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Öğe The Ameliorative Effects of Pycnogenol (R) on Liver Ischemia-Reperfusion Injury in Rats(TURKISH PHARMACISTS ASSOC, 2017) Tokac, Mehmet; Bacanli, Merve; Dumlu, Ersin Gurkan; Aydin, Sevtap; Engin, Merve; Bozkurt, Birkan; Yalcin, Abdussamed; Erel, Ozcan; Kilic, Mehmet; Basaran, NursenObjectives: Pycnogenol (R) (PYC (R)), a standardized extract from the bark of Pinus maritima, consists of different phenolic compounds. PYC (R) has shown to have protective effects on chronic diseases such as diabetes, asthma, cancer, and immune disorders. The aim of this study was to determine the effects of PYC (R) against the DNA damage and biochemical changes in blood, liver, and lung tissues of ischemia-reperfusion (IR)-induced Wistar albino rats. Materials and Methods: A sham group, IR injury-induced group, and IR+PYC (R) group were formed. Ischemia was induced and sustained for 45 min, then the ischemic liver was reperfused, which was sustained for a further 120 min at the end of this period. After anesthesia and before the IR inducement, 100 mg/kg PYC (R) was given to the IR+PYC (R) group through intraperitoneal injections. The total oxidant (TOS) and total antioxidant status (TAS), total thiol levels (TTL), advanced oxidation protein products (AOPP), and biochemical parameters [myeloperoxidase (MPO), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH)] in the rats were analyzed using spectrophotometric methods and DNA damage was assessed using single-cell gel electrophoresis. Results: The levels of TOS, TTL, MPO, AOPP, ALT, AST, and LDH were significantly decreased in the IR+PYC (R) group compared with the IR group (p<0.05). The levels of TAS were significantly increased in the IR+PYC (R) group compared with the IR group (p<0.05). PYC (R) reduced the DNA damage when compared with the IR group (p<0.05). Conclusion: The present results suggest that PYC (R) treatment might have a role in the prevention of IR-induced oxidative damage by decreasing DNA damage and increasing antioxidant status.Öğe Amniotic Membrane-Coated Polypropylene Mesh for the Repair of Incisional Hernia: An Experimental Study In a Rat Model of Abdominal Wall Defect(KOWSAR PUBL, 2018) Soylu, Sinan; Yildiz, Caglar; Bozkurt, Birkan; Karakus, Savas; Kurt, Begum; Kurt, AtillaBackground: Incisional hernia repairs are among common abdominal wall surgeries, can be primarily required or being reconstructed using a synthetic or biological material. Objectives: This study aimed at evaluating intra-abdominal adhesions and incisional site healing after the repair of abdominal wall by fresh amniotic membrane-coated polypropylene mesh in comparison to only polypropylene mesh in an experimental rat study. Methods: The study protocol was approved by Cumhuriyet University Institutional Ethics Committee for Animal Experiments (Sivas-Turkiye, date 24/06/2015). Sixteen pregnant female Wistar-Albino rats (mean weight, 275 g) were anesthetized on the 21st day of pregnancy and a 1-cm area of the abdominal wall was excised. The pregnancy was terminated, emerging amniotic membranes were dissected, and eight pieces of the 1-cm(2) polypropylene mesh were coated with these amniotic membranes without using any suture or adhesive. The polypropylene meshes were sutured on the abdominal wall of eight rats (control group), selected by simple random sampling. For the remaining eight rats, the same procedure was applied with the amniotic membrane-coated polypropylene meshes (experimental group). On the 28th postoperative day, the anterior abdominal wall was opened, and intra-abdominal adhesions were assessed macroscopically by Nair's adhesion scoring system. Strip-shaped biopsy samples were taken from incision lines for histopathological examination. Results: The experimental group had significantly less intra-abdominal adhesions (i.e. Nair's score of 2 to 4) compared to the control group (two and six rats, respectively; P= 0.046), and had significantly lower mean score for polymorphonuclear leukocyte infiltration (P = 0.039), hyperemia (P= 0.039), and epithelialization (P= 0.039). The score for increase in connective tissue (P = 0.018) was significantly higher in the experimental group, and the scores for edema (P= 0.590) and macrophage infiltration (P= 0.590) were similar between the two groups. Conclusions: The use of polypropylene mesh coated with fresh amniotic membrane provides advantage of decreasing postoperative intra-abdominal adhesions along with less inflammation and higher epithelialization after abdominal wall repair surgery.Öğe Co-existence of cecal volvulus with situs inversus totalis: A case report(KARE PUBL, 2016) Bostanci, Meric Emre; Atabey, Mustafa; Bozkurt, Birkan; Ozel, Ilker; Karadayi, KursatDetorsion, cecopexy, cecostomy and tube cecostomy are the treatment options for acute cecal volvulus if there is no intestinal ischemia. Resection required if intestinal viability, necrosis, gangrene or perforation exists. After resection, primary anastomosis or ileostomy can be performed. First colonoscopic decompression testing may be appropriate in terms of saving time for elective surgery. The co-existance of situs inversus totalis with cecal volvulus may cause uncertainty of the definite diagnosis and delay of surgical procedure. This is a case report about cecal volvulus together with situs inversus totalis. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Öğe Gastric Diverticulum On The Greater Curvature: a Case Report(Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2016) Mollaoğlu, Murat Can; Bozkurt, Birkan; Soylu, Sinan; Bostancı, Meriç Emre; Karadayı, KürşatGastric diverticulum is a rare pathological condition of the gastrointestinal system. It is seen in approximately 0.01% of all endoscopic examinations. Gastric diverticulum is commonly asymptomatic and usually detected incidentally during upper endoscopic examination. Gastric diverticulum is often located on the posteromedial wall of the fundus. Rarely, upper abdominal discomfort and pain may be presented. In this case, we report a 57 years old female patient with a gastric diverticulum on the greater curvatureÖğe Primary Sjogren's Syndrome Adversely Affects the Female Sexual Function Assessed by the Female Sexual Function Index: A Case-Control Study(TURKISH LEAGUE AGAINST RHEUMATISM, 2017) Yildiz, Caglar; Karakus, Savas; Bozoklu Akkar, Ozlem; Sahin, Ali; Bozkurt, Birkan; Yanik, AliObjectives: This study aims to evaluate the sexual function of females with primary Sjgren's syndrome (pSS) in comparison to healthy females by using the Female Sexual Function Index (FSFI). Patients and methods: This case-control study included 31 female patients (mean age 46.0 +/- 10.2 years; range 30 to 68 years) with pSS and 27 healthy females (mean age 44.2 +/- 8.5 years; range 30 to 55 years) as control group. The sexual function of the participants was assessed by 19-item FSFI. Results: Mean duration of pSS in the patient group was 35.9 months (range 3 to 264 months). Significantly higher number of pSS patients reported positive history for vaginal infection compared to controls (n= 26, 83.9% vs n= 7, 25.9%, respectively; p< 0.001) without any difference in endocervical culture result. Cervical smear assessment revealed more inflammation and atrophy in patient group compared to control group (p= 0.001). Mean FSFI total score was significantly lower in patient group than control group (18.9 +/- 9.9 vs 25.1 +/- 5.1, respectively; p=0.004). Similarly, five out of six domains of FSFI-arousal, lubrication, orgasm, satisfaction, and pain-were significantly lower in patient group. FSFI total and subscale scores, except for pain, were found to be negatively correlated with duration of pSS. Conclusion: The pSS causes sexual dysfunction in female patients. Furthermore, as disease duration increases, female sexual function decreases. Clinical management of female patients with pSS should cover the assessment of their sexual functionality and taking the necessary precautions to maintain satisfactory quality of life and treatment outcome.Öğe Well-differentiated abdominal liposarcoma: experience of a tertiary care center(BIOMED CENTRAL LTD, 2015) Karadayi, Kursat; Yildiz, Caglar; Karakus, Savas; Kurt, Atilla; Bozkurt, Birkan; Soylu, Sinan; Cicekli, Ayse A.; Egilmez, Reyhan; Cetin, AliBackground: We presented abdominal liposarcoma cases diagnosed and managed in a tertiary care center and also conducted a literature review on main features of this tumor. Methods: Chart reviews of eight cases were conducted, and clinical, surgical, histopathological, and follow-up data were recorded. Results: Overall, complete surgical resection was performed with adjacent organ resection in 25% of cases, and radiotherapy was not administered. Recurrence was developed in only one case and died after 2 years and 3 months, and other cases are under follow-up without recurrence. Histopatological examinations revealed findings of well-differentiated liposarcoma. Conclusions: According to our surgical experience, the surgical margin positivity may not be a determining factor for the survival of patients with well-differentiated liposarcoma, and in the absence of macroscopic invasion, adjacent organ resection may not be required. Radiotherapy may not be preferred when complete resection of abdominal mass was achieved.
