Yazar "Bucak, Efe Taha" seçeneğine göre listele

Listeleniyor 1 - 1 / 1
  • Küçük Resim Yok
    Öğe
    Investigation of The Effect of Compound B-47/2 Containing Azomethine Group On Angiogenesis
    (Sivas Cumhuriyet University, 2022) Bucak, Efe Taha; Tunçbilek, Zuhal; Huseynzada, Alakbar; Aghayev, Mirjavid; Hasanova, Ulviyya; Taş, Ayça; Siliğ, Yavuz
    Objective: Lung cancer is one of the most common cancers in the world. It is known that angiogenesis plays a role in the development and metastasis of lung cancer. Azomethine derivatives known as Schiff bases have many biological activities. In this study, we aimed to determine the anticancer activity of the newly synthesized azomethine derivative compound B-47/2 on lung cancer and to determine the effect of this component on vascular endothelial growth factor B (VEGFB) gene expression. Material and Method: Compound B-47/2 was synthesized for the first time. B-47/2 compound was applied to lung cancer cell line (A549) at varying concentrations (1-100 µg/mL) and its anticancer activity was found after 24, 48 and 72 hours incubations using the 3-