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    A Case of Hantavirus Renal Syndrome Detected in the COVID-19 Pandemic
    (Duzce Univ, Fac Medicine, 2022) Cakir, Yasemin; Ince, Nevin
    Hantaviruses are enveloped RNA viruses in the Bunyaviridae family that cause rodent -borne zoonotic infections. They cause two separate diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), as a result of transmission to humans through contact with rodent excrements and inhalation. The form seen more common in T & uuml;rkiye is HFRS, which progresses with acute kidney injury and thrombocytopenia. Coronavirus disease 2019 (COVID-19) is an infectious disease that ranges from asymptomatic infection to pneumonia, respiratory failure, and death. Because of symptoms such as fever, weakness, and flu -like clinical findings in the early days, it can be confused with many infectious diseases. In this case report, a case of hantavirus renal syndrome admitted with fever, weakness, and flu -like symptoms during the COVID-19 pandemic was presented.
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    A Case of Hantavirus Renal Syndrome Detected in the COVID-19 Pandemic
    (Duzce Univ, Fac Medicine, 2024) Cakir, Yasemin; Ince, Nevin
    Hantaviruses are enveloped RNA viruses in the Bunyaviridae family that cause rodent -borne zoonotic infections. They cause two separate diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), as a result of transmission to humans through contact with rodent excrements and inhalation. The form seen more common in T & uuml;rkiye is HFRS, which progresses with acute kidney injury and thrombocytopenia. Coronavirus disease 2019 (COVID-19) is an infectious disease that ranges from asymptomatic infection to pneumonia, respiratory failure, and death. Because of symptoms such as fever, weakness, and flu -like clinical findings in the early days, it can be confused with many infectious diseases. In this case report, a case of hantavirus renal syndrome admitted with fever, weakness, and flu -like symptoms during the COVID-19 pandemic was presented.
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    A Rare Manifestation of Leptospirosis: Long-Term Elevation in Liver Enzymes
    (Duzce Univ, Fac Medicine, 2023) Cakir, Yasemin; Yilmaz Gokce, Ozlem; Tunca, Bekir
    Leptospirosis is a bacterial zoonosis that is endemic in many tropical and subtropical regions. The disease is transmitted to humans by contact with the urine or an environment contaminated with the urine of infected animals. The clinical manifestations of leptospirosis vary from subclinical infection to severe illness with multiorgan dysfunction. This case report aimed to present a leptospirosis case diagnosed with detailed anamnesis and progressed with long-term elevation in liver function tests, in a non-endemic region. A 28-year-old male patient was admitted with complaints of weakness, fever, and vomiting. As a result of the detailed anamnesis, it was learned that the patient with hyperbilirubinemia, elevated liver enzymes, and kidney failure had contact with polluted water in a rural area, and the patient was followed up with a preliminary diagnosis of leptospirosis. Leptospirosis may present with different clinical presentations and be confused with many diseases, risk factors should be carefully questioned.
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    Frequency of Hepatosteatosis and Relationship Between Laboratory Parameters and Hepatosteatosis in Chronic Hepatitis B Patients
    (Galenos Publ House, 2024) Cakir, Yasemin; Sungur, Mehmet Ali; Oz, Murtaza; Buyuktuna, Seyit Ali
    Objectives: Hepatosteatosis is very common worldwide and is defined as the accumulation of lipid droplets in hepatocytes. Hepatosteatosis is often associated with metabolic factors such as obesity, insulin resistance, and hypertriglyceridemia. The relationship between chronic hepatitis B (CHB) and hepatosteatosis remains unknown. We investigated the frequency of hepatosteatosis in patients with CHB and to evaluate the relationship between hepatosteatosis and laboratory parameters. Materials and Methods: We retrospectively studied 262 patients with CHB. Patients were divided into two groups, hepatosteatosis and non-hepatosteatosis, according to liver ultrasonography findings. The groups were compared in terms of demographic characteristics and laboratory parameters. Results: A total of 262 patients with CHB were included. The mean age was 45.1 +/- 15.3 years, 136 (51.8%) of whom were male. Liver biopsy was performed in 86 (32.8%) of the patients, 20 (7.6%) had fibrosis, and 163 (62.2%) had steatosis. Among the patients with steatosis, grade 1 steatosis was observed in 30.9 (81/163), grade 2 in 26 (68/163), and grade 3 in 5.3 (14/163). Hypertension, hepatomegaly, and cirrhosis were correlated with the presence of steatosis. Patients with steatosis were older than those without. Fasting glucose levels, low-density lipoprotein levels, and triglyceride levels of patients with steatosis were higher than those of patients without steatosis. High-density lipoprotein levels were lower in the steatosis group. No correlation has been found with gender, body mass index, hepatitis delta virus co -infection, hepatitis B virus (HBV)-DNA levels, or hepatitis B e antigen status between steatosis. Conclusion: We found that hepatosteatosis is present in a significant proportion of patients with CHB. Although the presence of hepatosteatosis was associated with some metabolic parameters, the relationship between it and HBV parameters was not statistically significant.
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    HIV/HBV Coinfection with HBsAg Seroconversion: A Case Report
    (Bilimsel Tip Yayinevi, 2024) Cakir, Yasemin; Tunca, Bekir
    Mortality rates associated with human immunodeficiency virus (HIV) infection have declined with antiretroviral therapy, transforming HIV infection into a chronic disease. However, coinfections and opportunistic infections remain significant contributors to mortality and morbidity in individuals living with HIV. Since the transmission routes are similar, the coexistence of HIV and viral hepatitis infections is common. Human immunodeficiency virus infection and hepatitis B virus (HBV) infection affect the course of each other negatively. In this study, a patient with HIV-HBV co -infection who developed HBsAg seroconversion is presented.