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Öğe Endoscopic Ultrasound-Guided Fine Needle Aspiration Using a 22-G Needle for Hepatic Lesions: Single-Center Experience(Korean Soc Gastrointestinal Endoscopy, 2021) Akay, Ebru; Atasoy, Deniz; Altinkaya, Engin; Koc, Ali; Ertan, Tamer; Karaman, Hatice; Caglar, ErkanBackground/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has been accepted as a reliable tool in diagnosing and staging intra-abdominal tumors. In this study, we aimed to investigate the performance of EUS-FNA in the evaluation of liver masses and its impact on patient management and procedure-related complications retrospectively. Methods: Data of patients who underwent EUS-FNA biopsies due to liver masses between November 2017 and July 2018 were retrieved retrospectively. Biopsies were performed using 22-G needles. The demographics, EUS-FNA results, sensitivity and specificity of the procedure, negative predictive value, positive predictive value, and specimen sufficiency rates were assessed. Results: A total of 25 patients (10 females) were included in the study. The mean age was 62.73 +/- 15.2 years. The mean size of the masses was 34.50 +/- 16.04 mm. The technical success rate was 88%. During the EUS-FNA procedure, each patient had only one pass with 94.45% of aspirate sufficiency rate and 86.3% of biopsy sufficiency rate. The diagnostic accuracy rate was 86.3%. There were no complications. Conclusions: For the evaluation of liver masses, EUS-FNA using a 22-G needle with even one pass had high aspiration and biopsy success rates accompanied with high diagnostic accuracy rates.Öğe Large vessel involvement in Behcet's syndrome: A retrospective survery(WILEY-LISS, 2008) Melikoglu, Melike; Ugurlu, Serdal; Tascilar, Koray; Caglar, Erkan; Seyahi, Emire; Hamuryudan, Vedat; Yurdakul, Sebahattin; Yazici, Hasan…Öğe LIVER DISEASES IN PREGNANCY(Galenos Yayincilik, 2008) Sarkis, Cihat; Imir, Gonca; Ugurlu, Serdal; Caglar, Erkan; Yanik, AliLiver disease in pregnancy is rare and it is associated with the high maternal and neonatal mortality rate. Some of the liver diseases are specific for pregnancy. The most common liver diseases in pregnancy are Acute fatty liver of pregnancy, Intrahepatic cholestasis of pregnancy, HELLP syndrome, liver dysfunction due to preeclampsia, hyperemesis gravidarum, Hepatitis E of pregnancy, and other Hepatitis infections, and Budd-Chiari syndrome. In this review, incidence, risk factors, pathogenesis, clinical presentation, diagnosis, treatment and outcome of those liver diseases unique to pregnancy are discussed through the literature.Öğe Nonalcoholic Fatty Liver Disease and Familial Mediterranean Fever: Are They Related?(SRPSKO LEKARSKO DRUSTVO, 2012) Sarkis, Cihat; Caglar, Erkan; Ugurlu, Serdal; Cetinkaya, Emel; Tekin, Nilufer; Arslan, Mubeccel; Ozdemir, Sebati; Tuncer, MuratIntroduction Familial Mediterranean fever (FMF) is a periodic febrile disease characterized by acute recurrent episodes of serositis. Liver disease is not considered a part of the spectrum of clinical manifestations of FMF. Objective The purpose of this study was to characterize the nonalcoholic fatty liver disease (NAFLD) that could be associated with familial Mediterranean fever (FMF). Methods Clinical findings and treatment information of the patients with FMF were obtained from outpatient files. Weight, height, hip and waist circumference, blood pressure, blood C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatinine, alanine aminotransferase (ALT), and insulin levels were determined in all subjects, and additionally liver ultrasonography was performed for signs of hepatosteatosis. Results Fifty-two age and gender matched patients with FMF, and 30 healthy controls were included in the study. The prevalence of metabolic syndrome in the patient group was determined to be significantly higher in the patient group compared to the healthy group. When FMF patients with and without hepatosteatosis were compared, the prevalence of metabolic syndrome was determined to be 6 vs. 3, respectively (p<0.001). Eleven patients with FMF were found to have grade 1-2 hepatosteatosis, and only 6 of healthy subjects had grade 1 hepatoseatosis (p=0.901). Conclusion When compared with healthy controls, we found the prevalence of NAFLD was not increased in patients with FMF.Öğe Serum Levels of Mannan-Binding Lectin in Patients with Crimean-Congo Hemorrhagic Fever(MARY ANN LIEBERT, INC, 2010) Engin, Aynur; Ugurlu, Serdal; Caglar, Erkan; Oztop, Atifet Yasemin; Inan, Dursun; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, MehmetObjective: Mannan-binding lectin (MBL) is a central component of the innate immune response. Genetic variations in the MBL gene that reduce circulating levels and alter functional properties of the MBL are associated with susceptibility for many infectious diseases. Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by an arbovirus in the family Bunyaviridae. We have investigated serum MBL levels in CCHF patients and a possible association between circulating MBL concentrations and the severity of CCHF. Materials and Methods: Forty-seven patients found to have CCHF in Cumhuriyet University Hospital and 29 healthy controls were recruited for this study. There were no differences in terms of age and sex between the patients and the healthy controls (p = 0.64 and p = 0.484, respectively). This study was conducted between July 1 and August 31, 2007, in Cumhuriyet University Hospital in Sivas, a city located in the central Anatolian region of Turkey. Patients with CCHF were matched with healthy controls, and serum MBL levels were measured. Results: The median serum MBL level was significantly lower in the patient group than in the healthy control group (48.0 ng/mL [inter-quartile range (QR) 30.4-128.0] and 212.0 ng/mL [IQR: 115.8-524.0], respectively; p < 0.001). No significant difference was found between serum MBL levels in CCHF patients with severe and nonsevere form of the disease (p = 0.167). Conclusion: MBL levels were significantly lower in patients with CCHF than in healthy controls. There was no meaningful correlation between the serum MBL level and severity of CCHF disease. Low serum MBL level may be associated with the high consumption of MBL in CCHF infection and/or MBL gene polymorphism.Öğe Venous thromboembolism and inherited thrombophilia(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2009) Atahan, Erhan; Caglar, Erkan; Sarkis, Cihat; Ugurlu, SerdalInherited thrombophilia is a genetic tendency to venous thromboembolism. Coagulation abnormalities are common in the general population and therefore will present spontaneously in some individuals. Patients with a family history of thrombosis are at an increased risk for a mutation. Factor V Leiden and the prothrombin, G20210A mutation the commonest inherited risk factors for thrombosis, are associated with an increased risk of venous thromboembolism. These causes of thrombophilia increase the risk of venous thromboembolism recurrence. Deficiencies in protein C, protein S, and antithrombin-Ill account for most of the remaining cases of thrombophilia. Inherited thrombophilia should be suspected in patients with one or more of the following clinical features: idiopathic thrombosis, thrombosis at a young age, recurrent thrombosis, and thrombosis at an unusual site. Reliable assays are now available to test for the presence of the various causes of inherited thrombophilia.
