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Öğe Assessment of Joint Inflammation By Ultrasonography (US) in Patients with Rheumatoid Arthritis (RA) in Clinical Remission(CLINICAL & EXPER RHEUMATOLOGY, 2014) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, Ece…Öğe Assessment of Mitochondrial Functions and Occurrence of Oxidative Stress at Fibromyalgia Patients(CLINICAL & EXPER RHEUMATOLOGY, 2014) Peksen, Halil; Elden, Hasan; Dogan, Sevil Ceyhan; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Salihoglu, Salih…Öğe Association Between Familial Mediterranean Fever and Cachexia in Females(Turkish League Against Rheumatism, 2020) Durmaz, Yunus; Ilhanli, Ilker; Cengiz, Ahmet Kivanc; Kaptanoglu, Ece; Ozkan Hasbek, Zekiye; Hizmetli, SamiObjectives: This study aims to investigate the association between familial Mediterranean fever (FMF) and cachexia in females. Patients and methods: The study included 32 female FMF patients (median age 27.50 years; range, 18 to 50 years) and 30 female healthy controls (median age 32 years; range, 18 to 50 years). Patients were classified according to Tel-Hashomer criteria. Circumference of arm, waist, and thigh was recorded. Short form 36 (SF-36) and Multidimensional Assessment of Fatigue (MAF) scale were applied. Composition of the body was measured with dual X-ray absorption. Muscle strength was measured with an isokinetic dynamometer, and strength of hand grip was measured from dominant hand with a hand dynamometer. C-reactive protein, erythrocyte sedimentation rate, fibrinogen and serum creatinine kinase (CK) levels were recorded. Results: Body mass index was significantly higher in controls. Twelve patients and one control had cachexia. CK level was significantly higher in patients than controls. Mass of muscle without fat was significantly higher in patients than controls. Peak torque values of extension and flexion at the velocity of 60 degrees/second [Newton meter (Nm)], and value of total work during extension at the velocity of 240 degrees/second (Nm) in isokinetic measures were significantly higher in controls. MAF score was significantly higher in patients with cachexia than patients without cachexia where the subscale scores of SF-36, except the vitality score, were significantly lower in patients with cachexia. However, Tel-Hashomer score was significantly higher in patients with cachexia. Conclusion: This study pointed at a significant association between cachexia and FMF in females. Muscle endurance was not affected in FMF patients with cachexia; however, decreased muscle strength, impaired quality of life and increased fatigue were observed in these patients.Öğe Diffuse Alveolar Hemorrhage: A Life-Threatening Complication of Systemic Lupus Erythematosus(CLINICAL & EXPER RHEUMATOLOGY, 2014) Cengiz, Ahmet Kivanc; Durmaz, Yunus; Dinler, Mustafa; Dogan, Sevil Ceyhan; Hayta, Emrullah; Akin, Recep; Gumus, Cesur; Kaptanoglu, Ece; Hizmetli, Sami…Öğe Disease Activity, Fatigue and Quality of Life in Patients with Coexisting Ankylosing Spondylitis and Familial Mediterranean Fever(CLINICAL & EXPER RHEUMATOLOGY, 2014) Kaptanoglu, Ece; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Hayta, Emrullah; Dogan, Sevil Ceyhan; Hizmetli, Sami…Öğe Does Mean Platelet Volume Really Reflect Disease Activity in Rheumatoid Arthritis?(CLINICAL & EXPER RHEUMATOLOGY, 2014) Hizmetli, Sami; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Hayta, Emrullah; Dogan, Sevil Ceyhan; Kaptanoglu, Ece…Öğe Evaluation of Ovarian Reserve with Anti-Mullerian Hormone in Familial Mediterranean Fever(HINDAWI LTD, 2015) Sahin, Ali; Karakus, Savag; Durmaz, Yunus; Yildiz, Caglar; Aydin, Huseyin; Cengiz, Ahmet Kivanc; Guler, DuyguObjective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Mullerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18-45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd-4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P = 0.018). There was no statistically significant difference in median AMH levels between E148 Qmutation positive patients and the negative ones (P = 0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P = 0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P = 0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.Öğe In Urban Areas of Sivas City The Determination of Bone Mineral Density Reference Values of Healthy Women who Admitted to Cumhuriyet University Hospital Physical Medicine and Rehabilitation Outpatient Clinic(CLINICAL & EXPER RHEUMATOLOGY, 2014) Tunc, Gokay; Dogan, Sevil Ceyhan; Hizmetli, Sami; Hayta, Emrullah; Cengiz, Ahmet Kivanc…Öğe Ovarian reserve is preserved in Behcet's disease(WILEY, 2017) Sahin, Ali; Karakus, Savas; Durmaz, Yunus; Yildiz, Caglar; Aydin, Huseyin; Cengiz, Ahmet KivancAimTo compare ovarian reserve with anti-mullerian hormone (AMH) levels, antral follicle counts (AFCs) and ovarian volume in patients with Behcet's disease (BD) and healthy subjects. MethodThis study included 35 women with BD (mean age: 34.45.3years) and 35 healthy controls (mean age: 34.16.0years). Venous blood samples collected from groups on menstrual cycle Days 2-4 were analyzed using the enzyme-linked immunosorbent assay to measure follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E-2), prolactin (PRL) and AMH levels. The AFCs and ovarian volumes were estimated by ultrasonography on the same day. The body mass index (BMI), duration and severity of the disease, medications, and number of children were recorded. ResultsThere was no statistically significant difference in the mean age, median gravida/para/abortus and the number of live births and mean BMI between the patient and control groups (P>0.05). No statistically significant difference in the median FSH, LH, E2, PRL levels, right and left ovarian volumes, and right and left ovarian AFCs was observed among the patients and the controls (P>0.05). There was no statistically significant difference in the mean AMH levels (P=0.468). Bonferroni correction showed no statistically significant correlation between AMH levels and age, BMI, FSH, LH, E2, PRL levels, right and left ovarian AFCs, right and left ovarian volume (P>0.025) among the controls and the patients. ConclusionOur study results suggest that ovarian reserve is preserved in patients with BD. In addition, AMH levels of the BD patients were similar to levels of healthy subjects.Öğe Routine Assessment Of Patient Index Data 3 In Fibromyalgia: A Rapid and Reliable Instrument For Evaluating Disease Severity?(WILEY-BLACKWELL, 2013) Kaptanoglu, Ece; Sahin, Ozlem; Durmaz, Yunus; Cengiz, Ahmet Kivanc; Hizmetli, Sami…Öğe Ultrasound-defined remission for good functional status in rheumatoid arthritis(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2017) Ozer, Pinar Kaplan; Sahin, Ozlem; Ozer, Zafer; Cengiz, Ahmet Kivanc; Durmaz, Yunus; Kaptanoglu, EceBackground & objectives: It has been shown that joint damage due to subclinical synovitis progresses despite apparent clinical remission in rheumatoid arthritis (RA). Hence, finding more objective methods to investigate subclinical synovitis has become a current issue. Ultrasonography (US) has been among the most investigated methods. This study was conducted to detect whether there was subclinical inflammation in RA patients in clinical remission by power Doppler ultrasonography (PDUS) and to evaluate the effects of this inflammation on upper extremity function. Methods: Forty five RA patients fulfilled the remission criteria of disease activity score 28 using erythrocyte sedimentation rate (DAS28-ESR), were enrolled in the study. Bilateral wrist, 2nd and 3th metacarpophalangeal and proximal interphalangeal joints and 2nd and 5th metatarsophalangeal joints were examined by PDUS. Upper extremity function was assessed with Michigan Hand Outcomes Questionnaire (MHQ) and handgrip strength. The pain was evaluated by visual analogue scale (VAS). Results: In 29 of 45 RA patients in clinical remission, synovitis was detected by PDUS at least in one joint. VAS and DAS28-ESR scores were significantly lower and total MHQ, some subgroup scores of MHQ (overall hand function, activity of daily living and work performance) and grip strength of the dominant hand were higher in patients with PD signal negativity. Interpretation & conclusions: PDUS showed a crucial role in determining the subclinical synovitis. Subclinical synovitis negatively affects the upper extremity function. Ultrasound-defined remission may be considered for good functional status and real remission in patients with RA.
