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Öğe Bazı nitrosaminlerin fare karaciğer Na+-K+ ATPaz enzimi üzerindeki etkileri ve bağlanma özellikleri(1989) Çetinkata, Öge; Atalay, Atilla[Abstract Not Available]Öğe Bazı nitrozolu bileşiklerin insan lenfosit kromozomlarına DNA, RNA ve protein sentezine etkileri(1991) Atalay, Atilla; Sezgin, İlhan[Abstract Not Available]Öğe Sivas yöresinde 2,4-D ester adlı herbisitin balıklara biyolojik etkisinin incelenmesi(1989) Çolak, Ahmet; Atalay, Atilla; Cengiz, Salih[Abstract Not Available]Öğe The effects of malathion alkaline phosphatase activity in the liver, kidney and small intestine in mice(1999) Dere, Egemen; Bakir, Sevtap; Atalay, AtillaThe effects of malathion on alkaline phosphatase activity in the liver, kidney and small intestine was investigated. Malathion doses of 40 mg kg-1 were injected intreperitonally (I:P) into mice. At 0. 4, 8, 16 and 24 hours after treatment with malathion, mice were decapitated and tissues were removed. Homogenate of the tissues was centrifugated at 48000xg for 30 minutes. The supernatant was used as an enzyme source. It was found that the malathion increased alkaline phosphatase activity in the kidney and decreased alkaline phosphatase activity in the liver and small intestine.Öğe Treatment of ethylnitrosourea induced lymphocyte hyperproliferation by DNA hypomethylation in the rat colon(2002) Özdemir, Öztürk; Bulut, Hüseyin Eray; Korkmaz, Mehmet; E?ilmez, Reyhan; Atalay, AtillaN-ethyl-N-nitrosourea (ENU) is a potential carcinogenic agent commonly used in industry, and it may cause an uncontrollable cell proliferation and eventually tumourgenesis. On the other hand, the hypomethilation of DNA by 5-aza-2?-deoxycytidine is the best known anti-tumoural mechanism used for the treatment of leukemia. Therefore the present study aimed to find out the possible healing effects of 5-aza-2?-deoxycytidine on lymphocyte hyperproliferation in the rat colon through the above mentioned DNA hypomethylation mechanism. Rats were injected with 300 mg/kg body weight ENU (i.p.) in order to induce tumour development. Following 45 weeks when the tumourgenesis was proved visually, animals were treated with 5-aza-2?-deoxycytidine 100 ?g/100g body weight twice a week intraperitoneally for 15 weeks. After the experimental procedure, all animals were sacrificed and colonal tissues were obtained. Tissues were processed for light and electron microscopy. While no colonal tumour development was observed in the control group, an extensive tumour development was seen in the subcutaneous region in the high dose ENU treated group. The light and electron microscopical examination of the rat colonal tissue revealed a lymphocyte hyperproliferation and invasion in the submucosal region, an increased number of polimorphonuclear leukocytes (PMNLs) and occasional epithelial lesions. On the other hand, the evaluation of the 5-aza-2?-deoxycytidine treatment group rat colon demonstrated features similar to those seen in the control and PEG treated groups indicating a possible anti-neoplastic effect of 5-aza-2?-deoxycytidine via DNA hypomethylation.
