HP tests. The latencies of analgesia were converted to a percentage of maximal antinociceptive effects (% MPE). Results: When the maximum analgesic effect of the 5 mT MF was determined on the seventh day, the% MPEs were 5.37 +/- 0.51, 13.66 +/- 1.27, 25.89 +/- 3.00, and 25.37 +/- 2.41 in the sham, 1 mT, 5 mT, and 10 mT groups, respectively. The optimum effect was observed with 5 mT MF on the seventh day and with 90 min in the solenoid. Conclusion: We didn't find any differences between the analgesic responses to the TF and HP tests.Öğe The Effect of Apelin-13 on Penicillin-Induced Epileptiform Activity in Rats(WILEY-BLACKWELL, 2015) Ucar, Durmus; Arslan, Gokhan; Alici, Sabiha Kubra; Ayyildiz, Mustafa; Agar, Erdal…Öğe The Effect of beta-Carotene on Spike Wave Discharges in Genetic Absence Epileptic WAG/Rij Rats(WILEY-BLACKWELL, 2016) Derelioglu, Gamze; Olgen, Zuleyha; Taskiran, Ahmet Sevki; Ozdemir, Ercan; Gulturk, Sefa; Arslan, Gokhan…Öğe The Effect of CB1 Cannabinoid Receptor Antagonist AM-251 on Spike Wave Discharges in WAG/Rij Rat(WILEY-BLACKWELL, 2015) Aygun, Hatice; Arslan, Gokhan; Ayyildiz, Mustafa; Agar, Erdal…Öğe The Effect of Coenzyme Q10 on Absence Seizures and the Role of Nitric Oxide Pathway in this Effect(WILEY-BLACKWELL, 2016) Gunes, Handan; Ozdemir, Ercan; Gulturk, Sefa; Arslan, Gokhan…Öğe The Effect of Ghrelin Receptor on Morphine Analgesia and Tolerance in Rats(KARGER, 2018) Baser, Tayfun; Ozdemir, Ercan; Taskiran, Ahmet Sevki; Arslan, Gokhan…Öğe The Effect of Low Dose Memantine on Epileptic Activity in WAG/Rij Rats(WILEY-BLACKWELL, 2016) Sen, Elif; Aygun, Hatice; Arslan, Gokhan; Avci, Bahattin; Ayyildiz, Mustafa; Agar, Erdal…Öğe The Effect of P2X7 Receptor Antagonist A-438079 on Penicillin-induced Epileptiform Activity(WILEY-BLACKWELL, 2016) Arslan, Gokhan; Kocacan, Suleyman Emre; Ayyildiz, Mustafa; Rzayev, Emil; Avci, Bahattin; Agar, Erdal…Öğe The Effect of P2X7 Receptors on Penicillin-induced Epileptiform Activity and the Role of T-type Calcium Channel Inhibitor NNC 55-3069 on This Effect(WILEY, 2017) Arslan, Gokhan; Kocacan, Suleyman Emre; Ayyildiz, Mustafa; Rzayev, Emil; Avci, Bahattin; Agar, Erdal…Öğe Effect of The Cyclooxygenase-2 Inhibitor Tenoxicam on Pentylenetetrazole-Induced Epileptic Seizures in Rats(WILEY, 2017) Toptas, Hacer Aybike; Guney, Ozge; Kutlu, Rukiye; Gumus, Ekan; Gunes, Handan; Taskiran, Ahmet Sevki; Arslan, Gokhan…Öğe The Effect of Theophylline Ethylenediamine on Seizures in Older WAG/Rij Rat(WILEY-BLACKWELL, 2016) Aygun, Hatice; Arslan, Gokhan; Erbas, Oytun; Ayyildiz, Mustafa; Agar, Erdal…Öğe Effect of Timokinon and 7-Nitroindazol Combination on Penicilin Induced Epileptiform Activity in Rat(WILEY-BLACKWELL, 2015) Altinkaynak, Elif; Arslan, Gokhan; Alici, Sabiha Kubra; Ayyildiz, Mustafa; Agar, Erdal…Öğe Effects of 5-HT1 and 5-HT2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats(WILEY, 2019) Ozdemir, Ercan; Demirkazik, Ayse; Taskiran, Ahmet Sevki; Arslan, GokhanMuch evidence demonstrates the antinociceptive effect of magnetic fields (MFs). However, the analgesic action mechanism of the electromagnetic field (EMF) is not exactly understood. The aim of the present study was to investigate the effects of 5-HT1 and 5-HT2 receptor agonists (serotonin HCl and 2,5-dimethoxy-4-iodoamphetamine [DOI] hydrochloride) on EMF-induced analgesia. In total, 66 adult male Wistar albino rats with an average body mass of 225 +/- 13 g were used in this study. The animals were subjected to repeated exposures of alternating 50 Hz and 5 mT EMF for 2 h a day for 15 days. Prior to analgesia tests, serotonin HCl (5-HT1 agonist) 4 mg/kg, WAY 100635 (5-HT1 antagonist) 0.04 mg/kg, DOI hydrochloride (5-HT2 receptor agonist) 4 mg/kg, and SB 204741 (5-HT2 antagonist) 0.5 mg/kg doses were injected into rats. For statistical analysis of the data, analysis of variance was used and multiple comparisons were determined by Tukey's test. Administration of serotonin HCl MF (5 mT)-exposed rats produced a significant increase in percent maximal possible effect (% MPE) as compared with EMF group (P < 0.05). On the contrary, injection of WAY 100635 to MF-exposed rats produced a significant decrease in analgesic activity (P < 0.05). Similarly, the administration of DOI hydrochloride significantly increased % MPE values as compared with the EMF group while SB 204741 reduced it (P < 0.05). In conclusion, our results suggested that serotonin 5-HT1 and 5-HT2 receptors play an important role in EMF-induced analgesia; however, further research studies are necessary to understand the mechanism. Bioelectromagnetics. 2019;40:319-330. (c) 2019 Bioelectromagnetics Society.Öğe Effects of Dopamine D1 and D2 Receptors on Analgesia Created By a Very Low Frequency Electromagnetic Field in Rats(WILEY, 2017) Arslan, Gokhan; Demirkazik, Ayse; Ozdemir, Ercan; Taskiran, Ahmet Sevki; Kilinc, Olca…Öğe Effects of extremely low frequency electromagnetic fields on morphine analgesia and tolerance in rats(GENERAL PHYSIOL AND BIOPHYSICS, 2017) Ozdemir, Ercan; Demirkazik, Ayse; Gursoy, Sinan; Taskiran, Ahmet S.; Kilinc, Olca; Arslan, GokhanSeveral studies have demonstrated that the electromagnetic fields produce analgesic activity. The aim of this study was to investigate the effects of extremely low frequency (ELF) electromagnetic fields (EMF) on morphine analgesia and tolerance in rats. In the study, 78 adult male Wistar albino rats (approximately 240 +/- 12 g) were used. The application of 50 Hz magnetic field, each day the same times for 30 minutes for 15 days, and a total of four times every 15 minute intervals. To constitute morphine tolerance, high dose of morphine (50 mg/kg) were administered for 3 days in rats and tolerance was evaluated on day 4. Prior to analgesia tests, the effective dose (5 mg/kg) of morphine was injected into rats. In the statistical analyzes of the data, analysis of variance (two-way ANOVA) was used and the multiple comparison determined by Tukey tests. The maximum analgesic effect of the 5 mT magnetic field was determined on 7 days. Administration of morphine (5 mg/ kg) in rats exposed to a magnetic field, the analgesic effect was significantly higher compared to the morphine group (p < 0.05). Morphine tolerant animals exposed to a magnetic field, the analgesic effect was found significantly higher than morphine tolerant group rats (p < 0.05). Analgesia test data demonstrated that application of ELF-EMFs to rats increases the morphine analgesia and reduces morphine tolerance.Öğe Effects of Nitric Oxide Synthase (NOS) Inhibitors on Analgesia Induced by Extremely Low Frequency Magnetic Field in Rats(WILEY, 2017) Ozdemir, Ercan; Demirkazik, Ayse; Taskiran, Ahmet Sevki; Kilinc, Olca; Arslan, Gokhan…Öğe Effects of the Phosphodiesterase Type 5 Inhibitor Tadalafil on Morphine Analgesia and Tolerance in Rats(WILEY, 2017) Taskiran, Ahmet Sevki; Ozdemir, Ercan; Arslan, Gokhan…Öğe The Effects of Very Low Frequency Electromagnetic Fields on Morphine Analgesia and Tolerance in Rats(WILEY-BLACKWELL, 2016) Ozdemir, Ercan; Cancalar, Ayse Demirkazik; Taskiran, Ahmet Sevki; Kilinc, Olca; Arslan, Gokhan…Öğe Interaction between Cannabinoid CB1 Receptor and T-type Calcium Channel on Penicillin Induced Epileptiform Activity in Rat(WILEY-BLACKWELL, 2015) Alici, Sabiha Kubra; Arslan, Gokhan; Ayyildiz, Mustafa; Agar, Erdal…Öğe Protective effects of dietary omega-3 fatty acid supplementation on organophosphate poisoning(SAGE PUBLICATIONS INC, 2018) Avci, Bahattin; Bilge, S. Sirri; Arslan, Gokhan; Alici, Omer; Darakci, Ozge; Baratzada, Turkhan; Ciftcioglu, Engin; Yardan, Turker; Bozkurt, AyhanIn this study, we aimed to study the possible preventive effect of docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, on toxicity caused by chlorpyrifos (CPF). Six groups of Sprague Dawley rats (200-250 g) consisting of equal numbers of males and females (n = 8) were assigned to study. The rats were orally given for 5 days. The control group was administered pure olive oil, which was the vehicle for CPF. The CPF challenge groups were administered oral physiological saline, pure olive oil, or DHA (50, 100 and 400 mg/kg dosages) for 5 days. The animals were weighed on the sixth day and then administered CPF (279 mg/kg, subcutaneously). The rats were weighed again 24 h following CPF administration. The body temperatures and locomotor activities of the rats were also measured. Blood samples, brain and liver tissues were collected for biochemical, histopathological and immunohistochemical examinations. A comparison with the control group demonstrated that CPF administration increased malondialdehyde (MDA) levels in blood, brain and liver, while it reduced catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) concentrations (p < 0.05-0.001). Advanced oxidation protein products (AOPPs) increased only in the brain (p < 0.001). DHA reduced these changes in MDA and AOPP values (p < 0.05-0.001), while it increased CAT, SOD and GPx concentrations (p < 0.05-0.001). Similarly, DHA prevented the decreases in body weight, body temperature and locomotor activities caused by CPF at 100 mg/kg and 400 mg/kg dosages (p < 0.05-0.001). Similar to the physiological and biochemical changes, the histopathological damage scores, which increased with CPF (p < 0.05-0.01), decreased at all three dosages of DHA (p < 0.05-0.01). Our findings suggest that DHA, by supporting the antioxidant mechanism, reduces toxicity caused by CPF.
