DSpace Arşivi :: by Yazar "Arslan, Sulhattin" değerine göre listeleniyor

Yazar "Arslan, Sulhattin" seçeneğine göre listele

Listeleniyor 1 - 20 / 35

An analysis of 214 cases of rib fractures
(HOSPITAL CLINICAS, UNIV SAO PAULO, 2011) Karadayi, Sule; Nadir, Aydin; Sahin, Ekber; Celik, Burcin; Arslan, Sulhattin; Kaptanoglu, Melih
INTRODUCTION: Rib fractures are the most common type of injury associated with trauma to the thorax. In this study, we investigated whether morbidity and mortality rates increased in correlation with the number of fractured ribs. MATERIALS AND METHODS: Data from 214 patients with rib fractures who applied or were referred to our clinic between January 2007 and December 2008 were retrospectively evaluated. The patients were allocated into three groups according to the number of fractures: 1) patients with an isolated rib fracture (RF1) (n = 50, 23.4%), 2) patients with two rib fractures (RF2) (n = 53, 24.8%), and 3) patients with more than two rib fractures (RF3) (n = 111, 51.9%). The patients were evaluated and compared according to the number of rib fractures, mean age, associated chest injuries (hemothorax, pneumothorax, and/or pulmonary contusion), and co-existing injuries to other systems. FINDINGS: The mean age of the patients was 51.5 years. The distribution of associated chest injuries was 30% in group RF1, 24.6% in group RF2, and 75.6% in group RF3 (p < 0.05). Co-existing injuries to other systems were 24% in group RF1, 23.2% in group RF2, and 52.6% in group RF3 (p < 0.05). Two patients (4%) in group RF1, 2 patients (3.8%) in group RF2, and 5 patients (4.5%) in group RF3 (total n = 9; 4.2%) died. CONCLUSION: Patients with any number of rib fractures should be carefully screened for co-existing injuries in other body systems and hospitalized to receive proper treatment.
Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease
(KOREAN ASSOC INTERNAL MEDICINE, 2019) Arslan, Sulhattin; Yildiz, Gursel; Ozdemir, Levent; Kaysoydu, Erdal; Ozdemir, Bulent
Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction. Methods: We included 75 COPD patients in the study with 45 control cases. We evaluated age, sex, body mass index, smoking history, C-reactive protein levels, 24-hour ambulatory blood pressure Holter monitoring, arterial blood gas, and respiratory function tests of the patient and the control groups. Results: In COPD patients, the night time systolic, diastolic blood pressures and pulse per minute and the mean blood pressures readings were significantly elevated compared to the control group (p < 0.05). In the correlation analysis, night time systolic pressure was associated with all the parameters except forced expiratory volume in 1 second (FEV1%). Diastolic blood pressure was associated with pH and HCO3 levels. The mean night time, day time pulse pressures and 24-hour pulse per minute values were also associated with all the parameters except FEV1%. Conclusions: In this study we found that parameters of systolic and diastolic blood pressures and pulse pressures were significantly elevated in COPD patients compared to the control groups. Blood pressure was associated blood gas parameters and inflammation parameters in COPD patients. This, in turn, may cause understanding of the pathophysiology of COPD and its complications.
Association between C-reactive protein and chronic obstructive pulmonary disease
(2013) Arslan, Sulhattin; Özdemir, Levent; Yılmaz, Birsen; Ünal, Özge; Akkaya, Esen
Amaç: Bu çalışmadaki amacımız C-reaktif protein’nin (CRP) Akut eksezervasyonda kronik obstrüktif akciğer hastalığı (AEKOAH) ve stabil kronik obstrüktif akciğer hastalığında( SKOAH) artıp artmadığını tespit etmek, CRP deki artışın diğer inflamatuar markırlarla olan korelasyonunu belirlemektir. Gereç ve Yöntem: Anthonisen’in akut eksezervasyon kriterlerini taşıyan ve KOAH akut eksezervasyonu (AEKOAH) tanısı nedeniyle hastaneye yatan hastaların dosyaları retrospektif olarak tarandı. Tüm hastaların göğüs radyolografileri değerlendirildi. Göğüs radyografisinde yeni infiltrasyon, konsolidayon, hava bronkografi vb varsa pnömoni (PKOAH) olarak değerlendirildi. İki ay boyunca eksezervasyonu olmayan hastalar SKOAH olarak değerlendirildi. Aynı yaş ve cinsiyetten oluşan sağlıklı kontrol grubu oluşturuldu. Tüm hastaların İlk 24 saate yapılan solunum fonksiyon testi, arter kan gazı, venöz kan lökosit, nötrofil ve CRP ölçümleri kaydedildi. Bulgular: Ortalama CRP seviyesi akut ataktaki KOAH hastalarda kontrol grubuna ve SKOAH göre anlamlı derecede yüksekti (p<0.05). Aynı zamanda serum CRP düzeyi PaCO2 artış düzeyi ile pozitif, pH, FEV1 ve FEV1/FVC değerleri ile negatif ilişki gösterdiği belirlendi. SKOAH hastalarda ortalama CRP seviyesi kontrol grubuna göre yüksekti. Serum lökosit değeri ile serum CRP değeri arasında anlamlı bir korelasyon olduğunu belirledik. Sonuç: KOAH şideti ile serum CRP arasında anlamlı ilişki olduğu belirlendi. KOAH alevlenmelerinde serum lökosit değeri ile serum CRP değeri arasında anlamlı bir korelasyon olduğunu belirledik.
The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk
(SPRINGER, 2011) Arslan, Sulhattin; Karadayi, Sule; Yildirim, Malik Ejder; Ozdemir, Ozturk; Akkurt, Ibrahim
This study aimed to determine the relation between methylene-tetrahydrofolate reductase (MTHFR) gene polymorphism and lung cancer risk and the frequency of this polymorphism. The study involved 64 lung cancer patients (the study group) with definitive diagnosis and 61 noncancerous subjects (the control group). MTHFR C677T and A1298C mutation analysis was made using DNA isolated from peripheric blood and multiplex PCR and reverse hybridization strip test. Eighty-four percent of the patients were male. The age, gender, and history of alcohol use of the patients and control group were statistically similar. While MTHFR 677T and 677C allele frequency was 0.33 and 0.67 in the patients respectively, it was 0.29 and 0.71 in the control group. The frequencies of MTHFR 1298C and 1298A were 0.33 and 0.67 in the patients, and it was 0.31 and 0.69 in the control group respectively. When MTHFR 677TT and 677CT genotypes were compared with 677CC genotype, lung cancer risk was 2.4 times higher in the 677TT genotype. When MTHFR 1298AC and 1298CC genotypes were compared with 1298AA genotype, lung cancer risk was 1.5 times higher in 1298CC genotype. According to the results, allele frequency of homozygote T and C was high in lung cancer patients. It was 3.05 and 1.29 times higher in smokers than in non-smokers, and 3.05 and 1.64 times higher in males than in females; 3.0 and 2.44 times higher in those with non-small cell lung cancer than in those with small-cell lung cancer.
THE ASSOCIATION BETWEEN PLASMA D-DIMER LEVELS AND COMMUNITY-ACQUIRED PNEUMONIA
(HOSPITAL CLINICAS, UNIV SAO PAULO, 2010) Arslan, Sulhattin; Ugurlu, Serdal; Bulut, Gokten; Akkurt, Ibrahim
BACKGROUND: Plasma D-dimer levels are directly related to the intra- and extra-vascular coagulation that occurs in acute and chronic lung damage in patients with community-acquired pneumonia (CAP). OBJECTIVES: This study examines the relationship between the severity of community-acquired pneumonia and D-dimer levels. In addition, the study examines the correlations among community-acquired pneumonia, the radiological extent of the disease and mortality. METHODS: The Pneumonia Severity Index was used to classify patients into five groups. Patients were treated at home or in the hospital according to the guidelines for community-acquired pneumonia. Blood samples were taken from the antecubital vein with an injector and placed into citrated tubes. After they were centrifuged, the samples were evaluated with the quantitative latex method. RESULTS: The study included 60 patients who had been diagnosed with community-acquired pneumonia (mean age 62.5 +/- 11.7) and 24 healthy controls (mean age 59.63 +/- 6.63). The average plasma D-dimer levels were 337.3 +/- 195.1ng/mL in the outpatient treatment group, 691.0 +/- 180.5 in the inpatient treatment group, 1363.2 +/- 331.5 ng/mL in the intensive care treatment group and 161.3 +/- 38.1ng/mL in the control group (p<0.001). The mean D-dimer plasma level was 776.1 +/- 473.5ng/mL in patients with an accompanying disease and 494.2 +/- 280.1 ng/mL in patients without an accompanying disease (p<0.05). CONCLUSIONS: Plasma D-dimer levels were increased even in community-acquired pneumonia patients who did not have an accompanying disease that would normally cause such an increase.
Association of deep venous thrombosis with prothrombotic gene polymorphism identified in lung cancer cases
(SPRINGER, 2011) Arslan, Sulhattin; Manduz, Sinasi; Epozturk, Kursat; Karahan, Oguz; Akkurt, Ibrahim
Venous thrombosis is a significant cause of morbidity and mortality in patients with malignancies. We aimed to investigate the association between prothrombotic gene polymorphisms detected in lung cancer cases and deep venous thrombosis (DVT). Totally 66 patients with an established diagnosis of lung cancer, of which 33 developed DVT, were enrolled. Multiplex PCR technique and reverse hybridization strip assay were performed on DNA extracted from peripheral blood, in order to analyze prothrombin G20210A, factor V G1691A, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, angiotensin converting enzyme (ACE), plasminogen activator inhibitor-1 (PAI-1), and glycoprotein IIIa (Gp IIIa) gene mutations. Among prothrombotic gene polymorphisms investigated in this study, the commonest ones were PAI-1 4G/5G (56% heterozygous, 39% homozygous) and ACE gene mutations (58% heterozygous, 17% homozygous). The presence of homozygous MTHFR A1298C mutation was significantly associated with DVT (P = 0.020). Comparing the lung cancer patients with and without DVT, only MTHFR A1298C gene polymorphism differed significantly (P = 0.040). We determined a higher rate of prothrombotic gene mutations in lung cancer patients who developed DVT. However, statistical significance was achieved only for MTHFR A1298C gene mutation. Therefore, nongenetic factors for disturbance of hemostatic metabolism should also be considered in lung cancer patients.
Chest X-ray and bacteriology in the initial phase of treatment of 800 male patients with pulmonary tuberculosis
(SOC BRASILEIRA PNEUMOLOGIA TISIOLOGIA, 2011) Ozsahin, Sefa Levent; Arslan, Sulhattin; Epozturk, Kursat; El, Remziye; Dogan, Omer Tamer
Objective: To evaluate chest X-rays of patients with pulmonary tuberculosis and to determine whether the extent of radiographic lesions correlates with bacteriological parameters. Methods: In this retrospective, descriptive study, we evaluated chest X-rays, as well as AFB detection by smear microscopy and culture for Mycobacterium tuberculosis, initially and during the first two months of treatment, in 800 male patients hospitalized between 1995 and the present at a 250-bed hospital in northwestern Turkey. Results: The initial mean ESR was 58 +/- 37 mm/h. Initial sputum smears and cultures were positive in 83.8% and 89.5% of the patients, respectively. After the first month of treatment, the proportion of patients with positive sputum culture was higher among those with cavitary tuberculosis than among those with non-cavitary tuberculosis (53.7% vs. 37.7%, p < 0.001). The number of affected zones was not correlated with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes (p > 0.05 for all) but was positively correlated with the ESR (r = 0.23, p < 0.001). During the first and second months of treatment, conversion to smear-negative status was less common in patients with bilateral involvement than in those with unilateral involvement (p < 0.001 and p = 0.002 for months 1 and 2, respectively). Disease extent did not correlate with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes but did correlate with delayed bacteriological recovery. Conclusions: Chest X-ray and bacteriology are valuable tools for the evaluation of pulmonary tuberculosis.
CLINICO-PATHOLOGICAL CHARACTERISTICS IN YOUNG AND ELDERLY PATIENTS WITH LUNG CANCER
(GUNES KITABEVI LTD STI, 2011) Arslan, Sulhattin; Ozsahin, Sefa Levent; Akkurt, Ibrahim
Introduction: The aim of the present study was to determine the differences between the clinico-pathological characteristics of lung cancers among elder and young patients Materials and Method: 160 patients with lung cancer were included in the study retrospectively. Age, gender, diagnostic methods, performances, accompanying diseases and histological types of the cancer of patients were all investigated. Patients were divided into two groups; the younger group, under 65 years of age and the elderly group, over 65 years of age. Both groups were compared according to the clinico-pathological features. Results: There were 124 patients (13 female, 111 male) in the younger group, 36 patients (3 female, 33 male) in the elderly group. Medical comorbidity was significantly higher (p=0.045) in the elderly group. Coughing -expectoration rate was statistically higher (p=0.014) in the younger group. Hemoptysis was significantly higher (p=0.018) in the elderly group. Poor performances were significantly higher (p=0.008) in the elderly group. Adenocarcinoma of the lung was more frequent (p=.0.037) among the younger group whereas squamous cell cancer incidence was higher (p=0.049) in the elderly group. Conclusion: While coughing-expectoration symptoms and the lung adenocarcinoma were significantly higher in the younger group, hemoptysis, medical comorbidity, poor performance and the squamous cell carcinoma were sigficantly more frequent in the elderly group.
Clinico-pathological characteristics in young and elderly patients with lung cancer
(2011) Arslan, Sulhattin; Özşahin, Sefa Levent; Akkurt, Ibrahim
Introduction: The aim of the present study was to determine the differences between the clinico-pathological characteristics of lung cancers among elder and young patients Materials and Method: 160 patients with lung cancer were included in the study retrospectively. Age, gender, diagnostic methods, performances, accompanying diseases and histological types of the cancer of patients were all investigated. Patients were divided into two groups; the younger group, under 65 years of age and the elderly group, over 65 years of age. Both groups were compared according to the clinico-pathological features. Results: There were 124 patients (13 female, 111 male) in the younger group, 36 patients (3 female, 33 male) in the elderly group. Medical comorbidity was significantly higher (p=0.045) in the elderly group. Coughing- expectoration rate was statistically higher (p=0.014) in the younger group. Hemoptysis was signiŞcantly higher (p=0.018) in the elderly group. Poor performances were significantly higher (p=0.008) in the elderly group. Adenocarcinoma of the lung was more frequent (p=.0.037) among the younger group whereas squamous cell cancer incidence was higher (p=0.049) in the elderly group. Conclusion: While coughing-expectoration symptoms and the lung adenocarcinoma were significantly higher in the younger group, hemoptysis, medical comorbidity, poor performance and the squamous cell carcinoma were sigcantly more frequent in the elderly group.
Combined Germline Variations of Thrombophilic Genes Promote Genesis of Lung Cancer
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2013) Ozen, Filiz; Polat, Fikriye; Arslan, Sulhattin; Ozdemir, Ozturk
Background: A large variety of familiar and non-familiar lung carcinomas (LC) are caused by long term exposure to chemical carcinogens that are present in tobacco smoke. We aimed to investigate the prevalence of 5 thrombophilic germ-line mutations in patients with lung carcinomas. Materials and Methods: A total of 52 LC patients and 212 healthy controls from same population were analyzed for FV Leiden, factor V H1299R (R2), PAI-1, MTHFR C677T, MTHFR A1298C, ACE I/D, and Apo E genes and compared. Results: Overall, heterozygous and/or homozygous point mutations in FV Leiden Apo E2, PAI-1 and MTHFR C677T genes were associated with LC in the current cohort. There was no meaningful association between LC and ACE I/D gene markers. Conclusions: The current results showed that LC is related to combined thrombophilic gene mutations and individuals with homozygosity of 4G in PAI-1 and MTHFR C677T genes and heterozygosity of FV Leiden, Apo E4 genes have a germ-line risk for LC tumorigenesis.
Concomitant occurrence of tracheal bronchus, pulmonary sequestration and azygos lobe
(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2013) Arslan, Sulhattin; Sabanciogullari, Vedat; Akkurt, Ibrahim
A 53-year-old man was referred with the complaints of persistent cough ongoing for approximately two years with intervals, weakness and dyspnea on effort. Posteroanterior lung radiography showed normal lung parenchyma, except azygos fissure and lobe view. Fiber optic bronchoscopy demonstrated tracheal bronchus on the right lateral wall of trachea, 2.5-3 cm above the main carina. Thoracic computed tomography revealed a view in soft-tissue density located in the left lung posterior basal segment, sized 4x2.5 cm, which had an aberrant arterial supply originating from thoracic aorta and was consistent with intralobar pulmonary sequestration. We present this case with a literature review, as we did not find any other case having all these three anomalies together in the literature search.
Does hydatid disease have protective effects against lung cancer?
(SPRINGER, 2013) Karadayi, Sule; Arslan, Sulhattin; Sumer, Zeynep; Turan, Mustafa; Sumer, Haldun; Karadayi, Kursat
We hypothesized that solid tumors rarely occur in patients with hydatid disease. We obtained the serum of 14 patients diagnosed with hydatid disease, the serum of 10 patients who did not have a history of hydatid disease, and the hydatid cyst fluid from six patients. These sera and fluid samples were added at different concentrations to NCI-H209/An1 human lung small cell carcinoma cells and L929 mouse fibroblasts as a control group. Sera of patients with hydatid diseases had cytotoxic effects on NCI-H209/An1 cells, but they did not have cytotoxic effects on fibroblast cells. Sera from healthy subjects did not have a cytotoxic effect on the tumor cell line or control fibroblasts. Cyst fluid, also, did not have toxic effects on the NCI-H209/An1 cell line, but was toxic to fibroblasts up to a 1:32 dilution. Sera from patients with hydatid disease had cytotoxic effects on human small cell lung cancer cells in vitro.
Factors Related to Microalbuminuria in Patients with Chronic Obstructive Pulmonary Disease
(WROCLAW MEDICAL UNIV, 2014) Kaysoydu, Erdal; Arslan, Sulhattin; Yildiz, Guersel; Candan, Ferhan
Background. Chronic obstructive pulmonary disease (COPD) is characterized by inhaled particles and gases inducing chronic inflammation of the airways accompanied by a not fully reversible airflow limitation. Systemic inflammation has an important role in the pathogenesis of COPD. In parallel, several comorbidites can be observed. Microalbuminuria is related to endothelial dysfunction. Microalbuminuria was increased in exacerbation periods of COPD. Objectives. The aim of the study was evaluate to the presence of microalbuminuria (MA) in patients with chronic obstructive pulmonary disease (COPD) and its relationship to inflammation, arterial blood gas parameters and 24-hour ambulatory blood pressure alterations. Material and Methods. Seventy COPD patients and 40 healthy volunteers were enrolled in the study. 24-h ambulatory blood pressure monitoring (ABPM) results, including pressure and pulse rates of the subjects were recorded and the cases were classified as "dipper" if a normal fall of more than 10% in blood pressure was observed at night and "non-dipper" if not. Routine renal function tests were performed, C-reactive protein (CRP) values were examined and urine samples were obtained to scrutinize the presence of MA. Patients were allocated into two groups, those with and without MA. The spirometry and arterial blood gas results of the patients were recorded. Results. The urinary albumin creatinin ratio (64.8 +/- 91.8), CRP (21 +/- 14.8), nocturnal systolic and diastolic blood pressure (118 +/- 14 and 72 +/- 10), nocturnal and diurnal pulse (87 +/- 17 and 90 +/- 14), nocturnal pulse pressure (49 +/- 11), mean pulse (89 +/- 15), mean pulse pressure (48 +/- 10) and the number of non-dipper subjects (65) were found significantly higher in the COPD group than in the control group (10.6 +/- 6, 5.4 +/- 2.4, 105 +/- 6 and 68 +/- 7, 70 +/- 10 and 78 +/- 11, 42 +/- 1, 75 +/- 11, 42 +/- 7 and 5, respectively); (p < 0.001, < 0.001, < 0.001 and 0.041, < 0.001 and < 0.001, < 0.001, < 0.001, < 0.001 and < 0.001, respectively). Nocturnal pulse (89 +/- 17) and CRP (23.5 +/- 14.8) were found to be significantly higher in COPD patients with MA than in COPD patients without MA (78 +/- 8 and 8.8 +/- 6.3, respectively); (p = 0.021 and < 0.001, respectively). Conclusions. The facts that CRP, a systemic inflammation marker, and mean nocturnal pulse pressure values were significantly higher in the group with MA among COPD patients, and that ambulatory blood pressure values did not differ between COPD patients with and without MA, suggest both a possible role of inflammation in MA development in COPD patients and a relationship between MA and increased heart rate.
A Frame-Shift Mutation in the SLC34A2 Gene in Three Patients with Pulmonary Alveolar Microlithiasis in an Inbred Family
(JAPAN SOC INTERNAL MEDICINE, 2010) Dogan, Omer Tamer; Ozsahin, Sefa Levent; Gul, Eylem; Arslan, Sulhattin; Koksal, Binnur; Berk, Serdar; Ozdemir, Ozturk; Akkurt, Ibrahim
Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the presence of small calculi in the alveolar space. The SLC34A2 is thought to be responsible for the disease. We encountered three siblings of an inbred family who have PAM. We examined the family of the proband who was admitted with dyspnea on exertion and cough, and eventually was diagnosed with PAM. Genetic analysis revealed that both parents (a consanguineous marriage) of the proband were carriers with heterozygous mutation of SLC34A2 gene, and three of their children were diagnosed with PAM with homozygous mutation in the SLC34A2 gene. These findings suggest that impaired activity of the SLC34A2 gene may be responsible for familial PAM.
Habitual snoring in primary schoolchildren: prevalence, risk factors and school performance
(DRUNPP-SARAJEVO, 2010) Arslan, Sulhattin; Ozsahin, Sefa Levent; Dogan, Oemer Tamer; Berk, Erdar; Akkurt, Ibrahim
Objective: We aimed to determine the prevalence of snoring in primary school children in Sivas city and to evaluate the nighttime and daytime symptoms and learning problems that may be associated with sleep problems in these children. Subjects and Methods: The questionnaire was distributed to children by their teachers at the school and was filled out by their parents. Results: Of the 2196 given questionnaires, 1952 (88.7%) were filled in adequately and were included in the evaluation. Of the students, 50.9% were girls and 49.1% were boys. The mean age of the students was 10.27 +/- 2.25 years. The prevalence of habitual snoring was 4.9%. Occasional snoring and habitual snoring were significantly more prevalent in the boys than in the girls. Habitual snorers had significantly more nighttime symptoms, such as witnessed apneas (odds ratio [OR], 22.07; 95% confidence interval [CI]; 8.64-563.4), difficulty breathing (OR, 68.46; CI, 12.11-290.76), nocturnal enuresis (OR, 4.12; CI, 1.49-11.33), compared to never snorers. There were also increased prevalence of daytime symptoms, such as falling asleep while watching television (OR, 4.67; CI, 2.63-8.26) and morning headache (OR, 4.53; CI, 2.31-8.87). The presence of predisposing factors (frequent colds, frequent tonsillitis, hay fever, and history of tonsillectomy, etc.) increased the likelihood of habitual snoring. Conclusion: Both nighttime symptoms (apnea, difficulty breathing, restless sleep, nightmares, bruxism, etc.) and daytime symptoms (falling asleep in public places, morning headache, etc.) were highly correlated with habitual snoring in children and habitual snoring was related with parent-reported poor school performance.
Performance of regional tuberculosis dispensaries in a province of Turkey in pre-DOTS era (1989-2002)
(DRUNPP-SARAJEVO, 2010) Ozsahin, Sefa Levent; Arslan, Sulhattin; Dogan, Omer Tamer; Berk, Serdar; Akkurt, Ibrahim
Background: In recent years, very few dispensary staff has been striving to apply directly observed therapy (DOT) elsewhere in Turkey, but the overwhelming majority of TB dispensaries still continue their usual practice today. Therefore, practice of any regional TB dispensary may mirror Turkey's Tuberculosis Programme practice profile. Method: Statistical Year Books of Sivas Province Health Department (from 1989 to 2002) are the main sources of data. The mid-year population numbers obtained from Statistical Year Books of Sivas Province Health Department were preferred for calculating annual incidences. Pearson's correlation coefficients and, if data ordinal, Spearman's correlation coefficients were used to determine correlations. Results: There are three TB dispensaries in the Sivas Province. Total staff number at Sivas TB dispensaries decreased within years (r = -0.92, p < 0.001). TB incidence declined within years, also(r = -0.87, p < 0.0001). Chest X-ray examinations gradually decreased within years from 20,416 examinations in 1989 to 5856 examinations in 2002 (r = -0.75, p = 0.002). Annual microscopic examinations for acid-fast bacilli (AFB) declined within years with 1400 microscopy done in 1989 decreased to 445 examinations in 2002 (r=-0.62, p=0.018). Per each TB patient, the annual mean microscopy for AFB examination was 4.49 +/- 1.47 and the mean chest radiography was 8.25 +/- 3.27 at local dispensaries in this fourteen-year period. The annual tuberculin skin test (TST) and Bacillus Calmette-Guerin (BCG) vaccinations per 100,000 population performed by local dispensaries did not statistically different within years (r = -0.45, p = 0.106 and, p = -0.15, p = 0.605, respectively). Conclusion: TB incidence declined within years, but this situation seems to be not related with improving of dispensaries performance.
Predictive significance of KRAS point mutation in patients with non-small cell lung carcinoma relation to smoking and asbestos exposure in middle Anatolia population
(DRUNPP-SARAJEVO, 2010) Arslan, Sulhattin; Akkurt, Ibrahim; Koksal, Binnur; Karadayi, Sule; Ozdemir, Ozturk
Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras 2) has been assessed as a mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine-kinase inhibition in patients with non-small-cell lung cancer (NSCLC). The aim of the current study was to investigate the predictive significance of KRAS mutations in patient with NSCLC in relation to cigarette smoking and asbestos exposure. We have investigated 42 fresh tumoral tissue samples of cases that were histopathologically diagnosed as lung carcinomas. Patients were evaluated for clinical findings; tumoral tissue samples were examined histopathologically and genomic DNA from tumoral tissue samples were isolated. The KRAS point mutations were assessed by strip-Assay reverse hybridization method and compared with the healthy controls. A total of 24 patients (57%) demonstrated KRAS point mutations in their tumoral tissues, while 18 (43%) patients did not. Mutations were accumulated in current cases of NSCLC, which were active smokers and exposed to the asbestos. Current results showed that the combined effects of somatic mutations in KRAS may play an active role in development of primary lung carcinomas due to heavy smoke and asbestos exposure. Results also may have important implications for molecular diagnosis and targeted therapies in NSCLC.
Predictive significance of KRAS point mutation in patients with nonsmall cell lung carcinoma relation to smoking and asbestos exposure in middle anatolia population
(2010) Arslan, Sulhattin; Akkurt, Ibrahim; Koksal, Binnur; Karadayi, Sule; Ozdemir, Oztürk
Persons who have been occupationally exposed to environmental mutagens have a substantially increased risk for somatic oncogene mutations. Structural mutation in viral kristen rat sarcoma oncogene homolog 2 (KRAS; v-Ki-ras 2) has been assessed as a mechanism of de-novo resistance to epidermal growth factor receptor (EGFR) tyrosine-kinase inhibition in patients with non-smallcell lung cancer (NSCLC). The aim of the current study was to investigate the predictive significance of KRAS mutations in patient with NSCLC in relation to cigarette smoking and asbestos exposure. We have investigated 42 fresh tumoral tissue samples of cases that were histopathologically diagnosed as lung carcinomas. Patients were evaluated for clinical findings; tumoral tissue samples were examined histopathologically and genomic DNA from tumoral tissue samples were isolated. The KRAS point mutations were assessed by stripAssay reverse hybridization method and compared with the healthy controls. A total of 24 patients (57%) demonstrated KRAS point mutations in their tumoral tissues, while 18 (43%) patients did not. Mutations were accumulated in current cases of NSCLC, which were active smokers and exposed to the asbestos. Current results showed that the combined effects of somatic mutations in KRAS may play an active role in development of primary lung carcinomas due to heavy smoke and asbestos exposure. Results also may have important implications for molecular diagnosis and targeted therapies in NSCLC.
Prevalance of asthma and allergic diseases in Mid-Anatolia
(2012) Arslan, Sulhattin; U?urlu, Serdal; Demirel, Yeltekin; Can, Günay
Objective: Allergic diseases are commonly seen in childhood. In this study the prevalences of asthma and other allergic diseases were investigated among the school children in Sivas in the year 2008. Material and Method: The questionnaire was based on the "International Study of Asthma and Allergies in Childhood (ISAAC)" questionnaires. If children were younger than 12 years the questionnaire was distributed to children by their teachers at school and was filled out by their parents. Results: Mean age of 1947 children was 10.28±2.24 (7-16), 50.9%of them were girls and 49.1%were boys. Lifetime wheezing rate was 26.8%, physician-diagnosed asthma was 10.1%, allergic rhinitis was 25.2%, and allergic dermatitis was %28.3. The asthmatic subjects also reported the symptoms of allergic rhinitis (4.7%), conjunctivitis (4.2%) and dermatitis (4.3%). Conclusion: We determined the prevalence of asthma and other allergic disease of primary school children between ages of 7-15 in Sivas. One should bare in mind that one or more allergic diseases such as rhinitis, dermatitis and conjunctivitis may be observed in a student with asthma depending on the relationship between those diseases.
PREVALANCE OF ASTHMA AND ALLERGIC DISEASES IN MID-ANATOLIA
(NOBEL ILAC, 2012) Arslan, Sulhattin; Ugurlu, Serdal; Demirel, Yeltekin; Can, Gunay
Objective: Allergic diseases are commonly seen in childhood. In this study the prevalences of asthma and other allergic diseases were investigated among the school children in Sivas in the year 2008. Material and Method: The questionnaire was based on the "International Study of Asthma and Allergies in Childhood (ISAAC)" questionnaires. If children were younger than 12 years the questionnaire was distributed to children by their teachers at school and was filled out by their parents. Results: Mean age of 1947 children was 10.28 +/- 2.24 (7-16), 50.9%of them were girls and 49.1%were boys. lifetime wheezing rate was 26.8%, physician-diagnosed asthma was 10.1%, allergic rhinitis was 25.2%, and allergic dermatitis was %28.3. The asthmatic subjects also reported the symptoms of allergic rhinitis (4.7%), conjunctivitis (4.2%) and dermatitis (4.3%). Conclusion: We determined the prevalence of asthma and other allergic disease of primary school children between ages of 7-15 in Sivas. One should bare in mind that one or more allergic diseases such as rhinitis, dermatitis and conjunctivitis may be observed in a student with asthma depending on the relationship between those diseases.

Yazar "Arslan, Sulhattin" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri