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    Chemistry, Biochemistry and Autoimmunity
    (Cambridge Scholars Publishing, 2021) Daştan, Taner
    Many mechanisms, molecular and cellular events, and responses are interferenced under autoimmunity. The dynamic biological system formed by the realization of the laws of the sciences of chemistry and physics is constantly in motion in maintaining metabolic activities in the body, in the fight against foreign molecules, in the formation of the immune response, and in the realization of autoimmune reactions. The formation of the immune response in living systems, the synthesis and interactions of molecules that occur during the immune response, and even the molecules that cause the immune response are all regulated with biological reactions maintained by chemical mechanisms.
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    EVALUATION OF ANTIMICROBIAL ACTIVITIES AND INVITRO CYTOTOXIC ACTIVITIES OF GUNDELIA TOURNEFORTII L. PLANT EXTRACTS
    (2019) Özaltun, Betül; Daştan, Taner
    ObjectiveKenger, Gundelia tournefortii plant from Asteraceae family, is a medicinal plant. Flowers, leaves, seeds and roots of Kenger have been reported to be usedas a source of food.Material and MethodsIn this study, it was aimed to evaluate the antimicrobial and in vitro antiproliferative properties of Kenger which fresh sprouts are peeled and eated cooked or uncooked in Sivas. The water phase and essential oil extraction of the body parts of Kenger were aimed to be evaluated in terms of their antimicrobial and in vitroantiproliferative properties.ResultsCytotoxic activities were investigated using the Breast Cancer Cell Line (MCF-7) and human endothelial cell line (HUVEC). The effects of plant extracts on cellcultures were determined by the absorbance of Eliza reader by XTT method. Kenger plant extracts have been shown to have weak antimicrobial effects withMIC values. ConclusionsIn the province of Sivas, growing parts of the plant in the spring and summer are cut and peeled into the inner parts of the nutrients. Kenger, which is used in thetreatment of various diseases, has cytotoxic effects on the cells we tested and has a weak antimicrobial effect.
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    Evaluation of Bioactivity of Ethanol and Water Extracts and Determination of Nutrient Concentrations of Laurel (Laurus nobilis) Plants Grown in İzmir Province
    (2024) Daştan, Taner; Saraç, Handan; Daştan, Sevgi Durna; Demirbaş, Ahmet
    This study was conducted to determination of ethanol and water extracts obtained from the leaves of Laurus nobilis (Laurel) plant of the general content by GC-MS analysis, antimicrobial activities of these extracts on some microorganisms, total antioxidant levels (TAS), total oxidant levels (TOS), oxidative stress index (OSI) values, anti-carcinogenic effects on various cell lines and macro and micronutrient concentrations of Laurel (Laurus nobilis) plants cultivated for decorative purposes in parks and gardens of Izmir province of Turkey. TAS, TOS, and OSI values were determined with the aid of Rel Assay Diagnostics kits. In antimicrobial activity analysis, the minimum inhibition concentration (MIC) of the plant extracts against microorganisms was determined by microdilution broth method. Staphylococcus aureus (ATCC 29213), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922), Bacillus cereus (ATCC11778), Candida albicans (ATCC 10231) and Candida tropicalis (DSM11953) microorganisms were used in this analysis. Furthermore, cytotoxic activities of plant extracts were determined by XTT method in normal rat fibroblast cell line, HUVEC, and 2 different human cancer cell lines. At the end of the study, it was found that ethanol and water extracts of the Laurel plants had no antimicrobial activity, low oxidative stress index and good antioxidant activity, and moderate cytotoxic activity on experimented cell lines. Nitrogen (N), Phosphorus (P), Potassium (P), Calcium (Ca), Magnesium (Mg), Iron (Fe), Zinc (Zn), Manganese (Mn) and Copper (Cu) concentrations of plant extracts were respectively identified as 1.68% N, 0.72% P, 1.12% K, 2.40% Ca, 0.45% Mg, 147.4 mg/kg Fe, 13.6 mg/kg Zn, 326.3 mg/kg Mn and 27.8 mg/kg Cu.
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    Preface
    (Nova Science Publishers, Inc., 2023) Daştan, Sevgi Durna; Daştan, Taner
    [No abstract available]
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    Synthesis, Characterization and Biological Activities of Novel Chiral Bis 1,2-diolcarbothioamides
    (Niyazi BULUT, 2024) Karatepe, Arzu; Koparır, Pelin; Daştan, Taner; İnci, Şule; Keser, Serhat; Çetin, Ahmet
    2,2'- bis(N-aryl-alkylhydrazine-1-carbothioamide (T1–5) were obtained by the interaction of (2R,3R)-2,3-dihydroxybutanedihydrazide (1) with five different isothiocyanate alkyl(aryl) derivatives. The structures of the final compounds were confirmed by elemental analyses, FT-IR, ¹H-NMR and ¹³C-NMR. The antioxidant, antimicrobial and anticancer properties of the synthesized compounds were also investigated. Three of the triazole derivatives with p-tolyl, benzyl and phenyl substituents (T3–5) displayed good antioxidant and anticancer activity in comparison to the standards.