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Öğe Assessing the Efficiency of Intranasal Steroid Treatment in Cases with Eustachian Dysfunction Via the Turkish Version of Eustachian Tube Dysfunction Questionnaire-7(Wolters Kluwer Medknow Publications, 2020) Bora, Adem; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Altuntas, Emine ElifAim: The aim of this study was to evaluate the efficiency of the treatment in the cases, who were diagnosed with Eustachian tube dysfunction (ETD) via history, physical examination, and tympanometry and for whom intranasal steroid treatment was planned to be used before surgical treatment options, by using Eustachian Tube Dysfunction Questionnaire (ETDQ)-7. Materials and Methods: Fifty-five cases, who applied to the otorhinolaryngology outpatient clinic due to the complaints suggesting Eustachian dysfunction such as aural fullness and pressure sensation and for whom the diagnosis of Eustachian dysfunction was considered due to the results of the examination, history, and physical examination, were included in the study. The 3rd and 6th weeks of intranasal steroid treatment ETDQ-7 scores were recorded. Results: ETDQ-7 mean scores of the cases were 2.72 +/- 0.97 at the time of initial diagnosis (minimum-maximum: 1-4.71), 2.31 +/- 0.85 in the 3rd week of the treatment (minimum-maximum: 1-5), and 2.12 +/- 0.78 (minimum-maximum: 1-4, 14) in the 6th week. A statistically significant difference was observed when statistically assessing the ETDQ-7 scores determined at the time of diagnosis and in the 3rd and 6th weeks of the treatment (P < 0.001). When ETDQ-7 scores were assessed based on gender in assessment time, there was a statistically significant difference in the assessment conducted in the 3rd week (P < 0.05; P = 0.039). Conclusion: It is believed that the current study is the first study that evaluates the efficiency of intranasal corticosteroid treatment, which is frequently used by the doctors in daily practice in pharmacotherapy in the cases with ETD from young adult and adult age groups, on the symptoms via ETDQ-7. In addition, the results of the present study indicated that intranasal steroid treatment in early periods caused a significant recovery in the symptoms, however this recovery also reached a plateau after the treatment.Öğe Do Mean Values of the Peak Inspiratory Nasal Flowmeter Vary According to the Severity, Direction and Type of Nasal Septum Deviation?(Springer India, 2022) Bora, Adem; Aslan, Yasin; Durmus, Kasim; Demirkiran, Berat Baturay; Altuntas, Emine ElifThe aim is to investigate the contribution of the PNIF test in daily clinical practices in the objective evaluation of the early postoperative functional results of septoplasty and the effect of the severity, direction, and type of nasal septum deviation on mean PNIF values. Nasal septum deviation (NSDs) of the cases were grouped according to the Mladina classification and the severity of NSDs. An objective evaluation of the nasal airway was conducted via a peak flowmeter device in the preoperative and postoperative first month. When examining the mean PNIF values according to genders, it was observed that the values determined in male cases in the preoperative and postoperative period were higher. In the intragroup evaluation performed according the Mladina classification, a statistically significant increase was observed in the preoperative and postoperative PNIF values of the cases in Types 1-4. In the intragroup evaluation performed according to the severity of NSD, there was a significant increase in the preoperative and postoperative PNIF values of the mild and moderate cases. When comparing the preoperative and postoperative PNIF values of the groups in terms of the severity of NSD, it was observed that there was a significant difference. The PNIF can be used in routine clinical practices to evaluate the septoplasty results objectively. In the evaluation of functional results, the change in the mean PNIF values may also vary according to the direction and severity of septum deviation and the Mladina classification other than age, gender and ethnic origin.Öğe Investigating dizziness symptom in adult cases with Crimean-Congo hemorrhagic fever using various scales(Springer, 2021) Bora, Adem; Buyuktuna, Seyit Ali; Durmus, Kasim; Demirkiran, Berat Baturay; Aslan, Yasin; Oksuz, Caner; Altuntas, Emine ElifBackground This study was to investigate the frequency of self-reported dizziness symptom in cases with Crimean-Congo hemorrhagic fever (CCHF) and the severity of dizziness, if any, by using various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. The frequency and severity of the self-reported dizziness symptom of CCHF patients, level of disability caused by dizziness, and to what extent vestibular symptoms affected activities of daily living were assessed by various scales. Results The frequency of dizziness in CCHF cases included in the study was 11.11% and all the cases were involved in the mild category in terms of disease severity. When the results of the scales applied to all of the cases were evaluated in general, it was seen that there was no vertigo or dizziness. Conclusion According to the results of the present study, we consider that multicenter studies with large series investigating pathophysiological mechanisms underlying these clinical symptoms are needed in order to evaluate dizziness symptom and to make definitive interpretations in CCHF disease.Öğe Investigating the Healing Effect of Hyperici Oleum and Triticum vulgare on Septal Perforation in Rats A Preliminary Study(Aves, 2023) Bora, Adem; Durmus, Kasim; Inan, Zeynep Deniz Sahin; Aslan, Yasin; Altuntas, Emine ElifObjective: The aim of this study was to investigate histopathologically the possible beneficial effects of hyperici oleum and Triticum vulgare , having anti-inflammatory, antioxidant, and antiproliferative properties, on the healing process of nasal septum perforation experimentally.Methods: Circular perforations of 2 mm diameter were performed at the nasal septum of 32 rats. Intranasal administration of hyperici oleum (HO), Triticum vulgare (TV), and thiocilline (T) was carried out twice a day for 7 days. After the rats were sacrificed at the end of the seventh day, their nasal septum specimens were sent for histological examination. The groups were compared in terms of epithelial regeneration, presence of fibroblasts and inflammatory cells, and capillary density parameters.Results: There was a statistically significant increase in the epithelialization mean scores in groups HO and TV compared to group P. When the groups were examined in terms of inflammation, a statistically significant increase was found in group HO. In terms of the fibroblast scores, a statistically significant increase was seen between group P and groups HO and T. The vascularization mean scores both in group HO and group TV were statistically significant when they were compared with groups C and P.Conclusion: The present study provides clues for preferring the use of TV and HO as a healer for the perforation area in the treatment of septum perforation. Based on the findings, widening the experiment and including additional parameters for understanding the healing mechanism will contribute to the clarification of the healing mechanism and thus to the development of the treatment options.Öğe Ratlarda gentamisine bağlı ototoksisitenin önlenmesinde astaksantin’in etkisinin araştırılması(Sivas Cumhuriyet Üniversitesi, 2022) Aslan, Yasin; Durmuş, KasımAmaç: Gentamisin indüksiyonu ile ratlarda oluşturulan sensörinöral işitme kaybı üzerine güçlü bir antioksidan olan astaksantinin olası koruyucu etkisinin işitsel beyin sapı cevabı (ABR), distorsiyon ürünü otoakustik emisyon (DPOAE) testleri ve histopatolojik inceleme ile araştırılması amaçlanmıştır. Gereç ve Yöntemler: Dişi 16-18 haftalık, 230±10 gram ortalama ağırlığa sahip 32 Wistar albino rat üzerinde bu çalışma gerçekleştirildi. Ratlar randomize olarak; grup K (gavaj yoluyla ayçiçek yağı 0,5 mL/gün uygulanan kontrol grubu; n=8) , grup G (gentamisin120 mg/kg/gün uygulanan ototoksisite grubu ; n=8) , grup GA (intraperitoneal gentamisin 120 mg/kg/gün ve gavaj yoluyla astaksantin 16 mg/kg/gün uygulanan grup; n=8) ve grup A , (gavaj yoluyla astaksantin 16 mg/kg/gün uygulanan grup; n=8) olmak üzere dört gruba ayrıldı . Herhangi bir medikasyon uygulanmadan önce (0. Gün) ratların tümüne ABR ve DPOAE testleri yapılarak işitme kayıplarının olmadığı ortaya kondu. Deney prosedürünün 7, 14 ve 21 günlerinde ABR ve DPOAE testleri tekrarlandı. Deneyin 21 günün de işitme değerlendirmesini takiben ratların tümü sakrifiye edildikten sonra kokleaları diseke edilerek histopatolojik olarak incelendi. Bulgular: Ratların tümünde deneyin 0. gününde yapılan işitme ölçümlerinde herhangi bir işitme kaybı tespit edilmedi ve elde edilen değerler istatistiksel açıdan benzerdi. Grup A'da yer alan ratların (deneyin 7, 14 ve 21 günlerinde) işitme değerlendirmesinden elde edilen sonuçları kontrol grubu ile karşılaştırıldığında istatistiksel açıdan anlamlı bir farklılık tespit edilmedi. Grup G'de yer alan ratlarda elde edilen değerlendirme sonuçlarında deneyin 14. günüden sonra işitme eşiklerinde düşüş tespit edilmiş olup bu değişim grup K'de yer alan ratlardan elde edilen sonuçlar ile karşılaştırıldığında istatistiksel açıdan anlamlı idi. Grup GA'da ise ABR ve DPOAE değerlerindeki düşme grup G'ye göre göre daha az olarak tespit edildi ve değişim istatistiksel açıdan anlamlı idi. Histopatolojik bulgular özellikle stria vaskülaris bölümünde belirgindi ve bu bölge grup K ve grup A'da yer alan ratlarda düzenli olarak tespit edilmiş. Grup G'de bu bölge atrofiye uğramış, kapiller yapılar ve doku bütünlüğü kaybolmuştur. Grup GA'da ise doku bütünlüğü yeniden sağlanmaya başlamış, atrofik alanlar azalmış ve epitel hücrelerdeki kayıp grup G'ye göre daha az olduğu dikkat çekmiştir. Bu bulgular ABR ve DPOAE testlerini destekler nitelikteydi. Sonuç: Ratlarda gentamisin kullanılarak oluşturulan ototoksisitenin, gentamisin ile birlikte astaksantin uygulandığında anlamlı düzeyde azaldığı ve bu sonuçlarla güçlü bir antioksidan olan astaksantinin, gemtamisin ototoksisitesinde koruyucu etkisinin olduğu saptanmıştır. Anahtar Kelimeler: Gentamisin, Ototoksisite, Astaksantin, Antioksidanlar, Otoakustik Emisyon, ABR
