Yazar "Comakli, Selim" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim Yok
    Öğe
    Teratogenic and Neurotoxic Effects of n-Butanol on Zebrafish Development
    (Wiley, 2021) Kokturk, Mine; Comakli, Selim; Ozkaraca, Mustafa; Alak, Gonca; Atamanalp, Muhammed
    In recent years, n-butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n-butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n-butanol in acute semistatic applications. Teratogenic effects such as cardiac edema, scoliosis, lordosis, head development abnormality, yolk sac edema, and tail abnormality were determined at different time intervals (24, 48, 72, 96, and 120 h). Additionally, histopathological abnormalities such as vacuole formation in brain tissue and necrosis in liver tissue were observed at high doses (500, 750, and 1,000 mg/L) in all treatment groups at 96 h. It was determined that heart rate decreased at 48, 72, and 96 h due to an increase in concentration. In addition, alcohol-induced eye size reduction (microphthalmia) and single eye formation (cyclopia) are also among the effects observed in our research findings. In conclusion, n-butanol has been observed to cause intense neurotoxic, teratogenic, and cardiotoxic effects in Zebrafish embryos and larvae.
  • Küçük Resim Yok
    Öğe
    The effect of low-level laser therapy on rat unicortical femoral defect
    (Chulalongkorn Univ, 2021) Yanmaz, Latif Emrah; Ersoz, Ugur; Okur, Sitkican; Yildirim, Betul Apaydin; Comakli, Selim; Saglam, Yavuz Selim; Dogan, Elif
    The aim of this study was to determine the effectiveness of low-level laser therapy (LLLT) in the healing of experimentally created unicortical defect (UCD) of rat femurs. Twenty-four adult Wister rats were randomly divided into 2 groups: UCD and UCD+LLLT. The animals were subdivided into 3 groups (each group had 4 animals) and then they sacrificed at day 8,15 and 22 for radiological, pathological and biochemical analysis. Bone healing was significantly different between the groups at day 15 and 22 (P < 0.05), while bone formation was significantly increased in the UCD+LLLT group at day 22 compared to the UCD group (P < 0.05). On histopathological examination, significant difference was found between the UCD and UCD+LLLT groups on the 22nd day (P < 0.05) while there was no difference on the 8th and 15th day. In the UCD group, the plasma Alkaline phosphatase activity decreased on the 15th and 22nd days, Calcium on the 15th day and Phosphorus on the 8th and 22nd days compared to the UCD+LLLT group. In addition, Glutathione levels, Plasma Catalase, Glutathione Peroxidase and Superoxide Dismutase activity significantly reduced in the UCD group compared with UCD+LLLT on the 8th, 15th and 22nd day (P < 0.05). In conclusion, LLLT applied at a dose of 904 mu m accelerates fracture healing in UCD of a rat's femur. However, this effect shows an increase after the 22nd day of LLLT application.
  • Küçük Resim Yok
    Öğe
    The effects of low-level laser therapy on polycystic ovarian syndrome in rats: three different dosages
    (Springer London Ltd, 2023) Polat, Bulent; Okur, Damla Tugce; Colak, Armagan; Yilmaz, Kader; Ozkaraca, Mustafa; Comakli, Selim
    The main objective of this in vivo study was to investigate the effect of different low-level laser therapy (LLLT) doses on polycystic ovary syndrome (PCOS). In the present experimental study, a single dosage of estradiol valerate (EV) was administered to induce PCOS in female rats. After administration of the EV for induction of PCOS, rats were divided into 5 groups (n = 8/group): C group (animals that were not exposed to any form of procedure), PC group (no treatment following EV induction), L-1 group (1 J/cm(2) LLLT treatment following EV induction), L-2 group (2 J/cm(2) LLLT treatment following EV induction), L-3 group (6 J/cm(2) LLLT treatment following EV induction). The results indicated that no significant difference was found in the serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and progesterone (P4) between the C and L-2 groups (p < 0.05). Although the serum levels of testosterone (T) were significantly higher in the C group compared with other groups (p < 0.05), the L-2 group was determined to be the closest to the C group. Additionally, the LH, FSH, and T receptor level of the L-2 group was closest to the C group. In conclusion, a 2 J/cm(2) dosage of LLLT (L-2 group) can be considered the most potentially effective treatment of PCOS in the rat. However, more studies are needed to determine the optimal dose of LLLT for the treatment of PCOS.