Yazar "Calina, daniela" seçeneğine göre listele

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    Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review
    (2021) Durna Daştan, Sevgi; hossain, rajib; Quispe, christina; Herrera-Bravo, jesus; Islam, shahazul; Sarkar, chandan; Islam, Muhammed toregul; Morterell, Miguell; Cruz-martins, natalia; al-harrasi, Ahmed; Al-rawahi, Ahmed; Rad, Javad sharifi; Ibrayeva, Manshuk; Al-shehri, Mohammed; Calina, daniela; Cho, William c
    Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: “Lasia spinosa,” then combined with “ethnopharmacological use,” “phytochemistry,” and “pharmacological activity.” This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 1602437, 12 pages https://doi.org/10.1155/2021/1602437 mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.
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    Production, Transmission, Pathogenesis, and Control of Dengue Virus: A Literature-Based Undivided Perspective.
    (2021) Durna Daştan, Sevgi; Islam, Muhammed toregul; Quispe, christina; Herrera-Bravo, jesus; Sarkar, chandan; Sharma, rohit; Garg, Neha; Fredes, larry ıberra; Morterell, Miguell; Alshehri, Mohammed; Rad, Javad sharifi; Calina, daniela; Alsafi, radi; Alghamdi, saad; Batiha, gaber el-saber; Cruz-martins, natalia
    Dengue remains one of the most serious and widespread mosquito-borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths. Dengue virus infection is especially transmitted through bites of Aedes mosquitos, hugely Hindawi BioMed Research International Volume 2021, Article ID 4224816, 23 pages https://doi.org/10.1155/2021/4224816 spread in tropical and subtropical environments, mostly found in urban and semiurban areas. Unfortunately, there is no particular therapeutic approach, but prevention, adequate consciousness, detection at earlier stage of viral infection, and appropriate medical care can lower the fatality rates. This review offers a comprehensive view of production, transmission, pathogenesis, and control measures of the dengue virus and its vectors.
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    Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis
    (2021) Durna Daştan, Sevgi; jain, divya; Chaudhary, Priya; Varshey, Nidhi; Bin Razzak, Khandaker sabit; Verma, devret; Zahra, tasnim reza Khan; Janmeda, Pracheta; Rad, Javad sharifi; Mahmud, Shafi; Docea, anca Oana; Calina, daniela
    Smoking a cigarette generates over 4000 chemicals that have a deleterious impact on each part of the human body. It produces three main severe effects on the liver organ: oncogenic, immunological, and indirect or direct toxic effects. It results in the production of cytotoxic substances, which raises fibrosis and necro-inflammation. Additionally, it also directs the production of pro-inflammatory cytokines tumour necrosis factor alfa (TNF-α) and interleukins (IL-1β, IL-6) that will be responsible for the chronic liver injury. Furthermore, it gives rise to secondary polycythemia and successively raises the turnover and mass of red cells, which might be a common factor responsible for the development of oxidative stress in the liver due to iron overload. It also produces chemicals that are having oncogenic properties and raises the risk of liver cancer especially in sufferers of chronic hepatitis C. Smoking modulates both humoral and cell-mediated responses by restricting the proliferation of lymphocytes and inducing their apoptosis and ultimately decreasing the surveillance of cancer cells. Moreover, it has been determined that heavy smoking impacts the response of hepatitis C patients to interferon (IFN) therapy through different mechanisms, which can be improved by phlebotomy. Efforts are being made in different nations in decreasing the prevalence of smoking to improve premature death and ill effects of their nation’s individuals.