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Öğe Acute Phase Proteins, Clinical, Hematological and Biochemical Parameters in Dairy Cows Naturally Infected with Anaplasma Marginale(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2012) Coskun, Alparslan; Ekici, Ozlem Derinbay; Guzelbektes, Hasan; Aydogdu, Ugur; Sen, IsmailThe aim of the study was to evaluate acute phase response via Haptoglobin and serum amyloid-A concentrations in dairy cows naturally infected with Anaplasma marginale. The second aim of the study was to determine the changes in clinical, hematological and biochemical parameters in dairy cows naturally infected Anaplasma marginale. A total of 40 dairy cattle suffering from bovine anaplasmosis were included to the study from a dairy cattle herd. A total of 10 healthy dairy cattle were selected for control group. Analysis of acute phase proteins, hematologic analysis and biochemical analysis was performed in this study. Serum haptoglobin and serum amyloid-A concentrations significantly increased in cattle infected with Anaplasma marginale compared to healthy cattle. All cattle in infected group demonstrated clinical signs of anaplasmosis. Significantly decreased red blood cell count, packed cell volume, and hemoglobin concentration were observed in infected cattle compared to the control group. Serum aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin concentrations were significantly increased in infected cattle compared with the control group. In conclusion, the changes of biochemical and hematological parameters may be indicate of anemia and tissue damage in cattle with anaplasmosis. Serum haptoglobin and serum amyloid-A concentrations could be usefull in evaluate of acute phase response in cattle infected with Anaplasma marginale.Öğe CARDIAC BIOMARKERS IN PREMATURE CALVES WITH RESPIRATORY DISTRESS SYNDROME(AKADEMIAI KIADO RT, 2016) Aydogdu, Ugur; Yildiz, Ramazan; Guzelbektes, Hasan; Coskun, Alparslan; Sen, IsmailThe aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO(2), O-2 saturation and high pCO(2) values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.Öğe Comparison of the Effectiveness of Halofuginone Lactate and Paromomycin in the Treatment of Calves Naturally Infected with Cryptosporidium parvum(UNIV FED RIO GRANDE DO SUL, 2018) Aydogdu, Ugur; Isik, Nermin; Ekici, Ozlem Derinbay; Yildiz, Ramazan; Sen, Ismail; Coskun, AlparslanBackground: Cryptosporidiosis is one of the most important problems among neonatal ruminants. Cryptosporidium parvum is the agent causing the disease. Cryptosporidium infection, responsible for diarrhea, dehydration, weight loss and death in neonatal ruminants, leads to significant economic losses for producers. In calves naturally or experimentally infected with cryptosporidiosis, many agents have been reported to have therapeutic and protective effects. The objective of this study was to compare the effectiveness of halofuginone lactate and paromomycin in the treatment of calves naturally infected with Cryptosporidium parvum. Materials, Methods & Results: Twenty calves between 7 and 20 days of age and naturally infected were included in the study. There were two different treatment groups in the study. The first group of calves were administered 100 mu g/kg/day halofuginone lactate for 7 days and the second group of calves were administered 100 mg/kg/day paromomycin for 7 days. In addition, antibiotic and vitamin C were applied to all calves. Jugular venous blood samples were obtained pre-treatment and on the 7th day after the treatment. Routine clinical examinations of the calves were performed on days 0, 1, 3, 5 and 7 and rectal stool samples were collected for the detection of Cryptosporidium oocysts. Severe diarrhea, dehydration, depression and weight loss were observed in calves in both treatment groups. A significant decrease (P < 0.05) was observed for both groups in oocyst count on days 3, 5 and 7 compared to days 0 and 1. Improvements in blood parameters, stool characters and clinical scoring of both groups were observed in post-treatment. Discussion: Many pharmaceuticals or compounds have been tested for animal with cryptosporidiosis and only very few of them have shown a partial protective activity in ruminants when used prophylactically. Halofuginone lactate and paromomycin are commonly recommended as both therapeutic and protective agents. However, the effectiveness of the two therapeutic agents in natural infections has not been compared and, in the meantime, recommendations for a rational use are also not sufficiently documented in calves with cryptosporidiosis. Paromomycin is an aminoglycoside antibiotic used to control C. parvum infection in animals. Paromomycin reduces oocyst shedding and the number of days with diarrhea in experimentally infected calves when used prophylactically. Halofuginone lactate is a synthetic quinazolinone with cryptosporidial activity in the merozoite and sporozoite stages of C. parvum. It is recommended for both therapeutic and prophylactic use in cryptosporidiosis. In this study, although paromomycin (100 mg/kg/day for 7 days) and halofuginone lactate (100 mu g/kg/day for 7 days) led to a decrease in oocyst shedding from day 1, a statistically significant decrease (P < 0.05) was observed from day 3. The results of this study show that the decrease in oocyst shedding in both treatment groups, improvements in clinical findings and recoveries in hematologic, blood gas and serum biochemistry values are similar. Even though these drugs do not eliminate the infection, they decrease both the severity of diarrhea and contribute to recovery. In conclusion, the results of this study indicated that halofuginone lactate and paromomycin were effective in the treatment of calves naturally infected with cryptosporidiosis. Therefore, we recommend that both drugs should be used in the treatment of calves naturally infected with Cryptosporidium parvum.Öğe Comparison of the effectiveness of halofuginone lactate and paromomycin in the treatment of calves naturally infected with cryptosporidium parvum(Universidade Federal do Rio Grande do Sul, 2018) Aydogdu, Ugur; Isik, Nermin; Ekici, Ozlem Derinbay; Yildiz, Ramazan; Sen, Ismail; Coskun, AlparslanBackground: Cryptosporidiosis is one of the most important problems among neonatal ruminants. Cryptosporidium parvum is the agent causing the disease. Cryptosporidium infection, responsible for diarrhea, dehydration, weight loss and death in neonatal ruminants, leads to significant economic losses for producers. In calves naturally or experimentally infected with cryptosporidiosis, many agents have been reported to have therapeutic and protective effects. The objective of this study was to compare the effectiveness of halofuginone lactate and paromomycin in the treatment of calves naturally infected with Cryptosporidium parvum. Materials, Methods & Results: Twenty calves between 7 and 20 days of age and naturally infected were included in the study. There were two different treatment groups in the study. The first group of calves were administered 100 µg/kg/day halofuginone lactate for 7 days and the second group of calves were administered 100 mg/kg/day paromomycin for 7 days. In addition, antibiotic and vitamin C were applied to all calves. Jugular venous blood samples were obtained pre-treatment and on the 7th day after the treatment. Routine clinical examinations of the calves were performed on days 0, 1, 3, 5 and 7 and rectal stool samples were collected for the detection of Cryptosporidium oocysts. Severe diarrhea, dehydration, depression and weight loss were observed in calves in both treatment groups. A significant decrease (P < 0.05) was observed for both groups in oocyst count on days 3, 5 and 7 compared to days 0 and 1. Improvements in blood parameters, stool characters and clinical scoring of both groups were observed in post-treatment. Discussion: Many pharmaceuticals or compounds have been tested for animal with cryptosporidiosis and only very few of them have shown a partial protective activity in ruminants when used prophylactically. Halofuginone lactate and paromomycin are commonly recommended as both therapeutic and protective agents. However, the effectiveness of the two therapeutic agents in natural infections has not been compared and, in the meantime, recommendations for a rational use are also not sufficiently documented in calves with cryptosporidiosis. Paromomycin is an aminoglycoside antibiotic used to control C. parvum infection in animals. Paromomycin reduces oocyst shedding and the number of days with diarrhea in experimentally infected calves when used prophylactically. Halofuginone lactate is a synthetic quinazolinone with cryptosporidial activity in the merozoite and sporozoite stages of C. parvum. It is recommended for both therapeutic and prophylactic use in cryptosporidiosis. In this study, although paromomycin (100 mg/kg/day for 7 days) and halofuginone lactate (100 µg/kg/day for 7 days) led to a decrease in oocyst shedding from day 1, a statistically significant decrease (P < 0.05) was observed from day 3. The results of this study show that the decrease in oocyst shedding in both treatment groups, improvements in clinical findings and recoveries in hematologic, blood gas and serum biochemistry values are similar. Even though these drugs do not eliminate the infection, they decrease both the severity of diarrhea and contribute to recovery. In conclusion, the results of this study indicated that halofuginone lactate and paromomycin were effective in the treatment of calves naturally infected with cryptosporidiosis. Therefore, we recommend that both drugs should be used in the treatment of calves naturally infected with Cryptosporidium parvum. © 2018 Universidade Federal do Rio Grande do Sul. All rights reserved.Öğe Diagnostic value of C-reactive protein and soluble urokinase plasminogen activator receptor in canine monocytic ehrlichiosis(Chulalongkorn Univ, 2021) Erdogan, Songul; Basbug, Onur; Aydogdu, Ugur; Pasa, Serdar; Erdogan, Hasan; Ural, KeremCanine monocytic ehrlichiosis is a vector-borne disease that can induce renal failure in dogs. In this study we aimed to describe the potential diagnostic efficiency of CRP and suPAR in dogs infected with E. canis and the association between suPAR and CRP with renal failure. For this purpose, the study consisted of a total of 17 dogs, 8 of infected with E. canis and 9 of healty. For evaluating renal failure, plasma urea-creatinine and UPC were determined and also measurements of plasma CRP and suPAR were analysed with ELISA test kits. Mean CRP, suPAR, urea, creatinine and UPC levels of the infected dogs were significantly higher compared with healthy ones (P 0.01) but the correlation of all parameters with each group was not significant (P 0.05). As to be a result of ROC curve analysis and Youdens index, the cut-off values for diagnosis of ehrlichiosis were identified to be 9.68 mg/L for CRP and 168.2 ng/L for suPAR. Furthermore, the specificity and sensitivity of both markers according as a potential biomarkers cut-off values were determined higher. In conclusion, traditionally CRP and currently suPAR can be considered as potential biomarkers and have a diagnostic significance following inflammation in canine ehrlichiosis.Öğe The effect of dystocia on passive immune status, oxidative stress, venous blood gas and acid-base balance in lambs(ELSEVIER SCIENCE BV, 2018) Aydogdu, Ugur; Coskun, Alparsian; Yuksel, Murat; Basbug, Onur; Agaoglu, Zahid TevfikThe aim of this study was to research the effect of dystocia in lambs on passive immune status, oxidative stress, venous blood gas and acid-base balance. The study involved 20 lambs of both sexes. The lambs were divided into two groups, normal (n = 10) and dystocia (n = 10) births. Blood samples for blood gas, MDA, GSH, GSH-Px and IgG were collected at 0 h and at periodic intervals of 1, 3, 6, 24 and 48 h. Both groups' 0 h pH and glucose levels were under normal values and their pCO(2) and lactate levels were above normal values. The blood pH increased in both groups in the 1st, 3rd, 6th, 24th and 48th hours at a significant rate when compared to 0 h and the pCO(2) level decreased at a significant rate. Moreover, the blood pH of the dystotic lambs was found to be low according to the normal birth group in 0 h and the 1st, 3rd, 6th and 48th hours, but no statistical difference was determined. When it was compared to the normal birth group, the pO(2) and O-2 saturation in dystotic lambs was low at all hours but a statistical difference was determined only in the 48th hour. Lactate levels decreased in both groups. When the oxidative stress parameters were analysed, no statistical difference was determined although the malondialdehyde (MDA) level of the dystotic lambs was found to be higher than the normal birth group and its glutation (GSH) and glutation peroxidase (GSH-Px) levels were lower. When the IgG levels of the lambs at the postnatal 48th hour were examined, no difference was found between the two groups. In conclusion, it was deduced that dystocia caused negative effects on the oxidative stress and blood gases but the changes in the lambs' passive immunity, oxidative stress, blood gases and vital functions could be reduced to a minimum level with early intervention in dystocia.Öğe Evaluation of Acute Phase Proteins, Some Cytokines and Hemostatic Parameters in Dogs with Sepsis(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2015) Ok, Mahmut; Er, Cenk; Yildiz, Ramazan; Col, Ramazan; Aydogdu, Ugur; Sen, Ismail; Guzelbektes, HasanThe aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), interferon gamma (INF-gamma), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1 beta, TNF-alpha, INF-gamma, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1 beta and TNF-alpha parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC).Öğe Evaluation of C-Reactive Protein, Albumin, Neopterin, Urokinase Type Plasminogen Activator Receptor and Leukocyte Levels as Prognostic Parameters in Dogs with Parvoviral Enteritis(2020) Başbuğ, Onur; Aydogdu, Ugur; Ağaoğlu, Zahid TevfikThe aim of this study was to determine the changes in C-reactive protein (CRP), albumin, neopterin (Np), urokinase type plasminogen activator receptor (uPAR) and leukocyte levels in dogs with parvoviral enteritis and to show the prognostic importance of these. In the study, a total of 48 dogs, 40 with parvoviral enteritis and 8 were healthy, were used. The dogs with parvoviral enteritis were divided into two subgroups, non-surviving (n=12) and surviving (n=28). The non-surviving dogs with parvoviral enteritis in the study had significantly (p<0.05) lower leukocyte levels than the control group and the surviving dogs with parvoviral enteritis. Serum albumin concentrations of non-surviving dogs with parvoviral enteritis were also significantly (p<0.05) lower than the control group. On the contrary, the CRP levels of the non-surviving and surviving dogs with parvoviral enteritis were significantly (p<0.05) higher than the control group. There was also no statistically significant difference between the groups in terms of Np and uPAR levels. The cut-off values of leukocyte, CRP and albumin were $4.5×10^{9}L$, 120.50 mg/L and 2.28 g/dL, respectively. As a result, it can be stated that decreased leukocyte and albumin levels and increased CRP levels in dogs with parvoviral enteritis may be an indicator of poor prognosis. It was also determined that serum Np and uPAR levels in dogs with parvoviral enteritis do not have any prognostic importance.Öğe Hematologic, Blood Gas, Cardiac Biomarkers and Serum Biochemical Parameters in Calves with Atresia Coli and Theirs Relationship with Prognosis(UNIV FED RIO GRANDE DO SUL, 2017) Coskun, Alparslan; Aydogdu, Ugur; Altan, Semih; Erol, Muharrem; Erol, Hanifi; Guzelbektes, Hasan; Sen, IsmailBackground: Atresia coli is an intestinal anomaly. Generally, absence of defecation in calves less than 10 days old, diminishing appetite, progressing abdominal distention and time-developing depression are reported in atresia coli. Although a calf consumes its milk normally in first days, loss of appetite develops over time. Occasional minor pain indications are observed. The objective of this study was to evaluate of hematologic, blood gases, cardiac biomarkers and serum biochemical parameters before operation in calves with atresia coli, and to investigate relationship with prognosis of these parameters. Materials, Methods & Results: Thirty calves with atresia coli and 6 healthy calves for control were used as material. Poor suction reflex, anorexia, dehydration, abdomen-kicking, frequent leg movement, abdominal distension and depression were observed in calves brought to the clinic. Some calves presented swashing sound depending on content of intestines when abdomen was shaken. Intestine atresia was diagnosed by history and clinical examination. After clinical examination, operation was performed. All calves were observed during 10 days after operation. Fifteen of 30 calves died during 10 days after operation. The blood lactate, WBC, LDH and CK-MB levels in non-surviving calves with atresia coli were significantly higher compared to control calves. The venous blood pH level was significantly lower in non-surviving calves compared to surviving calves. In addition, when compared to the control group, the blood pCO(2) level was significantly higher in non-surviving and surviving calves with atresia coli while the pO(2) and O-2 saturation levels were significantly lower. Discussion: In calves with intestinal atresia, hematologic parameters are normal in first 48 h of disease. However, leukocytosis and shift to the left have been reported over time. However, leukocytosis due to peritonitis, bacterial overgrowth, etc. have been reported over time. It was seen that leukocyte numbers of non-surviving calves with atresia coli in this study were significantly higher, but leucocyte increase in surviving calves was seen to be statistically insignificant. Leukocyte increased in non-surviving calves with atresia may be associated with excessive bacterial reproduction and peritonitis. Blood lactate level is a commonly used marker for severity of disease in humans and lactate has a prognostic value in adult horses with colic and foals with critical disease. In this study, lactate level in non-surviving calves with atresia coli was significantly higher with respect to surviving calves and control calves. In this result, lactate can be evaluated as a prognostic indicator in calves with atresia coli. Creatine kinase-MB fraction and troponins are used in determination of cardiac damage in veterinary medicine. The fact that serum blood cTnI and CK-MB levels of non-surviving calves with intestinal atresia in this study were higher than surviving calves with atresia coli and control calves suggested that endotoxemia related cardiac damage may have developed. Surgical operation is necessary in the treatment of intestinal atresia. It was determined that the importance of calves age and colon integrity during time of surgical operation in survival of calves with atresia coli. The studies showed that survival rate in surgical operation conducted on calves under 3 days old was higher than calves over 5 day-old. Average of age of non-surviving calves with atresia coli in this study (4.67 +/- 1.23 days) was higher than average of age of surviving calves with atresia coli (3.27 +/- 0.51 days). It was also observed in our study that elapsed time affected prognosis of calves negatively. Thus, performing surgical operations as soon as possible may raise survival rate of calves with intestinal atresia as stated in previous studies.Öğe The right displacement of the abomasum complicated with abomasitis in a calf(ANKARA UNIV PRESS, 2018) Yurdakul, Ibrahim; Aydogdu, UgurIn this case, it was intended to define the right displacement of the abomasum complicated with abomasitis in 45 days old unweaned Brown Swiss male calf with clinical and ultrasonographic examination and further to report the operative treatment results. Metallic ping and splashing sounds were heard on the right side in the percussion of the 10-13th intercostal space. Right abomasal displacement was confirmed by ultrasonography. After the diagnosis of the illness, its treatment was done operatively through the right abdominal wall. During the operation, approximately 6 L content was emptied from the abomasum. Edema, ulceration and inflammation were seen on the abomasum wall. As a result, it was determined that abomasitis could develop together with the displacement of the abomasum to the right, which is rarely seen in calves. Successful results can be obtained by bringing the abomasum to its normal position during the treatment made through the right abdominal wall.Öğe The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis(Elsevier, 2019) Aydogdu, Ugur; Coskun, Alparslan; Atas, Ahmet Duran; Basbug, Onur; Agaoglu, Zahid TevfikIn this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts > 10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely.Öğe The Effect of Enteritis, Pneumonia and Omphalitis on Oxidative/Antioxidant Balance in the Calves(2019) Yurdakul, Ibrahim; Aydogdu, UgurIn this study, it was aimed to determine the effects of enteritis, pneumonia and omphalitis onoxidative/antioxidant balance in the calves. In total, 27 calves with neonatal disease and 10 healthycalves (control) were used. The sick calves were divided into 3 groups according to localizationof infection, omphalitis (n = 10), pneumonia (n = 8) and enteritis (n = 9). Blood samples of thecalves were taken from jugular vein for analysis. Blood in tubes without anticoagulant wascentrifuged at 5000 rpm for 5 min following clotting, and the sera were removed and stored at-80°C until analyzed. Serum malondialdehyde and nitric oxide levels of all groups weresignificantly higher, while glutathione, glutathione peroxidase, catalase and superoxide dismutaselevels were significantly lower compared to the control group. As a conclusion, diarrhea,pneumonia and omphalitis are caused by oxidative damage in the calves, and antioxidant treatmentmay be beneficial in the treatment of these diseases.Öğe The effects of local and systemic inflammatory status on iron metabolism and lipid profile in calves(2020) Aydogdu, Ugur; Yurdakul, IbrahimAim: The aim of this study was to determine the effects oflocal and systemic inflammatory status on iron metabolismand lipid profile in calves.Materials and Methods: A total of 56 calves, 39 sick and 17healthy, were used in the study in different races and gen-ders. The sick calves were divided into two groups as local (8omphalitis and 11 arthritis) and systemic (10 enteritis and10 pneumonia) inflammations. After routine clinical exami-nations of all the animals were performed, 8 ml of blood wastaken for blood analysis and biochemical analyses were per-formed.Results: Serum iron, total cholesterol (TC), high density li-poprotein (HDL) and albumin levels were significantly (p<0.05) lower in calves with local and systemic inflammationcompared to the control group. Serum urea and creatinine le-vels were significantly (p <0.05) higher in calves with syste-mic inflammation compared to the control group.Conclusion: As a result, it was evaluated that low iron, totalcholesterol, HDL and albumin levels may indicate to local andsystemic inflammation in calves.Öğe The Levels of Trace Elements and Macrominerals in Calves with Sepsis(Kafkas Univ, Veteriner Fakultesi Dergisi, 2020) Coskun, Alparslan; Aydogdu, Ugur; Guzelbektes, Hasan; Sen, IsmailThe aim of this study was to determine the levels of macrominerals and trace elements in the blood of newborn calves with sepsis.The study was carried out on a total of 30 calves, aged 2-35 days old, of which 25 with sepsis and 5 healthy. In clinical examination, prolonged capillary refill time and tachypnea were observed in calves with sepsis. The levels of Cu, K, P and Sin calves with sepsis were higher compared to the control group, and the levels of Na, total and ionized Ca, Fe and Zn were also lower compared to the control group. In conclusion, in this study, significant increase in K and Cu concentrations and significant decrease in Na and Ca concentrations were found in calves with sepsis. According to the results, K, Cu, Na and Ca may have important roles in the pathophysiology of sepsis.Öğe The relationship between the severity of azotemia and blood gases in 101 calves with neonatal diarrhea(Univ Zagreb Vet Faculty, 2023) Aydogdu, Ugur; Coskun, Alparslan; Basbug, Onur; Turk, Sefer; Agaoglu, Zahid T.The aim of this study was to determine the relationship between the severity of azotemia and blood gas parameters in 101 neonatal calves with diarrhea. The calves were divided into 3 groups on the basis of their creatinine levels. The 3 groups were defined as: the non-azotemia group (<2.00 mg/dL), the mild-moderate azotemia group (2.015.00 mg/dL), and the severe azotemia group (>5.01 mg/dL). Azotemia was not detected in 35 of the 101 calves with diarrhea, mild-moderate azotemia was identified in 34, and severe azotemia in 32. Blood pH was significantly lower in the severe azotemia group compared to the non-azotemia and mild-moderate azotemia groups, while K and lactate levels were significantly higher. Although the HCO3- and BE values of the severe azotemia group were lower than the other groups, a statistical difference was only found with the mild-moderate azotemia group. Ionized calcium (iCa(+2)) level was also lower in the severe azotemia group compared to the other groups, but the difference was only significant with the non-azotemia group. In conclusion, it was observed that azotemia is a common occurrence in neonatal calves with diarrhea, and there is a significant relationship between the severity of azotemia and blood gases. Therefore, it may be concluded that it would be beneficial to monitor renal functions during the treatment of calves with neonatal diarrhea.Öğe Tumour Necrosis Factor-alpha, Haptoglobin, Serum Amyloid A and Neopterin Levels in Cattle with Lumpy Skin Disease(KAFKAS UNIV, VETERINER FAKULTESI DERGISI, 2016) Basbug, Onur; Agaoglu, Zahid T.; Tuzcu, Nevin; Coskun, Alparslan; Aydogdu, Ugur; Yigin, AkinLumpy skin disease (LSD) is a viral disease of cattle, characterised by the formation of nodules in different parts of the body. In this study, it was conducted to assess the pattern of changes of albumin, tumour necrosis factor-alpha (TNF-alpha), haptoglobin (Hp), serum amyloid A (SAA) and neopterin levels in cattle with LSD, to assess the clinical course of the disease, and to the demonstration of inflammatory process in cattle with LSD. This study was carried out in 30 cattle, including 20 animals naturally infected with LSD and 10 healthy animals. It was determined that, in the cattle infected with LSD, while albumin concentrations had significantly decreased (P=0.004) in comparison to the control group, Hp (P<0.001), SAA (P<0.001) and neopterin (P<0.001) concentrations had significantly increased. Receiver operating characteristic (ROC) curve was used to calculate the sensitivity and specificity of Hp, SAA and neopterin. The cut-off values of the healthy and infected cattle for Hp, SAA and neopterin were determined to be 0.196 mg/mL, 41.38 mu g/mL and 23.93 nmol/mL, respectively. At these cut-off values, high levels of sensitivity (85% for Hp, 95% for SAA and 70% for neopterin) and specificity (90%) were detected. It was determined that SAA levels were of higher sensitivity and specificity compared to Hp and neopterin levels with respect to the demonstration of inflammation associated with LSD. Furthermore, the clinical picture of the disease was found to be significantly correlated with the Hp, SAA and neopterin levels.
