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Öğe Adenosine deaminase and xanthine oxidase levels in multiple sclerosis patients(Bayrakol Medical Publisher, 2020) Gokce, Seyda Figul; Demirpence, Ozlem; Cigdem, Burhanettin; Bolayir, Asli; Ersan, SerpilAim: Multiple sclerosis represents an autoimmune, chronic, inflammatory, and demyelinating disease of the central nervous system. Inflammation and oxidative stress are considered to take a significant part in its pathogenesis. Adenosine deaminase (ADA) and xanthine oxidase (XO) enzymes, which are involved in purine metabolism, are critical for regulating inflammation and oxidative stress. Therefore, this study's goal is to evaluate the levels of these two enzymes in patients with the relapsing-remitting type of multiple sclerosis (MS) in their remission period. Material and Methods: Thirty patients with relapsing-remitting multiple sclerosis (RRMS) who were in their remission period and diagnosed in accordance with the Mc Donald 2010 criteria along with 30 healthy volunteer controls, matched with regard to age and gender, were enrolled in the research. Serum ADA levels were studied by the sensitive colorimetric method that was defined by Giusti, while XO levels were studied by the Worthington method. Results: RRMS patients had significantly higher serum ADA and XO levels compared to the control subjects (both of the P values = 0.004). Discussion: In our study, we conclude that two of the most crucial underlying pathogenic mechanisms of MS, inflammation and oxidative stress, may be associated with the increased levels of ADA and XO, and an approach of targeting the activity of these two enzymes can be considered in treatment strategies. Furthermore, we also demonstrated that ADA and XO enzymes were elevated even in the remission phases of RRMS, reflecting the continuity of inflammation through the whole course of RRMS. Thus, in this disease, which is thought to have a dynamic process, the importance of continuous immunomodulatory treatment is emphasized once again.Öğe Aortic Dissection Presenting with Transient Paraplegia(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Donmez, Recep; Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Balaban, Hatice; Bolayir, Ertugrul; Topaktas, Suat…Öğe Can SCUBE1 be used to predict the early diagnosis, lesion volume and prognosis of acute ischemic stroke?(WALTER DE GRUYTER GMBH, 2019) Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Bolayir, Hasan Ata; Gulunay, Aydin; Celik, Veysel Kenan; Kapancik, Serkan; Yildiz, Oztem KayimObjective: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] is a novel biochemical marker. SCUBE1 is thought to play roles both in platelet activation and inflammation, which are important stages for the development of acute ischemic stroke (AIS). The purpose of our study was to determine the diagnostic and prognostic values and temporal change of plasma SCUBE1 levels in AIS patients. Materials and methods: Thirty-five patients diagnosed with AIS at the Cumhuriyet University Faculty of Medicine Neurology Department, between June and December 2017, and a control group of 35 healthy volunteers were included. Results: Median first day SCUBE1 value in the patient group was 97.51 ng/mL, and the median 7th day SCUBE1 value was 32.72 ng/mL. Median control group SCUBE1 value was 27.51 ng/mL. The first day SCUBE1 levels were significantly higher than the 7th day and the control group SCUBE1 levels (p = 0.001, p < 0.001, respectively). The ROC analysis showed that SCUBE1 levels above 68.8 ng/mL can be used as an indicator with high sensitivity and specificity for AIS diagnosis. Multivariate analysis revealed that the first day SCUBE1 had significant independent effects on development of AIS. In correlation analysis, plasma SCUBE1 levels showed a significantly positive correlation with lesion volume, NIHSS and MRS values (p < 0.01). Conclusion: First day plasma SCUBE1 values in AIS patients rised at significant levels compared to the control group. SCUBE1 could use both in the early diagnosis and prediction of prognosis and lesion volume of AIS patients.Öğe Delirium Awareness and Treatment Approach in Orthopedics Clinic(Aves, 2020) Pazarci, Ozhan; Kilinc, Seyran; Bekmez, Fatma; Cigdem, Burhanettin; Oztemur, ZekeriyaBACKGROUND/AIMS Orthopedic clinics are among the leading clinics in hospitals that request consultation for patients with delirium. However, delirium is often missed by nurses and physicians, resulting in an incorrect diagnosis. This study aimed to identify patients with delirium in the orthopedic clinics and describe our approach for these patients. MATERIAL and METHODS After forming a strategy for the diagnosis, treatment, and follow-up of patients with delirium, prospective follow-up was performed for patients hospitalized in the orthopedic ward. High-risk patients were screened using the Nursing Delirium Screening Scale, and patients diagnosed with delirium were evaluated using a prepared form. This approach was used to determine the risk factors for delirium, ensure patient safely, and treat the symptoms of delirium. RESULTS Total 988 patients were evaluated, and 34 (2.44%) were diagnosed with delirium. The mean age of the patients was 66.17 +/- 22.68 years. The mean duration of delirium was 2.88 +/- 0.84 days. An age group-based comparison showed that the duration of delirium in older patients was significantly longer than that in younger patients (3.08 +/- 0.9 vs. 2.45 +/- 0.52 d, p=0.042). Further, delirium duration was more among men than among women (3.0 vs. 2.2 d, p=0.031). CONCLUSION Rapid identification of delirium and determination of the etiological cause allows timely and appropriate correction of the condition Identification of delirium by the medical team and the use of a systemic approach are important in treatment. The duration of delirium is longer in men and the elderly; further, most delirious patients have more than one risk factor for delirium.Öğe Determination of levels of oxidative stress and nitrosative stress in patients with epilepsy(Elsevier, 2020) Ersan, Serpil; Cigdem, Burhanettin; Bakir, Deniz; Dogan, H. OkanBackground: Epilepsy is one of the most common neurological diseases. The underlying pathophysiological mechanisms in epilepsy are still unknown. Oxidative stress is believed to be one of the factors involved in the pathogenesis of epileptogenesis. In various pathophysiological conditions, reactive nitrogen species (RNS) such as nitrogen and peroxynitrite are produced and these RNSs can bind to free nucleosides and nucleotides or to nucleosides and nucleotides existing in the DNA/RNA structure. 8-Nitroguanine (8-NG) is a typical DNA nucleobase product of nitrosative damage generated by RNS. It has been proposed that F2-isoprostanes, in particular 8-iso-Prostaglandin F2a (8-isoPGF2a), are specific, reliable and non-invasive biomarkers of lipid peroxidation in vivo. In the present study, we compared the levels of lipid oxidative stress biomarker 8-isoPGF2a and nitrosative stress DNA biomarker 8-NG in patients with epilepsy undergoing antiepileptic drug (AEDs) treatment and with those in healthy participants. Methods: The present study comprised 90 patients aged between 17 and 53 who were admitted to the Neurology Clinic of Cumhuriyet University and diagnosed with epilepsy. The patients were assigned into the intervention (n = 45) and control (n = 45) groups. Of the participants in the intervention group, 37.7% (n = 17) were treated with levetiracetam (LEV), 33.3% (n = 15) with valproic acid (VA) and 29% (n = 13) with carbamazepine. Serum 8-iso-PGF2a and 8-NG levels of the participants in the intervention and control groups were determined by ELISA. Results: There was no significant difference between the medication (LEV, VA, Carbamazepine) used by the participants and their 8-iso-PGF2a and 8-NG levels (p> 0.05). However, 8-iso-PGF2a and 8-NG were significantly higher in the participants in the intervention than in the participants in the control group (p< 0.001). Conclusion: Our study demonstrated that there was an increase in oxidative and nitrosative stres markers in patients with epilepsy. There was no significant difference between the 8-iso-PGF2a and 8-NG levels of the participants taking three different AEDs.Öğe Development and validation of an HPLC method for determination of carbamazepine in human plasma and applications to a therapeutic drug monitoring study(Istanbul Univ, Fac Pharmacy, 2020) Dural, Emrah; Cetin, Suleyman; Bolayir, Asli; Cigdem, BurhanettinBackground and Aims: Carbamazepine (CBZ) is an antiepileptic drug, which is prescribed as a first-line drug for the treatment of partial and generalized tonic-clonic epileptic seizures. The aim of this study was to develop and validate a simple, fast and reliable HPLC method for the determination of carbamazepine in human plasma. Methods: Chlorpromazine (CPR) was used as an internal standard. The separation was conducted with a C18 reverse-phase column (150x3.9 mm, 5 mu m) at 30 degrees C, using a mobile phase prepared with 20 mM KH2PO4, acetonitrile and methanol (6:3:1, v/v/v) by isocratic elution. Results: The method was linear between 0.5 and 40 mu g/mL, determined by 10 individual calibration points. Total run time was <= 5 mins. Accuracy (RE%) values were determined between (-5.6) and 3.6%, and precision was determined at <= 4.2%. Limit of detection (LOD) was 0.04 mu g/mL. The robustness test results of the method showed good values. Plasma CBZ of (n=30) those receiving CBZ quantities ranging from 0.2 to 1.2 g/day were measured with this method, and following analyses of their concentrations were found to be between 0.1 and 11.4 mu g/mL (6.2 +/- 2.4 mu g/mL). While all plasma sample analyses were applied properly, it was observed that 16 (53.3%) of the plasma samples had CBZ lower than the recommended range. In addition to that, female patient plasma-CBZ levels were found significantly higher than male plasma contents (p<0.05). Conclusion: This method was found suitable for the analysis of plasma samples collected during the therapeutic drug monitoring (TDM) of patients treated with CBZ.Öğe A DWI study of the contralateral hemisphere in cerebral hemiatrophy(ELSEVIER SCIENCE BV, 2016) Oztoprak, Bilge; Oztoprak, Ibrahim; Bozkurt, Huseyin; Cigdem, Burhanettin; Yildiz, Ozlem KayimBackground and aim: Cerebral hemiatrophy (CHA) is a congenital or acquired loss of volume in one hemisphere of the brain. The MR findings of the affected hemisphere have been a subject of many studies, however, the contra-lateral hemisphere has not been investigated. There is, in fact, an integrity between two hemispheres of the brain through transverse connection fibers. The aim of this study is to investigate the changes in the contralateral hemisphere in CHA. Materials and methods: Apparent diffusion coefficient (ADC) values were measured in deep gray and white matter areas in the normal-appearing contralateral hemisphere in 23 patients with CHA, in order to get in vivo information about a possible Wallerian degeneration or microstructural changes. Results were compared with the control group. Results: Normal ADC values were encountered in the contralateral hemisphere in all (100%) CHA patients. The difference between the ADC values of gray and white matter in CHA patients and the control group was not statistically significant. Conclusion: Normal ADC values in the contralateral hemisphere in CHA patients suggests a compensatory mechanism restricting Wallerian degeneration or diffusion alteration. (C) 2016 Elsevier B.V. All rights reserved.Öğe The Effect of Eosinopenia on Mortality in Patients with Intracerebral Hemorrhage(ELSEVIER SCIENCE BV, 2017) Bolayir, Asli; Cigdem, Burhanettin; Gokce, Seyda Figul; Bolayir, Hasan Ata; Yildiz, Ozlem Kayim; Bolayir, Ertugrul; Topaktas, Suat AhmetIntroduction: Inflammation may determine the prognosis of intracerebral hemorrhage (ICH), which has high mortality and morbidity rates. Recent studies have increasingly demonstrated eosinopenia as a prognostic factor, particularly in bacteremia, chronic obstructive pulmonary disease, and myocardial and cerebral infarction. Nonetheless, its significance regarding the determination of prognosis in patients with ICH has not yet been clarified. Materials and Methods: Our study included 296 patients who presented to our clinic within 24 hours of the onset of symptoms and who were diagnosed with ICH between January 2008 and June 2016, along with 180 age- and sex-matched controls. During their hospitalization, 120 of these 296 patients died. Patients and controls were compared in terms of neutrophil count/percentage and eosinophil count/percentage; these were also compared between nonsurviving and surviving patients. The significance of eosinopenia in predicting mortality was also evaluated. Results: Patients had a significantly higher neutrophil count/percentage and a significantly lower eosinophil count/percentage than controls; these results were similar between nonsurviving and surviving patients (P < .001). Consequently, the patient group was divided into 4 subgroups depending on the presence of eosinopenia and/or neutrophilia. The mortality rate was highest (62%) in the group that had both eosinopenia and neutrophilia. Univariate and multivariate logistic regression analyses indicated that neutrophilia and eosinopenia were independent predictors of mortality in ICH (P = .002; P = .004) Discussion: These results indicate that eosinopenia can occur in patients with ICH and that although the mechanism is unclear, eosinopenia is closely associated with mortality in these patients, particularly when accompanied by neutrophilia.Öğe Effect of Preoperative Uric Acid Level and Neutrophil/Lymphocyte Ratio on Preoperative and Postoperative Visual Analogue Pain Scores in Patients with Lumbar Disc Herniation: A Cross-Sectional Study(Turkish Neurosurgical Soc, 2019) Bozkurt, Huseyin; Arac, Densel; Cigdem, BurhanettinAIM: To determine the relationship between the serum urate (SU) level, neutrophil / lymphocyte ratio (NLR), and pain severity using preoperative and postoperative visual analogue scale (VAS) scores in patients with lumbar disc herniation (LDH). MATERIAL and METHODS: This single-center, cross-sectional study included 20 consecutive patients who were operated for LDH by the same surgeon. The patients'pre- and postoperative UA levels, NLRB, and intensity severity VAS scores were investigated. Preoperative magnetic resonance imaging (MRI) findings, serum UA levels, and neutrophil and lymphocyte counts were recorded. Pain severity was recorded preoperatively and at 6 months postoperatively. Effects of the preoperative SU levels and NLRB on the pre- and postoperative VAS scores were statistically assessed. RESULTS: Statistically significant positive correlation coefficients were determined between NLR and the preoperative and postoperative VAS scores. Negative correlation coefficients were found between the SU levels and preoperative VAS scores; in contrast, positive correlation coefficients were found between the SU levels and the postoperative VAS scores. CONCLUSION: Our results demonstrate the importance of not ignoring the serum UA level and NLR in pre- and postoperative pain in patients with LDH. Nevertheless, further extensive studies are warranted.Öğe Effects of Levetiracetam Treatment on the Autonomic Nervous System Functions in Epilepsy Patients(Kare Publ, 2020) Yilmaz, Dilek; Cigdem, BurhanettinObjectives: Sudden unexpected death in epilepsy patients is considered to be the most significant epilepsy-related cause of death, and this is associated especially with uncontrolled generalized tonic-clonic seizures, cardiac arrhythmia, decreased heart rate variability, and the use of anti-epileptic drugs. In this study, we aimed to investigate the effects of levetiracetam on the autonomic nervous system by evaluating heart rate variability (HRV) in epilepsy patients using levetiracetam. Methods: The patients, in whom levetiracetam was started in monotherapy and polytherapy, were divided into two groups in this study. The first group consisted of 29 patients with newly diagnosed epilepsy, in whom levetiracetam was started, and the second group consisted of 11 patients in whom levetiracetam was added to antiepileptic drug treatment. In patients receiving monotherapy and polytherapy, the HRV values measured before levetiracetam was started and the HRV values measured three months after starting levetiracetam in the same patient groups were compared. HRV was measured by a BVP (blood volume pulse) sensor attached to the finger by performing 10-min recordings using the Nexus/BioTrace+ brand device and with frequency-domain spectral analysis. Results: According to the measurements made before starting the treatment and in the third month of the treatment, no significant difference was obtained between the Total Power (TP), Low-Frequency power (LF), High-Frequency power (HF), Very Low-Frequency power (VLF), and LF/HF values of 29 patients taking levetiracetam in monotherapy and 11 patients taking levetiracetam in polytherapy. Conclusion: This study demonstrated that the use of levetiracetam in monotherapy and polytherapy had no significant effect on the autonomic nervous system functions.Öğe Efficacy of mirtazapine in neuropathic pain model(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020) Figul Gokce, Seyda; Cigdem, BurhanettinObjective: Neuropathic pain, which is chronic pain, can affect the quality of life individuals. It can cause psychiatric problems such as depression and anxiety. Mirtazapine is an atypical antidepressant which has both noradrenergic and specific serotonergic receptor antagonism and shown to have anxiolytic, anti-emetic and appetite stimulating effects along with its antidepressant effect. It is generally tolerated better and has a different way of action when compared with other antidepressants used to treat neuropathic pain. Thus, we aimed to investigate its potential preventive effect in neuropathic pain in nerve ligated rat model. Methods: Forty rats were divided into five groups including the sham, the sciatic nerve ligation group and the third, fourth and fifth sciatic nerve ligation+mirtazepine groups which were treated with 5 mg, 10 mg and 15 mg/day mirtazapine, respectively. The tail flick and hot plate tests were performed on all the five groups, and the latency times were measured. Morphine was used as a positive control agent. Results: Administration of mirtazapine, restored both tail flick and hot plate latencies in a dose-dependent manner, meaning that mirtazapine is effective in treating neuropathic pain in this animal model. Mirtazapine also restored the antinociceptive response to morphine significantly. Discussion: Mirtazapine appears to be good candidate for both neuropathic pain treatment and accompanying psychiatric condition such as depression and anxiety with its dual effect on neurotransmitters.Öğe Evaluation of segmented brain regions for medical image steganography(Gazi Univ, Fac Engineering Architecture, 2021) Karakis, Rukiye; Gurkahraman, Kali; Cigdem, Burhanettin; Oztoprak, Ibrahim; Topaktas, A. SuatIn medical image steganography, diagnosis and treatment of a disease can be affected as a result of the distortion caused by the embedding data in the images. For this reason, data is embedded in the region of non-interest determined by basic techniques such as manual or thresholding, and none of these methods involve the segmentation of brain tissues such as tumours. The present study aims to hide the data used in the diagnosis and treatment of a disease without affecting the medical information in the images with a segmentation-based steganography method by combining them into one file format. Magnetic Resonance (MR) images of epilepsy patients were segmented as background, gray matter, white matter, and tumour by discrete wavelet transform (DWT) and k-means clustering-based segmentation method. The hidden data includes confidential patient information, doctor's comment, selected Electroencephalogram (EEG) signals, and EEG health reports. The high-capacity message, which encoded by DNA encryption using chaotic and hash functions, and then compressed, is hidden in the least significant bits of non-tumour pixels of images. In the study, the difference between the cover and the stego images was measured by the peak signal-to-noise ratio, the structural similarity measure, the universal quality index, and the correlation coefficient. These values were obtained as 64.0334 decibels (dB), 0.9979, 0.9971, 0.9993, respectively. A comparison of the results indicates that the proposed method combines the high capacity data of the patients in a single file format and increases both the security and recording space of medical data.Öğe H1N1-Related Encephalitis in the Postpandemic Era(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Oztoprak, Ibrahim…Öğe Is there a relationship between CSF Interleukin 34 Level and clinicoradiological activity and IgG index in patients with MS?(Elsevier Sci Ltd, 2024) Gokce, Seyda Figul; Bolayir, Asli; Cigdem, BurhanettinBackground: Multiple sclerosis is an autoimmune, inflammatory, and disabling disease that is subject to research, with the aspects of its pathogenesis awaiting clarification. It is essential to predict the prognosis of the disease and find the responsible mechanisms and molecules to become a treatment option. In this regard, researching the impact of Interleukin 34, with its immunomodulatory properties, on the clinicoradiological activity effect of MS and determining its role, if any, may be guiding. Methods: The study included 52 MS patients who underwent lumbar puncture at the diagnosis stage, and dimethyl fumarate treatment was initiated in these patients. During a one-year prospective follow-up, CSF IL-34 levels of 26 patients with clinical and/or radiological activity and 26 patients without activity were evaluated for prediction of disease activity. Additionally, CSF IL-34 levels of 26 control patients who underwent lumbar puncture due to pseudotumor cerebri but were not diagnosed with this disorder and whose CSF examinations were normal and were compared with MS patients. Our study also included the Immunoglobulin G index and investigated its relationship with IL-34. Results: The IL-34 level was higher in the MS patient group compared to the control group. No significant difference was identified between MS patient groups with and without clinical and/or radiological activity. A weak correlation without statistical significance was found between IL-34 and the IgG index. Conclusion: The IL-34 level did not correlate with clinical and radiological activity in MS patients. However, the high IL-34 level observed in the patient group in comparison with the control group may be significant for MS pathogenesis. Furthermore, IL-34 may be a useful biomarker candidate for MS diagnosis, similar to the IgG index.Öğe Magnetic Resonance Imaging in Delayed Carbon Monoxide Leukoencephalopathy: Diffusion and Spectroscopy Findings(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Yildiz, Bulent; Polat, Selim; Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin…Öğe Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients(ELSEVIER URBAN & PARTNER SP Z O O, 2018) Bolayir, Asli; Gokce, Seyda Figul; Cigdem, Burhanettin; Bolayir, Hasan Ata; Yildiz, Ozlem Kayim; Bolayir, Ertugrul; Topaktas, Suat AhmetObjective: The inflammatory process is a very important stage in the development and prognosis of acute ischemic stroke (AIS). The monocyte to high-density lipoprotein (HDL) ratio (MHR) is accepted as a novel marker for demonstrating inflammation. However, the role of MHR as a predictor of mortality in patients with AIS remains unclear. Methods: We retrospectively enrolled 466 patients who were referred to our clinic within the first 24 hours of symptom presentation and who were diagnosed with AIS between January 2008 and June 2016. Four hundred and eight controls of similar age and gender were also included. The patient group was classified into two groups according to 30-day mortality. The groups were compared in terms of monocyte counts, HDL, and MHR values. Results: The patient group had significantly higher monocyte counts and lower HDL levels; therefore, this group had higher values of MHR compared to controls. Additionally, the monocyte count and MHR value were higher, and the HDL level was lower in non-surviving patients (p < 0.001). The MHR value was also observed as a significant independent variable of 30-day mortality in patients with AIS (p < 0.001). The optimum cut-off value of MHR in predicting the 30-day mortality for patients with AIS was 17.52 (95% CI 0.95-0.98). Conclusion: Our study demonstrated that a high MHR value is an independent predictor of 30-day mortality in patients with AIS. (c) 2017 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.Öğe Neuroradiologic Findings of Intracranial Hypotension: Two Cases(TURKISH NEUROLOGICAL SOC, 2017) Yildiz, Ozlem Kayim; Donmez, Recep; Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin; Balaban, Hatice; Yildiz, Bulent; Bolayir, Ertugrul; Topaktas, Suat…Öğe Prevalence of multiple sclerosis in an urban population of Sivas province in Turkey(TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2019) Gokce, Seyda Figul; Cigdem, Burhanettin; Karaca, Sanem Nemmezi; Bolayir, Asli; Yildiz, Ozlem Kayim; Topaktas, Ahmet Suat; Balaban, HaticeBackground/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey. Materials and methods: This study sampled all registered residents of urban areas of provincial center in Sivas Province in April 2017 and 2018 January. All the included patients met the McDonald 2010 criteria. Medical records were reviewed, including all available previously acquired magnetic resonance imaging data. All patients were subsequently subjected to neurologic examination to confirm the MS diagnosis. Results: We identified 21 possible MS patients, with MS diagnosis confirmed in 19. The prevalence of MS was 288 per 100,000 inhabitants. Conclusion: For future studies, these high ratio results can be used in regional and national comparisons to determine cofactors contributing to the high prevalence of MS in our region and can help health-decision makers to better plan healthcare policies to improve neurological services and awareness about multifaceted clinical presentations of MS.Öğe Severity and frequency of restless legs syndrome in patients with familial Mediterranean fever(SAGE PUBLICATIONS LTD, 2017) Yilmaz, Samet; Cigdem, Burhanettin; Gokce, Seyda Figul; Ceyhan-Dogan, Sevil; Balaban, HaticeObjective: Restless legs syndrome (RLS) is a common sensory motor disorder. RLS an urge to move the extremities that may be accompanied by dysesthesias, and significantly affects quality of life of affected patients. The frequency of RLS is higher in different systemic inflammatory diseases. Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by attacks of polyserositis, arthritis, and fever. The prevalence of RLS in patients with FMF is unknown. This study aimed to evaluate the prevalence rate of RLS in a sample of patients with FMF and compare this prevalence with that of a matched normal population. Method: A total of 60 patients with FMF and 60 healthy controls were studied. All participants underwent a neurological examination. Diagnostic criteria as proposed by the International Restless Legs Syndrome Study Group (IRLSSG) were used to define RLS. The IRLSSG rating scale for the severity of RLS was applied to determine the severity of symptoms. Results: The prevalence of RLS was not significantly different between patients and controls. Although the mean International Restless Legs Syndrome Rating Scale (IRLSRS) scores tended to be higher in patients compared with controls, this difference was not significant. When each item of the severity scale was compared between the two groups, significantly higher scores were found in some items of the IRLSRS in patients with FMF compared with controls. Conclusion: According to this result, RLS symptoms in patients with FMF were more frequent and lasted longer than those in controls.Öğe The role of systemic immune inflammatory index in showing active lesion in patients with multiple sclerosis SII and other inflamatuar biomarker in radiological active multiple sclerosis patients(Bmc, 2023) Gokce, Seyda Figul; Bolayir, Asli; Cigdem, Burhanettin; Yildiz, BulentBackground Multiple sclerosis (MS) has two pathophysiological processes, one inflammatory and the other degenerative. We investigated the relationship between active lesions on magnetic resonance imaging showing the inflammatory phase in MS patients and serum parameters that can be used as inflammatory biomarkers. Thus, we aim to detect the inflammatory period in clinical and radiological follow-up and to reveal the period in which disease-modifying treatments are effective with serum parameters. Methods One hundred eighty-six MS patients presented to our hospital between January 2016 and November 2021 and 94 age- and sex-matched healthy volunteers were recruited for our study. While 99 patients had active lesions on magnetic resonance imaging, 87 patients did not have any active lesions. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) were determined. The SII (systemic immune inflammatory index) value was calculated according to the platelet X neutrophil/lymphocyte ratio formula. Results NLR, MLR, PLR and SII values were found to be statistically significantly higher in MS patients than in the control group. The NLR, MLR, PLR and SII were higher in the active group with gadolonium than in the group without active lesions. In addition, the cutoff values that we can use to determine the presence of active lesions were 1.53, 0.18, 117.15, and 434.45 for NLR, MLR PLR and SII, respectively. Conclusions We found that all parameters correlated with radiological activity. In addition, we showed that we can detect the inflammatory period with high sensitivity and specificity with the cutoff value used for SII and PLR. Among these easily accessible and inexpensive evaluations, we concluded that SII, including the values in the PLR formula, can come to the fore.
