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    Effects of acupuncture on pain and levels of IL-17 and IL-23 in the treatment of non-thermal endovenous ablation: A randomized clinical trial
    (Sage Publications Ltd, 2022) Orak, Yavuz; Eroglu, Erdinc; Baylan, Filiz Alkan; Yildiz, Sedat; Boran, Omer Faruk; Doganer, Adem; Altun, Ahmet
    Objectives Acupuncture is one of the oldest therapeutic interventions in the world for the treatment of pain, musculoskeletal diseases, and inflammation. This study aimed to investigate the effect of acupuncture on pain and IL-17 and IL-23 levels in the treatment of endovenous ablation. Methods The study was a randomized controlled trial. Patients were divided into group C (Control, n = 35) and group A (Acupuncture, n = 35). Group A patients were treated with acupuncture 24 h preoperatively. Follow-up checkups were conducted intraoperatively, postoperatively, and on the third day. Results There was no difference between men; there was a difference between women. Visual analog scale score was lower in group A at the intraoperative third and fifth minutes (0.00 vs. 1 and 0.00 vs. 0.5). Analgesic consumption was lower in group A at the end of third day (p = 0.024). Postoperative IL-17 levels were higher than preoperative levels in group A (23.58 vs. 19.33). Postoperative IL-23 levels were lower than preoperative levels in group A (13.66 vs. 29.51). Group C showed increased postoperative IL-23 levels (28.81 vs. 33.51). Preoperative IL-17 and postoperative IL-23 levels were lower in group A than in group C (19.33 vs. 27.69 and 13.66 vs. 33.51). Although no difference was observed between group A and group C in preoperative saphenous vein diameter, postoperative saphenous vein diameter was smaller in group A (p = 0.008). Saphenous vein diameter was smaller on day 3 in group A than in group C (p = 0.043). Conclusion Acupuncture is effective on acute pain and level of IL-23 in the treatment of endovenous ablation using cyanoacrylate.
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    Evaluation of the relationship of leptin, adiponectin and carnitine levels with lung function, asthma severity and BMI in children with asthma
    (Pamukkale University, 2021) Baylan, Filiz Alkan; Deveci, Köksal; Aygüneş, Utku; Haskoloğlu, Zehra Şule
    Purpose: The aim of this study is to evaluate the relationship between serum levels of leptin, adiponectin and carnitine with lung function, disease severity and BMI (Body Mass Index) in children with asthma. Materials and methods: 97 Pediatric patients with not in acute attack period bronchial asthma and 40 healthy control subjects were included in the study. Pulmonary function tests were done to all asthma patients with a spirometer. Children with asthma were divided into 3 groups according to GINA criteria, mild intermittent, mild persistent, and moderate persistent, with using symptoms and spirometric parameters according to the severity of airway obstruction. Leptin, total carnitine and adiponectin analyzes were performed from venous blood by ELISA method. Results: Patient group serum leptin values were found to be significantly higher than the control group serum leptin values (p=0.001). Patient group serum total carnitine values were found to be significantly lower than the control group (p=0.001). Moderate persistent group adiponectin and total carnitine values were found to be significantly lower than mild intermittent group (p<0.05). A weak negative correlation was found between leptin and total carnitine, eosinophil, BMI values. A weak negative correlation was found between total carnitine and eosinophil, BMI values. A moderate negative correlation was found between age and leptin, adiponectin, total carnitine values. Conclusions: It suggested that leptin levels increased, adiponectin and total carnitine levels decreased in children with asthma and at the same time the decrease in adiponectin and total carnitine levels may be associated with disease severity. © 2021, Pamukkale University. All rights reserved.