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Öğe Aneurysm formation in bovine mesenteric vein grafts after infrainguinal reconstructions(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2012) Katrancioglu, Nurkay; Manduz, Sinasi; Atahan, Erhan; Berkan, OcalThe use of autologous vein graft in infrainguinal arterial bypass grafting (IABG) is the gold standard. However, expanded polytetrafluoroethylene (ePTFE)/heterografts can be also used in cases where the use of autologous vein graft is inappropriate. Biological vascular grafts have been used for many years in the treatment of peripheral arterial diseases. In this report, we present a 62-year-old male who was admitted to our clinic with the symptoms of left lower leg ischemia and diagnosed with left superficial femoral artery occlusion. The patient who did not have an appropriate autologous vein graft underwent femoropopliteal bypass grafting (FPBG) surgery via bovine mesenteric vein graft. At eight months, the patient revisited our clinic with the complaint of a pulsatile mass on the grafting site of the left leg. Aneurysmal dilatation of graft was detected in the patient and aneurysmatic bovine mesenteric vein graft was replaced by ePTFE graft. The patient was discharged on day 8 following uneventful surgery.Öğe Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study(SAGE PUBLICATIONS INC, 2011) Katrancioglu, Nurkay; Manduz, Sinasi; Ozen, Filiz; Yilmaz, Mehmet Birhan; Atahan, Erhan; Ozdemir, Ozturk; Berkan, OcalMaterials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. Results: In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48). Conclusion: It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.Öğe Chemokine receptor 5 ?32 gene polymorphism and abdominal aortic aneurysms(2010) Aydin, Murat; Katrancio?lu, Nurkay; Manduz, Şinasi; Atahan, Erhan; Karahan, O?uz; Özdemir, Öztürk; Berkan, ÖcalBackground: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm (AAA) and chemokine receptor 5 ?32 (CCR5) gene polymorphism as a risk factor. Methods: Fifty-eight patients (41 males, 17 females; mean age 62.9±6.5 years; range 45 to 78 years) operated on our clinic between May 2008 and March 2009 with the diagnosis of AAA, and 58 healthy volunteers (38 males, 20 females; mean age 58.8±11.6 years; range 30 to 79 years) with normal aortic diameters measured by computed tomography were included in this study. Thirty-two base p deletions in the CCR5 gene were screened after obtaining genomic DNAs from peripheral blood samples of the patients. Results: When the groups were compared with the predisposing risk factors for the development of AAA, no significant difference was observed (p>0.05). Eleven patients (19.0%) had heterozygote CCR5 gene mutation in the AAA group, however, only one patient (1.7%) had heterozygote CCR5 gene mutation in the control group. While the CCR5 homozygote was normal in 47 (81.0%) patients, the CCR5 homozygote was normal in 57 (98.3%) volunteers in the control group. Chemokine receptor 5 ?32 heterozygote gene mutation was significantly higher in the AAA group. (p=0.004). Conclusion: Consequently, a relationship between CCR5 gene polymorphism and AAA was demonstrated in this study. We think that hereditary factors considered between unchanged etiologic factors play a role in the development of AAA and we believe that AAA can be treated before serious complications occur with frequent clinical check ups in people with hereditary predisposition.Öğe Chemokine receptor 5 Delta 32 gene polymorphism and abdominal aortic aneurysms(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2010) Aydin, Murat; Katrancioglu, Nurkay; Manduz, Sinasi; Atahan, Erhan; Karahan, Oguz; Ozdemir, Ozturk; Berkan, OcaiBackground: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm (AAA) and chemokine receptor 5 Delta 32 (CCR5) gene polymorphism as a risk factor. Methods: Fifty-eight patients (41 males, 17 females; mean age 62.9 +/- 6.5 years; range 45 to 78 years) operated on our clinic between May 2008 and March 2009 with the diagnosis of AAA, and 58 healthy volunteers (38 males, 20 females; mean age 58.8 +/- 11.6 years; range 30 to 79 years) with normal aortic diameters measured by computed tomography were included in this study. Thirty-two base p deletions in the CCR5 gene were screened after obtaining genomic DNAs from peripheral blood samples of the patients. Results: When the groups were compared with the predisposing risk factors for the development of AAA, no significant difference was observed (p>0.05). Eleven patients (19.0%) had heterozygote CCR5 gene mutation in the AAA group, however, only one patient (1.7%) had heterozygote CCR5 gene mutation in the control group. While the CCR5 homozygote was normal in 47 (81.0%) patients, the CCR5 homozygote was normal in 57 (98.3%) volunteers in the control group. Chemokine receptor 5 Delta 32 heterozygote gene mutation was significantly higher in the AAA group. (p=0.004). Conclusion: Consequently, a relationship between CCR5 gene polymorphism and AAA was demonstrated in this study. We think that hereditary factors considered between unchanged etiologic factors play a role in the development of AAA and we believe that AAA can be treated before serious complications occur with frequent clinical check ups in people with hereditary predisposition.Öğe eNOS G894T Polymorphism and Abdominal Aortic Aneurysms(SAGE PUBLICATIONS INC, 2010) Atli, Fahri Hayri; Manduz, Sinasi; Katrancioglu, Nurkay; Ozum, Unal; Disli, Olcay Murat; Atahan, Erhan; Ozdemir, Ozturk; Dogan, Kasim; Berkan, OcalBackground: The genetic risk factors that contribute to the risk of developing abdominal aortic aneurysm ( AAA) are poorly understood. We assessed the association of endothelial nitric oxide synthase ( eNOS) gene polymorphism with AAA. Methods: eNOS gene polymorphism of 61 patients with AAA and 62 control participants were analyzed by polymerase chain reaction (PCR)-restriction technique. Results: eNOS G894 homozygote T/T genotype polymorphism and 894T allele frequency in patients with AAA were significantly higher than those of the control participants (P=.01, P=.03). Among patients with AAA, the eNOS G894 T/T polymorphism and 894T allele frequency were associated with larger AAAs. Conclusion: The current study, in a small group of participants, showed a relationship between eNOS G894T polymorphism and AAA.Öğe The Investigation of the Antiangiogenic Potential of Amiodarone HCl in the Chick Embryo Chorioallantoic Membrane Model(SCIENTIFIC PUBLISHERS INDIA, 2013) Karahan, Oguz; Yavuz, Celal; Demirtas, Sinan; Caliskan, Ahmet; Atahan, ErhanAngiogenesis, which plays a significant role in a variety of physiological processes, such as embryonic growth and wound healing, is strictly delimited and finely tuned by a balance of proangiogenic and antiangiogenic factors. Cardiac rhythm disorders are diseases that are often accompanied by vascular pathologies. As such, the purpose of this study was to investigate the antiangiogenic effects of Amiodarone HCl in the chorioallantoic membrane model. In this study, the antiangiogenic effect of Amiodarone HCl was compared with a positive control group that was given pure paraffin and the vascular endothelial growth factor inhibitor Bevacizumab, as well as a negative control group in which clearly antiangiogenic activity was shown in this model previously. Concentrations of 10(-4), 10(-5), and 10(-6)M of each drug were administered. For the purpose of determining the antiangiogenic effects of the drugs, blood vessels of the chorioallantoic membranes were evaluated using a stereoscopic microscope. The antiangiogenic effect scores of Amiodarone HCl at the dose of 10(-4) molar (M) were higher than those of 10(-5)M and 10(-6)M, but that result was statistically insignificant. The antiangiogenic effect scores of Bevacizumab at the concentrations of 10(-4)M and 10(-5)M were significantly higher than that of 10(-6)M. This effect of Amiodarone may be important for determining routine antiarrhythmic doses.Öğe Is sustained release of vancomycin from fibrin glue effective to prevent methicillin-resistant Staphylococcus aureus graft infection?(ACADEMIC JOURNALS, 2012) Katrancioglu, Nurkay; Karahan, Oguz; Kilic, Ahmet Turhan; Katrancioglu, Ozgur; Celik, Cem; Bakici, Mustafa Zahir; Atahan, ErhanProsthetic vascular graft infection remains one of the most serious complications seen after vascular surgery. Recently, fibrin glue has gained attention as a possible means to deliver drug therapies. In this study, the efficacy of vancomycin incorporated fibrin glue for preventing methicillin-resistant Staphylococcus aureus (MRSA) infection of prosthetic grafts was investigated. The vascular grafts were implanted into subcutaneous pockets in the backs of 32 rats. Group 1: no graft contamination; Group 2: MRSA contamination; Group 3: vancomycin incorporated fibrin glue graft and MRSA contamination; and Group 4: vancomycin soaked graft and MRSA contamination. The grafts were removed after 7 days and evaluated by a quantitative culture analysis. The quantitative culture values for Groups 2, 3, and 4 were 1.8x10(11) +/- 1.4x10(11), 1.1x10(7) +/- 2.4x10(7), and 2.6x10(8) +/- 3.9x10(8), respectively. The culture values of the Group 2 was significantly higher than those of the Group 3 and Group 4 (p=0.014 and p=0.016, respectively), however, Groups 3 and 4 were comparable (p=0.161). In our study, efficacies of vancomycin-incorporated fibrin and vancomycin alone were comparable. The finding of the current study indicated that a fibrin-based delivery system might not be as effective an option as a vancomycin delivery.Öğe THE MYOCARDIAL INFARCTION IN A YOUNG WOMAN WITH HETEROZYGOUS MTHRF AND PAI-1 GENE MUTATIONS(ELSEVIER IRELAND LTD, 2010) Katrancioglu, Nurkay; Manduz, Sinasi; Karahan, Oguz; Atahan, Erhan; Kilinc, Ahmet Turan; Berkan, Ocal…Öğe PAI-1 4G/4G GENE POLYMORPHISM IS AFFECTING OF SERUM LIPID LEVEL IN TURKISH POPULATION(ELSEVIER IRELAND LTD, 2010) Katrancioglu, Nurkay; Manduz, Sinasi; Karahan, Oguz; Atahan, Erhan; Sanri, Umut Serhat; Berkan, Ocal…Öğe Protective Effect of Zinc Aspartate on Long-Term Ischemia-Reperfusion Injury in Rat Skeletal Muscle(HUMANA PRESS INC, 2010) Atahan, Erhan; Ergun, Yusuf; Kurutas, Ergul Belge; Alici, TugrulThe present study investigated the protective effect of zinc aspartate, in connection with reactive oxygen species and nitric oxide, on long-term ischemia-reperfusion injury (IRI) in rat skeletal muscle. Following ketamine anesthesia, 24 rats were randomly assigned to four groups: groups 1 and 2, each without tourniquet application, received no drug and zinc, respectively; groups 3 and 4, each subjected to tourniquet-induced IRI (3 + 24 h), received no drug and zinc, respectively. IRI was achieved by the application of an elastic rubber band in the left hind limb of the anesthetized rats. Gastrocnemius muscle samples were obtained for biochemical measurements. Malondialdehyde levels were lower in group 2 and higher in group 3 than those seen in group 1. However, zinc aspartate (group 4) totally reversed malondialdehyde levels to control levels. Superoxide dismutase activity was increased in group 2 compared with group 1; however, there was no difference between groups 1 and 3, and Zn injection (group 4) increased superoxide dismutase activity. While catalase values were similar in groups 1 and 2, significant increments were observed in 3 and 4. A similar enhancement in glutathione levels were observed in groups 2 and 4 compared with group 1. Nitric oxide levels were lower in group 2 than 1, and no difference between groups 1 and 3 was demonstrated. In conclusion, zinc seems to be an effective treatment option against IRI.Öğe The investigation of the antiangiogenic potential of amiodarone HCl in the chick embryo chorioallantoic membrane model(2013) Karahan, Oguz; Yavuz, Celal; Demirtas, Sinan; Caliskan, Ahmet; Atahan, ErhanAngiogenesis, which plays a significant role in a variety of physiological processes, such as embryonic growth and wound healing, is strictly delimited and finely tuned by a balance of proangiogenic and antiangiogenic factors. Cardiac rhythm disorders are diseases that are often accompanied by vascular pathologies. As such, the purpose of this study was to investigate the antiangiogenic effects of Amiodarone HCl in the chorioallantoic membrane model. In this study, the antiangiogenic effect of Amiodarone HCl was compared with a positive control group that was given pure paraffin and the vascular endothelial growth factor inhibitor Bevacizumab, as well as a negative control group in which clearly antiangiogenic activity was shown in this model previously. Concentrations of 10-4, 10-5, and 10-6M of each drug were administered. For the purpose of determining the antiangiogenic effects of the drugs, blood vessels of the chorioallantoic membranes were evaluated using a stereoscopic microscope. The antiangiogenic effect scores of Amiodarone HCl at the dose of 10-4 molar (M) were higher than those of 10-5M and 10-6M, but that result was statistically insignificant. The antiangiogenic effect scores of Bevacizumab at the concentrations of 10-4M and 10-5M were significantly higher than that of 10-6M. This effect of Amiodarone may be important for determining routine antiarrhythmic doses.Öğe Vascular graft infection by Staphylococcus aureus: efficacy of linezolid, teicoplanin and vancomycin systemic prophylaxis protocols in a rat model(CLINICS CARDIVE PUBL PTY LTD, 2009) Atahan, Erhan; Katrancioglu, Nurkay; Oztop, Yasemin; Tuncer, Ersin; Ozer, Hatice; Manduz, Sinasi; Engin, Aynur; Yalta, Tulin Deniz; Berkan, Ocal; Dogan, KasimObjective: We investigated experimentally the in vivo prophylactic efficacies of linezolid, teicoplanin and vancomycin in subcutaneously implanted dacron graft infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Materials and methods: Dacron grafts (1 cm(2)) were aseptically implanted into subcutaneous pockets that were surgically prepared in the backs of 50 rats. Ten of these rats were used as the control group (group I). Grafts in the remaining 40 rats were infected by inoculation of MRSA at the concentration of 2 x 10(7) colony-forming units (CFU)/ml. Ten of these rats constituted the contaminated, untreated group II. The other three study groups comprising 10 rats each were contaminated and then treated with linezolid (group III), teicoplanin (group IV) and vancomycin (group V), respectively. All rats were sacrificed and the grafts were removed after seven days and evaluated. Results: The bacterial count decreased in the rats from the groups treated with linezolid, teicoplanin and vancomycin. The linezolid and teicoplanin groups, however, showed a significantly lower bacterial number than the vancomycin group (p = 0.009 and p = 0.01). The intensity of inflammation was highest in the contaminated, untreated group, as expected. Conclusions: Single-dose linezolid, teicoplanin and vancomycin for peri-operative prophylaxis may prevent bacterial growth in vascular graft infections. The effect of linezolid and teicoplanin seemed similar and their effect was greater than that of vancomycin.Öğe Venous thromboembolism and inherited thrombophilia(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2009) Atahan, Erhan; Caglar, Erkan; Sarkis, Cihat; Ugurlu, SerdalInherited thrombophilia is a genetic tendency to venous thromboembolism. Coagulation abnormalities are common in the general population and therefore will present spontaneously in some individuals. Patients with a family history of thrombosis are at an increased risk for a mutation. Factor V Leiden and the prothrombin, G20210A mutation the commonest inherited risk factors for thrombosis, are associated with an increased risk of venous thromboembolism. These causes of thrombophilia increase the risk of venous thromboembolism recurrence. Deficiencies in protein C, protein S, and antithrombin-Ill account for most of the remaining cases of thrombophilia. Inherited thrombophilia should be suspected in patients with one or more of the following clinical features: idiopathic thrombosis, thrombosis at a young age, recurrent thrombosis, and thrombosis at an unusual site. Reliable assays are now available to test for the presence of the various causes of inherited thrombophilia.
