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Öğe Apoptosis and its relation with clinical course in patients with Crimean-Congo hemorrhagic fever(WILEY, 2019) Engin, Aynur; Aydin, Huseyin; Cinar, Ziynet; Buyuktuna, Seyit Ali; Bakir, MehmetCrimean-Congo hemorrhagic fever (CCHF) is a tick-mediated viral infection. Patients with CCHF may show various clinical presentations. The cause of this difference in the clinical course is not completely understood. Apoptosis is programmed cell death and plays an important role in regulating the immune system. Our knowledge of the role of apoptosis in CCHF disease is limited. We investigated the role of apoptosis and their relationship with the severity of the disease in CCHF. Thus, in 30 patients with CCHF and 30 healthy individuals, we analyzed the serum levels of cytochrome C, apoptotic protease activating factor-1 (Apaf 1), caspase 3, caspase 8, caspase 9, sFas, sFasL, perforin, granzyme B, and CK18 by enzyme-linked immunosorbent assay. This is the first study that research the serum levels of the mentioned apoptosis markers in adult patients with CCHF. We found that the serum levels of sFasL, cytochrome C, Apaf 1, caspase 3, caspase 8, caspase 9, perforin, granzyme B, and M30 were statistically significantly different in the acute phase of the disease compared with healthy individuals and patients in convalescent period. There was no association between the clinical severity of the disease and apoptosis markers. In conclusion, the results of our study suggested that the extrinsic and intrinsic apoptosis pathway play an important role in CCHF.Öğe Brucellosis: An electroneuromyography study(UNIVERSITATSVERLAG ULM GMBH, 2006) Bolayir, Ertugrul; Elaldi, Nazif; Uz, Uemit; Coemez, Neslihan; Bakir, MehmetIt is known that peripheral nerve involvement may occur in brucellosis. A total of 24 patients with brucellosis underwent nerve conduction study in 4 extremities in this present study. Of the patients, 16 were women and 8 were men. The mean age was calculated to be 45.6 years. Of the controls, consisting of healthy individuals, 13 were 13 women and 7 were men. The mean age of the controls was 44.3 years. We observed prolongation of bilateral median nerve latency in 5 of the brucellosis cases (20.8%). Furthermore, two of these 5 patients were established to have prolongation of peroneal nerve latency. We conclude that brucellosis may have a leading role in the etiopathogenesis of entrapment neuropathies in developing countries and nerve conduction studies can be of benefit for patients with such disorders.Öğe Clinical investigation of the transient evoked otoacoustic emission test in Crimean-Congo hemorrhagic fever(ELSEVIER SCI LTD, 2008) Engin, Aynur; Yildirim, Altan; Kunt, Tanfer; Bakir, Mehmet; Dokmetas, Ilyas; Ozdemir, LeventObjective: The aim of this study was to investigate cochlear damage in Crimean-Congo hemorrhagic fever (CCHF) infection. Methods: Thirty-two CCHF patients (study group) and 13 healthy people (controls) were included in the study. CCHF patients were also grouped for the presence of fever. CCHF was diagnosed with the presence of CCHF virus-specific IgM antibody or CCHF virus (CCHFV) antigen by ELISA. Cochlear damage was determined by a 'fail' in the transient evoked otoacoustic emission (TEOAE) test. Results: The proportion of TEOAE test 'fail' results in the CCHF patients was significantly higher than in the control group (p < 0.05). We found no increase in the proportion of TEOAE test 'fail' results related to fever in the study group. Conclusions: CCHF disease damages cochlear function regardless of fever. (c) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.Öğe Comparison of the Predictive Performances of qSOFA, APACHE II, and SGS for Evaluation of the Disease Prognosis of CCHF Patients at the Emergency Department(Natl Inst Infectious Diseases, 2020) Demirtas, Erdal; Bakir, Mehmet; Buyuktuna, Seyit Ali; Oksuz, Caner; Oz, Murtaza; Cebecioglu, Kivanc; Unlusavuran, MeltemIn this study, we compared the predictive performances of quick sequential organ failure assessment (qSOFA), the acute physiology and chronic health evaluation (APACHE II) scores, and the severity grading score (SGS) for evaluation of the disease prognosis of patients with Crimean-Congo hemorrhagic fever (CCHF) at the emergency department. We recorded the qSOFA, SGS, and APACHE II scores at admission and at the 72nd and 120th hour in 97 patients admitted to the emergency department and diagnosed with CCHF. In our study, the area under a receiver operating characteristic curve values of qSOFA, SGS, and APACHE II at admission were found to be 0.640, 0.824, and 0.576, respectively. No statistical significance was found for a qSOFA score >= 2 at admission as a predictor of mortality. The use of qSOFA score for diseases with a mortal prognosis such as CCHF is insufficient in predicting the prognosis.Öğe COVID-19 Co-infection in a patient with Crimean Congo Hemorrhagic Fever: A Case Report(Ankara Microbiology Soc, 2021) Buyuktuna, Seyit Ali; Hasbek, Mursit; Oksuz, Caner; Baysal, Cihad; Oz, Murtaza; Elaldi, Nazif; Bakir, MehmetCrimean-Congo Hemorrhagic Fever (CCHF) is an acute viral zoonotic disease. Coronavirus disease-2019 (COVID-19) is a newly emerging viral disease and it is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In this article, a case diagnosed with CCHF and COVID-19 coinfection confirmed by the polymerase chain reaction (PCR) method and its management was presented. A thirty-five years old female patient admitted to the hospital with the complaint of fever for one day and common body pain. It was learned that three days before the onset of her complaints, she removed a tick adhering to the anterior abdominal wall with no precaution. Her body temperature was 38 degrees C degrees and her respiratory rate was 22 per minute. The leucocyte count was 3660/mm(3) and the platelet count was 138.000/mm(3). It was determined that prothrombin time was 15.4 seconds, international normalized ratio (INR) was 1.35 seconds, and D-dimer level was 1310 ng/ml. The patient was hospitalized with prediagnosis of CCHF. Supportive treatment was started. On the second day at the clinical follow-up of the patient, complaints of sore throat and cough without sputum started. A combined nasopharyngeal and throat swab sample was taken from the patient because of the suspicion of COVID-19. COVID-19 PCR test result was reported as positive. Favipiravir treatment was started. The CCHF-PCR test, which was studied from the serum sample sent to the Microbiology Reference Laboratories was reported as positive. From the third day of favipiravir treatment; the patient did not have a fever and her complaints regressed. On the ninth day of her hospitalization, she was discharged. In this case; it is important to show that both diseases, especially in regions where CCHF disease is endemic, can be confused due to the similarity of the clinical picture with COVID-19 and to know that they can coexist.Öğe Crimean-congo heamorrhagic fever and EEG: Two cases(UNIVERSITATSVERLAG ULM GMBH, 2006) Bolayir, Ertugrul; Uz, Uemit; Duran, Nihal; Engin, Aynur; Bakir, MehmetCrimean-Congo haemorrhagic fever (CCHF) is an infectious and potentially lethal syndrome caused by various types of viruses. Infected ticks transmit the virus to humans via their bite. The symptoms include fever, jaundice, Diarrhea, headache, sore throat, encephalopathy, generally feeling unwell and muscular aches. In severe cases, haemorrhage (bleeding) from small blood vessels leads to a red rash forming on the membranes of the eyes, inside of the eyelids, mouth, skin the internal organs, seizures and death. We herein present neurological data and EEG results of two cases of CCHF which demonstrated confusional symptoms as neurological symptom and dominance of slow-wave in anterior quadrant.Öğe Crimean-Congo Hemorrhagic Fever Virus in High-Risk Population, Turkey(CENTERS DISEASE CONTROL, 2009) Gunes, Turabi; Engin, Aynur; Poyraz, Omer; Elaldi, Nazif; Kaya, Safak; Dokmetas, Ilyas; Bakir, Mehmet; Cinar, ZiynetIn the Tokat and Sivas provinces of Turkey, the overall Crimean-Congo hemorrhagic fever virus (CCHFV) seroprevalence was 12.8% among 782 members of a high-risk population. CCHFV seroprevalence was associated with history of tick bite or tick removal from animals, employment in animal husbandry or farming, and being > 40 years of age.Öğe Crimean-Congo hemorrhagic fever: does it involve the heart?(ELSEVIER SCI LTD, 2009) Engin, Aynur; Yilmaz, Mehmet Birhan; Elaldi, Nazif; Erdem, Alim; Yalta, Kenan; Tandogan, Izzet; Kaya, Safak; Bakir, Mehmet; Dokmetas, IlyasObjective: Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever with a high mortality rate. Despite increasing knowledge about viral hemorrhagic fevers, the pathogenesis of CCHF and causes of death have not been well described. In this study, we aimed to evaluate the cardiac functions of CCHF patients. Methods: This prospective study was performed among confirmed CCHF cases in Turkey in 2007. All the patients underwent a thorough cardiologic evaluation and transthoracic echocardiography examination within 24 hours of hospitalization. In addition, the patients were classified into two groups - 'severe' CCHF and 'non-severe' CCHF. Demographic characteristics, findings of echocardiography, and outcomes were recorded for each patient. Results: Among 52 consecutive patients with a tentative diagnosis of CCHF, 44 were confirmed as having CCHF. Seventeen (38.6%) patients were classified as severe, whereas the remaining 27 (61.4%) patients were classified as non-severe. Five of 17 severe CCHF patients died. Severe cases had a tower left ventricular ejection fraction (p = 0.04), a higher systolic pulmonary artery pressure (p = 0.02), and more frequent pericardial effusion (p < 0.001) compared to non-severe cases. Fatal CCHF cases also had a lower left ventricular ejection fraction (p = 0.03), a higher systolic pulmonary artery pressure (p = 0.03), and more frequent pericardial effusion (p = 0.01) compared to survivors. Conclusions: The results of this study indicate that severe and fatal CCHF cases have impaired cardiac functions, which may be associated with fatality in CCHF infection. Direct invasion of the heart muscles by the virus or endothelial damage of cardiac structures may have a rote in this. Molecular testing methods would be useful in order to investigate direct invasion by the CCHF virus. Clinicians should be aware of this complication. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.Öğe Cutaneous Anthrax in the Central Anatolia Region of Turkey: A Review of 39 Adults Cases(ORTADOGU AD PRES & PUBL CO, 2010) Engin, Aynur; Elaldi, Nazif; Dokmetas, Ilyas; Bakici, Mustafa Zahir; Kaya, Safak; Bakir, MehmetObjective: Anthrax is a zoonotic infectious disease that caused by Bacillus anthracis. Sporadic anthrax is still present world-wide, particularly in animal raising countries including Turkey. The aim of this study was to evaluate the epidemiological, clinical, and laboratory findings and treatment protocols of adult patients with cutaneous anthrax retrospectively. Material and Methods: A retrospective review of 39 adult patients with cutaneous anthrax presented between 1983 and 2005, in Cumhuriyet University Hospital in Sivas, a city located in the central Anatolia region of Turkey was carried out. Results: Of the 39 cases with the diagnosis of cutaneous anthrax, 27 (69.2%) were males and 12 (30.8%) were females. The mean age was 44 (range, 1674) years. The clinical presentations were severe edema due to anthrax in 10 (26%) and typical pustuler lesion in 29 (74%) patients. The lesions were mostly located on the hand and forearm. Twenty-five cases (64.1%) had a history of recent animal slaughtering activity. Culturing of 39 wound specimens yielded 17 (43.6%) B. anthracis strains. Thirty-six (92.3%) patients were treated with penicillin G. A patient with severe cutaneous anthrax and extensive edema died on the first admission day. Mortality rate was 2.6%. Conclusion: Although the incidence of anthrax is decreasing world-wide, it is still encountered in Turkey. Preventive measures such as education of the risk population and vaccinaton of animals against anthrax would reduce the incidence of the disease. We suppose that penicillin is still the antibiotic of choice for the treatment of cutaneous anthrax in endemic regions.Öğe Cytochrome P450 2D6 and MDR1 Gene Mutation in Relation to Mortality in Patients with Crimean-Congo Hemorrhagic Fever: A Preliminary Study(ORTADOGU AD PRES & PUBL CO, 2009) Engin, Aynur; Koksal, Binnur; Dogan, Omer Tamer; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, Mehmet; Ozdemir, OzturkObjective: The aim of this study was to investigate the role of multidrug transporter P-glycoprotein 1 (MDR1), cytochrome P450 isozyme 2D6 (CYP2D6) and C-C chemokine receptor 5 (CCR5) genes in the mortality of patients with Crimean-Congo Hemorrhagic Fever (CCHF). Material and Methods: Fifteen patients under drug therapy and conventional supportive measures were investigated. Diagnosis of the patients was confirmed by ELISA and/or reverse transcription-polymerase chain reaction (RT-PCR) technique. Clinical and laboratory features of three cases with fatal outcomes were compared with those of twelve patients with non-fatal CCHF. Genomic DNA was isolated from pheripheral blood samples and PCR based reverse hybridization strip assay was used for the genotyping. Results: The mortality rate was 20% (3/15) in this study. In two fatal cases the MDR1 gene had homozygous point mutation and in one fatal case heterozygous point mutation. All the fatal cases had poor drug metabolizer genotypes of CYP2D6 gene. Of the twelve surviving patients, three had heterozygous mutation in the MDR gene while only one had homozygous mutation of the same gene. Drug metabolizer genotypes of CYP450 gene were normal in all surviving patients. In fatal cases, ratios of mutable MDR1 and poor drug metabolizer genotypes of CYP450 genes were higher than those in non-fatal cases. The CCR5 gene was normal in all cases. Conclusion: Hypoexpression of CYP2D6 alleles and mutation in MDR I gene could cause impaired drug metabolism and/or lead to therapeutic failure in the CCHF patients. MDR1 and CYP2D6 genes may play a crucial role in pharmacokinetics, immunological response and drug metabolism in the management of CCHF infection. Further studies are necessary to substantiate these findings.Öğe DO Carriers of A MEFV Mutation Have Any Selective Advantage to A Pathogen Endemic In the Same Geography?(Wiley, 2011) Ugurlu, Serdal; Engin, Aynur; Hatemi, Gulen; Ozgon, Gulay; Akyayla, Elif; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe DOES CARRIERSHIP FOR FMF-ASSOCIATED MUTATIONS OFFER ANY ADVANTAGE IN CRIMEAN-CONGO HAEMORRHAGIC FEVER?(Oxford Univ Press, 2011) Ugurlu, Serdal; Engin, Aynur; Ozgon, Gulay; Hatemi, Gulen; Akyayla, Elif; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe Does electrocardiography at admission predict outcome in Crimean-Congo hemorrhagic fever?(MALARIA RESEARCH CENTRE, INDIAN COUNCIL MEDICAL RESEARCH-ICMR, 2011) Yilmaz, Mehmet Birhan; Engin, Aynur; Bektasoglu, Gokhan; Zorlu, Ali; Ege, Meltem Refiker; Bakir, Mehmet; Dokmetas, IlyasBackground & objectives: Crimean-Congo hemorrhagic fever is an acute viral hemorrhagic fever with considerable mortality. Despite increasing knowledge about hemorrhagic fever viruses, the pathogenesis of Crimean-Congo hemorrhagic fever and causes of death were not well described. We aimed to evaluate whether there were electrocardiographic parameters designating mortality among these patients. Study design: This retrospective study was performed among confirmed Crimean-Congo hemorrhagic fever cases in Turkey. Electrocardiography was available in 49 patients within 24 h of hospitalization. All electrocardiograms were evaluated by two expert cardiologists according to Minnesota coding system. Results: Among patients with available electrocardiograms, there were 31 patients who survived, and 18 patients who died of Crimean-Congo hemorrhagic fever. Both groups were similar in terms of age, sex, body temperature, heart rate, and blood parameters. T-wave changes and bundle branch block were more frequently encountered among those who died. Presence of T-wave negativity or bundle branch block in this cohort of patients with Crimean-Congo hemorrhagic fever predicted death with a sensitivity of 72.7%, specificity of 92.6%, positive predictive value of 88.9%, negative predictive value of 80.6%. Conclusions: We think within the light of our findings that simple electrocardiography at admission may help risk stratification among Crimean-Congo hemorrhagic fever cases.Öğe Effect of TLR10 (2322A/G, 720A/C, and 992T/A) polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease(WILEY, 2018) Kizildag, Sibel; Arslan, Serdal; Ozbilum, Nil; Engin, Aynur; Bakir, MehmetCrimean Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the Crimean Congo hemorrhagic fever virus (CCHFV). Toll-like receptors (TLRs) are type 1 transmembrane proteins of immune cells that play a critical role in innate and adaptive immunity. The present study first time aims to investigate the relation between TLR10 gene polymorphisms (720A/C, 992T/A, and 2322A/G), severity/non-severity, fatality/non-fatality, and CCFH disease by using PCR-RFLP assay in a Turkish population. TLR10 720A/C polymorphism was determined to be statistically significant both genotype and allele frequency (P=0,011, P=0.015, respectively). TLR10 992T/A polymorphism was found statistically significant relationships between patient and control (P=0.026) and individual with AA genotype have approximately three times greater risk than TT genotype (OR=2.93). There was not a significant difference in 2322A/G genotype distribution (P=0.152). There were also statistically significant associations between both TLR10 992T/A and 2322A/G polymorphism and patient mortality (P=0.001 and P=0.008, respectively). We have not found statistically any linkage among TLR10 haplotype, but individual AAA and GAT haplotype have higher risk than individual AAT haplotype (OR=3.22, OR=1.93, respectively). Consequently, this study shows that pathogenesis of CCHF disease is associated with the TLR10 720A/C and 992T/A polymorphisms. There is a statistically significant association in fatal/non-fatal patients with TLR10 720A/C and 992T/A. The TLR10 992AA genotype might increase and TLR10 720CC genotype might decrease susceptibility to pathogenesis of CCHF disease. TLR 10 polymorphisms may be also an important biomarker for CCHF susceptibility and fatality rate.Öğe Efficacy of oral ribavirin treatment in Crimean-Congo haemorrhagic fever: A quasi-experimental study from Turkey(W B SAUNDERS CO LTD, 2009) Elaldi, Nazif; Bodur, Hurrem; Ascioglu, Sibel; Celikbas, Aysel; Ozkurt, Zulal; Vahaboglu, Haluk; Leblebicioglu, Hakan; Yilmaz, Neziha; Engin, Aynur; Sencan, Mehmet; Aydin, Kemalettin; Dokmetas, Ilyas; Cevik, Mustafa Aydin; Dokuzoguz, Basak; Tasyaran, Mehmet Ali; Ozturk, Recep; Bakir, Mehmet; Uzun, RamazanObjective: The aim of this study was to evaluate the efficacy of oral ribavirin treatment in patients with Crimean-Congo haemorrhagic fever (CCHF). Methods: In 2004, all patients diagnosed with CCHF were treated with oral ribavirin, however in 2003 none of the CCHF patients had been given treatment due to Lack of confirmatory diagnostic information at that time in Turkey. In this study, patients treated with ribavirin in 2004 (n = 126) were compared with ribavirin-untreated CCHF patients (n = 92) in 2003. Patients only with a definitive diagnosis of CCHF (clinical symptoms plus the presence of specific IgM antibodies against CCHF virus and presence of viral antigen) were included in this study. Results: There was no difference in the case-fatality rate between treated and untreated patients (7.1% vs. 11.9%; P > 0.05). A Cox Proportional Hazards regression analysis revealed that altered sensorium and prolonged international normalized ratio were independent predictors of mortality. Conclusion: Our results showed that oral ribavirin treatment did not improve the survival rate in CCHF patients. Ribavirin and supportive care are the only available choices for treatment of CCHF patients, but to ascertain the efficacy of ribavirin, more laboratory and observational studies are necessary and ultimately, to elucidate these conflicting results and evaluate the efficacy undoubtedly, a multicenter randomised controlled trial will be needed. (C) 2009 The British Infection Society. Published by Elsevier Ltd. All rights reserved.Öğe Elevated chemokine levels during adult but not pediatric Crimean-Congo hemorrhagic fever(ELSEVIER SCIENCE BV, 2015) Arasli, Mehmet; Ozsurekci, Yasemin; Elaldi, Nazif; McAuley, Alexander J.; Oncel, Eda Karadag; Tekin, Ishak Ozel; Gozel, Mustafa Gokhan; Kaya, Ali; Icagasioglu, Fusun Dilara; Caglayik, Dilek Yagci; Korukluoglu, Gulay; Kokturk, Furuzan; Bakir, Mehmet; Bente, Dennis A.; Ceyhan, MehmetBackground: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral zoonosis. Clinical reports indicate the severity of CCHF is milder in children than adults. The chemokines are important chemoattractant mediators of the host immune system. Objectives: The main aim of the study was to identify whether or not there were any differences in chemokine levels between the pediatric and adult patients and control groups, and whether there was any correlation with disease severity. Study design: The serum levels of select chemokines including chemokine (C-C) ligand 2 (CCL2), CCL3, CCL4, chemokine (C-X-C) ligand 8 (CXCL8), CXCL9, and granulocyte-colony stimulating factor (G-CSF) in 29 adult and 32 pediatric CCHF patients and in 35 healthy children and 40 healthy adult control groups were studied by flow cytometric bead immunoassay method. Results: Great variability was detected in the serum levels of the chemokines for both the adult and pediatric patients and controls. With the exception of G-CSF, the median serum levels of CCL2, CCL3, CCL4, CXCL8, and CXCL9 were found to be significantly higher in the adult patients compared to adult controls (2364.7 vs. 761 pg/ml; 714.1 vs. 75.2 pg/ml; 88.6 vs. 25.5 pg/ml; 217.9 vs. 18.3 pg/ml; 875 vs. 352.2 pg/ml, respectively, p < 0.0001 for all comparisons). Among the chemokines the median CCL4 and G-CSF levels were significantly higher in the pediatric patients compared to pediatric controls (40.3 vs. 7.1 pg/ml, p < 0.0001; 0.1 vs. 0.1 pg/ml, p = 0.049, respectively). Conclusion: The results of this study showed prominent chemokine raising in adult CCHF patients compared to children CCHF patients. (C) 2015 Elsevier B.V. All rights reserved.Öğe Evaluation of Clinical and Laboratory Findings of Pediatric and Adult Patients with Oropharyngeal Tularemia in Turkey: a Combination of Surgical Drainage and Antibiotic Therapy Increases Treatment Success(NATL INST INFECTIOUS DISEASES, 2014) Gozel, Mustafa Gokhan; Engin, Aynur; Altuntas, Emine Elif; Salk, Ismail; Kaya, Ali; Ceik, Cem; Dokmetas, Ilyas; Bakir, Mehmet; Elaldi, NazifWe analyzed the clinical and laboratory findings of both pediatric and adult patients with oropharyngeal tularemia. We also compared the therapeutic outcomes of patients who underwent surgical drainage of lymph nodes early or late during antibiotic therapy. A total of 68 patients with oropharyngeal tularemia, including 26 children and 42 adults, were enrolled in this study. The average duration between symptom onset and hospital admission was 20.8 days (4-60 days) in the pediatric group and 32.6 days (4-90 days) in the adult group (P = 0.009). The most frequently observed clinical symptoms were sore throat (100% and 100%), fever (96.2% and 90.5%), tonsillitis (69.2% and 78.6%), and rash (15.4% and 11.9%) in the pediatric and adult groups, respectively. However, the frequencies of erythema, tenderness, and fluctuant of enlarged lymph nodes were significantly higher in the adult group than in the pediatric group (P = 0.005, P = 0.029, and P = 0.041, respectively). Treatment failure was observed in 2 (7.7%) pediatric patients and 4 (9.5%) adult patients, for a total of 6 (8.8%) treatment failures in the study group. Similar clinical findings and treatment outcomes were observed in both groups. We concluded that a combination of surgical drainage and antibiotic therapy increases treatment success for patients diagnosed with oropharyngeal tularemia.Öğe Evaluation of Imported Malaria Cases Detected in Sivas Province(Bilimsel Tip Yayinevi, 2024) Buyuktuna, Seyit Ali; Yesildag, Suemeyye Kara; Cubuk, Fatih; Elaldi, Nazif; Bakir, MehmetIntroduction: Malaria is an infectious disease that often presents with symptoms of fever, anemia, and splenomegaly and can result in mortality if left untreated. In this study, we aimed to examine the epidemiological characteristics, clinical findings, and prognosis of cases diagnosed with and treated for malaria in our center. Materials and Methods: This was a retrospective study conducted between May 2013 and September 2021 at the Infectious Diseases and Clinical Microbiology Clinic of Sivas Cumhuriyet University Hospital. The study included 23 adult patients aged 18 and above who were diagnosed, followed up, and treated for malaria. The diagnosis was made by detecting the parasite in thick and thin blood smears taken during the febrile period of the patients. Information about the patients was obtained by reviewing their medical records and dis- charge summaries in the hospital database. Results: The mean age of the patients included in the study group was 34 +/- 11 years (range= 18-51 years), and all except one were male. Six of the imported malaria cases were African students, and 16 were Turkish citizens who went to work in African countries. The only female patient in the study group had a history of a tourist trip. Upon examining the distribution of patients based on the geographic regions they originated from, Nigeria was identified as the most frequent origin (n= 6). P. falciparum (n= 18, 78%) was the most commonly detected pathogen. The most common symptoms observed in patients were fever accompanied by chills and shivering, myalgia/joint pain, and headache. Twelve patients had a history of previous malaria infection and treatment. It was found that none of the patients used prophylaxis. All patients were treated with artemisinin derivatives. Artesunate therapy was administered to two patients with a severe clinical course before oral treatment. Two of our patients required intensive care during follow-up. There was no mortality in any of our patients. Conclusion: As a result of the serious and successful implementation of malaria control programs, the World Health Organization reported in its 2011 malaria report that malaria had been eliminated in T & uuml;rkiye. The cases detected in our country are of foreign origin. To prevent these cases, preventive measures including prophylaxis should be increased, especially for work or tourist trips to regions where the disease is endemic.Öğe Evaluation of respiratory findings in Crimean-Congo hemorrhagic fever(SEAMEO TROPMED Network, 2011) Dogan, Omer Tamer; Engin, Aynur; Salk, Ismail; Epozturk, Kursat; Eren, Sevki Hakan; Elaldi, Nazif; Bakir, MehmetCrimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease with a high mortality rate causing viral hemorrhagic fever. We studies the respiratory system findings, demographics, clinical and laboratory findings of patients with CCHF admitted to our hospital. In this retrospective study we evaluated 108 patients with CCHF confirmed by laboratory findings. The charts of all hospitalized patients were reviewed, and the age, sex, occupation, city of residence, history of tick bite or of removing a tick, smoking history, chest X-ray results, outcome and clinical and laboratory findings were recorded for each patient. Sixty of the chest radiographs were read as normal, 33 were read as showing unilateral pathology and 15 showed bilateral pathology. Seven of the 108 patients died due to severe pulmonary infection and hemorrhage. The frequency of pathological chest radiographs was higher among the CCHF patients who died than among the survivors, but the difference was not significant. Pulmonary parenchyma hemorrhage can occur in CCHF patients with hemoptysis, dyspnea, chest pain and infiltration on chest radiographs and may lead to morality.Öğe EVALUATION OF RESPIRATORY FINDINGS IN CRIMEAN-CONGO HEMORRHAGIC FEVER(SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION, 2011) Dogan, Omer Tamer; Engin, Aynur; Salk, Ismail; Epozturk, Kursat; Eren, Sevki Hakan; Elaldi, Nazif; Bakir, Mehmet; Dokmetas, Ilyas; Akkurt, IbrahimCrimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease with a high mortality rate causing viral hemorrhagic fever. We studies the respiratory system findings, demographics, clinical and laboratory findings of patients with CCHF admitted to our hospital. In this retrospective study we evaluated 108 patients with CCHF confirmed by laboratory findings. The charts of all hospitalized patients were reviewed, and the age, sex, occupation, city of residence, history of tick bite or of removing a tick, smoking history, chest X-ray results, outcome and clinical and laboratory findings were recorded for each patient. Sixty of the chest radiographs were read as normal, 33 were read as showing unilateral pathology and 15 showed bilateral pathology. Seven of the 108 patients died due to severe pulmonary infection and hemorrhage. The frequency of pathological chest radiographs was higher among the CCHF patients who died than among the survivors, but the difference was not significant. Pulmonary parenchyma hemorrhage can occur in CCHF patients with hemoptysis, dyspnea, chest pain and infiltration on chest radiographs and may lead to morality.
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