Yazar "Bhuia, Md. Shimul" seçeneğine göre listele

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    Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
    (Wiley, 2024) Chowdhury, Raihan; Bhuia, Md. Shimul; Al Hasan, Md. Sakib; Hossain Snigdha, Shadid; Afrin, Sadia; Busselberg, Dietrich; Habtemariam, Solomon
    Cancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well-being due to its substantial morbidity and death rates worldwide. The potential of plant-derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti-inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy. The primary goal of the present study was to evaluate the anticancer abilities of mangrove plants and their compounds in great detail. In addition, we seek to investigate the molecular processes that give rise to mangrove plants and their phytochemical anticancer properties, focusing on their possible application in cancer treatment, which could provide valuable insights for future investigations and the development of novel therapeutic approaches.image
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    Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models
    (Universidad de Antioquia, 2024) Islam, Muhammad Torequl; Iriti, Marcello; Harhar, Hicham; Elouafy, Youssef; Bhuia, Md. Shimul; Chamkhi, Imane; Gürer, Eda Sönmez
    Background: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use. © 2024, Universidad de Antioquia. All rights reserved.
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    Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
    (Wiley-V C H Verlag Gmbh, 2023) Ali Khan, Muahmmad; El-Kersh, Dina M.; Islam, Md. Shafiqul; Khan, Shams Ara; Kamli, Hossam; Sarkar, Chandan; Bhuia, Md. Shimul
    Mikania micrantha is utilized as a therapeutic for the treatment of various human ailments including insect bites, rashes and itches of skin, chicken pox, healing of sores and wounds, colds and fever, nausea, jaundice, rheumatism, and respiratory ailments. This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. An up-to-date search was performed on M. micrantha in PubMed, Science Direct, clinicaltrials.gov, and Google Scholar databases with specific keywords. No language restrictions were imposed. Published articles, theses, seminar/conference papers, abstracts, and books on ethnobotany, phytochemistry and pharmacological evidence were considered. Based on the inclusion criteria, this study includes 53 published records from the above-mentioned databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-microbial, anti-dermatophytic, anti-protozoal, anthelmintic, cytotoxic, anxiolytic, anti-diabetic, lipid-lowering and antidiabetic, spasmolytic, memory-enhancing, wound-healing, anti-aging, and thrombolytic activities. No clinical studies have been reported to date. M. micrantha might be one of the potential sources of phytotherapeutic compounds against diverse ailments in humans. Studies are required to confirm its safety profile in experimental animals prior to initiating clinical trials. Moreover, adequate investigation is also crucial to clarify exact mechanism of action for each biological effect.
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    Neurobiological effects of gallic acid: current perspectives
    (Bmc, 2023) Bhuia, Md. Shimul; Rahaman, Md. Mizanur; Islam, Tawhida; Bappi, Mehedi Hasan; Sikder, Md. Iqbal; Hossain, Kazi Nadim; Akter, Fatama
    Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.