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Öğe A Bibliometric and Visual Analysis of Publications on Low-Density Lipoprotein Cholesterol Estimating Equations(Sivas Cumhuriyet Üniversitesi, 2024) Bolat, Serkan; Yerlitaş, Serra İlayda; Cephe, Ahu; Koçhan, Necla; Zararsız, Gözde Ertürk; Dogan, Halef Okan; Zararsız, GökmenThe concentration of low-density lipoprotein cholesterol (LDL-C) is recognized as a crucial factor in cardiovascular health. This study aims to conduct a comprehensive bibliometric and visual analysis to provide a comprehensive review of current research trends and patterns in this research area. We retrieved the publications from the Web of Science (WoS) database and conducted the bibliometric analyses using VOSviewer software, bibliometrix R package, and biblioshiny web tool. The analysis was conducted on 620 original articles and review papers published between 1990 and 2023 from institutions located in 62 different countries and published in 329 journals. The countries with the most articles were the US, China, and Japan. The most productive journals were Clinica Chemica Acta, Clinical Biochemistry, and Clinical Chemistry; while the most cited journals were Clinical Chemistry, Circulation, and JAMA-Journal of the American Medical Association. The co-occurrence network visualizations of keywords and terms provided a global overview of LDL-C estimating equations. The study presented provides valuable insights into potential research avenues within the examined field, serving as a foundation for future research initiatives.Öğe Analysis of liver fibrosis equations as a potential role of predictive models in Crimean-Congo hemorrhagic fever(Elsevier, 2024) Bolat, Serkan; Buyuktuna, Seyit Ali; Ipekten, Funda; Dogan, Kuebra; Zararsiz, Gokmen; Doang, Halef OkanCrimean-Congo Hemorrhagic Fever (CCHF) is a formidable global health concern, characterized by its rapid onset and high fatality rate. Distinguishing between patients at different stages remains challenging because of overlapping clinical features. This study aimed to evaluate the diagnostic efficacy of 14 hepatic fibrosis indices for distinguishing fatal cases and intensive care unit requirement (ICU) in CCHF. This study enrolled 194 patients with confirmed CCHF. Laboratory measurements were performed using auto analyzers. Indirect indicators of fibrosis were calculated for each patient based on previously described formulas. Time-dependent receiver operating characteristic (tdROC) curve analyses were employed to evaluate the predictive effects of hepatic fibrosis indices on both intensive care unit requirement and overall survival among patients. Regarding the tdROC analyses results, the highest area under the curve statistics were obtained for the baseline S-INDEX, KING, and GPRI scores (0.920, 0.913, and 0.909 respectively) in the estimation of ten-day survival, and the baseline KING, Goteborg University cirrhosis index (GUCI), and gamma-glutamyl transferase to platelet ratio index (GPRI) scores (0.783, 0.773, and 0.769 respectively) in the estimation of intensive care requirements for up to ten days. S-index and KING index emerged as early predictors of ten-day survival, while KING, GUCI, and GPRI indices demonstrated predictive capabilities for ICU admission on the first day. The identified indices have the potential to assist healthcare providers in making timely and informed decisions regarding patient management and treatment strategies. Further research and validation are warranted to solidify the role of these hepatic fibrosis indices in the clinical setting and enhance their broader applicability in the management of CCHF.Öğe Assessment of Serum Beta 2-Microglobulin Levels in Crimean-Congo Hemorrhagic Fever Patients: Implications for Immune Activation and Disease Pathogenesis(2024) Büyüktuna, Seyit Ali; Bolat, Serkan; Doğan, Kübra; Çakır, Yasemin; Doğan, Halef OkanCrimean-Congo Hemorrhagic Fever (CCHF) presents a spectrum of clinical manifestations, ranging from asymptomatic cases to severe, life-threatening conditions. Despite extensive research on CCHF pathogenesis, comprehensive understanding remains elusive. Our investigation focused on assessing serum beta 2-microglobulin (?2M) levels in CCHF patients, aiming to elucidate its potential as an immune activation marker and its involvement in disease pathogenesis. The study enrolled 45 CCHF patients and 45 healthy volunteers as a control group. Serum ?2M levels were quantified using the immunoturbidimetric analysis method. The patient group was divided into two groups, mild and moderate-severe, using scoring systems. The mean ?2M values for the control, mild, and moderate-severe patient groups were 2.27±0.50, 4.37±1.29, and 5.82±2.62 mg/L, respectively (p<0.001). Positive correlations were noted between ?2M concentrations and markers such as BUN, creatinine, uric acid, creatine kinase, and aPTT (p<0.001, r=0.684; p<0.001, r=0.602; p=0.003, r=0.439; p=0.008, r=0.392; p=0.019, r=0.348, respectively). Conversely, negative correlations were observed with total protein, albumin, and platelet count (p=0.021, r=-0.342; p=0.003, r=-0.434; p=0.048, r=-0.296, respectively). The findings suggest a prominent inflammatory response in CCHF, indicated by elevated ?2M levels, implying its potential role in the molecular mechanisms of the diseaseÖğe Comparison of lipemia interference created with native lipemic material and intravenous lipid emulsion in emergency laboratory tests(Croatian Soc Medical Biochemistry & Laboratory Medicine, 2024) Samsum, Emel Colak; Surer, Hatice; Bolat, Serkan; Senes, Mehmet; Yucel, DoganIntroduction: This study aimed to investigate the effects of lipemia on clinical chemistry and coagulation parameters in native ultralipemic (NULM) and intravenous lipid emulsion (IVLE) spiked samples. Materials and methods: The evaluation of biochemistry (photometric, ion-selective electrode, immunoturbidimetric method), cardiac (electrochemiluminescence immunoassay method) and coagulation (the viscosity-based mechanical method for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen and the immunoturbidimetric method for D-dimer) parameters were conducted. In addition to the main pools, five pools were prepared for both types of lipemia, each with triglyceride (TG) concentrations of approximately 2.8, 5.7, 11.3, 17.0 and 22.6 mmol/L. All parameters' mean differences (MD%) were presented as interferographs and compared with the desirable specification for the inaccu Results: Prothrombin time and APTT showed no clinically relevant interference in IVLE-added pools but were negatively affected in NULM pools (P < 0.001 in both parameters). For biochemistry, the most striking difference was seen for CRP; it is up to 134 MD% value with NULM (P < 0.001) at the highest TG concentration, whereas it was up to - 2.49 MD% value with IVLE (P = 0.009). Albumin was affected negatively upward of 5.7 mmol/L TG with IVLE, while there was no effect for NULM. Creatinine displayed significant positive interferences with NULM starting at the lowest TG concentration (P = 0.028). There was no clinically relevant interference in cardiac markers for both lipemia types. Conclusions: Significant differences were scrutinized in interference patterns of lipemia types, emphasizing the need for careful consideration of lipemia interferences in clinical laboratories. It is crucial to note that lipid emulsions inadequately replicate lipemic samples.Öğe Comparison of Prostate Specific Antigen and Neuropeptide Y Parameters in Patients with Prostate Cancer(Galenos Publ House, 2024) Ozturk, Abuzer; Saygin, Huseyin; Asdemir, Aydemir; Bolat, Serkan; Ergin, Ismail Emre; Kirac, Emre; Korgali, EsatObjective: Prostate cancer is a solid tumor that can be fatal in men. Early detection and proper management are essential for improving outcomes and reducing mortality rates associated with this disease. This study aimed to evaluate the potential of neuropeptide Y (NPY) as a biomarker to enhance the effectiveness of prostate specific antigen (PSA) testing in diagnosing and predicting prostate cancer prognosis. NPY, a well-known sympathetic neurotransmitter, possesses growth-promoting and angiogenic properties in various cell types, including those relevant to prostate cancer. Additionally, NPY has been linked to neuroendocrine differentiation of prostate cancer cells. By comparing the efficacy of PSA testing alone with the addition of NPY, this study aimed to determine whether NPY could offer additional predictive value for prostate cancer progression and prognosis. Materials and Methods: This study involved 90 patients each diagnosed with localized prostate cancer (LPC), metastatic prostate cancer (mPC) at diagnosis, and metastatic castration-resistant prostate cancer (mCRPC) who visited our urology clinic between 2022 and 2023. Blood samples were collected from all participants between 08:00 and 09:00 after a 12 hour fast. In the LPC and mPC groups, samples were collected upon diagnosis, whereas in the mCRPC group, samples were collected upon development of treatment resistance. NPY levels in blood samples were analyzed using enzyme-linked immunosorbent assay method. Serum NPY levels were compared between the LPC, mPC, and mCRPC groups. Results: PSA values were calculated as 12.6 (7.08-32.47) ng/L in the LPC group, 159 (73.1-405.2) ng/L in the mPC group, and 38.33 (18.4-132) ng/L in the mCRPC group, with a statistically significant difference between the groups (p<0.001). The average NPY values were 351.3 +/- 162.7 ng/L in the LPC group, 276.5 +/- 85 ng/L in the mPC group, and 272.13 +/- 94.7 ng/L in the mCRPC group. NPY values were found to be statistically significantly higher in the LPC group (p=0.018). Conclusion: The serum NPY levels were notably elevated in the LPC group compared with the mPC and mCRPC groups. This finding implies a potential association between low NPY levels and mPC as well as mCRPC.Öğe Concordance of LDL-C Estimating Equations with Direct Enzymatic Measurement in Diabetic and Prediabetic Subjects(Mdpi, 2023) Bolat, Serkan; Zararsiz, Gozde Erturk; Dogan, Kuebra; Kochan, Necla; Yerlitas, Serra I.; Cephe, Ahu; Zararsiz, GokmenLow-density lipoprotein cholesterol (LDL-C) is a well-established biomarker in the management of dyslipidemia. Therefore, we aimed to evaluate the concordance of LDL-C-estimating equations with direct enzymatic measurement in diabetic and prediabetic populations. The data of 31,031 subjects included in the study were divided into prediabetic, diabetic, and control groups according to HbA1c values. LDL-C was measured by direct homogenous enzymatic assay and calculated by Martin-Hopkins, Martin-Hopkins extended, Friedewald, and Sampson equations. The concordance statistics between the direct measurements and estimations obtained by the equations were evaluated. All equations evaluated in the study had lower concordance with direct enzymatic measurement in diabetic and prediabetic groups compared to the non-diabetic group. Even so, the Martin-Hopkins extended approach demonstrated the highest concordance statistic in diabetic and prediabetic patients. Further, Martin-Hopkins extended was found to have the highest correlation with direct measurement compared with other equations. Over the 190 mg/dL LDL-C concentrations, the equation with the highest concordance was again Martin-Hopkins extended. In most scenarios, the Martin-Hopkins extended performed best in prediabetic and diabetic groups. Additionally, direct assay methods can be used at low values of the non-HDL-C/TG ratio (<2.4), as the performance of the equations in LDL-C estimation decreases as non-HDL-C/TG decreases.Öğe Dysregulated Leukotriene Metabolism in Patients with COVID-19(National Institute of Health, 2024) Doğan, Halef Okan; Budak, Mahir; Doğan, Kübra; Zararsız, Gözde Ertürk; Yerlitaş, Serra İlayda; Bolat, Serkan; Şenol, OnurThis study aimed to examine the leukotriene metabolism during COVID-19. In total, 180 participants were included in this study, of which 60 were healthy controls, 60 required intensive care units (ICU), and 60 did not require intensive care (non-ICU). The serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP), and cysteinyl leukotriene (CYSLT) were measured, and the mRNA expression levels of 5-LO, ALOX5AP, and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. Compared with the control group, both the non-ICU and ICU groups had lower levels of 5-LO and mRNA expression. ICU patients had lower levels of 5-LO and mRNA expression than non-ICU patients. CYSLTR1 mRNA expression was highest in the ICU group, followed by the non-ICU group, and healthy controls had the lowest mRNA expression levels. CYSLT levels were higher in the control group than in the non-ICU and ICU groups. CYSLTR1 expression was higher in patients than in controls; therefore, selective leukotriene receptor blockers can be used as treatment options. CYSLTR1 expression was higher in the ICU group than in the non-ICU group. Furthermore, CYSLTR1 mRNA expression may be a promising biomarker of COVID-19 severity. © 2024, National Institute of Health. All rights reserved.Öğe Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly(Maik Nauka/Interperiodica/Springer, 2021) Dogan, Kubra; Yildiz, Seyma Nur; Sariakcali, Baris; Duman, Gulhan; Bolat, SerkanAlthough systemic inflammation has been linked to acromegaly, little is known about the abnormalities in cytokine networks during the disease. The aim of this study was to evaluate the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and activin-A in acromegaly, and to investigate the relationship between TNF-alpha, IL-6, activin-A and comorbidities of acromegaly. A total of 56 subjects were recruited to the study. Serum samples were collected from 31 acromegaly patients and 25 healthy control subjects. Serum activin-A, IL-6 and TNF-alpha were determined using the enzyme-linked immunosorbent assay. Circulating levels of activin-A, TNF-alpha, and IL-6 were higher in patients than in the control group. Receiver operating characteristic analysis for activin-A for the differentiation of acromegaly patients from healthy control subjects showed an area under the curve of 0.90. Higher activin-A levels were determined in patients with residual pituitary tumor. These findings provide evidence for the role of activin-A, TNF-alpha and IL-6 in acromegaly. Serum activin-A levels could be used as a novel biomarker to diagnose acromegaly. These findings confirm previous studies that inflammation might be involved in the pathogenesis of acromegaly. Finally, treatment strategies targeting the regulation of inflammation cannot be sufficient alone in reducing comorbidities.Öğe Evaluation of Serum Adipokine Levels in Girls With Central Precocious Puberty(Wiley, 2024) Caglayan, Ilkin Seda Can; Celik, Nurullah; Bolat, SerkanPurpose: Adipose tissue has an important endocrine function by secreting a variety of hormones known as adipokines, such as Visfatin, Omentin-1 and Chemerin. On the other hand, these hormones are also secreted from places other than fatty tissues in the girl's genital system. The goal of this study was to demonstrate the secretory status of adipokines in patients with central precocious puberty (CPP) and their utility in the diagnosis of precocious puberty. Method: A total of 105 patients were included in the study (53 in the CPP group and 52 in the control group). The following were used as the CPP diagnostic criteria; breast development, basal LH measurement higher than 0.3 IU/L, peak LH level >= 5 IU/L, peak LH/FSH ratio >= 0.66 (after 0.1 mg GnRH stimulation test) and a difference of at least 1 year between bone and chronological age. Results: A statistically significant difference was detected between the groups in serum Omentin-1 and Chemerin levels, and no significant differences were detected between the groups in Visfatin values. The cut-off values for the diagnosis of CPP were calculated as <= 48.9 with 81% sensitivity and 54% specificity for Omentin-1, and as >= 417 with 85% sensitivity and 60% specificity for Chemerin. Conclusion: In our study, we found that Omentin-1 level decreased and Chemerin level increased in lean girls with CPP. More studies are needed to elucidate how adipokines play roles in explaining the onset of CPP, and whether they may be used as a reliable marker for the diagnosis of CPP.Öğe Evaluation of the clinical characteristics, laboratory parameters, and antibiotic treatment in patients diagnosed with tularemia(Elsevier, 2025) Kiymaz, Yasemin cakir; Bolat, Serkan; Katirci, Bilge; Aldemir, Ozlem; Altinkaya, Isik; Ozcan, Merdan Mustafa; Hopoglu, Serhat MuratIntroduction: This retrospective, cross-sectional, multi-center study aimed to evaluate the impact of laboratory results and treatments on the treatment response in patients diagnosed with tularemia. Methods: The study included 190 adult patients diagnosed with tularemia between November 2023 and June 2024. Results: 67.9 % were female, mean age was 45.8 +/- 14.9 years. The most frequently detected symptoms were sore throat (74.2 %), fatigue (71.6 %), and neck swelling (56.3 %). The most common form of tularemia was oropharyngeal (82.6 %) and glandular (14.2 %). The most used monotherapy was ciprofloxacin (80.5 %, n = 136), and combination therapy was streptomycin-ciprofloxacin (81.0 %, n = 17). Treatment failure was observed in 29 patients (15.2 %). No difference was found between patients who responded and didn't respond to treatment regarding laboratory parameters. Lymph node drainage or excision was performed in 47 patients (23 %). Suppurative lymphadenitis, abscess, necrosis, and conglomerate lymphadenopathy were more common in the lymph node drainage group. Reactive lymph nodes were more common in the group without lymph node drainage. There was no difference between the two groups regarding laboratory parameters of patients with and without lymph node drainage. The duration of antibiotic treatment was longer in patients who underwent lymph node drainage than in those who didn't. Conclusion: Radiological evaluation of lymph nodes upon hospital admission, in addition to antibiotic therapy during treatment, may help predict which patients are more likely to require surgical drainage. Laboratory parameters may not provide significant benefits in predicting the need for lymph node drainage and long-term treatment did not affect the treatment response.Öğe Measuring the impact: Severity of harm from laboratory errors in 195 tests(Oxford Univ Press Inc, 2024) Cubukcu, Hikmet Can; Cihan, Murat; Alp, Hamit Hakan; Bolat, Serkan; Zengi, Oguzhan; Ucar, Kamil Taha; Topcu, Deniz IlhanObjectives This study aimed to objectively assess the potential severity of harm associated with erroneous results in 195 laboratory tests by surveying 514 specialist physicians and medical biochemistry experts.Methods The survey obtained participants' (75 medical biochemists, 439 clinicians) opinions on severity of harm for the erroneous results of 195 tests. The comprehensive list of errors and their effects on test results were obtained from the literature, and then matched with severity of harm scores, from 1 (negligible effect) to 5 (life-threatening injury/death), obtained from the survey responses.Results Participants perceived tests such as cardiac biomarkers, blood gases, coagulation parameters (activated partial thromboplastin time, prothrombin time, international normalized ratio, and dimerized plasmin fragment D), critical ions (potassium, sodium), toxic trace elements (lead, mercury), and specific serum drug levels (lithium, digoxin) to have a greater potential for patient harm in case of errors. Medical biochemistry specialists assigned higher severity scores to some laboratory tests, including total bilirubin, pseudocholinesterase, platelet indices, and some drug levels (cyclosporine, methotrexate, vancomycin).Conclusions A substantial agreement (91%) was observed between medical biochemists and clinicians in terms of the most frequently chosen severity of harm score. The study provided objective severity scores and identified high-risk tests for targeted quality improvement.Öğe Multipl Sklerozda Tam Kan Sayımı(Sivas Cumhuriyet Üniversitesi, 2024) Bolat, Serkan; Kablan, DemetMultipl skleroz (MS), öncelikle genç yetişkinlerde görülen ve merkezi sinir sistemini etkileyen kronik bir hastalıktır. MS'nin etiyolojisi tam olarak bilinmemekle birlikte, immün yanıtta önemli görevleri olan CD4+ T hücrelerini içeren otoimmün mekanizmaların rol oynadığı düşünülmektedir. T hücreleri ve makrofajların dahil olduğu inflamatuar reaksiyonlar, MS lezyonlarında yaygın olarak görülür. B lenfositleri, plazma hücreleri ve antikorlar da MS patogenezine katkıda bulunur. Temel bağışıklık sistemi bileşenleri olan nötrofiller, lenfositler ve monositlere ek olarak trombositler de inflamatuar süreçlerde rol oynar, ancak bu hücrelerin MS prognozu ile ilişkileri kesin değildir. Heterojen doğası nedeniyle, MS’nin klinik belirtileri etkilenen merkezi sinir sisteminin konumuna bağlı olarak değişir. MS tanı ve takibi için birkaç potansiyel biyobelirteç tanımlanmış olsa da bunların hiçbiri evrensel olarak kabul edilmemiştir. Çalışmalar, MS hastalarında eritrosit, trombosit ve lökosit popülasyonları dahil olmak üzere tam kan sayımı parametrelerini incelemiştir. MS hastalarında sağlıklı kontrollere kıyasla kan sayımı testlerinde gözlenen değişiklikler, hastalık prognozu ile ilişkili olabilir. Örneğin, MS hastalarında eritrosit frajilitesinde artış ve hemoglobin seviyelerinde değişiklikler bildirilmiştir. Lökosit sayıları ve nötrofil/lenfosit oranının hastalık şiddeti ile ilişkili olduğu gösterilmiştir. Trombosit aktivasyonu ve immün hücrelerle etkileşim de MS patofizyolojisine katkıda bulunmaktadır. Bununla birlikte, MS'de tam kan sayımı parametrelerinin rolü üzerine kesin bilgiler sağlamak için bu alandaki çalışmaların genişletilmesine ihtiyaç vardır. Erken tanı ve prognoz tahmini için güvenilir biyobelirteçlerin tanımlanması, MS hastalarını yönetimini büyük ölçüde geliştirecektir. Dahası, bu faydalar, mevcut semptomatik tedavilere odaklanmanın ötesine geçerek hastaların iyileşmesini sağlamada önemli gelişmelere yol açabilir.Öğe Platelet activating factor acetylhydrolase is associated with cardiac valvular calcification in dialysis patients(Walter De Gruyter Gmbh, 2024) Bolat, Serkan; Fidanci, Vildan; Elcik, Deniz; Tomar, Ozdem Kavraz; Murat, Sani Namik; Duranay, Murat; Yucel, DoganObjectives The cardiovascular mortality risk is greatly increased in patients with chronic kidney disease (CKD), especially in dialysis patients, due to atherosclerosis. Platelet activating factor acetylhydrolase (PAF-AH) is an enzyme that hydrolyzes platelet activating factor (PAF). Valvular calcifications and PAF-AH are associated with atherosclerosis. However, little is known about the status of PAF-AH activity and valvular calcification in dialysis patients. Therefore, the aim of this study was to investigate the status of these parameters in CKD patients. Methods This study included 92 chronic renal failure (CRF) (dialysis group), and 86 CKD patients (non-dialysis group). Echocardiography was performed to assess valvular calcification. Results There was no significant difference between the dialysis and CKD groups in terms of PAF-AH activities. However, when comparisons were stratified according to the presence of valve calcification, higher PAF-AH activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels were evident in patients with calcification compared to those without. Additionally, the CRF group also exhibited elevated PAF-AH and NT-proBNP levels. While elevated NT-proBNP persisted in the CKD group, in contrast, changes in PAF-AH were not significant. Conclusions The results of this study suggest that high PAF-AH and NT-proBNP levels are associated with valvular calcification in dialysis patients. Both biomarkers may be used as a risk factor for calcification. Furthermore, inhibition of PAF-AH activity may be a treatment target to reduce calcification.Öğe Predictive role of non-viral leukocyte parameters in tracking the development and progression of Crimean-Congo hemorrhagic fever(Academic Press Ltd- Elsevier Science Ltd, 2025) Kiymaz, Yasemin Cakir; Bolat, Serkan; Hasbek, Mursit; Buyuktuna, Seyit Ali; Ipekten, Funda; Zararsiz, Gokmen; Dogan, KubraThis study aims to investigate the extended leukocyte parameters, known as cell population data (CPD), in Crimean-Congo hemorrhagic fever (CCHF) and to evaluate their diagnostic performance in assessing mortality risk and intensive care unit (ICU) admission requirements. The study included a total of 260 participants, comprising 200 individuals diagnosed with CCHF and 60 healthy controls. CPD analyses were conducted using a Sysmex-XN 9000 complete blood count analyzer. Elevated levels of immature granulocyte (IG) percentage, neutrophil reactivity indices (Ne-X, Ne-Y), dispersion of neutrophil NE-SSC and NE-SFL signals (Ne-WX, Ne-WY), monocyte metabolic activity (Mo-X), and lymphocyte metabolic activity (Ly-X) were observed in CCHF patients compared to controls. Conversely, lymphocyte metabolic activity (Ly-Y) and monocyte fluorescence intensity (Mo-WY) were lower in patients than in controls. In discriminating mortality, IG#, IG%, Ne-WY, and Ly-Y exhibited higher AUC values than other CPDs. Additionally, for predicting ICU requirements, IG#, IG%, and Ne-WY demonstrated higher AUC values compared to other CPDs. IG, Ne-WY, and Ly-Y have the potential to serve as biomarkers for predicting mortality in CCHF. Furthermore, IG and Ne-WY may emerge as innovative and reliable biomarkers for identifying severe cases and predicting ICU admission requirements.Öğe The great tularemia outbreak in Sivas: Evaluation of 205 cases(Elsevier Science Inc, 2025) Kiymaz, Yasemin Cakir; Bolat, Serkan; Katirci, Bilge; Aldemir, Ozlem; Altinkaya, Isik; Ozcan, Merdan Mustafa; Hopoglu, Serhat MuratThis study aimed to report a tularemia outbreak in Sivas and describe the epidemiological and diagnostic characteristics of the patients. Patients aged 18 and over followed up with a diagnosis of tularemia in Sivas Cumhuriyet University Hospital, Sivas Numune State Hospital, and Sivas State Hospital Infectious Diseases Outpatient Clinics and wards between November 2023 and May 2024 were evaluated. 205 adult patients with tularemia were included. The most common symptoms were sore throat (73.2 %, n=150), swelling in the neck (70.2 %, n = 144), and fatigue (55.1 %, n = 113). The most common form was oropharyngeal (82.4 %, n = 169) and glandular (14.6 %, n = 30). Lymphadenopathy was detected in 182 (88.8 %) patients, the most is cervical lymphadenopathy (60 %, n = 123). Lymph node drainage/excision was performed on 50 patients (24.3 %). There have been no deaths in this outbreak. This study presents patient data from the tularemia outbreak in Sivas.Öğe Utilizing cell population data for diagnosis and intensive care unit requirement prediction in Fournier gangrene patients(Walter De Gruyter Gmbh, 2024) Saygin, Hueseyin; Bolat, Serkan; Asdemir, Aydemir; Ozturk, Abuzer; Ergin, Ismail E.; Dogan, Halef O.; Korgali, EsatObjectives: It is vital to rapid diagnosis and to determine the intensive care unit (ICU) requirement early to reduce the mortality rate in Fournier gangrene (FG) patients. Cell population data (CPD) are the parameters obtained from complete blood count (CBC) analysis and related to the activation of different leukocyte subgroups. The study aimed to find reliable markers to diagnose and determine the ICU requirement using CPD. Methods: We included 24 patients and 22 healthy controls in the study. CBC analyses were performed by using a Sysmex XN-9000 series hematology analyzer. ROC analyses and group comparisons were performed to evaluate the diagnostic accuracy and prognostic value of CPD parameters in ICU requirements. Results: Statistically significant differences were observed in terms of some CPD values of lymphocytes, neutrophils, and monocytes in patients compared to healthy controls. Neutrophile-Y or reactivity index (Ne-Y or RI) (p=0.004), neutrophile-X or granularity index (Ne-X or GI) (p=0.009), monocyte-X (Mo-X) (p<0.001), and lymphocyte-WY (Ly-WY) (p<0.001) were higher in patients than controls. Ne-Y (RI) (p=0.012), Mo-X (p=0.001), Mo-Y (p=0.022), and Ne-WY (p=0.025) levels were higher in ICU patients than in non-ICU patients. Conclusions: The severity of FG disease can be determined using CPD data. Ne-Y (RI) serves as a novel and reliable biomarker for determining disease severity. In addition, the neutrophile-lymphocyte ratio can be used to rule out FG, especially in combination with other well-known clinical and diagnostic parameters.
