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Öğe BODIPY-Lipit Bileşiğinden Yeni Lipozomların Sentezi ve PDT Özelliklerinin Araştırılması(Duzce University, 2024) Özler, Muhammed Emre; Bozkurt, Yasemin; Sözmen, FazlıKemoterapi, radyoterapi, cerrahi müdahale gibi geleneksel kanser tedavi yöntemlerinin yüksek toksisite, ilaç direnci ve enfeksiyon gibi çeşitli yan etkilerinden dolayı, fotodinamik terapi (PDT), fototermal terapi (PTT) veya sonodinamik terapi (STT) gibi invaziv olmayan nispeten daha az yan etkilere sahip kanser tedavi yöntemlerine olan ilgi giderek artmaktadır. Bu non-invaziv terapi yöntemleri içerisinde de PDT sahip olduğu özelliklerinden dolayı literatürde en çok çalışılan terapi yöntemlerinden biridir. Bu ve benzeri terapi yöntemleri çalışılırken göz önünde bulundurulması gereken en önemli hususlardan biri fizyolojik koşullardır. Bu nedenle yapı bakımından hücre zarına benzeyen lipozomal yapılar ilaç taşıyıcı sistemler başta olmak üzere yaygın bir şekilde araştırılmaktadırlar. Genellikle nano boyutta sentezlenen lipozomal yapılar kolloidal kararlılıkları, biyouyumlu olmaları, toksik olmamaları ve etkili bir şekilde hedeflenebilmeleri gibi özellikleri nedeniyle de son derece ilgi görmektedirler. Bu çalışmada PDT özelliğine sahip BODIPY bazlı yeni lipozomal yapıların sentezlenmesi amaçlanmıştır. Bu amaçla, öncelikle BODIPY türevi bir bileşik fotoduyarlaştırıcı olarak sentezlenip karakterize edilmiştir. Daha sonra, serbest karboksil grubu içeren bu BODIPY (4,4-Difloro-4-bora-3a, 4a-diaza-s-indasen) türevi, lizofosfatidilkolin ile esterleşme reaksiyonu vasıtasıyla konjuge edilmiştir. Elde edilen BODIPY-Lipit konjugatı kullanılarak ince film hidratlama yöntemiyle nano boyutta lipozomal yapılar sentezlenmiştir. Son olarak yapılarında bir fotoduyarlaştırıcı bileşik bulunduran bu lipozomal yapıların PDT özellikleri 530 nm dalga boyundaki LED ışığı kullanılarak belirlenmiştir.Öğe Effects of Heavy Iodine Atoms and ?-Expanded Conjugation on Charge Transfer Dynamics in Carboxylic Acid BODIPY Derivatives as Triplet Photosensitizers(2023) Akhüseyin-Yıldız, Elif; Yabaş, Ebru; Sözmen, Fazlı; Bozkurt, Yasemin; Karatay, Ahmet; Boyacıoğlu, Bahadır; Ünver, Hüseyin; Elmalı, AyhanBorondipyrromethene (BODIPY) chromophores are composed of a functional-COOH group at meso position with or without a biphenyl ring, and their compounds with heavy iodine atoms ... .Öğe Multifunctional Magnetic Nanoparticles in Electrochemical Sensors for Pharmaceuticals(CRC Press, 2024) Aylaz, Gülgün; Bozkurt, Yasemin; Tüzün, Burak; Sözmen, FazliElectrochemical sensors are used in the pharmaceutical industry for their sensitivity, high-accuracy, quick response times, low detection limits, user-friendliness, and reasonably priced analyses. Pharmaceutical sensing includes methods for pharmaceutical applications like drug recognition, detection, and analysis. The key to improving sensor sensitivity and performance is the integration of multifunctional magnetic nanoparticles into electrochemical sensors used for pharmaceutical drug recognition, monitoring, and research. By adding magnetic nanoparticles (MNPs), the specificity of antibodies related to electrochemical transduction gains additional alluring features. MNPs for sensing applications is necessary due to the rapid expansion of MNP applications. This chapter covers the scope of multifunctional magnetic nanoparticles in electrochemical sensors for pharmaceuticals. © 2025 selection and editorial matter, Edited by Elyor Berdimurodov, Chaudhery Mustansar Hussain, and Burak Tüzün; individual chapters, the contributors.Öğe Two-Photon Absorption Response of Functionalized BODIPY Dyes in Near-IR Region by Tuning Conjugation Length and Meso- Substituents(2023) Akhüseyin-Yıldız, Elif; Ünlü, Bekir Asilcan; Karatay, Ahmet; Bozkurt, Yasemin; Özler, Muhammed Emre; Sözmen, Fazlı; Yabaş, Ebru; Boyacıoğlu, Bahadır; Ünver, Hüseyin; Elmalı, AyhanBODIPY dyes substituted by phenol or −COOMe units at the meso-position (C8) with and without a distyryl group including a methoxy moiety at the -C3 and -C5 positions of the BODIPY have been synthesized to analyze the photophysical properties. To clarify the ground-state interaction, absorption and emission features were investigated in the THF environment. Extending the π-conjugation with the methoxy moiety at -C3 and -C5 positions of BODIPY leads to a spectral shifting of the absorption maxima toward red by 120 nm. In addition, attaching the −COOMe unit at the meso-position of the BODIPY structure increases nonradiative molecular relaxation as compared to compounds possessing phenol substituents at the same position. We have investigated the effect of phenol and a −COOMe group and π-extended conjugation length with a methoxy moiety on the properties of two-photon absorption (TPA) and electron transfer dynamics by performing open-aperture (OA) Z-scan and femtosecond transient absorption spectroscopy measurements, respectively. The synthesized BODIPY compounds with the distyryl group including the methoxy unit show TPA character due to the longer conjugation length and therefore intramolecular charge transfer ability. Based on the OA Z-scan experiments upon photoexcitation with 800 nm pulsed laser light, TPA cross-section values were obtained as 74 and 81 GM for the compounds possessing phenol and −COOMe units at the meso-position of BODIPY treated by distyryl group with methoxy moieties, respectively. Additionally, optical and electronic properties were calculated theoretically by using the DFT method.Öğe Two-Photon Absorption Response of Functionalized BODIPY Dyes in Near-IR Region by Tuning Conjugation Length and Meso-Substituents(Amer Chemical Soc, 2023) Yildiz, Elif Akhuseyin; Unlu, Bekir Asilcan; Karatay, Ahmet; Bozkurt, Yasemin; Ozler, Muhammed Emre; Sozmen, Fazli; Yabas, EbruBODIPY dyes substituted by phenol or -COOMe unitsat themeso-position (C8) with and without a distyryl group including a methoxymoiety at the -C3 and -C5 positions of the BODIPY have been synthesizedto analyze the photophysical properties. To clarify the ground-stateinteraction, absorption and emission features were investigated inthe THF environment. Extending the & pi;-conjugation with the methoxymoiety at -C3 and -C5 positions of BODIPY leads to a spectral shiftingof the absorption maxima toward red by 120 nm. In addition, attachingthe -COOMe unit at the meso-position of the BODIPY structureincreases nonradiative molecular relaxation as compared to compoundspossessing phenol substituents at the same position. We have investigatedthe effect of phenol and a -COOMe group and & pi;-extendedconjugation length with a methoxy moiety on the properties of two-photonabsorption (TPA) and electron transfer dynamics by performing open-aperture(OA) Z-scan and femtosecond transient absorption spectroscopy measurements,respectively. The synthesized BODIPY compounds with the distyryl groupincluding the methoxy unit show TPA character due to the longer conjugationlength and therefore intramolecular charge transfer ability. Basedon the OA Z-scan experiments upon photoexcitation with 800 nm pulsedlaser light, TPA cross-section values were obtained as 74 and 81 GMfor the compounds possessing phenol and -COOMe units at themeso-position of BODIPY treated by distyryl group with methoxy moieties,respectively. Additionally, optical and electronic properties werecalculated theoretically by using the DFT method.
