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Öğe Evaluation of Platelet Activity Markers in Prognostic Value of Children with Crimean-Congo Hemorrhagic Fever(Georg Thieme Verlag Kg, 2020) Guven, Ahmet Sami; Duksal, Fatma; Akcan, Ozge Metin; Aygunes, Utku; Oflaz, Mehmet BurhanObjective The aim of this study is to investigate the prognostic value of platelet (PLT) activity markers in children with Crimean-Congo hemorrhagic fever (CCHF) and compare results with healthy controls. Materials and Methods A total of 135 patients with CCHF and 100 healthy children were included in this retrospective study. Mean age was 12.4 +/- 3.3 years in CCHF group, and 92 patients were male. We measured PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and mean platelet mass (MPM) as PLT activity markers. Results A statistically significant decrease in MPM and PLT, and significantly higher levels of PDW and activated partial thromboplastin time (aPTT) and no significant difference in MPV were observed in patients with CCHF compared with controls. Although there were no significant differences between the severe and nonsevere CCHF groups in term of MPV and PDW, the MPM value was significantly decreased in severe patients ( p < 0.001). Furthermore, MPM values were inversely correlated with aPTT ( r = -0.617, p = 0.015), and positively correlated with PLT ( r = 0.703, p < 0.001) which are considered likely to be indicators of disease severity. Multivariate logistic regression analysis revealed MPM as an independent risk factor for severe disease. Conclusion Our study demonstrated that MPM values were decreased in severe cases compared with nonsevere in children with CCHF. The MPM as an indicator of PLT activation at the time of diagnosis in children with CCHF can be used as a prognostic index for disease severity.Öğe Evaluation of the Mean Platelet Volume and Platelet Distribution width in Children with Familial Mediterranean Fever(Bursa Uludag Univ, 2020) Duksal, Fatma; Guven, Ahmet Sami; Arslan, Mesut; Dogan, Melih Timucin; Aygunes, UtkuINTRODUCTION: Platelet activation plays a key part in the process of atherosclerosis. The risk of atherosclerosis increased in familial Mediterranean fever (FMF). Mean platelet volume (MPV), platelet distribution width (PDW) and platelet counts are important in platelet activation. The aim of present study was to evaluate the relationship between the MPV, PDW, PLT counts and mutation types of FMF in children in attack free period. MATERIALS and METHODS: PLT counts, MPV, PDW, age, sex and mutation types of patients were recorded retrospectively from medical records of patients. Three hundred sixty-eight children with FMF in attack-free period and 379 healthy children were included in the study. RESULTS: MPV of the patients were lower than those of control (p<0.001). However PDW counts of the patients were higher than those of control groups (p<0.001). The PLT counts were not different between patients and control subjects (p>0.05). Of 368 patients, homozygous, heterozygous, and compound mutations were seen, respectively, in 51, 267, and 51 patients. The MPV of patients with homozygous (p=0.029) and heterozygous(p=0.041) mutations were found higher than that of patients with compound mutations. There was no difference between heterozygous and homozygous mutation in terms of MPV (p>0.05). In addition, there was no difference between heterozygous, homozygous and compound mutations in terms of PDW and PLT counts (p>0.05). The most common mutations were M694V (n=131), E148Q (n=82), M6801, (n=37), and V726A (n=32). There wasn't seen significant difference among these mutations in terms of MPV, PDW and PLT counts (p > 0.05). CONCLUSIONS: Although, atherosclerosis risk is increased in high MPV levels, we couldn't find this relationship in current study. It may be due to all the patients were under colchicine treatment. On the other hand PDW levels were found higher in patients than control group. To verify this relationship between PDW and MPV values, further investigations are needed.Öğe The Prevalence and Outcomes of Thrombocytopenia in a Neonatal Intensive Care Unit: A Three-Year Report(TAYLOR & FRANCIS INC, 2012) Bolat, Fatih; Kilic, Suar Caki; Oflaz, Mehmet Burhan; Gulhan, Elif; Kaya, Ali; Guven, Ahmet Sami; Aygunes, Utku; Icagasioglu, Dilara; Gultekin, AsimNeonatal thrombocytopenia is one of the most common hematologic disorders in neonatal intensive care units (NICUs). The purpose of this study was to determine the prevalence of thrombocytopenia and whether thrombocytopenia has an effect on the occurrence of intraventricular hemorrhage (IVH) >= grade 2 and on mortality rate. This study was carried out retrospectively in neonates admitted to NICU of Cumhuriyet University in Sivas, Turkey, between 2009 and 2012. Among 2218 neonates evaluated, 208 (9.4%) developed thrombocytopenia. The prevalence of IVH >= grade 2 was more in infants with thrombocytopenia (7.2%) than in those without thrombocytopenia (4.4%), although this was not statistically significant (P=.08). In univariate analysis, IVH >= grade 2 was higher in cases with very severe thrombocytopenia (35.7%, n = 5) than in those with mild (2.1%, n = 2), moderate (4.7%, n = 3), and severe thrombocytopenia (15.2%, n = 5) (P=.04). Multivariate logistic regression analysis showed that birth weight <1500 g (OR 6.2, 95% CI 3.4-9.8; P=.0001), gram-negative sepsis (OR 2.5, 95% CI 1.8-4.2; P=.01), very severe thrombocytopenia (OR 1.3, 95% CI 1.1-2.1; P=.03), and platelet transfusion >= 2 (OR 7.3, 95% CI 4.1-12.1; P=.001) were significant risk factors for mortality. The results of our study suggest that outcomes of neonates with thrombocytopenia depend not only on platelet count but also on decreased gestational age or birth weight, prenatal factors, and sepsis.Öğe Psychopathological Evaluation In Children with Chronic Idiopathic Trombocytopenic Purpura(Galenos Publ House, 2022) Aygunes, Utku; Cicek, Ayla UzunIntroduction: Idiopathic thrombocytopenic purpura (ITP) is a disease with a risk of becoming chronic in which physical and mental difficulties are experienced during diagnosis, treatment and follow-up. In this study, we aimed to determine the psychological status, importance and significance of psychopathology in children with chronic ITP using psychiatric scales. Materials and Methods: It was planned to conduct a cross-sectional study by collecting the records of our patients with chronic ITP aged 3-18 years, who are being followed in the 3rd level health center, for evaluation. The study included 35 chronic ITP and 40 age- and sex-matched healthy volunteers. The psychological states of the patients, healthy control group and their parents were evaluated with the help of proven data collection tools under the guidance of a specialist psychiatrist. Results: In the chronic ITP group, a difference was found between the Rosenberg self-esteem scale mean scores, mother's Beck hopelessness scale median scores, mother's perceived stress scale mean scores, strengths difficulties parent form total difficulty score median, strengths parental form social behavior median values, median values of the adolescent form total strengths difficulty score (p<0.001; for each), and between the two groups in the assessment of strengths and difficulties adolescent form social behaviors (p=0.003). There was no statistically significant difference between the distribution of other variables between the patient and control groups (p>0.050). Conclusion: Attention deficit, hyperactivity, behavioral problems, emotional problems, peer problems, social behavior and ego problems are common in chronic ITP in childhood. This challenging situation also affects parents. It should be known that chronic ITP, like other chronic diseases, causes chronic and intractable mental problems, and this psychiatric process should be managed together with the medical treatment of the disease.Öğe Splenic rupture presenting with marked scrotal ecchymosis in a 2-day-old newborn(Taylor & Francis Ltd, 2022) Tunc, Gaffari; Guney, Cengiz; Aygunes, UtkuSplenic rupture is a rare and severe condition in neonates. The signs and symptoms are vague and non-specific and are often not recognised before the onset of hypovolaemic shock or death. A 2-day-old infant presented with scrotal ecchymosis, and ultrasonography detected haemorrhage in the scrotal, right inguinal and adrenal regions. Computed tomography demonstrated a peri-splenic haematoma. Haemoglobin (Hb) was 2.79 g/dL and, despite repeated transfusions, the Hb level could not be sustained. Exploratory laparotomy detected a large haematoma in the splenic region, and, because of the uncontrolled haemorrhage, splenectomy was required.Öğe The Association Between Loss Of Appetite And Sense Of Olfaction In Children With Iron Deficiency Anemia(Bursa Uludag Univ, 2020) Aygunes, Utku; Cicek, Ayla UzunINTRODUCTION: IDA (iron deficiency anemia) is the most common type of anemia in pediatric patients and very little is known about the effect of IDA on the sense of smell and about the effects of smell on appetite. This study shows the effect of IDA on the sense of smell and about the effects of smell on appetite. MATERIALS and METHODS: The study enrolled 57 IDA patients and 57 healthy subjects. Olfactory function was evaluated using the Sniffin' Sticks olfactory test. The evaluation was performed by using a semi-structured psychiatric interview using Sociodemographic Data Form, Kiddie Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime Version and The Child Eating Behaviour Questionnaire. RESULTS: Patients with IDA had a significantly lower threshold, discrimination, and identification value, and a lower threshold compared with the control group. Correlation analysis showed a significant correlation between an increase in the total olfactory test score and the total score for appetite indicators. CONCLUSIONS: In this study, it was observed that decreased appetite in children with IDA was accompanied by impaired odor functions. It suggests that odor dysfunction may be a significiant factor for decreased appetite.Öğe An unusual cause of abdominal ascites and acute kidney injury: Answers(SPRINGER, 2014) Alaygut, Demet; Guney, Cengiz; Oflaz, Mehmet Burhan; Guven, Ahmet Sami; Aygunes, Utku; Cevit, Omer…Öğe An unusual cause of abdominal ascites and acute kidney injury: Questions(SPRINGER, 2014) Alaygut, Demet; Guney, Cengiz; Oflaz, Mehmet Burhan; Guven, Ahmet Sami; Aygunes, Utku; Cevit, Omer…
