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    D-Glucose-fatty Acid Ester Synthesis with or without a Biocatalyst in the Same Organic Media
    (Japan Oil Chemists Soc, 2020) Cetinkaya, Serap; Yenidunya, Ali Fazil; Basoglu, Faika; Sarac, Kamuran
    Esterification of D-glucose with oleic- and palmitic acids were carried out in the absence and presence of a biocatalyst, Candida antarctica lipase. The reaction medium was a mixture of dimethyl sulphoxide and tert-butanol (1:4, v/v). The reaction products were analysed by FTIR, H-1-NMR and C-13-NMR, HSQC, and by ESI-MS. Results indicated that the ester products formed were 6-O-glucose oleate and 6-O-glucose palmitate both in the absence and in the presence of the biocatalyst, with yields above 90%.
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    Esterification of Fructose-oleic Acid by tert-Butanol/Dimethyl Sulfoxide and by 2-Methyl-2-butanol/Dimethyl Sulfoxide
    (Japan Oil Chemists Soc, 2020) Cetinkaya, Serap; Yenidunya, Ali Fazil; Basoglu, Faika; Polat, Zubeyda Akin; Savas, Sumeyra
    In this study two different strategy were followed to obtain a D-fructose-oleic acid ester. One of the strategies has been well established enzymatic synthesis of an ester bond. The other strategy excluded the biocatalyst and only used a mixture of two organic solvents as the reaction media, 2-methyl-2-butanol / dimethyl sulfoxide or tert-butanol / dimethyl sulfoxide for the production of D-fructose-oleic acid ester. Ester products obtained were characterised by using FT-IR, NMR, by MS. Product yield was also assessed by HPLC. Results of structural analyses and yield measurement indicated that two approaches produced almost identical ester products.
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    Novel imidazo[2,1-b]thiazole-based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation
    (Wiley, 2021) Basoglu, Faika; Ulusoy-Guzeldemirci, Nuray; Akalin-Ciftci, Gulsen; Cetinkaya, Serap; Ece, Abdulilah
    The purpose of this study was to synthesize imidazo[2,1-b]thiazole derivatives, characterize them with spectroscopical techniques and investigate for cytotoxic and apoptotic effects on glioma C6 cancer cell line. The in vitro anticancer activities were also investigated against focal adhesion kinase. Most of the compounds, particularly the derivatives carrying 3-oxo-1-tiya-4-azaspiro[4.5]decane moiety, exhibited higher or comparable activities in comparison with the reference drug, cisplatin. Compounds with methyl, propyl, phenyl moieties at the eighth and second position of the spirothiazolidinone ring showed high FAK inhibitory activities. In addition, molecular docking studies shed light on the binding modes of the synthesized compounds. The critical interactions with amino acid residues located in the active site were revealed. The results obtained from both biological assay data and computational results might provide insight into developing new inhibitors against focal adhesion kinase.
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    Synthesis of Ribose - Oleic Acid Esters in the Presence- and Absence of Candida antarctica Lipase B
    (Japan Oil Chemists Soc, 2020) Cetinkaya, Serap; Yenidunya, Ali Fazil; Basoglu, Faika; Sarac, Kamuran
    D-ribose-oleic acid esters were produced with or without a biocatalyst, using in the same organic media. dimethyl sulfoxide (DMSO): tort-butanol (TBU) or 2-methyl-2-butanol (2M2B). The yield of the ester product was above 90% in both of the reactions. The biocatalyst used was lipase B of Candida antarctica. Molecular characterization was performed by using all the analytical methods available: IR, H-1-NMR and C-13-NMR, HSQC, and ESI-MS.